Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
9
We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Read More
8
We explored the impact of folic acid supplementation on stroke risk by analyzing data from 21 randomized clinical trials involving over 115,000 participants.
This study revealed that folic acid reduces stroke risk by about 10%. Interestingly, it appeared more effective in areas without grain fortification and among individuals without a prior history of stroke or heart attack.
These findings suggest that folic acid could play a vital role in preventing strokes, particularly in specific populations.
This study revealed that folic acid reduces stroke risk by about 10%. Interestingly, it appeared more effective in areas without grain fortification and among individuals without a prior history of stroke or heart attack.
These findings suggest that folic acid could play a vital role in preventing strokes, particularly in specific populations.
Read More
8
We examined how tetrahydrofolate (THF), a form of folic acid, helps cognitive recovery after intracerebral hemorrhage (ICH), a common type of hemorrhagic stroke.
THF was shown to boost the growth of neural stem cells, supporting new brain cell formation. This, in turn, appears to enhance cognitive abilities following ICH. We discovered that THF works by lowering elevated PTEN levels and promoting important pathways for brain health.
While these findings offer hope, more research is needed to fully understand THF's benefits on cognition post-stroke.
THF was shown to boost the growth of neural stem cells, supporting new brain cell formation. This, in turn, appears to enhance cognitive abilities following ICH. We discovered that THF works by lowering elevated PTEN levels and promoting important pathways for brain health.
While these findings offer hope, more research is needed to fully understand THF's benefits on cognition post-stroke.
Read More
Most Useful Reviews
7.5
Beautiful skin
1 people found this helpful
Folic Acid is crucial. I take 6 pills twice a day, and it enhances my skin's appearance almost immediately. It also serves to prevent strokes. NOW usually offers excellent products.
Read More
6
Strengthens immunity
Profitable product: our immunity requires folic acid. A strong immune system protects us. I also wish to strengthen my blood vessels with this vitamin, as heart attacks and strokes are all too common. Folic acid may also support my nervous system and improve my mood. The dosage is suitable, and the supply will last a long time. I wish everyone good health!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.4
- All Researches
9
We explored the effects of folic acid and homocysteine levels on the outcomes of ischemic stroke in over 3,500 patients. Our findings revealed that higher folate levels were linked to a 29% lower risk of severe complications, such as death or major disability, within three months after a stroke.
In contrast, elevated homocysteine levels significantly increased the risk, suggesting that homocysteine may mediate some benefits of folate. Overall, maintaining high folate levels may play a protective role following ischemic stroke.
In contrast, elevated homocysteine levels significantly increased the risk, suggesting that homocysteine may mediate some benefits of folate. Overall, maintaining high folate levels may play a protective role following ischemic stroke.
Read More
9
We explored how platelet activation measures and specific genetic factors might shape the effectiveness of folic acid in preventing strokes. Our analysis, based on data from the China Stroke Primary Prevention Trial with over 11,000 hypertensive adults, revealed that individuals with low plateletcrit and certain MTHFR genotypes experienced significant benefits from folic acid treatment. Specifically, this group saw a striking 66% reduction in stroke risk. Thus, identifying low plateletcrit could help target folic acid treatment to those at highest risk.
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9
We examined a case involving a young man in his late 20s who suffered a sudden ischemic stroke. This incident was surprisingly linked to elevated homocysteine levels, a risk factor often associated with stroke. Through our observations, it became clear that hyperhomocysteinemia is an important factor to consider, even among younger adults who might otherwise seem healthy.
Following the stroke, the patient received targeted treatment along with a regimen that included folic acid, vitamin B6, vitamin B12, and methylcobalamin. As a result, we saw significant improvement in his condition, culminating in his discharge with normalized homocysteine levels.
Highlighting this case is particularly important in regions like Pakistan, where hyperhomocysteinemia is notably prevalent. Our experience emphasizes the need for healthcare providers to thoroughly evaluate potential stroke causes, including the role of homocysteine, especially in younger populations.
Following the stroke, the patient received targeted treatment along with a regimen that included folic acid, vitamin B6, vitamin B12, and methylcobalamin. As a result, we saw significant improvement in his condition, culminating in his discharge with normalized homocysteine levels.
Highlighting this case is particularly important in regions like Pakistan, where hyperhomocysteinemia is notably prevalent. Our experience emphasizes the need for healthcare providers to thoroughly evaluate potential stroke causes, including the role of homocysteine, especially in younger populations.
Read More
9
We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Read More
8
We investigated the link between serum folate levels and stroke risk over ten years in a community-based study of nearly 5,000 participants.
Our findings revealed that those in the highest folate group had a lower risk for strokes compared to those with minimal folate. Specifically, elevated folate resulted in a significant reduction in hazard ratio for strokes and ischemic strokes.
Interestingly, homocysteine levels appeared to play a substantial role in this relationship, while certain genetic factors influenced the association as well. Overall, inadequate folate concentrations were tied to increased stroke risk.
Our findings revealed that those in the highest folate group had a lower risk for strokes compared to those with minimal folate. Specifically, elevated folate resulted in a significant reduction in hazard ratio for strokes and ischemic strokes.
Interestingly, homocysteine levels appeared to play a substantial role in this relationship, while certain genetic factors influenced the association as well. Overall, inadequate folate concentrations were tied to increased stroke risk.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Beautiful skin
1 people found this helpful
Folic Acid is crucial. I take 6 pills twice a day, and it enhances my skin's appearance almost immediately. It also serves to prevent strokes. NOW usually offers excellent products.
Read More
6
Strengthens immunity
Profitable product: our immunity requires folic acid. A strong immune system protects us. I also wish to strengthen my blood vessels with this vitamin, as heart attacks and strokes are all too common. Folic acid may also support my nervous system and improve my mood. The dosage is suitable, and the supply will last a long time. I wish everyone good health!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Hu X, Jiang Y. The impact of SLCO1B1 polymorphisms on homocysteine concentrations: evidence for a stronger association in men. Front Nephrol. 2024;4:1465380. doi:10.3389/fneph.2024.1465380
- Liang Z, Fan F, Liu B, Li K, Chen H, et al. Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses. Nutrients. 2024;17. doi:10.3390/nu17010159
- Chen X, Bishai D. Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue. BMC Public Health. 2024;24:3540. doi:10.1186/s12889-024-21005-7
- Kadali S, Radhika A, Kanaka Durga Devi YR, Sreemanthula JB, Palakonda G, et al. High penetrance and phenotypic landscape of methylenetetrahydrofolate reductase c.665 C>T polymorphism in the absence of folate fortification. Clin Nutr ESPEN. 2025;65:126. doi:10.1016/j.clnesp.2024.11.027
- Shi M, Zheng J, Liu Y, Mao X, Wu X, et al. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke. J Am Heart Assoc. 2024;13:e036527. doi:10.1161/JAHA.124.036527
- Yaldiko A, Coonrod S, Marella P, Hurley L, Jadavji NM. Maternal dietary deficiencies in folic acid or choline reduce primary neuron viability after exposure to hypoxia through increased levels of apoptosis. Nutr Neurosci. 2024. doi:10.1080/1028415X.2024.2398365
- Yang J, Wang J, Li B, Zhang Y. Folic acid for the primary prevention of stroke: a systematic review and meta-analysis. Front Nutr. 2024;11:1288417. doi:10.3389/fnut.2024.1288417
- Zhang N, Zhou Z, Chi X, Fan F, Li S, et al. Folic acid supplementation for stroke prevention: A systematic review and meta-analysis of 21 randomized clinical trials worldwide. Clin Nutr. 2024;43:1706. doi:10.1016/j.clnu.2024.05.034
- Zhang X, Zhang Q, Zhang Q, Wang H, Yin Y, et al. Tetrahydrofolate Attenuates Cognitive Impairment after Hemorrhagic Stroke by Promoting Hippocampal Neurogenesis via PTEN Signaling. eNeuro. 2024;11. doi:10.1523/ENEURO.0021-24.2024
- Shi Y, Zhang Z, Wang B, Wang Y, Kong X, et al. Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention. Signal Transduct Target Ther. 2024;9:110. doi:10.1038/s41392-024-01817-0
- Zhang N, Wu Z, Bai X, Song Y, Li P, et al. Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review. Am J Clin Nutr. 2024;119:821. doi:10.1016/j.ajcnut.2023.12.021
- Chi X, Zhang N, Fan F, Jia J, Zheng J, et al. Systemic immune-inflammation index predicts first stroke and affects the efficacy of folic acid in stroke prevention. Heliyon. 2024;10:e24837. doi:10.1016/j.heliyon.2024.e24837
- Nri-Ezedi CA, Ulasi T, Efobi CC, Aneke JC, Ugwu N, et al. Bloodless management of significantly elevated transcranial Doppler velocity value in a Jehovah's witness child with sickle cell disease: A tertiary centre experience-A case report. J Natl Med Assoc. 2024;116:247. doi:10.1016/j.jnma.2024.01.016
- Li ZC, Huang M, Yao QY, Lin CH, Hong BC, et al. Association between Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia. J Integr Neurosci. 2024;23:3. doi:10.31083/j.jin2301003
- Wang P, Huang Y, Sun B, Chen H, Ma Y, et al. Folic acid blocks ferroptosis induced by cerebral ischemia and reperfusion through regulating folate hydrolase transcriptional adaptive program. J Nutr Biochem. 2024;124:109528. doi:10.1016/j.jnutbio.2023.109528
- Bennett DA, Parish S, Millwood IY, Guo Y, Chen Y, et al. MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults. Int J Epidemiol. 2023;52:1862. doi:10.1093/ije/dyad147
- Gonçalves-Pereira J, Mergulhão P, Froes F. Medications to Modify Aspiration Risk: Those That Add to Risk and Those That May Reduce Risk. Semin Respir Crit Care Med. 2024;45:694. doi:10.1055/s-0044-1791827
- Zhou L, Wang J, Wu H, Yu P, He Z, et al. Serum levels of vitamin B12 combined with folate and plasma total homocysteine predict ischemic stroke disease: a retrospective case-control study. Nutr J. 2024;23:76. doi:10.1186/s12937-024-00977-7
- Moti Wala S, AlEdani EM, Samuel EA, Ahmad K, Manongi NJ, et al. Exploring the Nexus: A Systematic Review on the Interplay of the Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T Genotype, Hyperhomocysteinemia, and Spontaneous Cervical/Vertebral Artery Dissection in Young Adults. Cureus. 2024;16:e60878. doi:10.7759/cureus.60878
- Rafay A, Abdul Fatir C, Hiba HT, Jamil M, Talha Awan M. Hyperhomocysteinemia Presenting as Stroke in a Young Individual: A Case Report. Cureus. 2024;16:e52381. doi:10.7759/cureus.52381
- Zhang J, Liao Q, Chen H, Liu F, Sun D, et al. Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression. Neuropsychiatr Dis Treat. 2024;20:2289. doi:10.2147/NDT.S480417
- Atam V, Srivastava S, Sharma A, Atam I, Tewari J, et al. Serum Vitamin B12 Levels as a Risk Factor and Prognostic Marker in Patients With Acute Ischemic Stroke at a Tertiary Care Center in Northern India: A Case-Control Study. Cureus. 2024;16:e70473. doi:10.7759/cureus.70473
- Jung E, Kook HY, Ryu SJ, Ryu HH, Kim HG. The Association of Vitamin B-12 Plasma Concentration with Stroke Incidence According to Sex. J Nutr. 2024;154:3012. doi:10.1016/j.tjnut.2024.08.002
- Ge Y, Yang C, Zadeh M, Sprague SM, Lin YD, et al. Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice. iScience. 2024;27:109480. doi:10.1016/j.isci.2024.109480
- Reis da Silva T. Can supplementing vitamin B12 improve mental health outcomes?: a literature review. Br J Community Nurs. 2024;29:137. doi:10.12968/bjcn.2024.29.3.137
- Zhang P, Xie X, Zhang Y. Associations between homocysteine and B vitamins and stroke: a cross-sectional study. Front Neurol. 2023;14:1184141. doi:10.3389/fneur.2023.1184141
- Park EJ. Association between vitamin B12 status and heart rate variability in patients with ischemic stroke. Medicine (Baltimore). 2023;102:e33428. doi:10.1097/MD.0000000000033428
- Rasyid A, Mesiano T, Kurniawan M, Hidayat R, Eddy Yunus R, et al. Comprehensive Management of Acute Ischemic Stroke in Psoriatic Patient. Case Rep Dermatol Med. 2023;2023:6580971. doi:10.1155/2023/6580971
