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SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
USERS' SCORE
Good
Based on 8 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Zinc(from 270 mg Zinc Picolinate)
50 mg
455%
Top Medical Research Studies
8
Zinc's role in cancer immunity
cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance.
Strong link between zinc and immunity
We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.
By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.
Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.
Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.
By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.
Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.
Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.
Read More
9
Zinc works alongside nanomedicine
Cascade specific endogenous Fe interference and catalysis for tumor therapy with stemness suppression.
Relevance score indicates effectiveness
We investigated an innovative approach to cancer treatment by using a special nanomedicine that combines zinc with a compound called 2,5-dihydroxyterephthalic acid (DHT). This combination aims to target the cancer stem-like cells, which are known for their role in tumor recurrence and spread.
The nanomedicine works by effectively pulling in the cancer's own iron and releasing zinc. This process not only helps in reducing the iron levels in tumors but also enhances the production of reactive oxygen species (ROS), which are crucial for damaging cancer cells. By lowering iron, we push the cancer stem cells towards differentiation, while the increased ROS levels help trigger cell death.
What's especially compelling about our findings is that this treatment appears to tackle both aggressive cancer stem-like cells and the bulk of the tumor, showing promise in preventing cancer growth, recurrence, and metastasis. The results have been especially notable in cases of triple-negative breast tumors, providing an exciting potential path for future cancer therapies that take advantage of these properties.
The nanomedicine works by effectively pulling in the cancer's own iron and releasing zinc. This process not only helps in reducing the iron levels in tumors but also enhances the production of reactive oxygen species (ROS), which are crucial for damaging cancer cells. By lowering iron, we push the cancer stem cells towards differentiation, while the increased ROS levels help trigger cell death.
What's especially compelling about our findings is that this treatment appears to tackle both aggressive cancer stem-like cells and the bulk of the tumor, showing promise in preventing cancer growth, recurrence, and metastasis. The results have been especially notable in cases of triple-negative breast tumors, providing an exciting potential path for future cancer therapies that take advantage of these properties.
Read More
8
Zinc's role in cancer immunity
Implanted Microneedles Loaded with Sparfloxacin and Zinc-Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple-Negative Breast Cancer to Prevent Recurrence and Metastasis.
Significant cancer treatment findings
We investigated the impact of zinc, specifically when combined with manganese sulfide, on preventing the recurrence of triple-negative breast cancer (TNBC) post-surgery. This approach involved microneedles loaded with Sparfloxacin and zinc-manganese sulfide, which were targeted for localized treatment to enhance immune response while also addressing wound infection risk.
Through this innovative design, we observed that the zinc-manganese formulation not only displayed strong antimicrobial and antibiofilm properties but also played a role in promoting immune activation. This led to significant reductions in tumor growth and lung metastasis, alongside improved wound healing. The therapy activated key immune pathways, particularly the cGAS-STING pathway, which further bolstered the body’s ability to fight cancer cells.
Overall, the results suggest that zinc, paired with manganese, can provide an effective strategy for enhancing both local and systemic immune responses. This has promising implications for preventing cancer recurrence, particularly in challenging cases like TNBC, paving the way for potential new treatment approaches in oncology.
Through this innovative design, we observed that the zinc-manganese formulation not only displayed strong antimicrobial and antibiofilm properties but also played a role in promoting immune activation. This led to significant reductions in tumor growth and lung metastasis, alongside improved wound healing. The therapy activated key immune pathways, particularly the cGAS-STING pathway, which further bolstered the body’s ability to fight cancer cells.
Overall, the results suggest that zinc, paired with manganese, can provide an effective strategy for enhancing both local and systemic immune responses. This has promising implications for preventing cancer recurrence, particularly in challenging cases like TNBC, paving the way for potential new treatment approaches in oncology.
Read More
Most Useful Reviews
9.5
Reduces cancer risk
Zinc effectively stimulates the immune system and shortens the duration of colds. It aids vision and reduces the risk of age-related macular degeneration. As an antioxidant, zinc plays a vital role in reducing oxidative stress and therefore lowers cancer risk.
Read More
8.8
Best value Zinc
Best value zinc! It's crucial for immunity and helps fight colds, while supporting heart and liver health. I recommend taking it before meals. This Allmax creatine is great quality and value too. Happy to share this information as it is so beneficial.
Read More
7.5
Cancer consideration
I love this zinc that excludes copper, as I'm managing cancer and want to avoid copper's metastatic effects. It’s a relief to find a good quality product that fits my health needs. Thank you, iherb!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
9
Zinc enhances TNBC treatment efficacy
Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy.
Zinc's role is complex here
We developed an innovative treatment approach for triple-negative breast cancer (TNBC) using zinc-copper bimetallic nanoplatforms. These specially designed nanostructures help promote a type of cell death known as cuproptosis while also boosting the immune system's response to tumors. By leveraging these properties, we aimed to find a way to make existing immune therapies more effective against TNBC, which is notoriously difficult to treat.
The mechanism behind this approach involves the nanoplatforms releasing both zinc and copper ions within the acidic environment of tumors. This releases hydroxyl radicals and impacts certain proteins in cancer cells, disrupting their function and leading to cell death. Additionally, the released mitochondrial DNA works alongside zinc to activate pathways that boost the immune response, ultimately helping to improve the effectiveness of anti-PD-L1 treatments.
Furthermore, we observed that using a near-infrared laser significantly enhances these effects. Together, the combination of our nanoplatforms and immune therapies results in a powerful treatment strategy, showcasing zinc's potential role in fighting TNBC.
Overall, our findings suggest a promising new direction for TNBC therapy by uniting the benefits of cuproptosis, immune activation, and laser therapy.
The mechanism behind this approach involves the nanoplatforms releasing both zinc and copper ions within the acidic environment of tumors. This releases hydroxyl radicals and impacts certain proteins in cancer cells, disrupting their function and leading to cell death. Additionally, the released mitochondrial DNA works alongside zinc to activate pathways that boost the immune response, ultimately helping to improve the effectiveness of anti-PD-L1 treatments.
Furthermore, we observed that using a near-infrared laser significantly enhances these effects. Together, the combination of our nanoplatforms and immune therapies results in a powerful treatment strategy, showcasing zinc's potential role in fighting TNBC.
Overall, our findings suggest a promising new direction for TNBC therapy by uniting the benefits of cuproptosis, immune activation, and laser therapy.
Read More
9
Zinc works alongside nanomedicine
Cascade specific endogenous Fe interference and catalysis for tumor therapy with stemness suppression.
Relevance score indicates effectiveness
We investigated an innovative approach to cancer treatment by using a special nanomedicine that combines zinc with a compound called 2,5-dihydroxyterephthalic acid (DHT). This combination aims to target the cancer stem-like cells, which are known for their role in tumor recurrence and spread.
The nanomedicine works by effectively pulling in the cancer's own iron and releasing zinc. This process not only helps in reducing the iron levels in tumors but also enhances the production of reactive oxygen species (ROS), which are crucial for damaging cancer cells. By lowering iron, we push the cancer stem cells towards differentiation, while the increased ROS levels help trigger cell death.
What's especially compelling about our findings is that this treatment appears to tackle both aggressive cancer stem-like cells and the bulk of the tumor, showing promise in preventing cancer growth, recurrence, and metastasis. The results have been especially notable in cases of triple-negative breast tumors, providing an exciting potential path for future cancer therapies that take advantage of these properties.
The nanomedicine works by effectively pulling in the cancer's own iron and releasing zinc. This process not only helps in reducing the iron levels in tumors but also enhances the production of reactive oxygen species (ROS), which are crucial for damaging cancer cells. By lowering iron, we push the cancer stem cells towards differentiation, while the increased ROS levels help trigger cell death.
What's especially compelling about our findings is that this treatment appears to tackle both aggressive cancer stem-like cells and the bulk of the tumor, showing promise in preventing cancer growth, recurrence, and metastasis. The results have been especially notable in cases of triple-negative breast tumors, providing an exciting potential path for future cancer therapies that take advantage of these properties.
Read More
8
Zinc's role in cancer immunity
Implanted Microneedles Loaded with Sparfloxacin and Zinc-Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple-Negative Breast Cancer to Prevent Recurrence and Metastasis.
Significant cancer treatment findings
We investigated the impact of zinc, specifically when combined with manganese sulfide, on preventing the recurrence of triple-negative breast cancer (TNBC) post-surgery. This approach involved microneedles loaded with Sparfloxacin and zinc-manganese sulfide, which were targeted for localized treatment to enhance immune response while also addressing wound infection risk.
Through this innovative design, we observed that the zinc-manganese formulation not only displayed strong antimicrobial and antibiofilm properties but also played a role in promoting immune activation. This led to significant reductions in tumor growth and lung metastasis, alongside improved wound healing. The therapy activated key immune pathways, particularly the cGAS-STING pathway, which further bolstered the body’s ability to fight cancer cells.
Overall, the results suggest that zinc, paired with manganese, can provide an effective strategy for enhancing both local and systemic immune responses. This has promising implications for preventing cancer recurrence, particularly in challenging cases like TNBC, paving the way for potential new treatment approaches in oncology.
Through this innovative design, we observed that the zinc-manganese formulation not only displayed strong antimicrobial and antibiofilm properties but also played a role in promoting immune activation. This led to significant reductions in tumor growth and lung metastasis, alongside improved wound healing. The therapy activated key immune pathways, particularly the cGAS-STING pathway, which further bolstered the body’s ability to fight cancer cells.
Overall, the results suggest that zinc, paired with manganese, can provide an effective strategy for enhancing both local and systemic immune responses. This has promising implications for preventing cancer recurrence, particularly in challenging cases like TNBC, paving the way for potential new treatment approaches in oncology.
Read More
8
Zinc may lower prostate cancer risk
Association of composite dietary antioxidant index with high risk of prostate cancer in middle-aged and elderly men: insights from NHANES.
Highlights zinc's protective role
Our exploration focused on how dietary antioxidants, particularly zinc, relate to prostate cancer risks in middle-aged and older men. We used data from the National Health and Nutrition Examination Survey, which included over 5,600 participants, to investigate these associations.
We discovered that higher levels of a composite dietary antioxidant index, which includes zinc, were linked to a reduced risk of prostate cancer. Specifically, zinc and selenium showed strong protective effects. This implies that including adequate amounts of these nutrients in our diet may help lower prostate cancer risk.
Ultimately, our findings suggest that maintaining a diet rich in antioxidants, like zinc, could offer significant benefits for prostate health, especially among older men. It's a fascinating area of research that underscores the importance of nutrition in cancer prevention.
We discovered that higher levels of a composite dietary antioxidant index, which includes zinc, were linked to a reduced risk of prostate cancer. Specifically, zinc and selenium showed strong protective effects. This implies that including adequate amounts of these nutrients in our diet may help lower prostate cancer risk.
Ultimately, our findings suggest that maintaining a diet rich in antioxidants, like zinc, could offer significant benefits for prostate health, especially among older men. It's a fascinating area of research that underscores the importance of nutrition in cancer prevention.
Read More
8
Zinc's role in cancer immunity
cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance.
Strong link between zinc and immunity
We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.
By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.
Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.
Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.
By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.
Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.
Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.7
9.5
Reduces cancer risk
Zinc effectively stimulates the immune system and shortens the duration of colds. It aids vision and reduces the risk of age-related macular degeneration. As an antioxidant, zinc plays a vital role in reducing oxidative stress and therefore lowers cancer risk.
9.5
Vital for cancer treatment
Taking Zinc Picolinate protects against oxidative stress and aids metabolism. It's crucial for numerous body functions, including insulin formation and immune support. Zinc deficiency is linked to several health issues, including cancer, and can affect overall health significantly.
Read More
9.5
Quality matters
Doctors suggest taking zinc in the morning, with certain forms taken before meals. Zinc aids enzyme production and supports blood and collagen synthesis for healing. I appreciate the natural ingredients and excellent quality of this product, which benefits my health.
9.5
Effective zinc supplement
Doctors recommend taking zinc in the morning for best results. It's vital for over 100 enzymes and supports collagen synthesis, vital for healing. I find this product's quality exceptional, with natural ingredients and impressive health benefits for cancer prevention.
8.8
Best value Zinc
Best value zinc! It's crucial for immunity and helps fight colds, while supporting heart and liver health. I recommend taking it before meals. This Allmax creatine is great quality and value too. Happy to share this information as it is so beneficial.
