Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.
We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.
Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.
Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.
Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
Read More
9
Zinc gel improves menopausal symptoms
Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study.
We evaluated the impact of a zinc-containing vaginal moisturizer gel on postmenopausal women experiencing genitourinary symptoms of menopause (GSM). Some women hesitate to use hormonal treatments like vaginal estrogen, which can be highly effective. To explore an alternative, we asked 37 participants to apply the gel daily for two weeks while tracking their symptoms.
Throughout the study, we used various methods to assess improvement. The Vaginal Health Index, which measures vaginal health, showed significant improvement after treatment. We also noted that participants reported reduced levels of vaginal pain and dryness on a visual analog scale, with the most notable benefit occurring for vaginal dryness. Additionally, the vulvovaginal symptom questionnaire indicated a substantial decrease in overall symptoms. Notably, side effects were minor and infrequent, which is encouraging for those considering this option.
In summary, our findings suggest that a novel zinc-containing vaginal moisturizer gel can effectively alleviate postmenopausal vulvovaginal symptoms without serious side effects, providing a viable solution for women who prefer non-hormonal treatments.
Read More
8
Zinc enhances antioxidant protection
Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial.
We assessed how zinc (Zn) supplementation can impact the health of postmenopausal women, particularly regarding their antioxidant status. In this study, fifty-one women participating were split into two groups: one receiving a placebo treatment and the other receiving zinc supplements. This double-blind randomized trial lasted for eight weeks and focused on measuring changes in mineral status along with different antioxidant markers in the blood.
Before the intervention, we noticed that many participants had low zinc levels, which can lead to weakened antioxidant defenses—especially critical for postmenopausal women due to hormonal changes. After eight weeks of zinc supplementation, we saw a marked improvement in zinc levels among the women receiving the supplements. There were also significant positive correlations between zinc levels and overall antioxidant capacity, as well as specific antioxidant enzymes like glutathione peroxidase.
From our findings, it seems clear that zinc supplementation is a promising way to address deficiencies and bolster antioxidant defenses in postmenopausal women. This could not only support their nutritional health but might also contribute positively to their overall well-being during this transitional life stage.
Read More
Most Useful Reviews
6
High dosage caution
7 people found this helpful
While this zinc form is bioavailable, caution is needed with dosages. High levels can deplete copper, leading to anaemia. Zinc is vital for ovarian, prostate, and thyroid health, and helps mitigate menopause symptoms, but this particular product didn’t contain copper in its formula.
Read More
7.5
Energy boost
5 people found this helpful
As a 63-year-old male, I began taking this due to a decline in energy and male function, which I attribute to menopause. The capsules are easy to swallow, and I noticed immediate effects. I have been using them daily since their arrival, and the packaging is compact.
Read More
9
Menopause relief
This has significantly helped my wife with her menopause problems.
Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.
We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.
Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.
Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.
Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
Read More
9
Zinc gel improves menopausal symptoms
Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study.
We evaluated the impact of a zinc-containing vaginal moisturizer gel on postmenopausal women experiencing genitourinary symptoms of menopause (GSM). Some women hesitate to use hormonal treatments like vaginal estrogen, which can be highly effective. To explore an alternative, we asked 37 participants to apply the gel daily for two weeks while tracking their symptoms.
Throughout the study, we used various methods to assess improvement. The Vaginal Health Index, which measures vaginal health, showed significant improvement after treatment. We also noted that participants reported reduced levels of vaginal pain and dryness on a visual analog scale, with the most notable benefit occurring for vaginal dryness. Additionally, the vulvovaginal symptom questionnaire indicated a substantial decrease in overall symptoms. Notably, side effects were minor and infrequent, which is encouraging for those considering this option.
In summary, our findings suggest that a novel zinc-containing vaginal moisturizer gel can effectively alleviate postmenopausal vulvovaginal symptoms without serious side effects, providing a viable solution for women who prefer non-hormonal treatments.
Read More
8
Zinc enhances antioxidant protection
Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial.
We assessed how zinc (Zn) supplementation can impact the health of postmenopausal women, particularly regarding their antioxidant status. In this study, fifty-one women participating were split into two groups: one receiving a placebo treatment and the other receiving zinc supplements. This double-blind randomized trial lasted for eight weeks and focused on measuring changes in mineral status along with different antioxidant markers in the blood.
Before the intervention, we noticed that many participants had low zinc levels, which can lead to weakened antioxidant defenses—especially critical for postmenopausal women due to hormonal changes. After eight weeks of zinc supplementation, we saw a marked improvement in zinc levels among the women receiving the supplements. There were also significant positive correlations between zinc levels and overall antioxidant capacity, as well as specific antioxidant enzymes like glutathione peroxidase.
From our findings, it seems clear that zinc supplementation is a promising way to address deficiencies and bolster antioxidant defenses in postmenopausal women. This could not only support their nutritional health but might also contribute positively to their overall well-being during this transitional life stage.
Read More
8
Zinc improves nutritional markers post-menopause
Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population.
In our study, we examined how zinc supplementation could affect menopausal women, particularly focusing on markers like homocysteine, vitamin B, and folate levels. We worked with 51 postmenopausal women aged between 44 and 76 years, dividing them into two groups: one received a placebo, while the other was given 50 mg of zinc daily for eight weeks.
After analyzing the results, we found that those who took zinc showed significantly higher folate levels compared to their baseline measurements. Additionally, we observed a noteworthy decrease in homocysteine levels when comparing the two groups after the intervention. Interestingly, we also noted a strong correlation between higher folate and vitamin B levels with lower homocysteine levels in the zinc group.
These findings suggest that zinc supplementation can have positive effects on certain nutritional markers in menopausal women. However, we emphasize the need for further research with larger sample sizes and refined dosing to validate and expand upon our results.
Read More
7
Zinc impacts postmenopausal obesity
Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice - Implications for postmenopausal obesity.
We investigated the effects of dietary zinc on obesity related to menopause, particularly in female mice that underwent ovariectomy (Ovx). Our findings revealed that excess zinc led to significant weight gain and symptoms resembling Cushing's syndrome, even though these mice did not consume more food.
The accumulation of zinc in the adrenal glands played a crucial role by interfering with steroid production. This is particularly important since, in Ovx mice, adrenal steroids are the only source of estrogen. The lack of estrogen triggered adrenal hyperplasia and an increase in glucocorticoids, which contributed to the development of Cushing's-like symptoms.
Interestingly, our results showed that supplementing with adrenal steroids could counteract the negative impacts of excess zinc. We also found a positive correlation between plasma zinc levels and cortisol while noting a negative correlation with adrenal steroids and estrogen levels in overweight postmenopausal women.
These insights suggest that it may be beneficial for postmenopausal women to avoid high dietary zinc and consider adrenal steroid supplementation to help manage obesity effectively.
While this zinc form is bioavailable, caution is needed with dosages. High levels can deplete copper, leading to anaemia. Zinc is vital for ovarian, prostate, and thyroid health, and helps mitigate menopause symptoms, but this particular product didn’t contain copper in its formula.
Read More
7.5
Energy boost
5 people found this helpful
As a 63-year-old male, I began taking this due to a decline in energy and male function, which I attribute to menopause. The capsules are easy to swallow, and I noticed immediate effects. I have been using them daily since their arrival, and the packaging is compact.
Read More
9
Menopause relief
This has significantly helped my wife with her menopause problems.
Read More
7.5
Oily skin control
The zinc picolinate works well for our family. It's a small capsule, which I appreciate. I use it for controlling oily skin and menopause issues, and I feel it strengthens our immune systems effectively.
Read More
7.5
Menopause support
Regular zinc supplementation helps maintain this essential trace element in the body and addresses deficiencies related to skin issues, memory, and vision. It's particularly crucial over 40 to manage age-related changes, including menopause and male erectile dysfunction.
Menopause is a natural biological process that marks the end of a woman's reproductive years, characterized by the cessation of menstruation and a decline in hormonal levels, particularly estrogen and progesterone. Typically occurring between the ages of 45 and 55, menopause can bring a variety of physical and emotional changes. Common symptoms may include hot flashes, night sweats, mood swings, and changes in sleep patterns. It is important to note that menopause is a gradual process and often begins with perimenopause, where women may experience irregular periods and increased symptoms for several years before periods stop completely.
While menopause is a natural phase of life, it can have significant impacts on a woman's health and well-being. This transition can increase the risk of certain health issues, such as osteoporosis and cardiovascular disease, due in part to lowered hormone levels. Therefore, it is advisable for women to consult with healthcare providers to discuss potential management strategies and lifestyle adjustments during this time. These may include hormone replacement therapy, dietary changes, regular physical activity, and alternative therapies, all aimed at alleviating symptoms and promoting overall health during and after menopause.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc may play a supportive role during menopause, as it is known for its importance in numerous bodily functions, including immune response and hormone regulation. Some studies suggest that adequate zinc levels might help alleviate certain menopausal symptoms, such as mood swings, sleep disturbances, and fatigue. Additionally, zinc contributes to bone health, which is particularly important during menopause, as the decline in estrogen levels can lead to increased bone density loss.
However, it's worth noting that while zinc can contribute to overall health, it should not be viewed as a primary treatment for menopause-related symptoms. Women experiencing significant discomfort or health changes during menopause should consult a healthcare provider for personalized advice and treatment options. Supplementation of zinc should be approached with caution, as excessive intake can lead to adverse health effects. In summary, while zinc may offer some benefits during menopause, more research is needed to fully understand its impact and effectiveness.
Based on user reviews, individuals taking this supplement for menopause commonly report varying timelines for experiencing noticeable results. Some users mention immediate effects after beginning supplementation, particularly highlighting improved energy levels and overall well-being, which are critical during menopause Read Review. Other reviews reflect significant improvements over a longer timeframe, suggesting that while immediate benefits can occur, the most substantial effects may take a few weeks of consistent use Read Review.
Furthermore, it's noted that regular zinc supplementation is crucial for addressing menopause-related issues and maintaining overall health, particularly for those over 40 Read Review. This indicates that while some may feel relief relatively quickly, continued daily intake is essential for optimal benefits. Users recommend maintaining a consistent regimen to effectively support the body's needs during menopause.
Zinc supplementation has garnered attention in recent studies for its potential benefits for postmenopausal women. Research indicates that zinc can improve antioxidant status, bolster vitamin D levels, and positively influence key nutritional markers during menopause. In a randomized trial, postmenopausal women who supplemented with zinc showed significant improvements in folate levels and reductions in homocysteine levels [3]. Additionally, zinc supplementation has been linked to enhanced antioxidant capacity and specific antioxidant enzyme activity, vital for managing hormonal changes during this transitional phase [2].
Moreover, zinc's role extends to addressing genitourinary symptoms associated with menopause. A study evaluated a zinc-containing vaginal moisturizer, which was effective in alleviating symptoms such as vaginal dryness and pain, offering a non-hormonal option for those reluctant to use hormonal treatments [7]. While further research is needed to fully understand the implications of zinc supplementation, these findings suggest a promising avenue for supporting menopausal health [4].
Based on user reviews, many individuals have reported significant improvements in menopause symptoms, particularly among middle-aged women. One review indicated that a user’s spouse experienced notable relief from menopause-related issues after starting supplementation, highlighting the product's effectiveness in addressing common discomforts associated with this life stage Read Review. Another user, while not a woman themselves, shared that they experienced immediate boosts in energy and male function, indicating broader benefits related to hormonal balance Read Review.
Additionally, several users acknowledged the importance of maintaining consistent zinc intake to combat deficiencies that can exacerbate menopause symptoms and enhance overall health, particularly as one ages. Some have noted benefits such as improved skin condition and memory function, which further illustrates the multifaceted impact of this essential trace element Read Review. While individual results can vary, the collective feedback suggests that regular zinc supplementation can play a supportive role in managing menopause-related challenges.
Based on user reviews, many individuals have reported positive outcomes when combining this zinc supplement with other supplements for managing menopause symptoms. One user noted that the zinc picolinate specifically aids in addressing menopause-related discomfort, highlighting its effectiveness when integrated into a broader supplement strategy Read Review. Additionally, another reviewer emphasized that regular zinc supplementation is crucial not only for managing menopause symptoms but also for overcoming deficiencies in nutrients that can diminish with age, particularly for those over 40 Read Review.
However, users also expressed caution regarding dosages, as high levels of zinc can lead to depletion of copper, which is essential for preventing potential issues like anemia Read Review. This suggests that while combining this supplement with others can be beneficial, it is essential to monitor dosages and possibly include a copper supplement to mitigate any adverse effects. Overall, the collective feedback indicates that a balanced approach to supplementation can effectively support women's health during menopause.
When considering zinc supplementation for treating menopause, research indicates that a daily dose of 50 mg may be optimal. One study focused on postmenopausal women showed that this dosage significantly improved markers related to folate and homocysteine levels, both critical for managing menopausal health [3]. Additionally, this same amount has been shown to enhance vitamin D levels and influence leptin balance, which is important for energy regulation [4].
It's vital to note, however, that while zinc supplementation can bolster overall well-being and alleviate specific symptoms during menopause, excess zinc may lead to negative health outcomes, as evidenced by research indicating that high dietary zinc can exacerbate obesity risks [1]. Therefore, if you're considering adding zinc to your regimen, a conservative approach starting at around 50 mg per day is advisable, while remaining mindful of potential adverse effects with higher doses.
7.5
Energy boost
5 people found this helpful
As a 63-year-old male, I began taking this due to a decline in energy and male function, which I attribute to menopause. The capsules are easy to swallow, and I noticed immediate effects. I have been using them daily since their arrival, and the packaging is compact.
9
Menopause relief
This has significantly helped my wife with her menopause problems.
7.5
Menopause improvement
Taking several courses of zinc yearly helps maintain proper trace element levels. It addresses deficiencies that affect skin, memory, and vision. It's vital for those over 40, particularly for regulating metabolism and aiding menopause in women, while also bolstering the immune system.
7.5
Oily skin control
The zinc picolinate works well for our family. It's a small capsule, which I appreciate. I use it for controlling oily skin and menopause issues, and I feel it strengthens our immune systems effectively.
7.5
Menopause support
Regular zinc supplementation helps maintain this essential trace element in the body and addresses deficiencies related to skin issues, memory, and vision. It's particularly crucial over 40 to manage age-related changes, including menopause and male erectile dysfunction.
6
High dosage caution
7 people found this helpful
While this zinc form is bioavailable, caution is needed with dosages. High levels can deplete copper, leading to anaemia. Zinc is vital for ovarian, prostate, and thyroid health, and helps mitigate menopause symptoms, but this particular product didn’t contain copper in its formula.
8
Zinc improves nutritional markers post-menopause
Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population.
In our study, we examined how zinc supplementation could affect menopausal women, particularly focusing on markers like homocysteine, vitamin B, and folate levels. We worked with 51 postmenopausal women aged between 44 and 76 years, dividing them into two groups: one received a placebo, while the other was given 50 mg of zinc daily for eight weeks.
After analyzing the results, we found that those who took zinc showed significantly higher folate levels compared to their baseline measurements. Additionally, we observed a noteworthy decrease in homocysteine levels when comparing the two groups after the intervention. Interestingly, we also noted a strong correlation between higher folate and vitamin B levels with lower homocysteine levels in the zinc group.
These findings suggest that zinc supplementation can have positive effects on certain nutritional markers in menopausal women. However, we emphasize the need for further research with larger sample sizes and refined dosing to validate and expand upon our results.
8
Zinc enhances antioxidant protection
Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial.
We assessed how zinc (Zn) supplementation can impact the health of postmenopausal women, particularly regarding their antioxidant status. In this study, fifty-one women participating were split into two groups: one receiving a placebo treatment and the other receiving zinc supplements. This double-blind randomized trial lasted for eight weeks and focused on measuring changes in mineral status along with different antioxidant markers in the blood.
Before the intervention, we noticed that many participants had low zinc levels, which can lead to weakened antioxidant defenses—especially critical for postmenopausal women due to hormonal changes. After eight weeks of zinc supplementation, we saw a marked improvement in zinc levels among the women receiving the supplements. There were also significant positive correlations between zinc levels and overall antioxidant capacity, as well as specific antioxidant enzymes like glutathione peroxidase.
From our findings, it seems clear that zinc supplementation is a promising way to address deficiencies and bolster antioxidant defenses in postmenopausal women. This could not only support their nutritional health but might also contribute positively to their overall well-being during this transitional life stage.
9
Zinc gel improves menopausal symptoms
Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study.
We evaluated the impact of a zinc-containing vaginal moisturizer gel on postmenopausal women experiencing genitourinary symptoms of menopause (GSM). Some women hesitate to use hormonal treatments like vaginal estrogen, which can be highly effective. To explore an alternative, we asked 37 participants to apply the gel daily for two weeks while tracking their symptoms.
Throughout the study, we used various methods to assess improvement. The Vaginal Health Index, which measures vaginal health, showed significant improvement after treatment. We also noted that participants reported reduced levels of vaginal pain and dryness on a visual analog scale, with the most notable benefit occurring for vaginal dryness. Additionally, the vulvovaginal symptom questionnaire indicated a substantial decrease in overall symptoms. Notably, side effects were minor and infrequent, which is encouraging for those considering this option.
In summary, our findings suggest that a novel zinc-containing vaginal moisturizer gel can effectively alleviate postmenopausal vulvovaginal symptoms without serious side effects, providing a viable solution for women who prefer non-hormonal treatments.
9
Zinc enhances vitamin D in menopause
Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.
We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.
Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.
Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.
Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
7
Zinc impacts postmenopausal obesity
Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice - Implications for postmenopausal obesity.
We investigated the effects of dietary zinc on obesity related to menopause, particularly in female mice that underwent ovariectomy (Ovx). Our findings revealed that excess zinc led to significant weight gain and symptoms resembling Cushing's syndrome, even though these mice did not consume more food.
The accumulation of zinc in the adrenal glands played a crucial role by interfering with steroid production. This is particularly important since, in Ovx mice, adrenal steroids are the only source of estrogen. The lack of estrogen triggered adrenal hyperplasia and an increase in glucocorticoids, which contributed to the development of Cushing's-like symptoms.
Interestingly, our results showed that supplementing with adrenal steroids could counteract the negative impacts of excess zinc. We also found a positive correlation between plasma zinc levels and cortisol while noting a negative correlation with adrenal steroids and estrogen levels in overweight postmenopausal women.
These insights suggest that it may be beneficial for postmenopausal women to avoid high dietary zinc and consider adrenal steroid supplementation to help manage obesity effectively.
References
Zhao Y, Wang Y, Hu L, Chen H, Xiao X, et al. Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice - Implications for postmenopausal obesity. Biochem Biophys Res Commun. 2022;630:101. doi:10.1016/j.bbrc.2022.09.042
Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, Quintero-Osso B, et al. Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial. Exp Gerontol. 2022;162:111766. doi:10.1016/j.exger.2022.111766
Vázquez-Lorente H, Herrera-Quintana L, Molina-López J, Gamarra Y, Planells E. Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population. J Trace Elem Med Biol. 2022;71:126942. doi:10.1016/j.jtemb.2022.126942
Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, López-González B, et al. Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial. J Trace Elem Med Biol. 2021;65:126730. doi:10.1016/j.jtemb.2021.126730
Csikós A, Kozma B, Pór Á, Kovács I, Lampé R, et al. Zinc Transporter 9 (SLC30A9) Expression Is Decreased in the Vaginal Tissues of Menopausal Women. Biol Trace Elem Res. 2021;199:4011. doi:10.1007/s12011-020-02525-w
Damjanovich P, Sipos AG, Larson K, Cunningham TD, Takacs P, et al. Cervicovaginal lavage fluid zinc level as a marker of vaginal atrophy. Menopause. 2020;27:776. doi:10.1097/GME.0000000000001536
Takacs P, Kozma B, Erdodi B, Jakab A, Larson K, et al. Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study. J Menopausal Med. 2019;25:63. doi:10.6118/jmm.2019.25.1.63