' 
SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.3
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
9
DHA's role in osteoporosis treatment
Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice.
Highly relevant study findings
We recently looked into how docosahexaenoic acid (DHA), through its enriched phosphatidylcholine form (DHA-PC), affects osteoporosis. Using a model that simulates the condition in women after ovariectomy, we compared the impact of DHA-PC with eicosapentaenoic acid (EPA) enriched phosphatidylcholine (EPA-PC). Our findings revealed that both DHA-PC and EPA-PC significantly improved the structural quality of trabecular bone, boosted the rate of new bone formation, and elevated bone mineral density, which are crucial factors in combating osteoporosis.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
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7
DHA linked to osteoporosis risk
Causal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study.
Study directly addresses DHA effects
We examined the relationship between docosahexaenoic acid (DHA) and osteoporosis using a method called 2-sample Mendelian randomization. This approach allowed us to investigate if higher levels of DHA could be a risk factor for osteoporosis.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area.
Read More
9
EPA helps balance bone health
Eicosapentaenoic acid supplementation modulates the osteoblast/osteoclast balance in inflammatory environments and protects against estrogen deficiency-induced bone loss in mice.
Strong relevance for osteoporosis study
We examined how eicosapentaenoic acid (EPA), an omega-3 fatty acid, influences bone health, particularly in conditions like osteoporosis caused by inflammation and estrogen deficiency. Through tests on mouse stem cells and a specific inflammatory environment, we discovered that EPA can enhance the formation of bone-building cells while reducing the activity of bone-resorbing cells.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
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Most Useful Reviews
8.3
Similar to others
Omega-3 fatty acids prevent osteoporosis, maintain joint health, and lessen pain during flare-ups. They combat bone loss and relieve inflammation, helping with rheumatoid arthritis and cartilage issues.
Read More
8.3
Eases arthritic symptoms
Omega-3s support joint health, prevent osteoporosis, and the fatty acids reduce inflammation and combat bone loss. They also alleviate joint pain and slow down cartilage deterioration in arthrosis.
Read More
7.5
Supports joint function
Omega-3s support joint health, prevent osteoporosis, and fatty acids reduce inflammation and combat bone loss. They also ease joint pain and slow the destruction of cartilage in arthrosis.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.6
- All Researches
9
EPA helps balance bone health
Eicosapentaenoic acid supplementation modulates the osteoblast/osteoclast balance in inflammatory environments and protects against estrogen deficiency-induced bone loss in mice.
Strong relevance for osteoporosis study
We examined how eicosapentaenoic acid (EPA), an omega-3 fatty acid, influences bone health, particularly in conditions like osteoporosis caused by inflammation and estrogen deficiency. Through tests on mouse stem cells and a specific inflammatory environment, we discovered that EPA can enhance the formation of bone-building cells while reducing the activity of bone-resorbing cells.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
Read More
9
Omega-3 benefits in osteoporosis treatment
Docosahexaenoic Acid-Enriched Phosphatidylcholine Exerted Superior Effects to Triglyceride in Ameliorating Obesity-Induced Osteoporosis through Up-Regulating the Wnt/β-Catenin Pathway.
High relevance to osteoporosis research
We explored the effects of different forms of omega-3 fish oil on obesity-induced osteoporosis in mice. The study showed that DHA-enriched phosphatidylcholine (DHA-PC) had superior benefits compared to traditional DHA triglyceride (DHA-TG).
Over 120 days, DHA-PC significantly improved bone mineral density and increased new bone formation while reducing bone marrow fat more effectively than DHA-TG. This indicates that DHA-PC not only supports bone health but also encourages beneficial cell differentiation in the treatment of osteoporosis.
Over 120 days, DHA-PC significantly improved bone mineral density and increased new bone formation while reducing bone marrow fat more effectively than DHA-TG. This indicates that DHA-PC not only supports bone health but also encourages beneficial cell differentiation in the treatment of osteoporosis.
Read More
9
Omega-3 oil boosts bone health
The opposite effects of Antarctic krill oil and arachidonic acid-rich oil on bone resorption in ovariectomized mice.
High relevance to osteoporosis treatment
We explored how different types of polyunsaturated fatty acids (PUFAs) affect bone health. Mice with postmenopausal osteoporosis were treated with Antarctic krill oil (rich in omega-3 PUFAs) or arachidonic acid-rich oil (rich in omega-6 PUFAs) over a 120-day period.
Our findings revealed that Antarctic krill oil improved bone density and strength, while arachidonic acid-rich oil worsened these conditions. This study highlights the potential benefits of omega-3 fatty acids for osteoporosis, suggesting that diet can play a crucial role in bone health.
Our findings revealed that Antarctic krill oil improved bone density and strength, while arachidonic acid-rich oil worsened these conditions. This study highlights the potential benefits of omega-3 fatty acids for osteoporosis, suggesting that diet can play a crucial role in bone health.
Read More
9
Omega-3 fish oil benefits bones
The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis.
Relevant findings on aging osteoporosis
We delved into how omega-3 fatty acids, particularly from fish oil, impact bone health in aging mice suffering from osteoporosis. Through a study involving several dietary groups, we found that those on a fish oil diet had significant improvements in bone mass and lower levels of marrow adipose tissue compared to controls.
While we noted positive changes in bone density, the hematopoietic bone marrow remained stable across all groups. This suggests that omega-3 fatty acids may help counteract some age-related bone loss by reducing harmful fat tissue in the marrow.
While we noted positive changes in bone density, the hematopoietic bone marrow remained stable across all groups. This suggests that omega-3 fatty acids may help counteract some age-related bone loss by reducing harmful fat tissue in the marrow.
Read More
9
Eicosapentaenoic acid protects bone health
Eicosapentaenoic acid supplementation modulates the osteoblast/osteoclast balance in inflammatory environments and protects against estrogen deficiency-induced bone loss in mice.
Directly addresses osteoporosis treatment
We evaluated the effects of eicosapentaenoic acid (EPA) on osteoporosis, particularly in how it impacts the balance between osteoblasts (the cells that build bone) and osteoclasts (the cells that break down bone). In an experimental setup, we used mouse bone marrow stem cells and macrophages to study how EPA could counteract the negative effects of inflammation, which can lead to osteoporosis.
By simulating an inflammatory environment with TNF-α, we discovered that EPA helped restore the ability of stem cells to differentiate into osteoblasts, which is crucial for bone formation. Furthermore, we explored how EPA influenced the communication between osteoblasts and osteoclasts, finding that it regulated important factors involved in bone resorption.
When we tested the effects of EPA in a mouse model of estrogen deficiency—an established cause of bone loss in postmenopausal women—we observed significant protective effects against osteoporosis. This suggests that EPA could play a valuable role in maintaining bone health and preventing bone loss related to hormonal changes, providing a promising avenue for future osteoporosis treatments.
By simulating an inflammatory environment with TNF-α, we discovered that EPA helped restore the ability of stem cells to differentiate into osteoblasts, which is crucial for bone formation. Furthermore, we explored how EPA influenced the communication between osteoblasts and osteoclasts, finding that it regulated important factors involved in bone resorption.
When we tested the effects of EPA in a mouse model of estrogen deficiency—an established cause of bone loss in postmenopausal women—we observed significant protective effects against osteoporosis. This suggests that EPA could play a valuable role in maintaining bone health and preventing bone loss related to hormonal changes, providing a promising avenue for future osteoporosis treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
8.3
Similar to others
Omega-3 fatty acids prevent osteoporosis, maintain joint health, and lessen pain during flare-ups. They combat bone loss and relieve inflammation, helping with rheumatoid arthritis and cartilage issues.
8.3
Eases arthritic symptoms
Omega-3s support joint health, prevent osteoporosis, and the fatty acids reduce inflammation and combat bone loss. They also alleviate joint pain and slow down cartilage deterioration in arthrosis.
7.5
Supports joint function
Omega-3s support joint health, prevent osteoporosis, and fatty acids reduce inflammation and combat bone loss. They also ease joint pain and slow the destruction of cartilage in arthrosis.
7.5
Reduces osteoporosis risk
Quality guaranteed. Omega-3s contain eicosapentaenoic acid, fish oil reduces heart disease risk and promotes hair growth. It is suitable for those over 18 and helps reduce osteoporosis.
