Last update
3/31/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 9 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin E (as d-alpha Tocopheryl Acetate)
268 mg
1787%
Top Medical Research Studies
We conducted a rigorous study to assess how vitamin E affects menopausal symptoms, especially hot flashes. In this triple-blind, randomized controlled trial with 93 postmenopausal women, participants were divided into groups receiving curcumin, vitamin E, or a placebo for eight weeks.
While both curcumin and vitamin E were found to significantly reduce hot flashes, they didn’t show any notable benefits for anxiety, sexual function, or other menopausal symptoms. This suggests that vitamin E may be helpful for hot flashes but not for a broader range of menopause-related challenges.
While both curcumin and vitamin E were found to significantly reduce hot flashes, they didn’t show any notable benefits for anxiety, sexual function, or other menopausal symptoms. This suggests that vitamin E may be helpful for hot flashes but not for a broader range of menopause-related challenges.
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8
We examined the effects of vitamin E suppositories on vaginal atrophy in postmenopausal women. In a clinical trial, 52 women were divided into two groups—one used vitamin E, while the other applied estrogen cream for 12 weeks.
We saw improvements in vaginal health measures in the vitamin E group, suggesting it could be a helpful option for those who prefer to avoid hormone therapy.
However, further research is essential to fully understand its effectiveness.
We saw improvements in vaginal health measures in the vitamin E group, suggesting it could be a helpful option for those who prefer to avoid hormone therapy.
However, further research is essential to fully understand its effectiveness.
Read More
7
We explored the effectiveness of vitamin E vaginal suppositories compared to conjugated estrogen cream for alleviating genitourinary syndrome in postmenopausal women.
In a trial involving 52 women aged 40 to 65, participants used either treatment for 12 weeks, with follow-ups assessing their sexual function.
Both treatments showed improvement in sexual function, suggesting that vitamin E could offer a viable alternative for those hesitant about hormone therapy.
In a trial involving 52 women aged 40 to 65, participants used either treatment for 12 weeks, with follow-ups assessing their sexual function.
Both treatments showed improvement in sexual function, suggesting that vitamin E could offer a viable alternative for those hesitant about hormone therapy.
Read More
Most Useful Reviews
9
Menopausal support
One tablet a day of this vitamin E helps me navigate menopause safely.
Read More
9
Improved menstrual flow
10 people found this helpful
During menopause, my menstrual cycle became irregular, and I experienced prolonged bleeding. After increasing my vitamin E intake from 400 IU to 1200 IU daily, my menstruation returned every 2 to 3 months, and the bleeding stopped. This vitamin has become essential for restoring my hormonal balance.
Read More
8
More effective supplement
3 people found this helpful
I previously took isoflavones for menopause relief but felt no effect. After trying vitamin E, I found it to be more effective than isoflavones! I will discontinue isoflavones.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
- All Researches
9
This study looked at how a combination of stable ozonides and vitamin E acetate, called Ozoile, helps relieve symptoms of genitourinary syndrome in menopausal women.
After 20 days of treatment, we observed a significant reduction in symptoms such as pain and dryness, with pain incidence decreasing from 16.7% to 11.8% and dryness dropping from 85.5% to 53.8%.
Although Ozoile demonstrated effectiveness in addressing these symptoms, more research is necessary to understand how it compares to other treatments for this condition.
After 20 days of treatment, we observed a significant reduction in symptoms such as pain and dryness, with pain incidence decreasing from 16.7% to 11.8% and dryness dropping from 85.5% to 53.8%.
Although Ozoile demonstrated effectiveness in addressing these symptoms, more research is necessary to understand how it compares to other treatments for this condition.
Read More
9
We aimed to explore the effects of annatto tocotrienol, especially when paired with a self-emulsifying drug delivery system (SEDDS), on bone loss in a rat model of postmenopause.
After conducting a comprehensive study, we found that the SEDDS formulation significantly boosted the levels of delta-tocotrienol and was effective in promoting bone strength and health.
While both SEDDS-formulated and unformulated tocotrienol improved bone structure, the SEDDS offered superior results in certain areas, such as trabecular microstructure.
Overall, this suggests a promising path for human trials to further investigate tocotrienol's impact on postmenopausal bone health.
After conducting a comprehensive study, we found that the SEDDS formulation significantly boosted the levels of delta-tocotrienol and was effective in promoting bone strength and health.
While both SEDDS-formulated and unformulated tocotrienol improved bone structure, the SEDDS offered superior results in certain areas, such as trabecular microstructure.
Overall, this suggests a promising path for human trials to further investigate tocotrienol's impact on postmenopausal bone health.
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9
We aimed to understand the effectiveness of the pollen extract Sérélys, combined with vitamin E, in reducing menopausal symptoms in women. In a multicenter study, 104 menopausal women took the extract for three months. Their symptoms were assessed, revealing significant reductions: hot flashes decreased by 48.5%, sleep disturbances by 50.1%, and depressive moods by 51.2%. Overall, the extract demonstrated a noticeable improvement in various alarming menopausal symptoms with minimal side effects, suggesting it could be a safe alternative for women seeking relief.
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8
We examined the effects of tocopherol acetate, commonly known as vitamin E, on vaginal health for women navigating menopause. In our study, 50 women aged 50-70 were divided into menopausal and premenopausal groups and used specialized vaginal ovules for two weeks.
After treatment, we found that many distressing symptoms like dryness and pain during intercourse improved significantly. Additionally, the vaginal environment showed healthier changes, particularly in premenopausal women. Overall, tocopherol acetate may provide effective relief for those experiencing menopausal challenges.
After treatment, we found that many distressing symptoms like dryness and pain during intercourse improved significantly. Additionally, the vaginal environment showed healthier changes, particularly in premenopausal women. Overall, tocopherol acetate may provide effective relief for those experiencing menopausal challenges.
Read More
8
Vitamin E aids menopause mood disorders
We aimed to understand how vitamin E affects mood disorders linked to menopause, particularly in ovariectomized mice. Through behavioral tests, we noticed that vitamin E, specifically α-tocopherol and tocotrienol-rich palm oil extract, reduced signs of anxiety and depression in these mice.
While both treatments helped regulate stress hormone levels, tocotrienol-rich extract showed more promise than α-tocopherol in responding to chronic stress. Ultimately, our findings highlight the potential of vitamin E as a supportive treatment for menopause-related mood challenges.
While both treatments helped regulate stress hormone levels, tocotrienol-rich extract showed more promise than α-tocopherol in responding to chronic stress. Ultimately, our findings highlight the potential of vitamin E as a supportive treatment for menopause-related mood challenges.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Menopausal support
One tablet a day of this vitamin E helps me navigate menopause safely.
Read More
9
Improved menstrual flow
10 people found this helpful
During menopause, my menstrual cycle became irregular, and I experienced prolonged bleeding. After increasing my vitamin E intake from 400 IU to 1200 IU daily, my menstruation returned every 2 to 3 months, and the bleeding stopped. This vitamin has become essential for restoring my hormonal balance.
Read More
8
More effective supplement
3 people found this helpful
I previously took isoflavones for menopause relief but felt no effect. After trying vitamin E, I found it to be more effective than isoflavones! I will discontinue isoflavones.
Read More
7.5
Essential for health
2 people found this helpful
My husband and I have taken vitamin E for a long time. It’s a vital antioxidant that supports health, beauty, and fertility. Consumption should increase during menopause, and it's key for those over 40 or experiencing stress. It should be paired appropriately with other vitamins for best absorption.
Read More
7.5
Overall wellbeing
1 people found this helpful
I take vitamin E for menopause treatment and feel great. My gynaecologist also endorses these supplements.
Read More
Frequently Asked Questions
9
Improved menstrual flow
10 people found this helpful
During menopause, my menstrual cycle became irregular, and I experienced prolonged bleeding. After increasing my vitamin E intake from 400 IU to 1200 IU daily, my menstruation returned every 2 to 3 months, and the bleeding stopped. This vitamin has become essential for restoring my hormonal balance.
8
More effective supplement
3 people found this helpful
I previously took isoflavones for menopause relief but felt no effect. After trying vitamin E, I found it to be more effective than isoflavones! I will discontinue isoflavones.
7.5
Essential for health
2 people found this helpful
My husband and I have taken vitamin E for a long time. It’s a vital antioxidant that supports health, beauty, and fertility. Consumption should increase during menopause, and it's key for those over 40 or experiencing stress. It should be paired appropriately with other vitamins for best absorption.
9
Menopausal support
One tablet a day of this vitamin E helps me navigate menopause safely.
8
We examined the effects of tocopherol acetate, commonly known as vitamin E, on vaginal health for women navigating menopause. In our study, 50 women aged 50-70 were divided into menopausal and premenopausal groups and used specialized vaginal ovules for two weeks.
After treatment, we found that many distressing symptoms like dryness and pain during intercourse improved significantly. Additionally, the vaginal environment showed healthier changes, particularly in premenopausal women. Overall, tocopherol acetate may provide effective relief for those experiencing menopausal challenges.
After treatment, we found that many distressing symptoms like dryness and pain during intercourse improved significantly. Additionally, the vaginal environment showed healthier changes, particularly in premenopausal women. Overall, tocopherol acetate may provide effective relief for those experiencing menopausal challenges.
8
Vitamin E aids menopause mood disorders
We aimed to understand how vitamin E affects mood disorders linked to menopause, particularly in ovariectomized mice. Through behavioral tests, we noticed that vitamin E, specifically α-tocopherol and tocotrienol-rich palm oil extract, reduced signs of anxiety and depression in these mice.
While both treatments helped regulate stress hormone levels, tocotrienol-rich extract showed more promise than α-tocopherol in responding to chronic stress. Ultimately, our findings highlight the potential of vitamin E as a supportive treatment for menopause-related mood challenges.
While both treatments helped regulate stress hormone levels, tocotrienol-rich extract showed more promise than α-tocopherol in responding to chronic stress. Ultimately, our findings highlight the potential of vitamin E as a supportive treatment for menopause-related mood challenges.
5
We assessed how vitamin E supplementation impacts menopausal symptoms in women, as many seek alternatives to hormone therapy. Our review analyzed 16 studies, including a range of menopausal symptoms such as hot flashes and vaginal changes.
While vitamin E did show some beneficial effects, such as reducing hot flashes and improving vascular profiles, it was found to be less effective than estrogen. We noted that it could be a supportive option for those unable to use hormones. However, more rigorous research is needed before we make definitive conclusions.
While vitamin E did show some beneficial effects, such as reducing hot flashes and improving vascular profiles, it was found to be less effective than estrogen. We noted that it could be a supportive option for those unable to use hormones. However, more rigorous research is needed before we make definitive conclusions.
4
We examined the effectiveness of vaginal vitamin E for treating genitourinary symptoms in postmenopausal women. Our systematic review analyzed four trials focused on patient-reported outcomes. While one small study indicated that 1 mg of vitamin E significantly reduced vaginal symptoms compared to placebo, other studies showed no clear advantage when compared with vaginal estrogen or other treatments. Overall, the findings hint at potential benefits, but more comprehensive studies are essential for reliable conclusions on efficacy and safety.
References
- Venditti N, Petronio Petronio G, Guarnieri A, Pietrangelo L, Spicciato A, et al. Retrospective Investigator-Initiated Trial on Tocopherol Acetate Vaginal Administration in Pre-and Postmenopausal Women. Diseases. 2024;12. 10.3390/diseases12100237
- Liang G, Kow ASF, Lee YZ, Yusof R, Tham CL, et al. Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopause-associated mood disorder in ovariectomized mice. Biochem Biophys Res Commun. 2024;734:150443. 10.1016/j.bbrc.2024.150443
- Ronsini C, Iavarone I, Lacerenza N, Andreoli G, Vastarella MG, et al. Stable Ozonides plus Vitamin E Acetate (Ozoile) for Treatment of Genitourinary Syndrome. Medicina (Kaunas). 2024;60. 10.3390/medicina60060880
- Na Takuathung M, Klinjan P, Sakuludomkan W, Dukaew N, Inpan R, et al. Efficacy and Safety of the Genistein Nutraceutical Product Containing Vitamin E, Vitamin B3, and Ceramide on Skin Health in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Clin Med. 2023;12. 10.3390/jcm12041326
- Feduniw S, Korczyńska L, Górski K, Zgliczyńska M, Bączkowska M, et al. The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review. Nutrients. 2022;15. 10.3390/nu15010160
- Farshbaf-Khalili A, Ostadrahimi A, Mirghafourvand M, Ataei-Almanghadim K, Dousti S, et al. Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized Controlled Trial. J Nutr Metab. 2022;2022:6339715. 10.1155/2022/6339715
- Porterfield L, Wur N, Delgado ZS, Syed F, Song A, et al. Vaginal Vitamin E for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review of Randomized Controlled Trials. J Menopausal Med. 2022;28:9. 10.6118/jmm.21028
- Mohamad NV, Ima-Nirwana S, Chin KY. Self-emulsified annatto tocotrienol improves bone histomorphometric parameters in a rat model of oestrogen deficiency through suppression of skeletal sclerostin level and RANKL/OPG ratio. Int J Med Sci. 2021;18:3665. 10.7150/ijms.64045
- Mohamad NV, Ima-Nirwana S, Chin KY. Therapeutic potential of annatto tocotrienol with self-emulsifying drug delivery system in a rat model of postmenopausal bone loss. Biomed Pharmacother. 2021;137:111368. 10.1016/j.biopha.2021.111368
- Ataei-Almanghadim K, Farshbaf-Khalili A, Ostadrahimi AR, Shaseb E, Mirghafourvand M. The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: A triple blind randomised controlled trial. Complement Ther Med. 2020;48:102267. 10.1016/j.ctim.2019.102267
- Fait T, Sailer M, Regidor PA. Prospective observational study to evaluate the efficacy and safety of the pollen extract Sérélys in the management of women with menopausal symptoms. Gynecol Endocrinol. 2019;35:360. 10.1080/09513590.2018.1538347
- Golmakani N, Parnan Emamverdikhan A, Zarifian A, Sajadi Tabassi SA, Hassanzadeh M. Vitamin E as alternative local treatment in genitourinary syndrome of menopause: a randomized controlled trial. Int Urogynecol J. 2019;30:831. 10.1007/s00192-018-3698-z
- Pourafshar S, Johnson SA, Keshavarz B, Feresin RG, Khalil DA, et al. The effects of supplemental vitamin E on hematological parameters in a rat model of ovarian hormone deficiency. Menopause. 2018;25:336. 10.1097/GME.0000000000001003
- Parnan Emamverdikhan A, Golmakani N, Tabassi SA, Hassanzadeh M, Sharifi N, et al. A survey of the therapeutic effects of Vitamin E suppositories on vaginal atrophy in postmenopausal women. Iran J Nurs Midwifery Res. 2016;21:475. PubMed
- Radzinskii VE, Kuznetsova IV, Uspenskaya YB, Repina NB, Gusak YK, et al. Treatment of climacteric symptoms with an ammonium succinate-based dietary supplement: a randomized, double-blind, placebo-controlled trial. Gynecol Endocrinol. 2016;32:64. PubMed
- Corzo L, Rodriguez S, Alejo R, Fernandez-Novoa L, Aliev G, et al. E-MHK-0103 (Mineraxin™): A Novel Nutraceutical with Biological Properties in Menopausal Conditions. Curr Drug Metab. 2017;18:39. 10.2174/1389200217666161014151341
