Infographics 
Overview
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.7
USERS' SCORE
Good
Based on 9 Reviews
8
Supplement Facts
Serving Size: 1 tbsp (15 ml)
Amount Per Serving
%DV
Calories
120
Total Fat
14 g
18%
Saturated Fat
2.5 g
13%
Polyunsaturated Fat
8 g
Monounsaturated Fat
2 g
Sodium
0 mg
0%
Total Carbohydrate
0 g
0%
Protein
0 g
Vitamin E
20 mg
130%
Top Medical Research Studies
1
We explored the effectiveness of vitamin E alongside isotretinoin, a common treatment for severe acne. In an investigator-blinded, randomized study involving 82 patients, participants were divided into two groups. One group received isotretinoin alone, while the other combined it with 800 IU of vitamin E, over a period of 16 weeks.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
Read More
9
We explored the potential of novel antimicrobial peptides (AMPs) designed to combat acne vulgaris, a common skin issue caused by the bacteria Cutibacterium acnes. Traditional treatments often lead to antibiotic resistance and unwanted side effects, prompting the need for alternative solutions.
Our approach involved creating short peptides made up of 13 amino acids. We specifically tweaked these peptides by adjusting the number and position of tryptophan residues to enhance their effectiveness. Among the various peptides synthesized, we found that DAP-7 and DAP-10 stood out for their strong antimicrobial properties against both antibiotic-sensitive and -resistant strains of C. acnes, while causing minimal damage to human cells.
By targeting the bacterial membrane, these peptides can disrupt the bacteria, leading to their breakdown. Additionally, DAP-7 and DAP-10 were effective in reducing the levels of inflammation linked to acne. Remarkably, DAP-7 resulted not only in fewer C. acnes colonies but also significantly decreased swelling in a mouse model of acne.
Our findings indicate that DAP-7 and DAP-10 are promising options for developing new acne treatments, offering a dual action that tackles both the bacteria and the associated inflammation.
Our approach involved creating short peptides made up of 13 amino acids. We specifically tweaked these peptides by adjusting the number and position of tryptophan residues to enhance their effectiveness. Among the various peptides synthesized, we found that DAP-7 and DAP-10 stood out for their strong antimicrobial properties against both antibiotic-sensitive and -resistant strains of C. acnes, while causing minimal damage to human cells.
By targeting the bacterial membrane, these peptides can disrupt the bacteria, leading to their breakdown. Additionally, DAP-7 and DAP-10 were effective in reducing the levels of inflammation linked to acne. Remarkably, DAP-7 resulted not only in fewer C. acnes colonies but also significantly decreased swelling in a mouse model of acne.
Our findings indicate that DAP-7 and DAP-10 are promising options for developing new acne treatments, offering a dual action that tackles both the bacteria and the associated inflammation.
Read More
8
We investigated how specific proteins influence the development of acne by analyzing extensive data from a large cohort. In a study involving over 54,000 participants, we examined the relationship between nearly 3,000 serum proteins and the onset of acne.
Our analysis revealed 19 proteins significantly linked to acne risk. Among these, two proteins stood out—FSTL1 and ANXA5. We found that higher levels of these proteins were associated with an increased likelihood of developing acne, with each one-standard deviation rise corresponding to a 24% and 32% increase in acne incidence, respectively.
Using advanced genetic analysis methods, we confirmed these findings and suggested that these proteins could be valuable targets for new acne treatments. This work highlights the potential for protein-based approaches in tackling acne effectively.
Our analysis revealed 19 proteins significantly linked to acne risk. Among these, two proteins stood out—FSTL1 and ANXA5. We found that higher levels of these proteins were associated with an increased likelihood of developing acne, with each one-standard deviation rise corresponding to a 24% and 32% increase in acne incidence, respectively.
Using advanced genetic analysis methods, we confirmed these findings and suggested that these proteins could be valuable targets for new acne treatments. This work highlights the potential for protein-based approaches in tackling acne effectively.
Read More
Most Useful Reviews
9
Wonderful results
36 people found this helpful
This product is amazing for anyone with problematic skin! My results have been fantastic, making this my go-to choice. I mix it with honey for facials and enjoy it in the bath, leaving my skin soft and doing wonders for my acne. Having tried countless expensive treatments, I've achieved better results with wheat germ oil. If I get a pimple, it nearly disappears by morning after application. Fantastic!
Read More
9
Significant improvement
Excellent! ❤️ It improves my skin. Thank you, IHERB! Though slightly pricey, it's well worth it and lasts two to three months. It doesn't leave my face oily, which I appreciate. At 26, I faced skin issues, and this product has notably helped with the acne. The quality is highly recommended.
Read More
9
Enhances overall health
I adore this oil! Post-cleanse, I feel rejuvenated. Its composition, rich in amino acids, fatty acids, and antioxidants, supports health and beauty. It cleanses the skin beautifully and effectively treats acne, enhancing overall complexion and aiding in wrinkle reduction.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.7
- All Researches
9
We focused on exploring how afzelin, a natural flavonoid known for its anti-inflammatory effects, influences acne-related inflammation and sebum production in a specific type of skin cell called SZ95 sebocytes. To set the stage for our investigation, we simulated an acne-like condition by introducing heat-killed bacteria into the cells, along with exposure to particulate matter (PM).
We observed that PM may worsen acne by increasing inflammatory responses and promoting sebum secretion. Excitingly, when we treated these cells with afzelin, we found that it significantly reduced the inflammatory cytokine levels and inhibited the processes that lead to excess oil production. This suggests that afzelin could serve as a beneficial treatment option for alleviating PM-related acne.
Overall, our findings highlight the dual role of afzelin in combating acne by addressing both inflammation and sebum overproduction, positioning it as a potential therapeutic agent in skincare treatments.
We observed that PM may worsen acne by increasing inflammatory responses and promoting sebum secretion. Excitingly, when we treated these cells with afzelin, we found that it significantly reduced the inflammatory cytokine levels and inhibited the processes that lead to excess oil production. This suggests that afzelin could serve as a beneficial treatment option for alleviating PM-related acne.
Overall, our findings highlight the dual role of afzelin in combating acne by addressing both inflammation and sebum overproduction, positioning it as a potential therapeutic agent in skincare treatments.
Read More
9
We investigated the impact of two peptides, RL-QN15 and OH-CATH30, on treating acne in mice. Our findings revealed that when applied together, these peptides significantly reduced the growth of Propionibacterium acnes, the bacteria responsible for acne, and decreased the associated swelling.
Alongside tackling the bacteria, this combination also helped lower the production of inflammatory molecules, such as IL-1β and TNF-α, which are known to worsen acne condition. Notably, the treatment encouraged collagen production, promoting better skin repair and healing.
From a biological standpoint, we learned that RL-QN15 and OH-CATH30 work by suppressing the toll-like receptor 2 (TLR2) and the NF-κB signaling pathway, which ultimately reduces inflammation and aids in skin recovery. This points to their potential as a promising strategy for acne therapy, emphasizing the importance of looking at innovative protein combinations.
Overall, our study highlights a new, effective approach in tackling the persistent issue of acne. By focusing on these combined proteins, we are paving the way for advanced treatment options that could significantly improve the quality of life for those suffering from this common skin condition.
Alongside tackling the bacteria, this combination also helped lower the production of inflammatory molecules, such as IL-1β and TNF-α, which are known to worsen acne condition. Notably, the treatment encouraged collagen production, promoting better skin repair and healing.
From a biological standpoint, we learned that RL-QN15 and OH-CATH30 work by suppressing the toll-like receptor 2 (TLR2) and the NF-κB signaling pathway, which ultimately reduces inflammation and aids in skin recovery. This points to their potential as a promising strategy for acne therapy, emphasizing the importance of looking at innovative protein combinations.
Overall, our study highlights a new, effective approach in tackling the persistent issue of acne. By focusing on these combined proteins, we are paving the way for advanced treatment options that could significantly improve the quality of life for those suffering from this common skin condition.
Read More
9
We explored the potential of novel antimicrobial peptides (AMPs) designed to combat acne vulgaris, a common skin issue caused by the bacteria Cutibacterium acnes. Traditional treatments often lead to antibiotic resistance and unwanted side effects, prompting the need for alternative solutions.
Our approach involved creating short peptides made up of 13 amino acids. We specifically tweaked these peptides by adjusting the number and position of tryptophan residues to enhance their effectiveness. Among the various peptides synthesized, we found that DAP-7 and DAP-10 stood out for their strong antimicrobial properties against both antibiotic-sensitive and -resistant strains of C. acnes, while causing minimal damage to human cells.
By targeting the bacterial membrane, these peptides can disrupt the bacteria, leading to their breakdown. Additionally, DAP-7 and DAP-10 were effective in reducing the levels of inflammation linked to acne. Remarkably, DAP-7 resulted not only in fewer C. acnes colonies but also significantly decreased swelling in a mouse model of acne.
Our findings indicate that DAP-7 and DAP-10 are promising options for developing new acne treatments, offering a dual action that tackles both the bacteria and the associated inflammation.
Our approach involved creating short peptides made up of 13 amino acids. We specifically tweaked these peptides by adjusting the number and position of tryptophan residues to enhance their effectiveness. Among the various peptides synthesized, we found that DAP-7 and DAP-10 stood out for their strong antimicrobial properties against both antibiotic-sensitive and -resistant strains of C. acnes, while causing minimal damage to human cells.
By targeting the bacterial membrane, these peptides can disrupt the bacteria, leading to their breakdown. Additionally, DAP-7 and DAP-10 were effective in reducing the levels of inflammation linked to acne. Remarkably, DAP-7 resulted not only in fewer C. acnes colonies but also significantly decreased swelling in a mouse model of acne.
Our findings indicate that DAP-7 and DAP-10 are promising options for developing new acne treatments, offering a dual action that tackles both the bacteria and the associated inflammation.
Read More
9
Lactoferrin and zinc reduce acne
We observed how a combination of lactoferrin, vitamin E, and zinc might affect mild to moderate acne. In a rigorously designed study, 168 participants aged 13 to 40 were randomly assigned to receive either a treatment capsule containing these ingredients or a placebo twice a day over the course of three months.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
Read More
9
We explored the effects of vitamin E on acne by conducting an open-label study with 17 patients who had mild to moderate acne vulgaris. Over eight weeks, these patients followed a standard regimen involving salicylic acid and benzoyl peroxide, with the addition of topical vitamin E in sunflower seed oil.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Wonderful results
36 people found this helpful
This product is amazing for anyone with problematic skin! My results have been fantastic, making this my go-to choice. I mix it with honey for facials and enjoy it in the bath, leaving my skin soft and doing wonders for my acne. Having tried countless expensive treatments, I've achieved better results with wheat germ oil. If I get a pimple, it nearly disappears by morning after application. Fantastic!
Read More
9
Significant improvement
Excellent! ❤️ It improves my skin. Thank you, IHERB! Though slightly pricey, it's well worth it and lasts two to three months. It doesn't leave my face oily, which I appreciate. At 26, I faced skin issues, and this product has notably helped with the acne. The quality is highly recommended.
Read More
9
Enhances overall health
I adore this oil! Post-cleanse, I feel rejuvenated. Its composition, rich in amino acids, fatty acids, and antioxidants, supports health and beauty. It cleanses the skin beautifully and effectively treats acne, enhancing overall complexion and aiding in wrinkle reduction.
Read More
6
Faded acne scars
20 people found this helpful
Great buy for my skin as I have certain scars I'm trying to diminish, and within the first week, I noticed the acne scars on my face starting to fade. It has helped with leg scars too, though less noticeably.
Read More
7.5
Effective for regeneration
9 people found this helpful
Excellent! This oil, rich and pleasantly fragrant, improves skin elasticity and rejuvenates. It regenerates problematic skin with acne and smooths texture effectively.
Read More
Frequently Asked Questions
7.5
Significant improvements
I've used wheat germ oil for months, yielding remarkable improvements in both my skin and hair. Its vitamins and antioxidants enhance texture and elasticity while significantly reducing inflammation and acne on my skin.
9
Wonderful results
36 people found this helpful
This product is amazing for anyone with problematic skin! My results have been fantastic, making this my go-to choice. I mix it with honey for facials and enjoy it in the bath, leaving my skin soft and doing wonders for my acne. Having tried countless expensive treatments, I've achieved better results with wheat germ oil. If I get a pimple, it nearly disappears by morning after application. Fantastic!
7.5
Effective for regeneration
9 people found this helpful
Excellent! This oil, rich and pleasantly fragrant, improves skin elasticity and rejuvenates. It regenerates problematic skin with acne and smooths texture effectively.
2
Breakout experienced
Unfortunately, I experienced an acne breakout after using this. It may not be suitable for sensitive skin like mine.
9
Enhances overall health
I adore this oil! Post-cleanse, I feel rejuvenated. Its composition, rich in amino acids, fatty acids, and antioxidants, supports health and beauty. It cleanses the skin beautifully and effectively treats acne, enhancing overall complexion and aiding in wrinkle reduction.
9
We focused on exploring how afzelin, a natural flavonoid known for its anti-inflammatory effects, influences acne-related inflammation and sebum production in a specific type of skin cell called SZ95 sebocytes. To set the stage for our investigation, we simulated an acne-like condition by introducing heat-killed bacteria into the cells, along with exposure to particulate matter (PM).
We observed that PM may worsen acne by increasing inflammatory responses and promoting sebum secretion. Excitingly, when we treated these cells with afzelin, we found that it significantly reduced the inflammatory cytokine levels and inhibited the processes that lead to excess oil production. This suggests that afzelin could serve as a beneficial treatment option for alleviating PM-related acne.
Overall, our findings highlight the dual role of afzelin in combating acne by addressing both inflammation and sebum overproduction, positioning it as a potential therapeutic agent in skincare treatments.
We observed that PM may worsen acne by increasing inflammatory responses and promoting sebum secretion. Excitingly, when we treated these cells with afzelin, we found that it significantly reduced the inflammatory cytokine levels and inhibited the processes that lead to excess oil production. This suggests that afzelin could serve as a beneficial treatment option for alleviating PM-related acne.
Overall, our findings highlight the dual role of afzelin in combating acne by addressing both inflammation and sebum overproduction, positioning it as a potential therapeutic agent in skincare treatments.
9
Lactoferrin and zinc reduce acne
We observed how a combination of lactoferrin, vitamin E, and zinc might affect mild to moderate acne. In a rigorously designed study, 168 participants aged 13 to 40 were randomly assigned to receive either a treatment capsule containing these ingredients or a placebo twice a day over the course of three months.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
5
Our study aimed to understand the impact of vitamin E, along with vitamins A and zinc, on acne severity. We analyzed the plasma levels of these nutrients in 94 newly diagnosed acne patients compared to 56 healthy volunteers. Utilizing the Global Acne Grading System, we categorized the patients into different severity groups: mild, moderate, severe, and very severe.
We found that the levels of vitamin E, along with vitamin A and zinc, were significantly lower in the acne patients than in the control group. While we observed that vitamin A levels did not differ significantly between mild to moderate and severe to very severe cases, we found that vitamin E and zinc levels were notably lower in the more severe cases. This suggests a concerning link between acne severity and lower levels of these nutrients.
Given these findings, we believe that maintaining a diet rich in vitamins A and E, as well as zinc, could support acne treatment. However, the study does not isolate vitamin E's individual effectiveness, making it difficult to draw firm conclusions about its specific benefits. Nevertheless, incorporating supportive dietary measures could lead to better outcomes for those struggling with severe acne.
We found that the levels of vitamin E, along with vitamin A and zinc, were significantly lower in the acne patients than in the control group. While we observed that vitamin A levels did not differ significantly between mild to moderate and severe to very severe cases, we found that vitamin E and zinc levels were notably lower in the more severe cases. This suggests a concerning link between acne severity and lower levels of these nutrients.
Given these findings, we believe that maintaining a diet rich in vitamins A and E, as well as zinc, could support acne treatment. However, the study does not isolate vitamin E's individual effectiveness, making it difficult to draw firm conclusions about its specific benefits. Nevertheless, incorporating supportive dietary measures could lead to better outcomes for those struggling with severe acne.
7
Isotretinoin effective; vitamin E limited
We designed a study to assess whether adding vitamin E could enhance the effectiveness of isotretinoin, a common treatment for severe acne. The study involved 60 participants who received isotretinoin at a dose of 0.5 mg/kg/day for six months. We divided the participants into two groups: one received 800 IU of vitamin E daily, while the other was given cod liver oil capsules with the same dosage.
During the study, we monitored the participants for side effects at various intervals—specifically at one, four, and six weeks into the treatment. The results indicated that cheilitis, or chapped lips, was the most frequently reported side effect, affecting 69% of the patients. Additionally, both groups experienced epistaxis (nosebleeds) in about 22% of the cases. We also noted other side effects like dry skin, itching, stomach discomfort, and brittle nails.
Importantly, we observed that while isotretinoin remains a highly effective option for treating severe and stubborn acne, the addition of vitamin E did not show a significant benefit. The frequency and severity of complications were generally lower at four and six weeks, suggesting that the body might adapt to the treatment over time.
In summary, while isotretinoin is effective, vitamin E might not offer additional advantages in managing acne treatment.
During the study, we monitored the participants for side effects at various intervals—specifically at one, four, and six weeks into the treatment. The results indicated that cheilitis, or chapped lips, was the most frequently reported side effect, affecting 69% of the patients. Additionally, both groups experienced epistaxis (nosebleeds) in about 22% of the cases. We also noted other side effects like dry skin, itching, stomach discomfort, and brittle nails.
Importantly, we observed that while isotretinoin remains a highly effective option for treating severe and stubborn acne, the addition of vitamin E did not show a significant benefit. The frequency and severity of complications were generally lower at four and six weeks, suggesting that the body might adapt to the treatment over time.
In summary, while isotretinoin is effective, vitamin E might not offer additional advantages in managing acne treatment.
9
We explored the potential of novel antimicrobial peptides (AMPs) designed to combat acne vulgaris, a common skin issue caused by the bacteria Cutibacterium acnes. Traditional treatments often lead to antibiotic resistance and unwanted side effects, prompting the need for alternative solutions.
Our approach involved creating short peptides made up of 13 amino acids. We specifically tweaked these peptides by adjusting the number and position of tryptophan residues to enhance their effectiveness. Among the various peptides synthesized, we found that DAP-7 and DAP-10 stood out for their strong antimicrobial properties against both antibiotic-sensitive and -resistant strains of C. acnes, while causing minimal damage to human cells.
By targeting the bacterial membrane, these peptides can disrupt the bacteria, leading to their breakdown. Additionally, DAP-7 and DAP-10 were effective in reducing the levels of inflammation linked to acne. Remarkably, DAP-7 resulted not only in fewer C. acnes colonies but also significantly decreased swelling in a mouse model of acne.
Our findings indicate that DAP-7 and DAP-10 are promising options for developing new acne treatments, offering a dual action that tackles both the bacteria and the associated inflammation.
Our approach involved creating short peptides made up of 13 amino acids. We specifically tweaked these peptides by adjusting the number and position of tryptophan residues to enhance their effectiveness. Among the various peptides synthesized, we found that DAP-7 and DAP-10 stood out for their strong antimicrobial properties against both antibiotic-sensitive and -resistant strains of C. acnes, while causing minimal damage to human cells.
By targeting the bacterial membrane, these peptides can disrupt the bacteria, leading to their breakdown. Additionally, DAP-7 and DAP-10 were effective in reducing the levels of inflammation linked to acne. Remarkably, DAP-7 resulted not only in fewer C. acnes colonies but also significantly decreased swelling in a mouse model of acne.
Our findings indicate that DAP-7 and DAP-10 are promising options for developing new acne treatments, offering a dual action that tackles both the bacteria and the associated inflammation.
References
- Zhu J, Zhang Y, Wang W, Wang H, Guo Y, et al. Treatment of acne scars using subcision combined with concentrated growth factors versus subcision monotherapy: a retrospective cohort study. Arch Dermatol Res. 2025;317:481. 10.1007/s00403-025-04027-y
- Hong JY, Choi YH, Roh YJ, Lee MK, Zouboulis CC, et al. Effect of afzelin on inflammation and lipogenesis in particulate matter-stimulated treated SZ95 sebocytes. Front Med (Lausanne). 2025;12:1518382. 10.3389/fmed.2025.1518382
- Huang Y, Liu C, Fu Z, Li C, Wu Y, et al. The combination of RL-QN15 and OH-CATH30 promotes the repair of acne via the TLR2/NF-κB pathway. Eur J Pharmacol. 2025;989:177233. 10.1016/j.ejphar.2024.177233
- Kim H, Jang JH, Kim HR, Cho JH. Novel-designed antimicrobial peptides with dual antimicrobial and anti-inflammatory actions against Cutibacterium acnes for acne vulgaris therapy. Biochem Pharmacol. 2025;232:116708. 10.1016/j.bcp.2024.116708
- Deng S, Mao R, He Y. Unveiling new protein biomarkers and therapeutic targets for acne through integrated analysis of human plasma proteomics and genomics. Front Immunol. 2024;15:1452801. 10.3389/fimmu.2024.1452801
- Liu X, Yang G, Luo M, Lan Q, Shi X, et al. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis. PLoS One. 2021;16:e0261259. 10.1371/journal.pone.0261259
- Chan H, Chan G, Santos J, Dee K, Co JK. A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris. Int J Dermatol. 2017;56:686. 10.1111/ijd.13607
- Mills OH, Criscito MC, Schlesinger TE, Verdicchio R, Szoke E. Addressing Free Radical Oxidation in Acne Vulgaris. J Clin Aesthet Dermatol. 2016;9:25.
- Fabbrocini G, Cameli N, Lorenzi S, De Padova MP, Marasca C, et al. A dietary supplement to reduce side effects of oral isotretinoin therapy in acne patients. G Ital Dermatol Venereol. 2014;149:441.
- Capitanio B, Lora V, Ludovici M, Sinagra JL, Ottaviani M, et al. Modulation of sebum oxidation and interleukin-1α levels associates with clinical improvement of mild comedonal acne. J Eur Acad Dermatol Venereol. 2014;28:1792. 10.1111/jdv.12431
- Goforoushan F, Azimi H, Goldust M. Efficacy of vitamin E to prevent dermal complications of isotretinoin. Pak J Biol Sci. 2013;16:548.
- Ozuguz P, Dogruk Kacar S, Ekiz O, Takci Z, Balta I, et al. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol. 2014;33:99. 10.3109/15569527.2013.808656
- Aktürk AŞ, Güzel S, Bulca S, Demirsoy EO, Bayramgürler D, et al. Effects of isotretinoin on serum vitamin E levels in patients with acne. Int J Dermatol. 2013;52:363. 10.1111/j.1365-4632.2012.05676.x
- Erturan İ, Naziroğlu M, Akkaya VB. Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study. Cell Biochem Funct. 2012;30:552. 10.1002/cbf.2830
- El-Akawi Z, Abdel-Latif N, Abdul-Razzak K. Does the plasma level of vitamins A and E affect acne condition?. Clin Exp Dermatol. 2006;31:430.
- Strumia R. Dermatologic signs in patients with eating disorders. Am J Clin Dermatol. 2005;6:165.
- Kus S, Gün D, Demirçay Z, Sur H. Vitamin E does not reduce the side-effects of isotretinoin in the treatment of acne vulgaris. Int J Dermatol. 2005;44:248.
- Bellei E, Rota C, Bergamini S, Manfredini P, Albertazzi A, et al. Effect of alpha-tocopherol and N-acetylcysteine on benzoyl peroxide toxicity in human keratinocytes. J Biochem Mol Toxicol. 2004;18:107.
- Weber SU, Thiele JJ, Han N, Luu C, Valacchi G, et al. Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin. Free Radic Biol Med. 2003;34:170.
- Strauss JS, Gottlieb AB, Jones T, Koo JY, Leyden JJ, et al. Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in acne vulgaris: a randomized trial. J Am Acad Dermatol. 2000;43:777.
- Michaëlsson G, Edqvist LE. Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment. Acta Derm Venereol. 1984;64:9.
