' 
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.7
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 tbsp (15 ml)
Amount Per Serving
%DV
Calories
120
Total Fat
14 g
18%
Saturated Fat
2.5 g
13%
Polyunsaturated Fat
8 g
Monounsaturated Fat
2 g
Sodium
0 mg
0%
Total Carbohydrate
0 g
0%
Protein
0 g
Vitamin E
20 mg
130%
Top Medical Research Studies
1
No significant benefit of vitamin E
Vitamin E does not reduce the side-effects of isotretinoin in the treatment of acne vulgaris.
Highly relevant to vitamin E usage
We explored the effectiveness of vitamin E alongside isotretinoin, a common treatment for severe acne. In an investigator-blinded, randomized study involving 82 patients, participants were divided into two groups. One group received isotretinoin alone, while the other combined it with 800 IU of vitamin E, over a period of 16 weeks.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
Read More
9
Promising peptides for acne treatment
Novel-designed antimicrobial peptides with dual antimicrobial and anti-inflammatory actions against Cutibacterium acnes for acne vulgaris therapy.
High relevance to acne treatment
We explored the potential of novel antimicrobial peptides (AMPs) designed to combat acne vulgaris, a common skin issue caused by the bacteria Cutibacterium acnes. Traditional treatments often lead to antibiotic resistance and unwanted side effects, prompting the need for alternative solutions.
Our approach involved creating short peptides made up of 13 amino acids. We specifically tweaked these peptides by adjusting the number and position of tryptophan residues to enhance their effectiveness. Among the various peptides synthesized, we found that DAP-7 and DAP-10 stood out for their strong antimicrobial properties against both antibiotic-sensitive and -resistant strains of C. acnes, while causing minimal damage to human cells.
By targeting the bacterial membrane, these peptides can disrupt the bacteria, leading to their breakdown. Additionally, DAP-7 and DAP-10 were effective in reducing the levels of inflammation linked to acne. Remarkably, DAP-7 resulted not only in fewer C. acnes colonies but also significantly decreased swelling in a mouse model of acne.
Our findings indicate that DAP-7 and DAP-10 are promising options for developing new acne treatments, offering a dual action that tackles both the bacteria and the associated inflammation.
Our approach involved creating short peptides made up of 13 amino acids. We specifically tweaked these peptides by adjusting the number and position of tryptophan residues to enhance their effectiveness. Among the various peptides synthesized, we found that DAP-7 and DAP-10 stood out for their strong antimicrobial properties against both antibiotic-sensitive and -resistant strains of C. acnes, while causing minimal damage to human cells.
By targeting the bacterial membrane, these peptides can disrupt the bacteria, leading to their breakdown. Additionally, DAP-7 and DAP-10 were effective in reducing the levels of inflammation linked to acne. Remarkably, DAP-7 resulted not only in fewer C. acnes colonies but also significantly decreased swelling in a mouse model of acne.
Our findings indicate that DAP-7 and DAP-10 are promising options for developing new acne treatments, offering a dual action that tackles both the bacteria and the associated inflammation.
Read More
8
Identifying proteins linked to acne
Unveiling new protein biomarkers and therapeutic targets for acne through integrated analysis of human plasma proteomics and genomics.
Significant findings on acne treatment
We investigated how specific proteins influence the development of acne by analyzing extensive data from a large cohort. In a study involving over 54,000 participants, we examined the relationship between nearly 3,000 serum proteins and the onset of acne.
Our analysis revealed 19 proteins significantly linked to acne risk. Among these, two proteins stood out—FSTL1 and ANXA5. We found that higher levels of these proteins were associated with an increased likelihood of developing acne, with each one-standard deviation rise corresponding to a 24% and 32% increase in acne incidence, respectively.
Using advanced genetic analysis methods, we confirmed these findings and suggested that these proteins could be valuable targets for new acne treatments. This work highlights the potential for protein-based approaches in tackling acne effectively.
Our analysis revealed 19 proteins significantly linked to acne risk. Among these, two proteins stood out—FSTL1 and ANXA5. We found that higher levels of these proteins were associated with an increased likelihood of developing acne, with each one-standard deviation rise corresponding to a 24% and 32% increase in acne incidence, respectively.
Using advanced genetic analysis methods, we confirmed these findings and suggested that these proteins could be valuable targets for new acne treatments. This work highlights the potential for protein-based approaches in tackling acne effectively.
Read More
Most Useful Reviews
8
Faded acne scars
Great buy for my skin as I have certain scars I'm trying to diminish, and within the first week, I noticed the acne scars on my face starting to fade. It has helped with leg scars too, though less noticeably.
Read More
6.8
Helps soften skin
This product does well for its purpose. I got it to help soften my skin and with acne scars and it is effective. However, the smell is rather strong.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.7
9
Afzelin reduces acne inflammation
Effect of afzelin on inflammation and lipogenesis in particulate matter-stimulated treated SZ95 sebocytes.
Study highlights protein's limited impact
We focused on exploring how afzelin, a natural flavonoid known for its anti-inflammatory effects, influences acne-related inflammation and sebum production in a specific type of skin cell called SZ95 sebocytes. To set the stage for our investigation, we simulated an acne-like condition by introducing heat-killed bacteria into the cells, along with exposure to particulate matter (PM).
We observed that PM may worsen acne by increasing inflammatory responses and promoting sebum secretion. Excitingly, when we treated these cells with afzelin, we found that it significantly reduced the inflammatory cytokine levels and inhibited the processes that lead to excess oil production. This suggests that afzelin could serve as a beneficial treatment option for alleviating PM-related acne.
Overall, our findings highlight the dual role of afzelin in combating acne by addressing both inflammation and sebum overproduction, positioning it as a potential therapeutic agent in skincare treatments.
We observed that PM may worsen acne by increasing inflammatory responses and promoting sebum secretion. Excitingly, when we treated these cells with afzelin, we found that it significantly reduced the inflammatory cytokine levels and inhibited the processes that lead to excess oil production. This suggests that afzelin could serve as a beneficial treatment option for alleviating PM-related acne.
Overall, our findings highlight the dual role of afzelin in combating acne by addressing both inflammation and sebum overproduction, positioning it as a potential therapeutic agent in skincare treatments.
Read More
9
Peptide combination enhances acne treatment
The combination of RL-QN15 and OH-CATH30 promotes the repair of acne via the TLR2/NF-κB pathway.
Combination treatment shows promise
We investigated the impact of two peptides, RL-QN15 and OH-CATH30, on treating acne in mice. Our findings revealed that when applied together, these peptides significantly reduced the growth of Propionibacterium acnes, the bacteria responsible for acne, and decreased the associated swelling.
Alongside tackling the bacteria, this combination also helped lower the production of inflammatory molecules, such as IL-1β and TNF-α, which are known to worsen acne condition. Notably, the treatment encouraged collagen production, promoting better skin repair and healing.
From a biological standpoint, we learned that RL-QN15 and OH-CATH30 work by suppressing the toll-like receptor 2 (TLR2) and the NF-κB signaling pathway, which ultimately reduces inflammation and aids in skin recovery. This points to their potential as a promising strategy for acne therapy, emphasizing the importance of looking at innovative protein combinations.
Overall, our study highlights a new, effective approach in tackling the persistent issue of acne. By focusing on these combined proteins, we are paving the way for advanced treatment options that could significantly improve the quality of life for those suffering from this common skin condition.
Alongside tackling the bacteria, this combination also helped lower the production of inflammatory molecules, such as IL-1β and TNF-α, which are known to worsen acne condition. Notably, the treatment encouraged collagen production, promoting better skin repair and healing.
From a biological standpoint, we learned that RL-QN15 and OH-CATH30 work by suppressing the toll-like receptor 2 (TLR2) and the NF-κB signaling pathway, which ultimately reduces inflammation and aids in skin recovery. This points to their potential as a promising strategy for acne therapy, emphasizing the importance of looking at innovative protein combinations.
Overall, our study highlights a new, effective approach in tackling the persistent issue of acne. By focusing on these combined proteins, we are paving the way for advanced treatment options that could significantly improve the quality of life for those suffering from this common skin condition.
Read More
9
Promising peptides for acne treatment
Novel-designed antimicrobial peptides with dual antimicrobial and anti-inflammatory actions against Cutibacterium acnes for acne vulgaris therapy.
High relevance to acne treatment
We explored the potential of novel antimicrobial peptides (AMPs) designed to combat acne vulgaris, a common skin issue caused by the bacteria Cutibacterium acnes. Traditional treatments often lead to antibiotic resistance and unwanted side effects, prompting the need for alternative solutions.
Our approach involved creating short peptides made up of 13 amino acids. We specifically tweaked these peptides by adjusting the number and position of tryptophan residues to enhance their effectiveness. Among the various peptides synthesized, we found that DAP-7 and DAP-10 stood out for their strong antimicrobial properties against both antibiotic-sensitive and -resistant strains of C. acnes, while causing minimal damage to human cells.
By targeting the bacterial membrane, these peptides can disrupt the bacteria, leading to their breakdown. Additionally, DAP-7 and DAP-10 were effective in reducing the levels of inflammation linked to acne. Remarkably, DAP-7 resulted not only in fewer C. acnes colonies but also significantly decreased swelling in a mouse model of acne.
Our findings indicate that DAP-7 and DAP-10 are promising options for developing new acne treatments, offering a dual action that tackles both the bacteria and the associated inflammation.
Our approach involved creating short peptides made up of 13 amino acids. We specifically tweaked these peptides by adjusting the number and position of tryptophan residues to enhance their effectiveness. Among the various peptides synthesized, we found that DAP-7 and DAP-10 stood out for their strong antimicrobial properties against both antibiotic-sensitive and -resistant strains of C. acnes, while causing minimal damage to human cells.
By targeting the bacterial membrane, these peptides can disrupt the bacteria, leading to their breakdown. Additionally, DAP-7 and DAP-10 were effective in reducing the levels of inflammation linked to acne. Remarkably, DAP-7 resulted not only in fewer C. acnes colonies but also significantly decreased swelling in a mouse model of acne.
Our findings indicate that DAP-7 and DAP-10 are promising options for developing new acne treatments, offering a dual action that tackles both the bacteria and the associated inflammation.
Read More
9
Lactoferrin and zinc reduce acne
A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris.
Difficult to isolate vitamin E's effect
We observed how a combination of lactoferrin, vitamin E, and zinc might affect mild to moderate acne. In a rigorously designed study, 168 participants aged 13 to 40 were randomly assigned to receive either a treatment capsule containing these ingredients or a placebo twice a day over the course of three months.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
Read More
9
Vitamin E may reduce acne lesions
Addressing Free Radical Oxidation in Acne Vulgaris.
Study design limits isolated assessment
We explored the effects of vitamin E on acne by conducting an open-label study with 17 patients who had mild to moderate acne vulgaris. Over eight weeks, these patients followed a standard regimen involving salicylic acid and benzoyl peroxide, with the addition of topical vitamin E in sunflower seed oil.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
8
Faded acne scars
Great buy for my skin as I have certain scars I'm trying to diminish, and within the first week, I noticed the acne scars on my face starting to fade. It has helped with leg scars too, though less noticeably.
6.8
Helps soften skin
This product does well for its purpose. I got it to help soften my skin and with acne scars and it is effective. However, the smell is rather strong.
