We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
Read More
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
Read More
Most Useful Reviews
9
Reduces illness severity
4 people found this helpful
Excellent vitamin C! One of the primary benefits is its ability to bolster the immune system. I find I cope better with diseases and infections, getting colds and flu less often, and symptoms pass much quicker. With strong antioxidant properties, it protects my cells from damage. Additionally, my skin and hair have improved, appearing brighter and healthier. I recommend this to anyone wanting to boost their immune system, enhance energy, and improve overall well-being.
Read More
9
Quick relief from flu
1 people found this helpful
Excellent vitamin C with flavonoids! At the first symptoms of flu, I take 1-2 capsules and find that the next day, there are no more symptoms. My skin also looks better since I started taking it.
Read More
9
Highly effective supplementation
Excellent! I highly recommend this. I trust this manufacturer. The dietary supplements are well absorbed, and this vitamin C is no exception. It helps maintain immunity, and is also a beauty vitamin. I took one capsule every morning in winter and if I felt slightly unwell or came into contact with someone suffering from a cold or flu, I took another in the evening. As a result, I was spared from illness, which I am very pleased about. The vitamins work well and are gentle on the stomach.
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
Read More
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
Read More
8
Vitamin C mitigates flu pneumonia
A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
7
Vitamin C's promise against flu
Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
Read More
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
Read More
User Reviews
USERS' SCORE
Good
Based on 27 Reviews
8.5
All Reviews
Positive Reviews
Negative Reviews
9
Reduces illness severity
4 people found this helpful
Excellent vitamin C! One of the primary benefits is its ability to bolster the immune system. I find I cope better with diseases and infections, getting colds and flu less often, and symptoms pass much quicker. With strong antioxidant properties, it protects my cells from damage. Additionally, my skin and hair have improved, appearing brighter and healthier. I recommend this to anyone wanting to boost their immune system, enhance energy, and improve overall well-being.
Read More
9
Quick relief from flu
1 people found this helpful
Excellent vitamin C with flavonoids! At the first symptoms of flu, I take 1-2 capsules and find that the next day, there are no more symptoms. My skin also looks better since I started taking it.
Read More
9
Highly effective supplementation
Excellent! I highly recommend this. I trust this manufacturer. The dietary supplements are well absorbed, and this vitamin C is no exception. It helps maintain immunity, and is also a beauty vitamin. I took one capsule every morning in winter and if I felt slightly unwell or came into contact with someone suffering from a cold or flu, I took another in the evening. As a result, I was spared from illness, which I am very pleased about. The vitamins work well and are gentle on the stomach.
Read More
9
Highly recommend it
Vitamin C works! I’ve ordered it several times and like it very much. At the first sign of a cold or flu, I recommend taking it.
Read More
9
Improves immune system
I've been taking this vitamin C for a while now and have noticed a significant improvement in my immune system against cold and flu.
The flu, short for influenza, is a contagious respiratory illness caused by influenza viruses. It affects the nose, throat, and sometimes the lungs, leading to a range of symptoms that can vary in severity. Common symptoms include fever, chills, muscle aches, cough, congestion, runny nose, headaches, and fatigue. The flu can lead to serious complications, particularly in vulnerable populations such as young children, the elderly, pregnant women, and those with underlying health conditions.
The flu virus spreads primarily through respiratory droplets when an infected person coughs, sneezes, or talks. It can also be transmitted by touching surfaces contaminated with the virus and then touching one's face. Vaccination is the most effective way to prevent the flu, and the vaccine is typically updated annually to provide protection against the most common circulating strains. In addition to vaccination, practicing good hygiene, such as frequent handwashing and respiratory etiquette, can help minimize the risk of infection.
Ascorbic acid, commonly known as vitamin C, is a water-soluble vitamin that is essential for various bodily functions, including the synthesis of collagen, the absorption of iron, and the maintenance of a healthy immune system. Found naturally in a variety of fruits and vegetables, especially citrus fruits, strawberries, kiwi, and bell peppers, it serves as a potent antioxidant, helping to protect cells from damage by free radicals. Given that the human body cannot synthesize ascorbic acid on its own, it must be obtained through diet or supplementation.
In addition to its fundamental role in supporting overall health, ascorbic acid has garnered interest for its potential benefits in skincare and wound healing. Topical applications of vitamin C can help reduce the appearance of fine lines and improve skin texture, making it a popular ingredient in various cosmetic formulations. Additionally, it plays a crucial role in the body's ability to repair tissues and produce important neurotransmitters. For those looking to boost their vitamin C intake, incorporating a variety of vitamin C-rich foods into your diet or considering a supplement can be effective strategies.
Ascorbic acid, commonly known as vitamin C, is often touted for its immune-boosting properties. While some studies suggest that high doses of vitamin C can reduce the duration and severity of cold symptoms, the evidence regarding its effectiveness for the flu specifically is less concrete. The flu is caused by the influenza virus, and ascorbic acid may not directly combat the virus itself. However, maintaining adequate levels of vitamin C is crucial for overall immune function, which could potentially help your body respond better to illnesses, including the flu.
If you're considering using ascorbic acid as a supplement for flu prevention or treatment, it's important to consult with a healthcare professional. They can provide guidance based on your individual health needs and advise on proper dosages. In general, while incorporating vitamin C-rich foods, like oranges, strawberries, and bell peppers, into your diet can be beneficial for your immune health, relying solely on ascorbic acid to combat the flu is not a substitute for vaccines, antiviral medications, or other proven preventive measures.
Based on user reviews, the timeline for seeing results from taking vitamin C for flu symptoms can vary. Many users report an almost immediate effect, stating that symptoms diminish quickly upon onset. For example, one reviewer noted that after taking 1-2 capsules at the first sign of flu symptoms, they found the next day, there were no more symptoms Read Review. Another user mentioned they typically avoid illness altogether by starting the supplement when the first signs of a cold appear Read Review.
In general, users tend to report significant improvements in their immune response within a short period, often just a day or two after starting the supplement during flu season Read Review. However, the timing can vary from person to person based on individual health conditions and the severity of their symptoms. The consensus seems to be that maintaining a regular intake of vitamin C can bolster immunity and reduce the duration of flu symptoms when they do arise.
Vitamin C appears to be a promising supplement in the realm of flu management, bolstered by several research studies. One study found that vitamin C supplementation may slightly reduce the risk of acute respiratory infections, including influenza, by approximately 4%, and shorten the duration of flu symptoms by around 9% [1]. Furthermore, in combinations with other compounds, vitamin C demonstrated potential in reducing viral load and lung inflammation in models infected with the flu virus, suggesting its role in enhancing immune response [3].
Additionally, studies exploring the synergy between vitamin C and specific compounds showed that vitamin C could inhibit neuraminidase activity, a crucial feature of influenza viruses, though its efficacy was moderate compared to established antiviral drugs [2]. Research also indicated that vitamin C might modulate immune responses and help protect against more severe influenza complications, particularly in stressful conditions [5]. While these findings highlight vitamin C as a valuable supplement in supporting flu management, it is essential to consider it as part of a broader strategy rather than a standalone solution.
Users have reported a variety of improvements in their symptoms when taking vitamin C, particularly regarding their immune health. Many reviewers noted that they experienced fewer colds and flu episodes, with one user highlighting that their family had been flu-free for an entire year after starting the supplement Read Review. Others mentioned that when they did feel unwell, their symptoms resolved more quickly, often stating they returned to normal within a day after taking the vitamin C at the first signs of illness Read Review.
Additionally, numerous users claimed improvements not just in immunity but also in overall well-being, highlighting better skin appearance and boosted energy levels Read Review. Some individuals specifically called out the gentle absorption of the supplement, making it a preferred choice for those with sensitive stomachs Read Review. However, it is essential to note that individual results may vary, and while many users experienced these beneficial effects, others may not see the same level of improvement.
Users have reported positive experiences when combining this vitamin C supplement with other supplements for handling flu symptoms. Many find that taking additional supplements, such as vitamin E or glutathione, enhances the protective effects of vitamin C during flu season. One user mentioned that vitamin C works effectively in collaboration with vitamin E and glutathione to shield cell membranes from damage caused by reactive oxygen species (ROS) Read Review. Additionally, some users noted that maintaining a regimen of vitamin C helps to fortify their immune system, making them less susceptible to illness when combined with other essential nutrients Read Review.
Moreover, individuals who reported proactively taking vitamin C at the first sign of flu symptoms also mentioned the benefits of pairing it with other immune-supporting supplements, which they believe contributes to quicker recovery times Read Review. For instance, one user stated that consistent use of vitamin C in conjunction with their daily supplement routine resulted in fewer episodes of colds and flu, indicating a synergistic effect in managing their overall health Read Review. Overall, the user experiences suggest that combining vitamin C with other supplements may enhance its efficacy in flu prevention and recovery.
According to a collection of research studies, there isn't a universally established optimal dose of Ascorbic Acid (Vitamin C) specifically for treating the flu, but some findings suggest doses in the range of 125 to 250 mg/kg may have beneficial effects. In one study focused on pneumonia from the H1N1 strain, mice receiving these doses of Vitamin C showed a significant reduction in severe outcomes related to flu symptoms, indicating a positive effect on immune response and disease severity [5].
Additionally, while higher millimolar concentrations have been observed in laboratory settings to inhibit the neuraminidase activity of influenza viruses, the practical application of these findings to human dosage remains unclear [2]. Overall, while Vitamin C supplementation shows promise in combating flu symptoms and potentially shortening their duration [1], more definitive guidelines are needed for standardized dosages in human populations. Always consult with a healthcare provider for personalized recommendations.
9
Quick relief from flu
1 people found this helpful
Excellent vitamin C with flavonoids! At the first symptoms of flu, I take 1-2 capsules and find that the next day, there are no more symptoms. My skin also looks better since I started taking it.
7.5
Avoids cold symptoms
It seems very effective and helps me a lot with flu. When I have the first symptoms of a cold, I start taking this vitamin (5-10k mg per day), and I'm almost always able to avoid it.
9
Boosts energy levels
Outstanding immune support! Thorne Vitamin C has been excellent for my daily routine. I’ve noticed a significant boost in my immune system and energy levels, especially during cold and flu season.
9
Prevents flu effectively
It's worth every penny! This is my second bottle of vitamin C, and I’ve been flu-free for a year. 😊🙏
9
Reduces illness severity
4 people found this helpful
Excellent vitamin C! One of the primary benefits is its ability to bolster the immune system. I find I cope better with diseases and infections, getting colds and flu less often, and symptoms pass much quicker. With strong antioxidant properties, it protects my cells from damage. Additionally, my skin and hair have improved, appearing brighter and healthier. I recommend this to anyone wanting to boost their immune system, enhance energy, and improve overall well-being.
9
Best brand found
This vitamin C is fantastic. After trying many brands, I find the Thorne one to be the best. It’s essential during winter, and it helps me avoid flu and viruses. I have a sensitive stomach but can tolerate this vitamin C without any problems. I would certainly recommend it.
9
Daily preventive measure
Thank you for the product. I even give it to my children. I can feel the effect. It helps against flu and colds, as well as fatigue, functioning as an antioxidant. We need vitamin C daily. It collaborates with vitamin E and glutathione to protect cell membranes from the effects of ROS.
9
Boosts vitality significantly
Thorne’s Vitamin C has greatly enhanced my overall vitality and resistance to colds and flu.
7.5
Speeds up recovery
Thorne is one of the best brands for supplements and vitamins; their vitamin C is excellent. I take it to reinforce my immune system when I have the flu or a cold, and it speeds up my recovery time.
7.5
Excellent for stress recovery
Прекрасно! It works very well! This quality product is something I take daily to recover from tiredness or stress, and I feel significantly better. It helps combat cold and flu as well, and the capsules are easy to manage. They don't upset my stomach.
7
Vitamin C's promise against flu
Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
9
Immune booster for flu treatment
Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection.
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
8
Vitamin C mitigates flu pneumonia
A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
References
Abioye AI, Bromage S, Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Glob Health. 2021;6. doi:10.1136/bmjgh-2020-003176
Márquez-Domínguez L, Reyes-Leyva J, Herrera-Camacho I, Santos-López G, Scior T. Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus. Molecules. 2020;25. doi:10.3390/molecules25184248
Kim H, Jang M, Kim Y, Choi J, Jeon J, et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. J Pharm Pharmacol. 2016;68:406. doi:10.1111/jphp.12529
Wang H, Xu R, Shi Y, Si L, Jiao P, et al. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur J Med Chem. 2016;110:376. doi:10.1016/j.ejmech.2016.01.005
Cai Y, Li YF, Tang LP, Tsoi B, Chen M, et al. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int. 2015;2015:675149. doi:10.1155/2015/675149