Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: One Gelcap
Amount Per Serving
%DV
Vitamin E (as d-Alpha Tocopherol from 1,000 mg Mixed Tocopherols)
335 mg
2,233%
Top Medical Research Studies
8
We investigated how long-term exposure to urban air pollution affects the recovery from ischemic stroke in mice. Our findings showed that breathing in fine particulate matter increases neuroinflammation and cardiac injury, leading to higher mortality rates after a stroke.
Interestingly, incorporating a vitamin E-rich diet helped reduce cardiac damage and lung inflammation caused by this exposure. We saw a noteworthy improvement in survival rates among mice with ischemic strokes who received the vitamin E, highlighting its potential protective effects against the dangers of urban air pollution.
Interestingly, incorporating a vitamin E-rich diet helped reduce cardiac damage and lung inflammation caused by this exposure. We saw a noteworthy improvement in survival rates among mice with ischemic strokes who received the vitamin E, highlighting its potential protective effects against the dangers of urban air pollution.
Read More
8
Vitamin E intake and heart health
We investigated how dietary vitamin E intake relates to cardiovascular disease and mortality using data from over 39,000 participants in the NHANES study from 2003 to 2018.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
Read More
8
We examined various studies comparing tocotrienol and tocopherol, types of vitamin E, in managing atherosclerotic cardiovascular disease. After reviewing 516 articles, we found that tocotrienol significantly reduced cholesterol and inflammatory markers, showing promising benefits for heart health. In contrast, tocopherol presented mixed results, sometimes increasing mortality risk. This suggests that tocotrienol may be a safer and more effective choice for improving cardiovascular health.
Read More
Most Useful Reviews
9
Alleviates discomfort
4 people found this helpful
This product significantly helped me with the discomfort caused by fibrocystic breast disease. I previously suffered intense pain leading up to my period, making daily activities difficult. After taking this vitamin E supplement, I experienced substantial relief. It’s a worthwhile investment for anyone dealing with similar issues, especially regarding cardiovascular disease.
Read More
7.5
Effective antioxidant support
Thorne's Ultimate-E offers vital antioxidant activity and supports cardiovascular health. Clinical studies indicate that vitamin E is beneficial for the cardiovascular system. The mixed tocopherols in this supplement demonstrate a stronger effect against lipid peroxidation compared to alpha-tocopherol alone, enhancing its antioxidant properties.
Read More
7.5
Boosts immune function
Vitamin E is a fat-soluble vitamin with powerful antioxidant properties that protect cells from damage. It plays a vital role in maintaining immune function and supports cardiovascular health by reducing risks associated with cardiovascular disease. This supplement is advisable for better overall health.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
- All Researches
8
Antioxidants reduce CVD mortality risk
We investigated the connection between dietary antioxidants, including vitamin E, and mortality risks in patients with cardiovascular disease (CVD). In our research with 1,395 participants, we found that higher levels of antioxidants were linked to decreased all-cause and cardiovascular-cause deaths.
Specifically, vitamins like C and E showed beneficial effects. This suggests that boosting our antioxidant intake could be a helpful strategy for improving health outcomes in those with CVD.
Specifically, vitamins like C and E showed beneficial effects. This suggests that boosting our antioxidant intake could be a helpful strategy for improving health outcomes in those with CVD.
Read More
8
We investigated how long-term exposure to urban air pollution affects the recovery from ischemic stroke in mice. Our findings showed that breathing in fine particulate matter increases neuroinflammation and cardiac injury, leading to higher mortality rates after a stroke.
Interestingly, incorporating a vitamin E-rich diet helped reduce cardiac damage and lung inflammation caused by this exposure. We saw a noteworthy improvement in survival rates among mice with ischemic strokes who received the vitamin E, highlighting its potential protective effects against the dangers of urban air pollution.
Interestingly, incorporating a vitamin E-rich diet helped reduce cardiac damage and lung inflammation caused by this exposure. We saw a noteworthy improvement in survival rates among mice with ischemic strokes who received the vitamin E, highlighting its potential protective effects against the dangers of urban air pollution.
Read More
8
Higher vitamin E linked to decreased mortality
In this extensive study of over 16,000 adults with hypertension, we found that higher dietary antioxidant intake, including vitamin E, is linked to a reduced risk of deaths from all causes and specifically from cardiovascular disease (CVD).
Over about seven years of following participants, those with the highest levels of vitamin E intake showed a lower likelihood of CVD mortality compared to those with lower intakes.
While these findings are promising, further research is still needed to solidify these conclusions.
Over about seven years of following participants, those with the highest levels of vitamin E intake showed a lower likelihood of CVD mortality compared to those with lower intakes.
While these findings are promising, further research is still needed to solidify these conclusions.
Read More
8
Vitamin E intake and heart health
We investigated how dietary vitamin E intake relates to cardiovascular disease and mortality using data from over 39,000 participants in the NHANES study from 2003 to 2018.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
Read More
8
We examined various studies comparing tocotrienol and tocopherol, types of vitamin E, in managing atherosclerotic cardiovascular disease. After reviewing 516 articles, we found that tocotrienol significantly reduced cholesterol and inflammatory markers, showing promising benefits for heart health. In contrast, tocopherol presented mixed results, sometimes increasing mortality risk. This suggests that tocotrienol may be a safer and more effective choice for improving cardiovascular health.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Alleviates discomfort
4 people found this helpful
This product significantly helped me with the discomfort caused by fibrocystic breast disease. I previously suffered intense pain leading up to my period, making daily activities difficult. After taking this vitamin E supplement, I experienced substantial relief. It’s a worthwhile investment for anyone dealing with similar issues, especially regarding cardiovascular disease.
Read More
7.5
Effective antioxidant support
Thorne's Ultimate-E offers vital antioxidant activity and supports cardiovascular health. Clinical studies indicate that vitamin E is beneficial for the cardiovascular system. The mixed tocopherols in this supplement demonstrate a stronger effect against lipid peroxidation compared to alpha-tocopherol alone, enhancing its antioxidant properties.
Read More
7.5
Boosts immune function
Vitamin E is a fat-soluble vitamin with powerful antioxidant properties that protect cells from damage. It plays a vital role in maintaining immune function and supports cardiovascular health by reducing risks associated with cardiovascular disease. This supplement is advisable for better overall health.
Read More
7.5
Natural tocopherol blend
Ultimate E is a blend of natural tocopherols, utilising molecular distillation to remove allergenic soy residues. This vitamin E supplement effectively supports cardiovascular health. Studies indicate that mixed tocopherols provide a superior antioxidant effect compared to alpha-tocopherol alone, making it an excellent choice for cardiovascular disease support.
Read More
Frequently Asked Questions
9
Alleviates discomfort
4 people found this helpful
This product significantly helped me with the discomfort caused by fibrocystic breast disease. I previously suffered intense pain leading up to my period, making daily activities difficult. After taking this vitamin E supplement, I experienced substantial relief. It’s a worthwhile investment for anyone dealing with similar issues, especially regarding cardiovascular disease.
7.5
Natural tocopherol blend
Ultimate E is a blend of natural tocopherols, utilising molecular distillation to remove allergenic soy residues. This vitamin E supplement effectively supports cardiovascular health. Studies indicate that mixed tocopherols provide a superior antioxidant effect compared to alpha-tocopherol alone, making it an excellent choice for cardiovascular disease support.
7.5
Effective antioxidant support
Thorne's Ultimate-E offers vital antioxidant activity and supports cardiovascular health. Clinical studies indicate that vitamin E is beneficial for the cardiovascular system. The mixed tocopherols in this supplement demonstrate a stronger effect against lipid peroxidation compared to alpha-tocopherol alone, enhancing its antioxidant properties.
7.5
Boosts immune function
Vitamin E is a fat-soluble vitamin with powerful antioxidant properties that protect cells from damage. It plays a vital role in maintaining immune function and supports cardiovascular health by reducing risks associated with cardiovascular disease. This supplement is advisable for better overall health.
8
Vitamin E intake and heart health
We investigated how dietary vitamin E intake relates to cardiovascular disease and mortality using data from over 39,000 participants in the NHANES study from 2003 to 2018.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
8
Higher vitamin E linked to decreased mortality
In this extensive study of over 16,000 adults with hypertension, we found that higher dietary antioxidant intake, including vitamin E, is linked to a reduced risk of deaths from all causes and specifically from cardiovascular disease (CVD).
Over about seven years of following participants, those with the highest levels of vitamin E intake showed a lower likelihood of CVD mortality compared to those with lower intakes.
While these findings are promising, further research is still needed to solidify these conclusions.
Over about seven years of following participants, those with the highest levels of vitamin E intake showed a lower likelihood of CVD mortality compared to those with lower intakes.
While these findings are promising, further research is still needed to solidify these conclusions.
2
We explored how certain antioxidants, especially vitamin E (α-tocopherol), relate to cardiovascular disease risk using a two-sample Mendelian randomization approach.
Surprisingly, our findings suggest that higher levels of α-tocopherol might be associated with an increased risk of serious heart conditions like myocardial infarction and arrhythmias.
Similarly, retinol was linked to greater risks for cardiomyopathy and heart failure. This challenges the common perception of antioxidants as solely beneficial, indicating that some may actually pose health risks.
More research is needed to fully understand these relationships and their implications for our dietary choices.
Surprisingly, our findings suggest that higher levels of α-tocopherol might be associated with an increased risk of serious heart conditions like myocardial infarction and arrhythmias.
Similarly, retinol was linked to greater risks for cardiomyopathy and heart failure. This challenges the common perception of antioxidants as solely beneficial, indicating that some may actually pose health risks.
More research is needed to fully understand these relationships and their implications for our dietary choices.
7
We explored how a six-week high-antioxidant-capacity diet affects patients with cardiovascular disease. This experimental study included 48 participants, and we measured various health markers, like oxidative stress and inflammation, before and after the dietary intervention.
Our findings showed that the diet significantly shifted antioxidant levels and reduced inflammatory markers, particularly interleukin-6. Although individual results depended on each person's initial antioxidant capacity, the overall trend suggested a reduction in oxidative stress.
Unfortunately, this study did not yield a clear significant benefit regarding cardiovascular outcomes, indicating that more research is needed in this area.
Our findings showed that the diet significantly shifted antioxidant levels and reduced inflammatory markers, particularly interleukin-6. Although individual results depended on each person's initial antioxidant capacity, the overall trend suggested a reduction in oxidative stress.
Unfortunately, this study did not yield a clear significant benefit regarding cardiovascular outcomes, indicating that more research is needed in this area.
References
- Hu X, Zhao Z, An Q, Li Y, Wang B. Association of independent dietary antioxidant intake, and CDAI level with risks of all-cause and cardiovascular-cause death among population with cardiovascular disease. BMC Public Health. 2025;25:1327. 10.1186/s12889-025-22481-1
- Yang R, Lv M, Yang X, Zhai S. A Mendelian randomized study of circulating antioxidants in the diet and risk of cardiovascular disease. Sci Rep. 2025;15:10341. 10.1038/s41598-025-94369-4
- Czlapka-Matyasik M, Wadolowska L, Gut P, Gramza-Michałowska A. Changes in Oxidative Stress, Inflammatory Markers, and Lipid Profile After a 6-Week High-Antioxidant-Capacity Dietary Intervention in CVD Patients. Nutrients. 2025;17. 10.3390/nu17050806
- Ishihara N, Tanaka M, Namba K, Kawano S, Nishimura S, et al. Long-term exposure to urban particulate matter exacerbates mortality after ischemic stroke in mice. J Toxicol Sci. 2025;50:147. 10.2131/jts.50.147
- Zhao S, Cao Y, Liu H, Liu A. Joint and independent associations of dietary antioxidant intakes with all-cause and cardiovascular mortality among patients with hypertension: a population-based cohort study. Nutr J. 2025;24:14. 10.1186/s12937-024-01062-9
- Zeng Q, Liao M, Li Y, She F, Zhang P. Association between dietary vitamin E intake and incident cardiovascular disease, cardiovascular, and all-cause mortality: A prospective cohort study using NHANES 2003-2018 data. Int J Cardiol Cardiovasc Risk Prev. 2025;24:200340. 10.1016/j.ijcrp.2024.200340
- Ren W, Li Y, Lu C, Liu S, Shao Y, et al. Comprehensive assessment on the association of dietary vitamins with all-cause and cardiovascular mortality among individuals with prediabetes: evidence from NHANES 1999-2018. Food Funct. 2024;15:10037. 10.1039/d4fo02893g
- Li B, Hu M, Ma Y, Sun X, Wu D, et al. Association between Vitamin E, Vitamin B6, and Vitamin B12 with coronary heart disease. Sci Rep. 2024;14:19960. 10.1038/s41598-024-68413-8
- Wang Y, Han L, Ling S, Sha Y, Sun H. Dietary intake of potassium, vitamin E, and vitamin C emerges as the most significant predictors of cardiovascular disease risk in adults. Medicine (Baltimore). 2024;103:e39180. 10.1097/MD.0000000000039180
- Rafique S, Khan DA, Farhat K, Khan MA, Noor M, et al. Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans. J Pak Med Assoc. 2024;74:1124. 10.47391/JPMA.9227
- Sun Y, Zhang H, Qi G, Tian W. Nutrient deficiency patterns and all-cause and cardiovascular mortality in older adults with hypertension: a latent class analysis. BMC Public Health. 2024;24:1551. 10.1186/s12889-024-19003-w
- Masle AM, Kibel A, Jukić I, Čičak P, Selthofer-Relatić K, et al. Enhancing Endothelial Function with Nutrient-Enriched Table Hen Eggs: A Randomized Study in Patients Recovering from Acute Coronary Syndrome. Clin Interv Aging. 2024;19:953. 10.2147/CIA.S461821
- Yakoubi S. Synergistic integration of deep learning with protein docking in cardiovascular disease treatment strategies. IUBMB Life. 2024;76:666. 10.1002/iub.2819
- Liu C, Liang D. Association between Dietary Vitamin E Intake and the Risk of Hypertension in US Adults. Curr Vasc Pharmacol. 2024;22:391. 10.2174/0115701611297956240425115501
