Last update
5/2/2026
Reviewed By
Infographics
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 capsules
Amount Per Serving
%DV
Proprietary BlendBoswellia (Indian Frankincense) (gum) extract, Bromelain (600 GDU/g), Ginger (root) extract, White Willow (bark) (Salix alba) extract, Cayenne (fruit) powder
800 mg
**
Hyaluronic Acid (as Sodium Hyaluronate)
100 mg
**
Top Medical Research Studies
8
We looked into how a new treatment combining hyaluronic acid with a peptide from fibroblast growth factor 2 could help combat acne. This method targets specific receptors involved in acne development, showing promise by reducing both acne lesions and excess oil production in lab tests. Importantly, our study revealed that this treatment does not encourage certain reactions that would typically hinder acne management. While the results are positive, we acknowledge that ongoing research is necessary for further confirmation of these findings.
Read More
9
We explored the effectiveness of a high-concentration (4.5%) hyaluronic acid filler designed to treat facial acne scars. Participants received two treatments, and we evaluated improvements after four months.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Read More
8
We evaluated how two types of hyaluronic acid fillers can impact acne scarring. In a well-structured study, thirty patients received injections of a new formulation with high and low molecular weight HA on one side of their face and a traditional HA filler on the other.
While the traditional filler showed quicker results, the new combined HA formulation provided more pronounced improvements over time. This suggests that hyaluronic acid treatments may offer varying benefits depending on the formulation used.
While the traditional filler showed quicker results, the new combined HA formulation provided more pronounced improvements over time. This suggests that hyaluronic acid treatments may offer varying benefits depending on the formulation used.
Read More
Most Useful Reviews
8
Effective acne treatment
I found this product to be wonderful and unique. The combination of salicylic acid, Indian frankincense, cayenne pepper, ginger powder, antioxidants, and vitamin C significantly enhances the effectiveness of hyaluronic acid. I observed a notable reduction in acne on both my face and body.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.7
- All Researches
9
We explored the effectiveness of a high-concentration (4.5%) hyaluronic acid filler designed to treat facial acne scars. Participants received two treatments, and we evaluated improvements after four months.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Read More
9
Promising treatment for acne scars
We examined how needle-free electronic pneumatic injections of hyaluronic acid could treat facial acne scars. In a carefully designed study, thirty Japanese participants received treatments on one side of their face, with follow-ups conducted for three months after completing three sessions.
Remarkably, 48.3% of the treated sides showed significant improvement, while none of the untreated sides did. Participants reported high satisfaction rates and the results were confirmed by imaging analysis. Overall, this treatment demonstrated promising effects on rolling acne scars with minimal side effects.
Remarkably, 48.3% of the treated sides showed significant improvement, while none of the untreated sides did. Participants reported high satisfaction rates and the results were confirmed by imaging analysis. Overall, this treatment demonstrated promising effects on rolling acne scars with minimal side effects.
Read More
9
Hyaluronic acid shows scar improvement
This study explored the effectiveness of using hyaluronic acid filler alongside subcision for treating post-acne scars.
In a controlled trial with 40 participants, we observed that both the subcision combined with hyaluronic acid and with fractional CO laser treatments showed significant improvements.
However, when comparing the two enhanced methods, neither was found to be statistically better than the other. Importantly, subcision alone still provided some improvement, even if modest. Overall, combining these treatments appears beneficial without serious side effects.
In a controlled trial with 40 participants, we observed that both the subcision combined with hyaluronic acid and with fractional CO laser treatments showed significant improvements.
However, when comparing the two enhanced methods, neither was found to be statistically better than the other. Importantly, subcision alone still provided some improvement, even if modest. Overall, combining these treatments appears beneficial without serious side effects.
Read More
9
We evaluated the impact of combining subcision with hyaluronic acid (HA) on atrophic acne scars. Forty patients received subcision treatments over three sessions, followed by either HA or threads on one side of the face, while the other side served as a control.
The results showed that after 6 months, 94.1% of patients in the HA group experienced significant improvement compared to 67.3% with subcision alone. Patient satisfaction was notably higher for those who received the combined treatment. Side effects were mild and temporary, making this combination a promising option for better scar management.
The results showed that after 6 months, 94.1% of patients in the HA group experienced significant improvement compared to 67.3% with subcision alone. Patient satisfaction was notably higher for those who received the combined treatment. Side effects were mild and temporary, making this combination a promising option for better scar management.
Read More
8
We evaluated how two types of hyaluronic acid fillers can impact acne scarring. In a well-structured study, thirty patients received injections of a new formulation with high and low molecular weight HA on one side of their face and a traditional HA filler on the other.
While the traditional filler showed quicker results, the new combined HA formulation provided more pronounced improvements over time. This suggests that hyaluronic acid treatments may offer varying benefits depending on the formulation used.
While the traditional filler showed quicker results, the new combined HA formulation provided more pronounced improvements over time. This suggests that hyaluronic acid treatments may offer varying benefits depending on the formulation used.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8
Effective acne treatment
I found this product to be wonderful and unique. The combination of salicylic acid, Indian frankincense, cayenne pepper, ginger powder, antioxidants, and vitamin C significantly enhances the effectiveness of hyaluronic acid. I observed a notable reduction in acne on both my face and body.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Stefancu ME, Barattini DF, Botnaru I, Vizman C, Stucchi L, et al. Performance and Safety of the Medical Device Ialuxid Gel in the Treatment of Mild-Moderate Acne Vulgaris: An Open-Label, Noncomparative Multicentre Interventional Clinical Trial. J Cosmet Dermatol. 2025;24:e70084. 10.1111/jocd.70084
- Sparavigna A, Grimolizzi F, Cigni C, Lualdi R, Bellia G. Dual-Plane Treatment With Highly Concentrated Hybrid Cooperative Complexes of Hyaluronans for Facial Atrophic Acne Scars. Dermatol Surg. 2025;51:152. 10.1097/DSS.0000000000004387
- Mohamed SH, Omar GA, Hamdy AE. Microneedling with Topical Insulin Versus Microneedling with Non-Cross-Linked Hyaluronic Acid for Atrophic Post-Acne Scars: A Split-Face Study. Dermatol Pract Concept. 2024;14. 10.5826/dpc.1403a183
- Dastgheib M, Heidari S, Azizipour A, Kavyani M, Lajevardi V, et al. Investigating the impact of added Profhilo mesogel to subcision versus subcision monotherapy in treating acne scars; a single-blinded, split-face randomized trial. J Cosmet Dermatol. 2024;23:1992. 10.1111/jocd.16258
- Bano R, Brar BK, Kumar S. Comparative Evaluation of Therapeutic Efficacy and Safety of Microneedling Alone Versus Microneedling with Hyaluronic Acid in Post-Acne Scarring. J Cutan Aesthet Surg. 2023;16:279. 10.4103/JCAS.JCAS_6_23
- Behrangi E, Dehghani A, Sheikhzadeh F, Goodarzi A, Roohaninasab M. Evaluation and comparison of the efficacy and safety of cross-linked and non-cross-linked hyaluronic acid in combination with botulinum toxin type A in the treatment of atrophic acne scars: A double-blind randomized clinical trial. Skin Res Technol. 2024;30:e13541. 10.1111/srt.13541
- Kaminaka C, Sakata M, Nishiguchi M, Kunimoto K, Mikita N, et al. Clinical evaluation of needle-free electronic pneumatic hyaluronic acid injection treatment for facial atrophic acne scars: A prospective, randomized comparative trial. J Dermatol. 2023;50:971. 10.1111/1346-8138.16830
- Mehrabi J, Shehadeh W, Gallo ES, Artzi O, Horovitz T. Comparison of 2 Hyaluronic Acid-based Fillers for the Treatment of Acne Scars: Structural Lifting Versus Biostimulatory Effect. Dermatol Surg. 2023;49:581. 10.1097/DSS.0000000000003789
- Su Z, Zhang Y, Cao J, Sun Y, Cai Y, et al. Hyaluronic acid-FGF2-derived peptide bioconjugates for suppression of FGFR2 and AR simultaneously as an acne antagonist. J Nanobiotechnology. 2023;21:55. 10.1186/s12951-023-01812-7
- Abdelwahab AA, Omar GAB, Hamdino M. A combined subcision approach with either fractional CO laser (10,600 nm) or cross-linked hyaluronic acid versus subcision alone in atrophic post-acne scar treatment. Lasers Med Sci. 2022;38:20. 10.1007/s10103-022-03677-y
- Mohammed GF, Al-Dhubaibi MS. Triple steps acne scar revision technique: A new combination therapeutic modality for atrophic acne scars. J Cosmet Dermatol. 2022;21:4659. 10.1111/jocd.14944
- Ebrahim HM, Nassar A, ElKashishy K, Artima AYM, Morsi HM. A combined approach of subcision with either cross-linked hyaluronic acid or threads in the treatment of atrophic acne scars. J Cosmet Dermatol. 2022;21:3334. 10.1111/jocd.14675
- MacGillis D, Vinshtok Y. High-velocity pneumatic injection of non-crosslinked hyaluronic acid for skin regeneration and scar remodeling: A retrospective analysis of 115 patients. J Cosmet Dermatol. 2021;20:1098. 10.1111/jocd.14002
- Roohaninasab M, Jafarzadeh A, Zare S, Alavi S, Zare S, et al. Evaluation of the Efficacy, Safety, and Satisfaction Rates of Platelet-Rich Plasma, Non-Cross-Linked Hyaluronic Acid, and their Combination in Patients with Acne Scars Treated with Fractional CO Laser: A Randomized, Double-Blind, Split-Face Comparative Study. Aesthetic Plast Surg. 2026;50:1277. 10.1007/s00266-025-05359-w
- Crainic D, Popescu R, Vlad CD, Serban DV, Popa D, et al. Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence. Biomedicines. 2025;13. 10.3390/biomedicines13092156
- Lee SD, Ahn HJ, Lee SJ, Suh DH, Song KY, et al. Comparison of a Single Treatment of Needleless Microsubcision With Hyaluronic Acid and Carbon Dioxide Pinhole Method for Atrophic Acne Scars. Dermatol Surg. 2026;52:260. 10.1097/DSS.0000000000004837
- Watanabe C. Skin Improvement in Japanese Patients With Inflammatory Dermatologic Conditions Using the Injectable Hyaluronic Acid VYC-12. J Cosmet Dermatol. 2025;24:e70275. 10.1111/jocd.70275
- Zhu J, Wen T, Ma Y, Zeng Q, Li P, et al. Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach. J Control Release. 2025;382:113754. 10.1016/j.jconrel.2025.113754
