Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
USERS' SCORE
Good
Based on 17 Reviews
8.4
Supplement Facts
Serving Size:
Amount Per Serving
%DV
†Daily Value not established.
Top Medical Research Studies
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Read More
8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Read More
8
We explored melatonin's potential to impact neurodevelopment in autism by using stem cells from children with autism. In our study, we differentiated these cells into dopaminergic neurons and tested the effects of melatonin on their growth and function. We discovered that, without melatonin, these neurons showed reduced growth and mitochondrial dysfunction.
However, when melatonin was added, we observed significant improvements in neuron growth and mitochondrial health. Melatonin appears to enhance calcium signaling crucial for development. Nevertheless, further research is needed to confirm these findings and their practical applications for autism treatment.
However, when melatonin was added, we observed significant improvements in neuron growth and mitochondrial health. Melatonin appears to enhance calcium signaling crucial for development. Nevertheless, further research is needed to confirm these findings and their practical applications for autism treatment.
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Most Useful Reviews
7.5
Sleep onset improvement
10 people found this helpful
What can I say? This melatonin truly helps! My son has autism and consequently struggles with sleep. Since giving him this melatonin, he falls asleep within 30 minutes. I follow a specific routine, putting him to bed and administering the melatonin while keeping the room dark. It's been two weeks now; I'm considering a break from it. I took it upon my doctor's recommendation, and I appreciate that it’s non-addictive!
Read More
9
Helps with sleep
8 people found this helpful
Excellent! This dietary supplement is highly effective! My husband’s child has autism and often struggles with sleep. After coming across this melatonin, I decided to try it for our 8-year-old. It works wonders, especially during times of strong over-excitement. We see results within an hour. I tried it on myself first and increased the dose to four, and the taste is pleasant, like candy, which makes it easy for the child to take!
Read More
9
Transformed bedtime
5 people found this helpful
I have a 7-year-old and a 5-year-old diagnosed with autism, and this has revolutionised our nighttime routine. My kids, who would typically be awake until 9:30-10:00 pm, now go to sleep by 7:30 pm, and they adore the taste. With improved sleep, their behaviour has also significantly improved.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
- All Researches
8
We examined the link between insomnia and Autism Spectrum Disorder (ASD), particularly how melatonin can help manage sleep issues in affected children. The analysis, conducted by a team of experts, emphasized the importance of understanding sleep challenges to improve treatment outcomes for both kids and their caregivers.
Encouragingly, melatonin has been found to be both effective and safe for managing insomnia associated with ASD, particularly in prolonged-release forms. Although promising, more research is needed to further validate these findings and improve sleep management strategies.
Encouragingly, melatonin has been found to be both effective and safe for managing insomnia associated with ASD, particularly in prolonged-release forms. Although promising, more research is needed to further validate these findings and improve sleep management strategies.
Read More
8
Melatonin helps autistic zebrafish models
We explored the impact of Nomo1 deficiency on behavior in zebrafish, which mimics aspects of neuropsychiatric disorders, including autism. The study demonstrated that these zebrafish exhibited abnormal brain development and various neuropsychiatric symptoms.
Notably, we found that treating these fish with melatonin not only restored normal locomotor activity but also reduced repetitive behaviors and addressed inflammation in the brain. This suggests that melatonin could be a promising therapeutic option for managing neuropsychiatric conditions linked to NOMO1 deficiency.
Notably, we found that treating these fish with melatonin not only restored normal locomotor activity but also reduced repetitive behaviors and addressed inflammation in the brain. This suggests that melatonin could be a promising therapeutic option for managing neuropsychiatric conditions linked to NOMO1 deficiency.
Read More
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Read More
8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Read More
8
We conducted a detailed look into sleep-related rhythmic movement disorder (SR-RMD) in children, involving data from 66 patients at a UK hospital.
Our assessment included questionnaires to explore autism traits and behavioral impacts. Notably, families reported the burden of sleeplessness and concerns for their children's safety.
Intriguingly, many parents noted improvements in their children’s sleep after administering extended-release melatonin, suggesting this could be a viable treatment option in the future.
Our assessment included questionnaires to explore autism traits and behavioral impacts. Notably, families reported the burden of sleeplessness and concerns for their children's safety.
Intriguingly, many parents noted improvements in their children’s sleep after administering extended-release melatonin, suggesting this could be a viable treatment option in the future.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Sleep onset improvement
10 people found this helpful
What can I say? This melatonin truly helps! My son has autism and consequently struggles with sleep. Since giving him this melatonin, he falls asleep within 30 minutes. I follow a specific routine, putting him to bed and administering the melatonin while keeping the room dark. It's been two weeks now; I'm considering a break from it. I took it upon my doctor's recommendation, and I appreciate that it’s non-addictive!
Read More
9
Helps with sleep
8 people found this helpful
Excellent! This dietary supplement is highly effective! My husband’s child has autism and often struggles with sleep. After coming across this melatonin, I decided to try it for our 8-year-old. It works wonders, especially during times of strong over-excitement. We see results within an hour. I tried it on myself first and increased the dose to four, and the taste is pleasant, like candy, which makes it easy for the child to take!
Read More
9
Transformed bedtime
5 people found this helpful
I have a 7-year-old and a 5-year-old diagnosed with autism, and this has revolutionised our nighttime routine. My kids, who would typically be awake until 9:30-10:00 pm, now go to sleep by 7:30 pm, and they adore the taste. With improved sleep, their behaviour has also significantly improved.
Read More
9
First effective product
2 people found this helpful
This is the best product on the market! After trying various options for my 12-year-old with autism, this is the first that has worked, allowing him to sleep within 20 minutes of taking it. I would highly recommend it to anyone facing similar difficulties.
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9
Quickly falls asleep
I've been buying Zarbee’s chewable melatonin for my youngest daughter, who has autism. It is truly fantastic! She used to struggle to fall asleep, but since starting with Zarbee’s, she drifts off within 15-20 minutes of taking her tablet. She enjoys the delicious taste, making it easy for her to chew and swallow.
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Frequently Asked Questions
9
First effective product
2 people found this helpful
This is the best product on the market! After trying various options for my 12-year-old with autism, this is the first that has worked, allowing him to sleep within 20 minutes of taking it. I would highly recommend it to anyone facing similar difficulties.
9
Quick sleep onset
I previously bought this product and returned to purchase it again for my 11-year-old son with autism, who struggles with sleep. I give it to him during times when his sleep is disturbed, and honestly, it works well. Two pills help him fall asleep within 10 minutes. The quantity is good, and my son enjoys the sweet taste. The size is also excellent.
7.5
Cumulative effect
This is an excellent tool; my sister bought it for her son with autism, who previously could not sleep until 3 am. After taking the pill, he typically falls asleep in about half an hour. It has a cumulative effect, and after a week, I noticed improvements in his sleep. I also give it to my child when travelling, especially on long train journeys. At two years old, half a pill was sufficient for her to fall asleep within half an hour.
7.5
Cumulative improvements
With autism, we consume this melatonin in courses of 30-40 days, followed by a break of 1-2 weeks. It has cumulative effects, helping us fall asleep around day five, establishes our night sleep, and prevents waking up. At five years old, I take one piece 30 minutes before bed, noticing daytime sleep normalising by day ten.
9
Transformed bedtime
5 people found this helpful
I have a 7-year-old and a 5-year-old diagnosed with autism, and this has revolutionised our nighttime routine. My kids, who would typically be awake until 9:30-10:00 pm, now go to sleep by 7:30 pm, and they adore the taste. With improved sleep, their behaviour has also significantly improved.
7.5
Sleep onset improvement
10 people found this helpful
What can I say? This melatonin truly helps! My son has autism and consequently struggles with sleep. Since giving him this melatonin, he falls asleep within 30 minutes. I follow a specific routine, putting him to bed and administering the melatonin while keeping the room dark. It's been two weeks now; I'm considering a break from it. I took it upon my doctor's recommendation, and I appreciate that it’s non-addictive!
9
Cumulative benefits
This melatonin is excellent; it is an irreplaceable solution for sleep issues in children and shows cumulative benefits. The child takes it in courses, and it is essential for children with autism.
9
Easier bedtime
My two-year-old with autism has significant difficulties falling asleep. Initially, I couldn't envision how we'd manage. However, these pills have made a remarkable difference. Within 30 minutes of taking them, he calms down and can peacefully enjoy a story. He is now sleeping better and is much happier, with improved focus. Highly recommend this product; I plan to buy two more packs!
7.5
Essential supplement
Excellent supplement! This is not my first experience with it. It is crucial for families with children who have autism or those who struggle to sleep. Importantly, it does not lead to dependency.
References
- Bruni O, Biggio G, Malorgio E, Nobili L. Insomnia in children affected by autism spectrum disorder: The role of melatonin in treatment. Sleep Med. 2024;119:511. 10.1016/j.sleep.2024.05.046
- Rezzani R, Gianò M, Pinto D, Rinaldi F, van Noorden CJF, et al. Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis. Int J Mol Sci. 2024;25. 10.3390/ijms25021086
- Zhang Q, Li F, Li T, Lin J, Jian J, et al. Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO Rep. 2024;25:570. 10.1038/s44319-023-00036-y
- Wang L, Xu M, Wang Y, Wang F, Deng J, et al. Melatonin improves synapse development by PI3K/Akt signaling in a mouse model of autism spectrum disorder. Neural Regen Res. 2024;19:1618. 10.4103/1673-5374.387973
- Tse ACY, Lee PH, Sit CHP, Poon ET, Sun F, et al. Comparing the Effectiveness of Physical Exercise Intervention and Melatonin Supplement in Improving Sleep Quality in Children with ASD. J Autism Dev Disord. 2024;54:4456. 10.1007/s10803-023-06172-7
- Sadeh H, Meiri G, Zigdon D, Ilan M, Faroy M, et al. Adherence to treatment and parents' perspective about effectiveness of melatonin in children with autism spectrum disorder and sleep disturbances. Child Adolesc Psychiatry Ment Health. 2023;17:123. 10.1186/s13034-023-00669-w
- Joels H, Benny A, Sharpe A, Postigo B, Joseph B, et al. Sleep related rhythmic movement disorder: phenotypic characteristics and treatment response in a paediatric cohort. Sleep Med. 2023;112:21. 10.1016/j.sleep.2023.09.020
- Dong S, Kifune T, Kato H, Wang L, Kong J, et al. Effects of melatonin on dopaminergic neuron development via IP3-mediated mitochondrial Ca regulation in autism spectrum disorder. Biochem Biophys Res Commun. 2023;681:7. 10.1016/j.bbrc.2023.09.050
- Bernardi K, Prono F, Bruni G, Panerai S, Ferri R, et al. Sleep disturbances in subjects with autism spectrum disorder: A parental perspective. Sleep Med. 2023;110:220. 10.1016/j.sleep.2023.08.020
- Horsnell J, Mangar S, Dimitriou D, Halstead EJ. Parental Experiences of Melatonin Administration to Manage Sleep Disturbances in Autistic Children and Adolescent in the UK. Healthcare (Basel). 2023;11. 10.3390/healthcare11121780
