Doctor&#039;s Best High Absorption CoQ10 with BioPerine

Vrentzos E, Ikonomidis I, Pavlidis G, Katogiannis K, Korakas E, et al. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial. Cardiovasc Diabetol. 2024;23:245. doi:10.1186/s12933-024-02326-8

Based on 11 Researches

Coenzyme Q10 improves liver health

We conducted a study to explore the effects of high-dose coenzyme Q10 supplementation on patients suffering from liver disease related to metabolic dysfunction, known as Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD). In a well-structured double-blind, placebo-controlled trial with sixty participants, half received 240 mg of coenzyme Q10 daily, while the other half received a placebo for six months.

Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.

Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.

Promotes detoxification

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1 people found this helpful

Q10 is a powerful antioxidant that protects against free radicals, crucial for liver disease. I ordered it for my mother, who needed detox support, and it significantly boosts energy levels and reduces fatigue.

Parkinson details

CoQ10 boosts motor function in mice

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Based on 12 Researches

Takahashi K, Ohsawa I, Shirasawa T, Takahashi M. Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q. Exp Gerontol. 2016;81:65. doi:10.1016/j.exger.2016.04.023

We examined how coenzyme Q10 (CoQ10) treatment impacts age-related motor issues and changes related to Parkinson's disease in mice. Aged mice displayed reduced motor functions and increased levels of a harmful protein, α-synuclein, in their brains compared to younger mice.

By giving aged mice CoQ10 in their drinking water, we found that their motor abilities improved significantly, and the harmful protein levels decreased. These findings suggest that CoQ10 can positively influence motor function and may help address early signs of Parkinson-like changes in the brain.

Tremors reduced

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2 people found this helpful

The trembling in my hands has subsided. As an 80-year-old man with a relative suffering from Parkinson’s disease, I have been taking CoQ10 for over 10 years. Although I’m unsure if it's directly responsible, the tremors in my hands, which I've experienced since my youth, have not worsened. However, I accidentally missed taking CoQ10 for some months and noticed my left hand tremors intensified. Realising my mistake, I promptly reordered and resumed taking it. After about two weeks, the tremors diminished, and I'm back to how I was before. Despite clinical trials of CoQ10 for Parkinson's seemingly failing, I remain convinced of its efficacy.

Swollen Lymph Nodes details

This product has had a remarkable impact on my health. Unlike other brands, this iHerb CoQ10 is pure, enriched with BioPerine for heart health. Since I began using it, I no longer struggle to catch my breath during walks or runs. I also no longer experience swelling in my feet, particularly during long flights or while standing for extended periods. Additionally, it seems to have anti-aging benefits, making my skin look much younger at 59. My doctor advised a cycle of 4 to 6 months with breaks, which I plan to follow as long as it benefits my health. Highly recommended!

Adenoiditis details

Significant effect noted

I purchased these lozenges for myself and consistently take them. Previously, I opted for picolinate, but I have no regrets about switching to these lozenges (even though the zinc here is in a different form)! They have a delightful taste and help to soothe my throat as they dissolve. Occasionally, zinc from pharmaceutical sources has made me feel nauseous, but these lozenges did not cause that issue. If you experience this, avoid taking it on an empty stomach. I particularly notice the effects when I start to feel a sore throat, using them every two hours as recommended, which significantly eases my discomfort. I highly recommend them!

Alzheimer details

Ubiquinol may combat Alzheimer's effects

Llanos-González E, Sancho-Bielsa FJ, Frontiñán-Rubio J, Rabanal-Ruíz Y, García-Carpintero S, et al. Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12030747

We explored the effects of ubiquinol, a form of coenzyme Q10, on Alzheimer's disease through a model using 3xTG-AD mice. Our research aimed to understand how disrupted protein modules in the brain correlate with the progression of Alzheimer's, particularly in terms of oxidative stress and protein regulation.

By employing advanced techniques like MALDI-MSI and functional bioinformatics, we examined how these protein modules are altered based on the age of the mice. We found significant deregulation in specific protein modules related to oxidative stress and metabolism, especially in the hippocampus of younger mice (6 months old) and in the cortical regions of older mice (12 months old). This suggests that early intervention might be crucial to address these changes.

Remarkably, we observed that introducing ubiquinol at an early stage could help restore these protein modules back to a healthier state. This is exciting because it means dietary adjustments, particularly an increase in ubiquinol, could be beneficial in preventing the progression of Alzheimer’s symptoms, both in mice and potentially in humans.

Our findings not only highlight the impact of early dietary intervention but also reinforce the significance of exploring coenzyme Q10 and its benefits for brain health as we age. We believe these insights could pave the way for promising new strategies to combat Alzheimer's disease.

7.5

Alzheimer’s support

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Love it. I take it daily. I have alzheimer and believe it helps with various issues while I manage this condition.

Attention Deficit Hyperactivity Disorder details

This supplement has been excellent for my memory. After having Covid, my memory declined, but since taking this supplement, I’ve already noticed improvements.

Autoimmune Disorder details

Blanco LP, Pedersen HL, Wang X, Lightfoot YL, Seto N, et al. Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone. Arthritis Rheumatol. 2020;72:454. doi:10.1002/art.41128

Based on 14 Researches

Idebenone improves lupus symptoms

We explored the potential benefits of idebenone, a synthetic analog of coenzyme Q10, in treating autoimmune disorders, specifically lupus, in mouse models. By administering idebenone to mice with lupus for eight weeks, we aimed to investigate its impact on disease activity and organ damage.

Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.

Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.

This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.

Tremors reduced

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2 people found this helpful

I've taken CoQ10 for over 10 years as I have a relative with Parkinson's disease. I noticed my hand tremors haven't worsened, and my hearing loss has barely progressed. After a few months without it, my tremors increased, so I reordered. Within two weeks of taking CoQ10 again, they improved significantly. I believe it is effective for my autoimmune disorder.

Back Pain details

Effective cramp relief

2 people found this helpful

Leg cramp relief is effective for pain caused by statin medication.

Rash details

Enhanced energy levels

1 people found this helpful

On the 10th day of taking this product, I found it easier to wake up and I no longer feel fatigued during the day. It feels like a spark for my body. Additionally, I've observed that my skin has improved with the minor rashes disappearing. It's quite impressive!

Atrial Flutter details

3 people found this helpful

I experience stress-induced arrhythmias which led to frequent emergency visits. Initially, I feared it was angina, but it was diagnosed as arrhythmia. When my heart races, I struggle to breathe. After learning about CoQ10, I've been consistently taking it. It’s effective, as I can see my condition improving, and I am managing well. It has become an essential nutrient for me, and I hope it remains available.

Diabetes details

Improved diabetes symptoms

8 people found this helpful

I requested this for my friend who has suffered from diabetes for 10 years and experienced numbness in his limbs. A doctor recommended this vitamin with B12, and over time, he felt a great improvement and decided to continue using it. If you find this comment helpful, please like it. Thank you.

Weight Loss details

6 people found this helpful

I can feel the effects immediately. This is the best CoQ10 I've tried among at least three different brands. Perhaps this brand suits my body's chemistry better. I also lost 100 pounds with fasting, keto, exercise, meditation, and various weight loss supplements from Iherb. Please see my profile for more details and other reviews. Thanks!

Migraine details

Dahri M, Tarighat-Esfanjani A, Asghari-Jafarabadi M, Hashemilar M. Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers. Nutr Neurosci. 2019;22:607. doi:10.1080/1028415X.2017.1421039

Based on 29 Researches

CoQ10 improves migraine symptoms

We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.

Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.

Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.

Significant pain relief

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9 people found this helpful

I suffer from migraine and chronic neck and shoulder pain. My doctors suggested 200mg of CoQ10 three times daily, which has made a remarkable difference! After running out once, I noticed the pain returned. It's been a staple supplement since, and I advocate its use to anyone enduring migraine pain.

Sleep Apnea details

Mermigkis C, Bouloukaki I, Mastorodemos V, Plaitakis A, Alogdianakis V, et al. Medical treatment with thiamine, coenzyme Q, vitamins E and C, and carnitine improved obstructive sleep apnea in an adult case of Leigh disease. Sleep Breath. 2013;17:1129. doi:10.1007/s11325-013-0816-5

Likely Very Effective

Coenzyme Q10 in sleep apnea study

We explored the impact of various treatments, including coenzyme Q10, on obstructive sleep apnea (OSA) in a patient with adult-onset Leigh disease. This condition often presents with severe neurological symptoms, complicating the patients’ overall health and quality of life.

An overnight sleep study revealed the presence of OSA, which had developed shortly before the neurological symptoms became apparent. Treatment included high doses of thiamine, coenzyme Q, L-carnitine, and vitamins C and E, along with effective management of OSA through continuous positive airway pressure (CPAP).

Following this combined approach, we observed a marked clinical improvement not only in the patient's sleep quality but also in their neurological outcomes. While coenzyme Q10 was part of this combination therapy, its specific contribution to alleviating sleep apnea symptoms cannot be isolated from the other treatments. Overall, the findings suggest that recognizing and treating sleep apnea promptly can enhance patients’ well-being and potentially improve neurological conditions associated with Leigh disease.

Increased energy

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1 people found this helpful

A potent antioxidant! After a week of taking it, I feel more energetic, and my sleep has improved dramatically without any side effects. I plan to continue this for optimal heart and brain support.

Cancer details

Hussein Z, Michel HE, El-Naga RN, El-Demerdash E, Mantawy EM. Coenzyme Q10 ameliorates cyclophosphamide-induced chemobrain by repressing neuronal apoptosis and preserving hippocampal neurogenesis: Mechanistic roles of Wnt/ β-catenin signaling pathway. Neurotoxicology. 2024;105:21. doi:10.1016/j.neuro.2024.08.003

Based on 5 Researches

CoQ10 mitigates chemobrain effects

We explored the potential benefits of Coenzyme Q10 (CoQ10) on cancer patients dealing with a condition commonly referred to as "Chemobrain," which is associated with treatment using the chemotherapy drug cyclophosphamide (CYP). In our study, male rats were given a daily dose of CoQ10 for ten days, while they also received a single dose of CYP to model the effects of chemotherapy on cognition and motor skills.

The findings were promising. CoQ10 not only helped counteract cognitive and motor dysfunctions triggered by CYP but also showed significant neuroprotective effects. Behavioral tests demonstrated improvements, and histopathological analysis confirmed that CoQ10 reduced brain damage linked to oxidative stress caused by CYP. This micronutrient effectively restored levels of the antioxidant enzyme catalase and lowered harmful substances like malondialdehyde.

Furthermore, CoQ10 appeared to inhibit neuronal apoptosis, or cell death, by balancing expressions of key proteins involved in the process. It supported neurogenesis in the hippocampus by increasing important growth factors. Most notably, CoQ10 activated the Wnt/β-catenin signaling pathway, which is crucial for brain health and development.

Overall, our study highlights how CoQ10 may offer a multi-faceted approach to mitigating the adverse effects of chemotherapy on cognitive function, bolstering both brain protection and regeneration.

7.5

Supports heart health

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1 people found this helpful

My husband and I took this product to support heart health. There were some slight pains, but I read that coenzyme assists in heart function and slows ageing. I have been taking one capsule daily with food for a month. Coenzyme Q10 absorbs better with dietary fats at breakfast or lunch, helping to avoid sleep disturbances. I feel better after a month of use, noting benefits such as improved heart function and reduced cancer cell degeneration. Coenzyme Q10 boosts cellular energy, aids immune function, and enhances oxygen uptake, thus preserving skin beauty and youth.

Cardiovascular Disease details

CoQ-10 reduces mortality, improves capacity

Based on 10 Researches

Qazi SU, Bin Naeem MA, Umar M, Zahid MJ, Kan Changez MI, et al. Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. Future Cardiol. 2024;20:221. doi:10.1080/14796678.2024.2352308

We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.

In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.

Supports cardiovascular system

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149 people found this helpful

Coenzyme Q10 is vital for heart, kidney, and liver function. As we age, our body produces less CoQ10, increasing the risk of complex diseases. It acts as an antioxidant, enhancing energy, improving immunity, and lowering bad cholesterol while promoting a healthy cardiovascular system. It aids recovery after high physical stress and improves sleep quality.

Heart Disease details

CoQ-10 improves heart failure outcomes

We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.

However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.

In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.

Boosts heart function

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210 people found this helpful

This "enzyme of youth" fuels our body and boosts energy. I buy it for my family, and it significantly helps my 69-year-old mother. Coenzyme Q10 is crucial for heart support and energy production, especially important as levels decrease with stress and statins. Take as advised by a healthcare professional.

Blood Clot details

Ya F, Xu XR, Shi Y, Gallant RC, Song F, et al. Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin αIIbβ3 Signaling and Thrombus Growth. Mol Nutr Food Res. 2019;63:e1900662. doi:10.1002/mnfr.201900662

Based on 5 Researches

CoQ10 reduces harmful blood clots

We explored how coenzyme Q10 (CoQ10), a natural compound found in various foods, impacts blood clotting functions. Through a well-structured study, we utilized a randomized, double-blind, placebo-controlled trial with dyslipidemic patients, alongside in vitro tests on human platelets.

Our findings demonstrated that CoQ10 effectively reduces platelet aggregation, granule secretion, platelet spreading, and clot retraction. This means that CoQ10 can help prevent excessive blood clot formation, which is crucial for cardiovascular health.

We observed that CoQ10 works mainly by enhancing a signaling pathway involving cyclic AMP (cAMP) which ultimately diminishes the signaling of integrin αIIbβ3, a key player in platelet function. In addition, the treatment showed promising results in reducing thrombus growth in an animal model, suggesting significant in vivo benefits as well.

This study highlights the potential of CoQ10 supplementation as a protective measure for individuals at risk of cardiovascular diseases by regulating platelet-related processes involved in clotting.

Normal blood pressure

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35 people found this helpful

My grandmother had issues with her blood pressure, both high and low. With the help of this medication, it returned to normal! I recommend purchasing it!

Heart Attack details

Singh RB, Fedacko J, Mojto V, Pella D. Coenzyme Q10 Modulates Remodeling Possibly by Decreasing Angiotensin-Converting Enzyme in Patients with Acute Coronary Syndrome. Antioxidants (Basel). 2018;7. doi:10.3390/antiox7080099

Coenzyme Q10 aids heart recovery

We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.

Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.

Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.

Heart muscle support

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48 people found this helpful

Pure coenzyme Q10 significantly enhances heart muscle function, reducing the risk of heart attacks considerably.

High Cholesterol details

Liu Z, Tian Z, Zhao D, Liang Y, Dai S, et al. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials. J Clin Endocrinol Metab. 2022;108:232. doi:10.1210/clinem/dgac585

Based on 12 Researches

CoQ10 lowers cholesterol levels

We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.

Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.

Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.

7.5

Blood pressure stabilised

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12 people found this helpful

As I aged, my blood pressure rose, reaching around 150-160, which caused heart failure symptoms. After consulting with the hospital, I was advised to take blood pressure medication. Concerned by acquaintances needing dialysis due to high cholesterol, I opted for nutrients to lower my blood pressure. I took CoQ10 200mg, magnesium 500mg, and Eltheanine 200mg, noticing improvements quickly. My blood pressure now stays at 120-130, and heart symptoms have subsided. I'll continue using this product.

Chronic Fatigue Syndrome details

Ubiquinol-10 benefits chronic fatigue syndrome

Based on 15 Researches

Fukuda S, Nojima J, Kajimoto O, Yamaguti K, Nakatomi Y, et al. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome. Biofactors. 2016;42:431. doi:10.1002/biof.1293

We embarked on a study to investigate the impact of ubiquinol-10—an active form of coenzyme Q10—on patients suffering from chronic fatigue syndrome (CFS). Our research comprised two parts: an open-label study involving 20 patients and a randomized, double-blind, placebo-controlled trial with 43 participants.

In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.

Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.

Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.

Rejuvenating energy

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14 people found this helpful

This supplement truly provides ENERGY! CoQ10 improves cardiovascular health, has a rejuvenating effect, enhances carbohydrate metabolism, and boosts the immune system. I take it alongside Omega and Resveratrol. After a month, I felt noticeable improvements in my well-being and energy, with deeper sleep and a stable mood. I plan to keep incorporating it into my routine.

Cold details

2 people found this helpful

I have been taking CoQ10 for many years and cannot do without it. I feel more energetic, and my feet, which were always cold, have improved due to better circulation. My foggy brain is gone, and at my age, I need all the help I can get, and CoQ10 is the answer.

Headache details