Doctor&#039;s Best High Absorption CoQ10 with BioPerine 200 mg

CoQ-10 reduces mortality, improves capacity

Based on 10 Researches

Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis.

Most Relevant Research

We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.

In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.

8.3

Supports cardiovascular system

Most Useful Review

Coenzyme Q10 is vital for heart, kidney, and liver function. As we age, our body produces less CoQ10, increasing the risk of complex diseases. It acts as an antioxidant, enhancing energy, improving immunity, and lowering bad cholesterol while promoting a healthy cardiovascular system. It aids recovery after high physical stress and improves sleep quality.

Heart Disease

CoQ-10 improves heart failure outcomes

Based on 16 Researches

Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis.

Most Relevant Research

We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.

However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.

In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.

9.5

Boosts heart function

Most Useful Review

This "enzyme of youth" fuels our body and boosts energy. I buy it for my family, and it significantly helps my 69-year-old mother. Coenzyme Q10 is crucial for heart support and energy production, especially important as levels decrease with stress and statins. Take as advised by a healthcare professional.

Leg Cramps

Great for leg cramps. I was suffering from horrible calf and thigh cramps, and nothing seemed to help until I tried this magnesium, which is better absorbed. I had previously taken another brand without relief, but this one truly helps. I also take "Hyland's Leg Cramp" caplets at the first sign of leg cramps and have faced fewer problems since. You won't regret trying these two.

Heart Attack

Coenzyme Q10 aids heart recovery

Based on 16 Researches

Coenzyme Q10 Modulates Remodeling Possibly by Decreasing Angiotensin-Converting Enzyme in Patients with Acute Coronary Syndrome.

Most Relevant Research

We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.

Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.

Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.

9.5

Heart muscle support

Most Useful Review

Pure coenzyme Q10 significantly enhances heart muscle function, reducing the risk of heart attacks considerably.

Knee Pain

CoQ10 alleviates knee osteoarthritis

Based on 2 Researches

Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines.

Most Relevant Research

We explored the impact of Coenzyme Q10 (CoQ10) on knee pain and cartilage health using a rat model of osteoarthritis (OA). Our investigation involved inducing OA in rats through an injection of monosodium iodoacetate into the knee joint. Subsequently, we administered CoQ10 orally starting on the fourth day after the injection.

Pain severity was evaluated by assessing tactile sensitivity, and we also examined the state of cartilage by measuring its thickness and proteoglycan levels. Notably, CoQ10 demonstrated a significant reduction in pain, indicated by increased pain withdrawal thresholds. We observed that the treatment led to a decrease in cartilage degeneration as well.

Moreover, CoQ10 lowered the levels of several inflammatory markers associated with OA, including matrix metalloproteinase-13 and various interleukins. Based on our findings, we conclude that CoQ10 is a promising option for alleviating pain and protecting cartilage in individuals suffering from osteoarthritis.

9.5

Joint pain relief

Most Useful Review

I have been taking COQ10 for at least six months before ordering it from you. Doctors often neglect to mention that if you're on cholesterol medication, you need to replenish with this supplement to alleviate joint pain, ideally 200 mg daily.

Liver Disease

Coenzyme Q10 improves liver health

Based on 11 Researches

Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.

Most Relevant Research

We conducted a study to explore the effects of high-dose coenzyme Q10 supplementation on patients suffering from liver disease related to metabolic dysfunction, known as Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD). In a well-structured double-blind, placebo-controlled trial with sixty participants, half received 240 mg of coenzyme Q10 daily, while the other half received a placebo for six months.

Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.

Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.

9.5

Promotes detoxification

Most Useful Review

Q10 is a powerful antioxidant that protects against free radicals, crucial for liver disease. I ordered it for my mother, who needed detox support, and it significantly boosts energy levels and reduces fatigue.

Pelvic Pain

Leg cramp relief works well for statin-induced pelvic pain.

Autoimmune Disorder

Idebenone improves lupus symptoms

Based on 14 Researches

Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone.

Most Relevant Research

We explored the potential benefits of idebenone, a synthetic analog of coenzyme Q10, in treating autoimmune disorders, specifically lupus, in mouse models. By administering idebenone to mice with lupus for eight weeks, we aimed to investigate its impact on disease activity and organ damage.

Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.

Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.

This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.

9.5

Tremors reduced

Most Useful Review

I've taken CoQ10 for over 10 years as I have a relative with Parkinson's disease. I noticed my hand tremors haven't worsened, and my hearing loss has barely progressed. After a few months without it, my tremors increased, so I reordered. Within two weeks of taking CoQ10 again, they improved significantly. I believe it is effective for my autoimmune disorder.

The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial.

Most Relevant Research

We investigated how Coenzyme Q10 (Co-Q10) affects migraine symptoms in a well-structured clinical trial. Over the course of 12 weeks, 84 women aged 18 to 50 diagnosed with episodic migraines participated in a randomized, double-blind study, where they received either Co-Q10 (400 mg/day) or a placebo.

Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.

However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.

9.5

Significant pain relief

Most Useful Review

I suffer from migraine and chronic neck and shoulder pain. My doctors suggested 200mg of CoQ10 three times daily, which has made a remarkable difference! After running out once, I noticed the pain returned. It's been a staple supplement since, and I advocate its use to anyone enduring migraine pain.

Sleep Apnea

Coenzyme Q10 in sleep apnea study

Likely Very Effective

Medical treatment with thiamine, coenzyme Q, vitamins E and C, and carnitine improved obstructive sleep apnea in an adult case of Leigh disease.

Most Relevant Research

We explored the impact of various treatments, including coenzyme Q10, on obstructive sleep apnea (OSA) in a patient with adult-onset Leigh disease. This condition often presents with severe neurological symptoms, complicating the patients’ overall health and quality of life.

An overnight sleep study revealed the presence of OSA, which had developed shortly before the neurological symptoms became apparent. Treatment included high doses of thiamine, coenzyme Q, L-carnitine, and vitamins C and E, along with effective management of OSA through continuous positive airway pressure (CPAP).

Following this combined approach, we observed a marked clinical improvement not only in the patient's sleep quality but also in their neurological outcomes. While coenzyme Q10 was part of this combination therapy, its specific contribution to alleviating sleep apnea symptoms cannot be isolated from the other treatments. Overall, the findings suggest that recognizing and treating sleep apnea promptly can enhance patients’ well-being and potentially improve neurological conditions associated with Leigh disease.

9.5

Increased energy

Most Useful Review

A potent antioxidant! After a week of taking it, I feel more energetic, and my sleep has improved dramatically without any side effects. I plan to continue this for optimal heart and brain support.

Brain Tumor

CoQ10 reduces glioblastoma growth

Based on 5 Researches

CoQ reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation.

Most Relevant Research

The study focused on understanding how coenzyme Q10 (CoQ) could help manage glioblastoma, a particularly challenging type of brain tumor. We utilized xenograft models with U251 cells implanted in mice to observe tumor growth, inflammation, and vascular changes, alongside assessing the effects of CoQ on various related behaviors, including cell migration and invasion.

We found that CoQ treatment significantly reduced tumor volume in both xenograft and orthotopic models. Interestingly, while it did not directly hinder tumor cell proliferation, it was effective in creating a less hypoxic and vascularized environment. This indicates that CoQ can influence the tumor’s growth dynamics by targeting the underlying conditions that support tumor survival and expansion.

Additionally, CoQ treatment led to a noticeable downregulation of proteins involved in inflammation and angiogenesis, like HIF-1α and NF-kB. This change in molecular activity caused an entire reshaping of the tumor's protein landscape, ultimately impacting how the tumor interacts with its environment. Notably, we observed a restriction in tumor cell migration and invasion, attributed to changes in the cell's structural components.

Overall, our findings suggest that incorporating CoQ into current treatment protocols could provide a holistic approach to combat glioblastoma by simultaneously addressing multiple pathways that facilitate tumor growth and infiltration.

8.8

Disease delay

Most Useful Review

My father has Paskin's disease. The doctor recommends this treatment to help delay its progression, though higher doses are necessary. For ongoing maintenance, a dosage of 200 can be taken, which may protect the heart and brain.

Diabetes

Improved diabetes symptoms

Most Useful Review

I requested this for my friend who has suffered from diabetes for 10 years and experienced numbness in his limbs. A doctor recommended this vitamin with B12, and over time, he felt a great improvement and decided to continue using it. If you find this comment helpful, please like it. Thank you.

Hypothyroidism

CoQ10 levels and thyroid health

Questionable

Based on 4 Researches

[Circulating levels of CoQ10 in hypo- and hyperthyroidism].

Most Relevant Research

We evaluated the levels of Coenzyme Q10 (CoQ10) in patients with hypothyroidism and hyperthyroidism to understand its role in thyroid health. The study included participants from both groups, as well as a control group without thyroid issues, ensuring that no subjects had other cardiovascular or metabolic diseases that could interfere with the results.

Our findings showed that hypothyroid patients had a higher average level of CoQ10 in their blood compared to those with hyperthyroidism. Specifically, hypothyroid patients showed levels of 0.97 mcg/ml, while hyperthyroid patients had only 0.51 mcg/ml, with the control group at 0.73 mcg/ml. This suggests that patients with hypothyroidism may have a greater prevalence of higher CoQ10 levels.

However, we found that the differences were not enough to clearly separate those with normal thyroid function from those with either hypothyroidism or hyperthyroidism. While there is a noted inverse relationship between CoQ10 levels and certain thyroid hormones, this indicates that CoQ10 alone may not provide significant benefits for those specifically dealing with hypothyroidism. More research—especially longitudinal studies—is needed to see how treatment and therapy could potentially affect CoQ10 levels and overall thyroid health in these patients.

8.8

Energy improvement

Most Useful Review

I have AIT and hypothyroidism, and my doctor recommended coenzyme Q10, particularly in autumn, to sustain my energy levels. It has notably alleviated my fatigue, normalised my blood pressure, and relieved muscle aches associated with cervical osteochondrosis. Additionally, I take a vitamin complex, which helps me maintain my fitness. I haven’t experienced any side effects, despite having a sensitive stomach and pancreas. I highly recommend it.

Back Pain

Effective cramp relief

Most Useful Review

Leg cramp relief is effective for pain caused by statin medication.

Chronic Fatigue Syndrome

Ubiquinol-10 benefits chronic fatigue syndrome

Based on 15 Researches

Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome.

Most Relevant Research

We embarked on a study to investigate the impact of ubiquinol-10—an active form of coenzyme Q10—on patients suffering from chronic fatigue syndrome (CFS). Our research comprised two parts: an open-label study involving 20 patients and a randomized, double-blind, placebo-controlled trial with 43 participants.

In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.

Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.

Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.

9.5

Rejuvenating energy

Most Useful Review

This supplement truly provides ENERGY! CoQ10 improves cardiovascular health, has a rejuvenating effect, enhances carbohydrate metabolism, and boosts the immune system. I take it alongside Omega and Resveratrol. After a month, I felt noticeable improvements in my well-being and energy, with deeper sleep and a stable mood. I plan to keep incorporating it into my routine.

Bone Pain

This works wonderfully for my statin-induced bone pain.

High Cholesterol

CoQ10 lowers cholesterol levels

Based on 12 Researches

Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.

Most Relevant Research

We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.

Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.

Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.

8.8

Blood pressure stabilised

Most Useful Review

As I aged, my blood pressure rose, reaching around 150-160, which caused heart failure symptoms. After consulting with the hospital, I was advised to take blood pressure medication. Concerned by acquaintances needing dialysis due to high cholesterol, I opted for nutrients to lower my blood pressure. I took CoQ10 200mg, magnesium 500mg, and Eltheanine 200mg, noticing improvements quickly. My blood pressure now stays at 120-130, and heart symptoms have subsided. I'll continue using this product.

Blood Clot

CoQ10 reduces harmful blood clots

Based on 5 Researches

Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin αIIbβ3 Signaling and Thrombus Growth.

Most Relevant Research

We explored how coenzyme Q10 (CoQ10), a natural compound found in various foods, impacts blood clotting functions. Through a well-structured study, we utilized a randomized, double-blind, placebo-controlled trial with dyslipidemic patients, alongside in vitro tests on human platelets.

Our findings demonstrated that CoQ10 effectively reduces platelet aggregation, granule secretion, platelet spreading, and clot retraction. This means that CoQ10 can help prevent excessive blood clot formation, which is crucial for cardiovascular health.

We observed that CoQ10 works mainly by enhancing a signaling pathway involving cyclic AMP (cAMP) which ultimately diminishes the signaling of integrin αIIbβ3, a key player in platelet function. In addition, the treatment showed promising results in reducing thrombus growth in an animal model, suggesting significant in vivo benefits as well.

This study highlights the potential of CoQ10 supplementation as a protective measure for individuals at risk of cardiovascular diseases by regulating platelet-related processes involved in clotting.

9.5

Normal blood pressure

Most Useful Review

My grandmother had issues with her blood pressure, both high and low. With the help of this medication, it returned to normal! I recommend purchasing it!

Headache

Coenzyme Q10 shows effectiveness against migraines

Based on 16 Researches

A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial.

Most Relevant Research

We investigated the effectiveness of coenzyme Q10 in treating migraines in children, comparing it with the commonly prescribed medication, amitriptyline. Our study involved 72 children, aged 5 to 15, who met the criteria for migraine diagnosis set by the International Headache Society.

Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.

Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.

2.3

No headache relief

Most Useful Review

Not for me. I purchased this brand of CoQ10 to combine it with the magnesium I already take in hopes of addressing my migraines. The capsule is a bit large but easy to take, with a neutral flavour and reasonable price. Unfortunately, I experienced dreadful nausea and headache the next afternoon and only felt better after stopping it two nights later, realising it was the cause of my discomfort. I'm truly disappointed that it didn't work out for me.

Nausea