' 
Supplement Facts
Serving Size: 1 Spray (Approx. 0.41 ml)
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin from Saccharomyces cerevisiae)
500 mcg
20,833%
Certified Organic Food BlendOrganic Beet (root), Organic Carrot (root), Organic Spinach (leaf), Organic Broccoli (flower & stem), Organic Tomato (fruit), Organic Kale (leaf), Organic Cabbage (leaf), Organic Parsley (leaf), Organic Brussels Sprout (leaf), Organic Green Bell Pepper (fruit), Organic Cucumber (gourd), Organic Celery (stalk), Organic Garlic (bulb), Organic Ginger (root), Organic Onion (root), Organic Cauliflower (flower & stem), Organic Asparagus (flower & stem), Organic Strawberry (fruit), Organic Cherry (fruit), Organic Blackberry (fruit), Organic Blueberry (fruit), Organic Raspberry (fruit)
2 mg
+
The product is found useful for the following medical conditions
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.9
USERS' SCORE
Excellent
Based on 8 Reviews
9.1
9
Pernicious anemia treatment effectiveness
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
Most Relevant Research
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
10
B12 normalised
Most Useful Review
According to the test results, my child was deficient in B12, which I ordered upon the doctor's recommendation. This vitamin is fantastic and has a pleasant taste, so my child takes it willingly. After 14 days, my child's B12 levels were back to normal—what a relief!
Anemia
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.8
USERS' SCORE
Good
Based on 36 Reviews
8.9
9
Saccharomyces effectively treats anemia
Production of iron-enriched yeast and it's application in the treatment of iron-deficiency anemia.
Most Relevant Research
We aimed to explore whether Saccharomyces cerevisiae, enriched with iron, could serve as a beneficial treatment for iron-deficiency anemia (IDA) in mice. Our study involved dividing 60 mice into groups that received various forms of iron supplements, including the enriched yeast strain.
Remarkably, those treated with the iron-enriched yeast showed significant recovery. Their weights and blood parameters returned to normal, and levels of key antioxidants in their blood improved. This suggests that strain no. F8, which thrives in iron-rich conditions, could be a promising avenue for developing new organic iron supplements.
Remarkably, those treated with the iron-enriched yeast showed significant recovery. Their weights and blood parameters returned to normal, and levels of key antioxidants in their blood improved. This suggests that strain no. F8, which thrives in iron-rich conditions, could be a promising avenue for developing new organic iron supplements.
9.5
Convenient anaemia solution
Most Useful Review
I have a positive impression of these vitamins. The vitamin B12 spray format is convenient for children, avoiding injections or pills. As someone with low hemoglobin and a restricted diet, I find these vitamins helpful. No side effects, and after a month, my hair stopped falling out, and chronic fatigue disappeared.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.6
USERS' SCORE
Good
Based on 10 Reviews
8.9
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Most Relevant Research
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
9.5
Fatigue improvement
Most Useful Review
I find these vitamins effective. The vitamin B12 spray is convenient for children—no injections or pills needed. As I have low hemoglobin and do not eat meat, I thought these would benefit me. I experienced no allergies or gastrointestinal changes. My hair stopped falling out after a month, and the chronic fatigue syndrome vanished.
Allergies
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 12 Reviews
8.6
9
Potential asthma management via yeast
Perinatal administration of Saccharomyces cerevisiae UFMG A-905 prevents asthma development in the offspring of mice.
Most Relevant Research
We explored how perinatal administration of Saccharomyces cerevisiae UFMG A-905 could help prevent asthma in mouse offspring. This study involved various groups of mice receiving the yeast at different stages: before conception, during pregnancy, or only during lactation.
Our results showed that those exposed to S. cerevisiae exhibited significantly less airway hyperresponsiveness and lower levels of certain inflammatory markers compared to those that didn’t receive the treatment. Notably, the greatest protection occurred when the yeast was given during lactation.
Overall, it seems that S. cerevisiae UFMG A-905 shows promise in the management of asthma, especially when administered early in the offspring's development.
Our results showed that those exposed to S. cerevisiae exhibited significantly less airway hyperresponsiveness and lower levels of certain inflammatory markers compared to those that didn’t receive the treatment. Notably, the greatest protection occurred when the yeast was given during lactation.
Overall, it seems that S. cerevisiae UFMG A-905 shows promise in the management of asthma, especially when administered early in the offspring's development.
9.5
No allergies noted
Most Useful Review
The impression of these vitamins is positive. The vitamin B12 comes in a convenient spray format, making it easy to administer to children without injections or pills. As I have low hemoglobin and don't consume meat, I found these vitamins helpful. There were no allergies or gastrointestinal issues, and my hair stopped falling out after a month. Chronic fatigue also disappeared.
Back Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
Vitamin B12 aids low back pain
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Most Relevant Research
We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
9.5
Effective B12 treatment
Most Useful Review
Perfectly raises vitamin B12 levels. I was deficient and purchased this spray, which provides 500 mcg per puff under the tongue for better absorption. It effectively boosted my B12, allowing me to quickly recover. Now, for prevention, I take one puff at times and two doses once a month under the tongue.
Leg Cramps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
8.3
Nervous pain healed
Most Useful Review
Very good! The nerve pain at the base of my leg has healed and I’m extremely pleased!
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Sake yeast shows potential for anxiety
Neurobehavioral protective effects of Japanese sake yeast supplement against chronic stress-induced anxiety and depression-like symptoms in mice: Possible role of central adenosine receptors.
Most Relevant Research
We explored the potential benefits of Japanese sake yeast on anxiety and depression in mice subjected to stress. Over a week, we treated the mice with different doses of sake yeast and assessed its effects on anxiety, mood, and sleep.
Our findings indicated that the yeast improved anxiety and antidepressant-like behaviors, particularly at higher doses. It also increased sleep duration and influenced certain brain levels related to mood. However, the overall results suggest that while sake yeast shows promise, it may not significantly alter all biological markers associated with stress.
Our findings indicated that the yeast improved anxiety and antidepressant-like behaviors, particularly at higher doses. It also increased sleep duration and influenced certain brain levels related to mood. However, the overall results suggest that while sake yeast shows promise, it may not significantly alter all biological markers associated with stress.
8.8
Quick anxiety relief
Most Useful Review
Fast Relief for your Nerves! My sister mentioned this product to me, and it helps greatly with my nerves and anxiety. A couple of sprays really seems to provide me with more tolerance on those days I feel overwhelmed.
Cold
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.6
8
Vitamin B12 shows cold pain relief
The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats.
Most Relevant Research
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
9.5
Immediate cold relief
Most Useful Review
Love this B12! My family is vegan, so we need a B vitamin that is easily processed, vegan, and affordable. We adore this spray. During a period of 1-2 months without it, I noticed a significant change. Oddly, my skin broke out with pimples, I felt exhausted, and I caught 2 colds, which is unusual for me. After just one week of daily use, my skin and energy returned to normal, and the cold vanished! I won't go without it again.
Headache
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 1 Review
8.6
8
Vitamin B12 deficiency linked to migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Most Relevant Research
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
9.5
Energy and relief
Most Useful Review
My 17-year-old son had fatigue, headaches, and dry lips. After trying this product, I noticed he had more energy and his dry lips improved. He hasn't had any headaches since starting this, so I believe it genuinely works!
Hot Flashes
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Life changing experience
Most Useful Review
As a woman over 50 with typical perimenopausal symptoms, particularly fatigue, mood swings, and hot flashes, trying the Garden of Life B12 spray was life-changing. The difference was so dramatic that my son immediately noticed it and encouraged me to continue. My energy levels returned to normal, and I felt happy again with no mood swings. I take one spray in the morning and another in the afternoon. I’ve tried many supplements before but never had such an obvious improvement—highly recommend this product!
Insomnia
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.6
8
Vitamin B12 promotes sleep in rats
Effects of intravenously administered vitamin B12 on sleep in the rat.
Most Relevant Research
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
9.5
Life-changing sleep
Most Useful Review
This product changed my life. I have various medical conditions that cause insomnia, low energy, and fatigue. Since I started taking this, I've been sleeping better and my energy has increased tremendously. It’s hard to express how grateful I am for this product, which has been working perfectly for nearly four weeks now.
Menopause
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 1 Review
8.6
9
Vitamin B12 may aid menopause relief
Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9.
Most Relevant Research
We observed the effects of a nutritional product that combined various ingredients, including vitamin B12, on menopausal symptoms. This study involved 156 menopausal women who took the product daily for 12 weeks and reported their symptoms using a validated scale.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
9.5
Restored energy
Most Useful Review
Game Changer for Female 50+. As a woman over 50, I experienced perimenopause symptoms like fatigue, mood swings, and hot flashes. I tried Garden of Life B12 spray, which transformed my life. This dramatic change led me to write a review! My son noticed the difference immediately. My energy levels returned to normal; I’m happier now with no mood swings. No issues with flavour; I’d use it regardless of taste. This has been truly beneficial.
Hypothyroidism
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.2
USERS' SCORE
Good
Based on 5 Reviews
8.5
7
Vitamin B12 and hypothyroid patients
A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital.
Most Relevant Research
We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
9.5
Improvement noticed
Most Useful Review
This supplement worked wonders for my hypothyroidism and B12 deficiency. After a two-month course, my results improved significantly, and my naturopath was pleased. The goitre I thought was normal has reduced, and my husband's levels improved as well. We'll continue taking B12 until it's optimal.
Liver Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.8
USERS' SCORE
Good
Based on 5 Reviews
8.5
9
Methylcobalamin aids liver health
Methylcobalamin protects against liver failure via engaging gasdermin E.
Most Relevant Research
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
9.5
Salvation for deficiency
Most Useful Review
An essential vitamin for the body, especially for those with liver disease. This product provides effective support and can be a real lifesaver!
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8
Reduced body pain
Most Useful Review
This product is excellent for alleviating pelvic pain, especially if you have low levels of vitamin B complex. I frequently purchase vitamin B, but I believe this is one of the best supplements I have bought.
Pneumonia
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Supports pneumonia treatment
Most Useful Review
Only in this form is the drug effective. I have taken vitamin B12 for years; it is the only one that works for me, supports my immune system, and alleviates anaemia. After testing, my levels are normal. I also give it to my husband. The taste is pleasant, and there are no side effects. It's vital for maintaining immunity, especially concerning pneumonia.
Tinnitus
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.5
9.5
Tinnitus improvement
Most Useful Review
It's excellent! Although I haven't tested my B12 levels, my tinnitus and tachycardia have diminished. I appreciate the convenient sweet berry spray for taking the vitamin.
Bone Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 3 Reviews
8.4
7
β-Glucans improve bone health
β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease.
Most Relevant Research
We investigated how β-glucans derived from Saccharomyces cerevisiae can impact bone loss and metabolic health. In our study, diabetic rats underwent a treatment regimen of β-glucans for 28 days.
We observed that these glucans significantly reduced the loss of alveolar bone in both diabetic and non-diabetic groups, as well as lowered blood glucose and triglyceride levels. Additionally, they appeared to improve metabolic markers related to inflammation and bone health.
Overall, β-glucans show promise for enhancing both metabolic and periodontal health in diabetic conditions.
We observed that these glucans significantly reduced the loss of alveolar bone in both diabetic and non-diabetic groups, as well as lowered blood glucose and triglyceride levels. Additionally, they appeared to improve metabolic markers related to inflammation and bone health.
Overall, β-glucans show promise for enhancing both metabolic and periodontal health in diabetic conditions.
8.8
Reduced body pain
Most Useful Review
This is excellent for alleviating bone pain if you have low vitamin B levels. I purchase vitamin B frequently, and I believe this is one of the best I have had.
Heart Disease
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.9
9
Vitamin B12 helps heart recovery
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Most Relevant Research
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
9.5
Positive heart effects
Most Useful Review
I chose this natural vitamin because of its pleasant raspberry taste. Taking it once a day under the tongue has positively affected my heart muscles, thyroid glands, immunity, and blood pressure, while providing antiallergenic, antitoxic, and antitumour benefits. Despite B12 being poorly absorbed, this form worked well for me, alleviating muscle aches and pains.
Cancer
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
USERS' SCORE
Moderately Good
Based on 1 Review
7.8
8
Hydrothermal yeast impacts breast cancer
Hydrothermal treatment of yeast cell wall generates potent anti-proliferative agents targeting MCF7 breast cancer cells effectively even under culture conditions separated by a plastic wall.
Most Relevant Research
We investigated the ability of a hydrothermally treated yeast cell wall to fight against MCF-7 breast cancer cells. This innovative method improved solubility and produced a potent anti-proliferative agent.
The treatment significantly reduced cancer cell growth by nearly 59%, even when separated by a plastic barrier.
This suggests that a diffusible factor in the treated yeast contributes to this anti-cancer effect, likely linked to reactive carbon species generated during treatment.
Overall, our findings hint at a promising potential for this approach in cancer therapy development.
The treatment significantly reduced cancer cell growth by nearly 59%, even when separated by a plastic barrier.
This suggests that a diffusible factor in the treated yeast contributes to this anti-cancer effect, likely linked to reactive carbon species generated during treatment.
Overall, our findings hint at a promising potential for this approach in cancer therapy development.
1.3
Risky dosage warning
Most Useful Review
20833% RDA is excessive. Such extreme levels in any supplement are unhealthy. Excess vitamin B12 may increase cancer risk, according to studies. A headache soon after taking it can indicate the body struggles to cope with such large amounts. Manufacturers promote high dosages since they are inexpensive to produce, but this does not ensure efficacy. It’s advisable to use only a small amount daily to gain benefits without the undesirable risks and side effects.
Sore Throat
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
0
Ineffective treatment
Most Useful Review
Doesn't work. Don't waste your money. My throat was sore, and despite the positive reviews, it didn't help me at all. I attempted to return the product, but I received NO REFUND. This product was a disappointment, so avoid wasting your money or time on this ineffective spray.
Heart Attack
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.9
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.2
9.5
β-Glucan shows cardioprotective effects
Pretreatment with β-glucan attenuates isoprenaline-induced myocardial injury in rats.
Most Relevant Research
We explored whether pretreatment with β-glucan, a compound from the yeast Saccharomyces cerevisiae, could shield against heart damage induced by isoprenaline in rats. Through a well-structured experiment involving control and treatment groups, we discovered that β-glucan significantly reduced heart strain by improving cardiac markers and minimizing harmful changes in heart tissue.
This suggests that β-glucan has the potential to aid in preventing damage from heart attacks. However, it’s essential to note that more research is needed to see if these promising results can translate to humans.
This suggests that β-glucan has the potential to aid in preventing damage from heart attacks. However, it’s essential to note that more research is needed to see if these promising results can translate to humans.
8
Positive heart support
Most Useful Review
I previously bought this supplement in gelatin capsules, and it's difficult to immediately gauge the difference. I take it for heart support and find it effective. When I tried increasing the dosage, my heartbeat became erratic. I'm grateful to IHERB and the reviewers, as their insights really help in choosing supplements, given that doctors are not always knowledgeable, sadly.
