' 
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
The product is found useful for the following medical conditions
Constipation
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.3
USERS' SCORE
Excellent
Based on 73 Reviews
9
7
Folate's role in constipation explored
Formulation and Physical-Chemical Analysis of Functional Muffin Made with Inulin, Moringa, and Cacao Adapted for Elderly People with Parkinson's Disease.
Most Relevant Research
We formulated a functional food product designed specifically for elderly individuals with Parkinson's disease, focusing on the common issue of constipation. Our approach involved creating a muffin recipe enriched with inulin, cacao, and Moringa, all of which play a role in supporting digestive health.
In this study, we conducted physical-chemical analyses to assess the nutritional components of the muffins, including soluble and insoluble fiber content. Our findings revealed a significant increase in fiber levels compared to control samples, which may alleviate constipation symptoms.
While we noted that the incorporation of inulin and cacao improved the muffins' nutritional value—particularly their dietary fiber and antioxidant properties—it’s essential to clarify that the specific role of folate, a nutrient present in these muffins, was not isolated in relation to constipation. However, the overall enhancements in fiber and nutrition could positively impact bowel health.
Sensory evaluations demonstrated a strong preference from participants, particularly for the muffins enriched with inulin and cacao, indicating potential acceptance of these products among the target population. Our study suggests that muffins fortified with these ingredients could be a practical dietary strategy to aid in managing constipation in individuals facing the challenges of Parkinson’s disease.
In this study, we conducted physical-chemical analyses to assess the nutritional components of the muffins, including soluble and insoluble fiber content. Our findings revealed a significant increase in fiber levels compared to control samples, which may alleviate constipation symptoms.
While we noted that the incorporation of inulin and cacao improved the muffins' nutritional value—particularly their dietary fiber and antioxidant properties—it’s essential to clarify that the specific role of folate, a nutrient present in these muffins, was not isolated in relation to constipation. However, the overall enhancements in fiber and nutrition could positively impact bowel health.
Sensory evaluations demonstrated a strong preference from participants, particularly for the muffins enriched with inulin and cacao, indicating potential acceptance of these products among the target population. Our study suggests that muffins fortified with these ingredients could be a practical dietary strategy to aid in managing constipation in individuals facing the challenges of Parkinson’s disease.
10
Aiding anemia
Most Useful Review
These pills truly work! They have significantly improved my anemia, as my recent blood test numbers show improvement. I still experience coldness, but my doctor confirms my numbers are getting better. I've just started my second bottle, and best of all, there is NO CONSTIPATION whatsoever!
Heartburn
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 7 Reviews
8.8
8
Long-term PPI effects analyzed
Gastric atrophy and intestinal metaplasia in a patient on long-term proton pump inhibitor therapy.
Most Relevant Research
We explored the case of a 74-year-old man who had been taking proton pump inhibitors for 20 years to manage symptoms of gastroesophageal reflux disease. Despite stopping his acid-reducing medications for a month, he showed an unusually high gastric pH level, indicating a significant decrease in stomach acidity. This condition may have led to gastric atrophy and intestinal metaplasia, as revealed through multiple biopsies of his stomach lining. Interestingly, after halting all anti-secretory drugs and starting only prokinetic treatment, the patient reported a significant improvement in heartburn symptoms.
During follow-up, although he developed symptoms of peripheral neuropathy—which were found to be related to a low level of vitamin B12—prompt treatment with vitamin B12 injections alleviated this issue. However, the correlation between improved heartburn symptoms and the vitamin B12 therapy is difficult to establish because the patient was also on prokinetics, which could have contributed to his symptom relief. Overall, our findings indicate that while vitamin B12 treatment offered benefits in this case, isolating its specific effect on heartburn remains challenging due to the combination therapy involved.
During follow-up, although he developed symptoms of peripheral neuropathy—which were found to be related to a low level of vitamin B12—prompt treatment with vitamin B12 injections alleviated this issue. However, the correlation between improved heartburn symptoms and the vitamin B12 therapy is difficult to establish because the patient was also on prokinetics, which could have contributed to his symptom relief. Overall, our findings indicate that while vitamin B12 treatment offered benefits in this case, isolating its specific effect on heartburn remains challenging due to the combination therapy involved.
9.5
Significant improvement
Most Useful Review
Great iron supplement! My Ferritin level was extremely low, and after trying another brand that worsened my heartburn, I switched to Garden of Life. In just a few weeks, my Ferritin increased by 10 points! I've had no digestive upset and haven’t taken Zantac in over two months. The addition of a probiotic/enzyme blend seems to have helped as well. I highly recommend this gentle iron supplement, though it’s important to give it time as it contains less iron than some alternatives.
Leg Cramps
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 4 Reviews
8.8
7
Iron treatment improves leg cramps
Iron deficiency associates with deterioration in several symptoms independently from hemoglobin level among chronic hemodialysis patients.
Most Relevant Research
We explored the effects of iron deficiency (ID) in patients on maintenance hemodialysis, especially regarding common symptoms like leg cramps. The study included 154 patients, all of whom had reached target hemoglobin levels, which means they were not anemic. This allowed us to focus on the impact of ID without the confounding factor of low hemoglobin.
Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.
The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.
The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
9.5
Cured leg cramps
Most Useful Review
Excellent product! This is the second time I have ordered it due to severe iron deficiency, which caused me leg cramps during sleep. This natural and safe extract has alleviated the problem. It importantly does not adversely affect my kidneys and does not cause constipation like other iron supplements.
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.6
USERS' SCORE
Good
Based on 18 Reviews
8.7
9
Pernicious anemia treatment effectiveness
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
Most Relevant Research
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
9.5
Increased ferritin levels
Most Useful Review
I had latent iron deficiency anaemia and tried various pharmaceutical iron supplements, but my ferritin level remained low. In desperation, I ordered Iron from Garden of Life, and after three months, my ferritin rose to normal levels. This product works excellently and is gentle on the stomach. I'm feeling stronger, my hair has stopped falling out, and my general well-being has improved. I highly recommend this complex!
Blood Clot
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.6
USERS' SCORE
Good
Based on 5 Reviews
8.7
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Most Relevant Research
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
9.5
Hemoglobin recovery
Most Useful Review
This supplement marked my first experience with iHerb. After an emergency operation in March, I struggled to recover my haemoglobin for two months. Despite various medications failing to raise it even slightly, this product elevated my levels to those of a healthy individual within a month. It feels miraculous. Now, I am also addressing other aspects of my health.
Irritable Bowel Syndrome
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.4
USERS' SCORE
Good
Based on 4 Reviews
8.7
8
Folic Acid reduces IBS-related pain
Folic acid attenuates chronic visceral pain by reducing clostridiales abundance and hydrogen sulfide production.
Most Relevant Research
We investigated the effects of Folic Acid (FA) on chronic visceral pain linked to Irritable Bowel Syndrome (IBS). Chronic visceral hyperalgesia (pain sensitivity) was induced in rats through neonatal colonic inflammation, enabling us to examine how FA might alleviate this condition.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
9.5
Calms digestive issues
Most Useful Review
This iron supplement is remarkable! I have irritable bowel syndrome and most iron products upset my stomach, but this one actually improves and soothes it. With added digestive enzymes, my digestion has significantly improved alongside my low iron levels.
Migraine
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.9
USERS' SCORE
Good
Based on 2 Reviews
8.7
8
Folate intake reduces migraine frequency
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Most Relevant Research
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
9.5
Life-changing iron supplement
Most Useful Review
This product truly saved me. After struggling with anaemia and constant migraines, I began taking these supplements. Instead of stomach issues, I regained energy and clarity. I finished a whole bottle — a first for me! I won’t use any other iron supplement again; this one is exceptional.
Cold
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.7
8
Iron improves cold tolerance
Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism in .
Most Relevant Research
We investigated how dihydroporphyrin iron (DH-Fe) acts as a plant growth regulator, particularly in enhancing cold tolerance. Our research focused on plants that are usually sensitive to low temperatures, finding that DH-Fe plays a vital role in helping these plants cope with cold stress by using different concentrations of this treatment.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
9.5
Cold symptom relief
Most Useful Review
I started taking iron because I was cold all the time, had stubborn dark circles under my eyes, and experienced hair loss. This was alarming. I began taking iron despite my fear of tests and needles, suspecting iron deficiency. Thankfully, my hair has stopped falling out, I’m no longer cold in warm rooms, and the dark circles have significantly improved. Clearly, the raw iron is effective and working wonders!
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.6
8
Vitamin B12 may reduce anxiety
Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach.
Most Relevant Research
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
9.5
Anxiety improvement
Most Useful Review
My anaemia has improved! The capsule is larger, and I’ve noticed a reduction in the anxiety associated with anaemia. I can genuinely feel the positive effects. Unlike Japanese iron supplements that did nothing for me, I've experienced noticeable improvements in a short time.
Bruise
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin B12 benefits thrombocytopenia
Vitamin B12 Deficiency, a Rare Cause of Isolated Thrombocytopenia in Adults.
Most Relevant Research
We examined the case of a 38-year-old male who experienced bruising and fatigue due to isolated thrombocytopenia, a condition marked by a low platelet count. This situation was particularly interesting because the underlying cause turned out to be a significant deficiency in vitamin B12, which is quite rare in adults when it comes to isolated thrombocytopenia. As we explored the case, we found that the patient's vitamin B12 levels were extraordinarily low, prompting treatment with subcutaneous mecobalamin, a form of vitamin B12.
After several doses, not only did the vitamin B12 levels increase, but so did the platelet count, contributing to the resolution of the bruising issue. This highlights the role that vitamin B12 can play in improving hematological health, specifically in cases of thrombocytopenia. Although the lack of hypersegmented neutrophils usually linked to vitamin B12 deficiency was noted, it emphasized the complex nature of diagnosing such conditions and the need for careful evaluation of symptoms and lab results.
After several doses, not only did the vitamin B12 levels increase, but so did the platelet count, contributing to the resolution of the bruising issue. This highlights the role that vitamin B12 can play in improving hematological health, specifically in cases of thrombocytopenia. Although the lack of hypersegmented neutrophils usually linked to vitamin B12 deficiency was noted, it emphasized the complex nature of diagnosing such conditions and the need for careful evaluation of symptoms and lab results.
9.5
Reduced bruising
Most Useful Review
Great product! My doctor recommended this brand for iron, and I’ve been taking it daily with no issues typical of iron supplements. I've noticed fewer bruises since starting.
Cancer
SCIENTIFIC SCORE
Moderately Effective
Based on 26 Researches
8.3
USERS' SCORE
Good
Based on 1 Review
8.6
9
Folate-enhanced nanoparticle effectiveness
Cell membrane-inspired chitosan nanoparticles for prolonged circulation and tumor-targeted drug delivery.
Most Relevant Research
We explored innovative ways to improve cancer treatment by using folate-targeted nanoparticles. The study focused on the development of chitosan nanoparticles that mimic cell membranes, enhancing their ability to evade the immune system and prolong circulation in the body. By integrating folate, a nutrient known to target cancer cells, we hoped to increase the effectiveness of drug delivery directly to tumors.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
9.5
Stable haemoglobin levels
Most Useful Review
My mother is undergoing chemotherapy for her ovarian cancer at stage three. After starting this supplement post her second chemotherapy session, she managed to maintain her haemoglobin levels above 10, without any side effects. It has been very convenient for her to use. After her second cycle of chemotherapy, she returned to this product to help stabilise her levels once again. It consistently works.
Chest Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Endometrial cancer-induced angina case
An atypical presentation of endometrial cancer as angina secondary to critically low hemoglobin and iron deficiency associated pancytopenia: A case report.
Most Relevant Research
We explored the intriguing link between iron treatment and angina symptoms in a unique case involving a 46-year-old woman with endometrial cancer. This patient arrived in the emergency department with acute chest pain, yet her heart was healthy based on ECG results. Instead, we found that her chest pain was a result of critically low hemoglobin levels caused by severe iron deficiency anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
8.8
Reduced chest pain
Most Useful Review
Iron is crucial! After being diagnosed with anaemia, I was prescribed iron but discontinued due to stomach pain and nausea. I switched to this product, which contains iron, vitamins C and B12, folic acid, and probiotics. After 10 days, I noticed reduced shortness of breath and chest pain when climbing stairs. My energy has improved, and I felt happier. I experienced mild diarrhoea initially but now have no stomach issues. The iron content seems correct for me, and I'm excited to keep taking it daily.
Cold Sores
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.6
9
Iron therapy reduces cold sore frequency
Response to replacement iron therapy in sideropenic individuals with recrudescent herpes labialis.
Most Relevant Research
We investigated how iron replacement therapy affects the occurrence of cold sores, also known as recurrent herpes labialis, in people with low iron levels, a condition known as sideropenia. In our study, ten patients with confirmed sideropenia and a history of cold sores took ferrous sulphate for three months.
Before starting the treatment, these individuals reported experiencing an average of 0.78 episodes of cold sores each month. After the iron therapy, this number significantly dropped to just 0.2 episodes monthly. Furthermore, we found that there was a noteworthy increase in serum ferritin levels, a marker indicative of iron status, after treatment.
The results suggest that iron therapy may play a significant role in reducing the frequency of cold sores for those affected by iron deficiency. These findings are intriguing and warrant further exploration into iron supplementation as a potential option for managing cold sores in individuals with low iron levels.
Before starting the treatment, these individuals reported experiencing an average of 0.78 episodes of cold sores each month. After the iron therapy, this number significantly dropped to just 0.2 episodes monthly. Furthermore, we found that there was a noteworthy increase in serum ferritin levels, a marker indicative of iron status, after treatment.
The results suggest that iron therapy may play a significant role in reducing the frequency of cold sores for those affected by iron deficiency. These findings are intriguing and warrant further exploration into iron supplementation as a potential option for managing cold sores in individuals with low iron levels.
9.5
Helps cold sores
Most Useful Review
It’s beneficial for vegetarians and seems to alleviate cold sores on a vegetarian diet. I often suffered from cold sores until I began taking these. So far, it has been effective.
Dizziness
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
USERS' SCORE
Good
Based on 24 Reviews
8.6
9
We explored the effectiveness of L-methylfolate, a form of folate, on alleviating dizziness, particularly in individuals with a specific genetic mutation. In one case, a patient experienced prolonged symptoms like headache, fatigue, and dizziness after taking terbinafine, known as Lamisil.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
10
Normalised levels
Most Useful Review
I had low haemoglobin and iron, which caused constant fatigue and dizziness. After taking Solgar and Garden life supplements, everything returned to normal. I recommend these products for anyone facing similar issues.
Gastritis
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Iron treatment impacts gastritis
Iron Pill-Induced Gastritis in a Pediatric Patient Taking Ferrous Sulfate Tablets.
Most Relevant Research
We examined a case involving an 11-year-old male who experienced adverse effects from taking oral ferrous sulfate tablets to treat iron deficiency anemia. Over two months of treatment, he developed gastritis, which was confirmed through histological analysis during an endoscopy.
The findings revealed iron deposits in the stomach lining, prompting a reassessment of his iron supplementation strategy. We switched him from tablets to a liquid form of iron, which seemed to be gentler on his system.
After four months, a repeat endoscopy indicated a remarkable improvement, with the histological signs of gastritis resolving. This case illustrates that while iron is necessary for treating anemia, the form in which it's administered can significantly impact side effects like gastritis.
The findings revealed iron deposits in the stomach lining, prompting a reassessment of his iron supplementation strategy. We switched him from tablets to a liquid form of iron, which seemed to be gentler on his system.
After four months, a repeat endoscopy indicated a remarkable improvement, with the histological signs of gastritis resolving. This case illustrates that while iron is necessary for treating anemia, the form in which it's administered can significantly impact side effects like gastritis.
8.8
No stomach issues
Most Useful Review
Very good iron preparation. I took my teenage daughter to boost her hemoglobin levels. I was concerned about potential reactions to iron due to her gastritis. Her haemoglobin is now around 150, and thankfully, there have been no negative stomach reactions!
Menopause
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Iron treatment in menopause study
Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation.
Most Relevant Research
We investigated how iron treatment affects iron levels and blood production in rats that underwent ovariectomy, a procedure mimicking menopause. By using Deferasirox, a medication often prescribed for iron overload conditions, we aimed to understand its role in managing iron levels and supporting blood health in this context.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
9.5
Anemia alleviated
Most Useful Review
This version of iron has been excellent for those with sensitive stomachs. After being diagnosed as anaemic, I've taken it for years and have not been anaemic since. It digests easily, with no stomach issues, and I will continue using it even though I'm now in menopause and don't experience the monthly issues that caused my anaemia.
Bloating
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
USERS' SCORE
Good
Based on 1 Review
8.6
8
Iron treatment’s impact on bloating
Sucrosomial Iron Supplementation in Anemic Patients with Celiac Disease Not Tolerating Oral Ferrous Sulfate: A Prospective Study.
Most Relevant Research
We explored how iron supplementation impacts patients with celiac disease who suffer from iron deficiency anemia, particularly focusing on those unable to tolerate traditional iron sulfate. In this study, patients were divided into two groups: one receiving a new formulation called sucrosomial iron and the other taking iron sulfate.
After a 90-day follow-up, both groups showed significant improvements in hemoglobin levels and overall iron metrics. Interestingly, those taking sucrosomial iron experienced a marked reduction in abdominal symptoms like bloating and pain. They reported feeling a 33% increase in general well-being compared to 21% in the iron sulfate group.
This suggests sucrosomial iron could be a preferable option for individuals with celiac disease who struggle with gastrointestinal discomfort from standard iron treatments. Overall, while both forms of iron supplementation were effective, sucrosomial iron may ease some of the unpleasant side effects commonly associated with iron therapy.
After a 90-day follow-up, both groups showed significant improvements in hemoglobin levels and overall iron metrics. Interestingly, those taking sucrosomial iron experienced a marked reduction in abdominal symptoms like bloating and pain. They reported feeling a 33% increase in general well-being compared to 21% in the iron sulfate group.
This suggests sucrosomial iron could be a preferable option for individuals with celiac disease who struggle with gastrointestinal discomfort from standard iron treatments. Overall, while both forms of iron supplementation were effective, sucrosomial iron may ease some of the unpleasant side effects commonly associated with iron therapy.
10
No more bloating
Most Useful Review
This has worked wonders for me, and I’m grateful! Although I'm not usually one to leave reviews, I heavily rely on them, so I wanted to contribute. Suffering from chronic anaemia, I've taken OTC iron and prescription tablets, but always faced digestive issues like burping a metallic taste when doing so. After trying this GOL product, I’m thrilled! I experienced no stomach pain, constipation, or bloating, and I no longer have that metallic taste. I’ve subscribed for automatic deliveries and will continue using it since it works for me.
Flu
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Iron levels improved
Most Useful Review
My iron levels skyrocketed. I'm always hesitant to write a review on vitamins because it's hard to determine their exact influence on overall health. However, Vitamin Code Raw Iron has prompted me to share my experience. A year ago, I was diagnosed with low iron levels and anaemia. The prescribed iron sulfate upset my stomach, making me feel worse. A friend recommended Vitamin Code Raw Iron, which I've now taken for six months without side effects. The best news came today; my doctor praised my iron levels! This vitamin compensated for my deficiency and brought my levels to near perfection. I'm now a firm believer in raw vitamins and am gradually switching my other supplements to the Vitamin Code brand. I highly recommend them!
Reflux
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.6
9
Iron and biogas synergy improves digestion
Effect of zero-valent iron (ZVI) and biogas slurry reflux on methane production by anaerobic digestion of waste activated sludge.
Most Relevant Research
We explored how the addition of zero-valent iron (ZVI) and the refluxing of biogas slurry can enhance the efficiency of anaerobic digestion. The research made it clear that the best methane production occurred when the biogas slurry reflux was set at a 60% ratio.
Interestingly, while ZVI didn't enhance its own bioavailability in the anaerobic digestion process, it worked well in combination with the biogas slurry. We observed that this combination notably increased the presence of key microorganisms that play a significant role in the process of direct interspecific electron transfer, which is crucial for methane production.
The dominant bacteria in this mix included Methanosaeta, Methanobacterium, Methanobrevibacter, and Methanolinea, making up more than 60% of the total methanogenic population. By promoting hydrogen production due to the corrosion of ZVI, we found that biogas slurry reflux provided necessary conditions for thriving anaerobic microorganisms.
This cooperative effect not only advanced the growth of hydrogen-producing methanogens but also boosted the functioning of vital enzymes involved in the breakdown and conversion of waste materials, thus enhancing the entire anaerobic digestion system. Ultimately, our findings suggest that while ZVI alone didn’t show a strong effect, it plays an important role when paired with biogas slurry reflux in making the anaerobic digestion process more efficient.
Interestingly, while ZVI didn't enhance its own bioavailability in the anaerobic digestion process, it worked well in combination with the biogas slurry. We observed that this combination notably increased the presence of key microorganisms that play a significant role in the process of direct interspecific electron transfer, which is crucial for methane production.
The dominant bacteria in this mix included Methanosaeta, Methanobacterium, Methanobrevibacter, and Methanolinea, making up more than 60% of the total methanogenic population. By promoting hydrogen production due to the corrosion of ZVI, we found that biogas slurry reflux provided necessary conditions for thriving anaerobic microorganisms.
This cooperative effect not only advanced the growth of hydrogen-producing methanogens but also boosted the functioning of vital enzymes involved in the breakdown and conversion of waste materials, thus enhancing the entire anaerobic digestion system. Ultimately, our findings suggest that while ZVI alone didn’t show a strong effect, it plays an important role when paired with biogas slurry reflux in making the anaerobic digestion process more efficient.
9.5
Gentle iron solution
Most Useful Review
This iron supplement has been excellent! I've suffered from acid reflux for years and took Zantac when needed. But after switching to the Garden of Life brand, my Ferritin levels increased significantly within weeks. I haven't had to take Zantac in over two months, and I believe this improved my digestive issues.
Depression
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7
USERS' SCORE
Good
Based on 1 Review
8.5
2
Vitamin B12 shows no benefit for depression
Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.
Most Relevant Research
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
8.8
Improved condition
Most Useful Review
Let me go; I have been taking it for six months. The blood test didn’t require re-examination the first time, and my depression has improved. Iron is truly important.
Frozen Shoulder
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Shoulder pain relief
Most Useful Review
I purchased this to help with my frozen shoulder and improve my anaemia. It seems to contain many nutrients beyond just iron. Since taking it, I no longer wake up with stiff shoulders. However, the tablet is larger than I anticipated, so I recommend swallowing it with plenty of water.
High Cholesterol
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
USERS' SCORE
Good
Based on 1 Review
8.5
8
Iron's influence on cholesterol levels
Association between exposure to plasma mixture of essential and toxic elements and the lipid profile in institutionalized older adults.
Most Relevant Research
We examined the relationship between essential and toxic elements in the plasma of institutionalized older adults and their cholesterol levels. Focusing on a group of 149 Brazilian seniors living in nursing homes, our goal was to understand how these elements influence lipid profiles and blood sugar levels.
Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.
These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.
These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
8.8
Effective treatment noted
Most Useful Review
I must say, during her previous pregnancy, my daughter had very low haemoglobin levels that didn’t improve with good pharmaceutical preparations, leading to her hospitalisation for iron infusion. Thankfully, we managed to raise it to 100. Now that she is expecting again, she takes iron supplements, including chelated iron from Ayherb. Her latest tests show her haemoglobin levels are as per the textbook! She feels no fatigue, which is wonderful. I recommend these supplements for better health, as they have significantly helped her without causing stomach issues.
Hypothyroidism
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.3
USERS' SCORE
Good
Based on 1 Review
8.5
9
Folic acid aids hypothyroid cognition
Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats.
Most Relevant Research
Our study aimed to understand how folic acid (FA) impacts cognitive issues linked to hypothyroidism. We used a rat model, treating them with propylthiouracil (PTU) to induce hypothyroidism. After administering various doses of folic acid over several weeks, we monitored behavior through tests designed to assess learning and memory skills.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
8.8
Stable health
Most Useful Review
I am prone to iron deficiency due to hypothyroidism, so I cannot do without iron supplements. I appreciate the safe ingredients that keep my health stable and do not upset my stomach. I would purchase it again.
Liver Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.5
9
Folate treatment aids liver fat reduction
DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner.
Most Relevant Research
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
8.3
Natural iron boost
Most Useful Review
No stress on the stomach; it's 100% natural, so it doesn't harm my stomach or liver. It significantly raises my iron levels.
Hair Loss
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.5
7
Folic acid shows limited protective effects
In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio).
Most Relevant Research
We explored the effects of folic acid on hair loss in zebrafish larvae after exposure to different concentrations of ethanol. This study revealed how gestational ethanol exposure can harm the development of sensory hair cells. We found that even small amounts of ethanol lead to a significant decrease in hair cell count.
When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.
Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.
Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
9.5
Magical results
Most Useful Review
I rarely review products but felt compelled to share my experience. Suffering from very low ferritin and numerous symptoms of anaemia, I struggled to find an iron supplement that didn't bloat me. This product has been life-changing; after a week, my iron levels significantly improved. I previously experienced hair loss and felt cold all the time, but this supplement helped immensely.
Common Cold
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.4
8
Folate benefits in colds unclear
[Dietary efficacy of a micronutrient combination in patients with recurrent upper respiratory tract infections. Results of a placebo-controlled double-blind study].
Most Relevant Research
We explored the effectiveness of a special combination of micronutrients, including folate, in helping patients who suffer from recurrent upper respiratory tract infections, commonly known as colds. Our study involved 192 participants over 16 weeks in a randomized, placebo-controlled, double-blind trial that allowed us to compare results objectively.
The findings indicate that patients who had vitamin D deficiency or were low in vitamin C experienced significant benefits when taking the micronutrient combination, and symptoms improved notably compared to those on a placebo. Specifically, individuals with multiple cold symptoms showed greater relief in the active group, with a significant reduction in symptom intensity.
While folate was part of the mix, the study did not isolate its specific impact on cold symptoms. Instead, it highlighted the effectiveness of the whole nutrient combination in reducing the frequency of colds and the intensity of symptoms. Overall, those who received the micronutrient supplement reported improved health outcomes compared to those who didn't.
The findings indicate that patients who had vitamin D deficiency or were low in vitamin C experienced significant benefits when taking the micronutrient combination, and symptoms improved notably compared to those on a placebo. Specifically, individuals with multiple cold symptoms showed greater relief in the active group, with a significant reduction in symptom intensity.
While folate was part of the mix, the study did not isolate its specific impact on cold symptoms. Instead, it highlighted the effectiveness of the whole nutrient combination in reducing the frequency of colds and the intensity of symptoms. Overall, those who received the micronutrient supplement reported improved health outcomes compared to those who didn't.
7.5
Prevented common cold
Most Useful Review
Good. I can use it with confidence due to its natural ingredients. While there hasn't been a dramatic change in my physical condition, I believe this supplement has helped me avoid catching the common cold.
Hemorrhoids
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.4
7
Prevents constipation
Most Useful Review
Worked well for me. I adopted a vegan diet for over a year and needed iron supplementation. My iron levels were fine upon testing, but I did experience significant constipation, which is common with any iron supplement. I recommend taking psyllium husks daily, two to three times, to help prevent that along with getting hemorrhoids. Once you experience those, they are not easy to eliminate! It took considerable trial and error to find the right fibre for my body.
Allergies
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.3
8
Allergy management in iron treatments
From diagnosis to desensitization in immediate hypersensitivity reactions to both oral and parenteral iron salts.
Most Relevant Research
We examined the rise of hypersensitivity reactions (HRs) linked to iron agents, especially as their usage in treating iron deficiency has increased. In this study, we evaluated the clinical features of patients who experienced immediate hypersensitivity reactions (IHRs) to both oral and intravenous (IV) iron preparations.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
7.5
Effective, minor issues
Most Useful Review
I've been taking it for two weeks without nausea or allergies. Initially, there were minor toilet issues, but now all is normal. It's a good preparation that includes vitamin C for absorption and other beneficial components.
Bone Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.3
8
Folic acid alleviates bone pain
Folic acid relieves bone cancer pain by downregulating P2X2/3 receptors in rats.
Most Relevant Research
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
8.8
Eased joint pain
Most Useful Review
The smell is quite off-putting, but it has alleviated my joint pain. I previously suffered from bone pain in my legs, and this product has helped ease that pain significantly.
Headache
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.3
9
Folate intake may reduce headaches
Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey.
Most Relevant Research
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
9.5
No pain experienced
Most Useful Review
These are the best iron pills I've used. Most cause headaches or stomach pain, but this one doesn't. I can take it either on an empty stomach or with food without issues. Just remember not to take it with dairy, as it hampers iron absorption.
Nausea
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 13 Reviews
8.3
9
Iron treatment eases nausea in pregnancy
Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy.
Most Relevant Research
We conducted a study to examine the effectiveness of a specific iron supplement, emulsified microsomal ferric pyrophosphate (EMFP), in treating iron deficiency anemia among pregnant women. Our focus was not only on improving hemoglobin levels but also on alleviating related symptoms, including nausea.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
9.5
Nausea-free experience
Most Useful Review
They work well! UPDATE: My teen and I have been using this for low iron, and it works perfectly! It does not constipate us, and we feel better within 20-30 minutes. My iron levels have improved, and neither of us experiences nausea, despite having sensitive stomachs. I'll keep purchasing this!
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.3
6.3
Lighter pain
Most Useful Review
I feel my period pain is becoming lighter.
Rosacea
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.3
9
Hydroxocobalamin reduces rosacea erythema
Hydroxocobalamin: An Effective Treatment for Flushing and Persistent Erythema in Rosacea.
Most Relevant Research
We explored the potential benefits of hydroxocobalamin, a form of vitamin B12, for treating facial flushing and persistent redness in individuals with rosacea. The study included thirteen patients who received intramuscular injections of hydroxocobalamin ranging from 1 to 2 mg once to four times weekly.
To evaluate the treatment's effectiveness, we used the Clinician's Erythema Assessment (CEA) and measured skin temperature before and after the injections. Remarkably, just thirty minutes after the first dose, we observed a significant decrease in both the erythema scores and the skin surface temperature, indicating that hydroxocobalamin could be a quick and effective option for those struggling with the symptoms of rosacea.
Our findings suggest that this treatment can provide immediate relief from facial redness associated with rosacea, helping patients manage their symptoms better. With its ability to inhibit nitric oxide synthase, hydroxocobalamin shows promise as a powerful tool in addressing the troublesome aspects of this skin condition.
To evaluate the treatment's effectiveness, we used the Clinician's Erythema Assessment (CEA) and measured skin temperature before and after the injections. Remarkably, just thirty minutes after the first dose, we observed a significant decrease in both the erythema scores and the skin surface temperature, indicating that hydroxocobalamin could be a quick and effective option for those struggling with the symptoms of rosacea.
Our findings suggest that this treatment can provide immediate relief from facial redness associated with rosacea, helping patients manage their symptoms better. With its ability to inhibit nitric oxide synthase, hydroxocobalamin shows promise as a powerful tool in addressing the troublesome aspects of this skin condition.
5.8
Mixed results noted
Most Useful Review
Although these vitamins helped my energy and even my rosacea redness at first, I had to stop taking them after a fortnight due to stomach pains and worsening rosacea symptoms. Despite feeling less fatigued and experiencing clearer thinking, the constipation they caused was unsustainable for me. I switched to a B-complex with better results, but these could suit others.
Anemia
SCIENTIFIC SCORE
Possibly Effective
Based on 41 Researches
7.6
USERS' SCORE
Good
Based on 68 Reviews
8.1
9.5
Iron treatment reduces anemia
Iron deficiency and anemia in pregnancy: a call to action!: -"If you don't take a temperature, you can't find a fever".
Most Relevant Research
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
8.3
Enhanced wellbeing
Most Useful Review
Perfect iron supplement for the health-conscious. After a diagnosis of iron deficiency anaemia, I was advised to take ferrous sulfate. However, I wanted a high-quality, whole food-based alternative. After finding Garden of Life Vitamin Code Raw Iron, I've noticed an increase in energy and mental clarity. I no longer feel as depressed, and after three months of taking this, I'm pleased to report that I am no longer anemic.
Cough
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8
7
Vitamin B-12's role in chronic cough
Unexplained chronic cough and vitamin B-12 deficiency.
Most Relevant Research
We explored the connection between vitamin B-12 deficiency and chronic cough, examining how this condition might contribute to persistent coughing in some individuals. Our study involved assessing 42 patients suffering from unexplained chronic cough, 27 of whom had vitamin B-12 deficiency, while the remaining 15 did not.
By measuring their responses to inhaled histamine, we identified thresholds for laryngeal sensitivity, bronchial response, and cough reflex before and after two months of vitamin B-12 injections. The results highlighted that patients with vitamin B-12 deficiency showed heightened sensitivity, which might indicate that this deficiency plays a role in sensory nerve issues related to chronic cough.
Notably, we observed that markers of nerve growth increased in pharyngeal biopsies of patients with vitamin B-12 deficiency, supporting the idea that these changes may be linked to their chronic cough. This suggests that addressing vitamin B-12 deficiency could be an important factor in managing persistent coughs, especially when other causes remain unidentified.
By measuring their responses to inhaled histamine, we identified thresholds for laryngeal sensitivity, bronchial response, and cough reflex before and after two months of vitamin B-12 injections. The results highlighted that patients with vitamin B-12 deficiency showed heightened sensitivity, which might indicate that this deficiency plays a role in sensory nerve issues related to chronic cough.
Notably, we observed that markers of nerve growth increased in pharyngeal biopsies of patients with vitamin B-12 deficiency, supporting the idea that these changes may be linked to their chronic cough. This suggests that addressing vitamin B-12 deficiency could be an important factor in managing persistent coughs, especially when other causes remain unidentified.
3.5
Cough worsened experience
Most Useful Review
Stopped taking these as I’m uncertain they were effective for me. After starting, I developed a very dry cough which made me miserable. I don't know if it was due to the vitamins alongside my other prescriptions. After three days without them, the coughing decreased. I won't be retaking these vitamins.
Heart Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Most Relevant Research
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
9.5
Supports iron levels
Most Useful Review
Garden of Life, Vitamin Code, RAW Iron, 30 Vegan Capsules is excellent for naturally supporting iron levels. Made from high-quality, allergen-free ingredients, it benefits blood and heart health. I've experienced a notable improvement in my iron levels since using it, making it vital for managing heart disease.
Diarrhea
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.4
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
9.5
Vitamin B12 aids chronic diarrhea
CHRONIC DIARRHOEA: NOT A RARE PRESENTATION OF VITAMIN B 12 DEFICIENCY.
Most Relevant Research
We aimed to explore how vitamin B12 supplementation affects individuals suffering from chronic diarrhea. In our quasi-experimental study conducted at Pakistan Ordinance Factory Hospital, we focused on new patients aged between 12 and 65 years who exhibited low serum vitamin B12 levels and normal folate levels.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
5
No more diarrhea
Most Useful Review
Iron is vital! After a blood test revealed anaemia, I was prescribed iron, but I struggled with stomach pain and nausea. This product, containing iron, vitamins C and B12, folic acid, and probiotics, has worked well. After ten days, I noticed improvements: shortness of breath and chest pain have lessened, my energy has returned, and my complexion improved. I experienced diarrhea only on the first day. Now, my stomach is fine, and I believe the iron is being absorbed properly.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.5
USERS' SCORE
Medium or Average
Based on 25 Reviews
6.7
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Most Relevant Research
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
9.5
Reduced fatigue
Most Useful Review
This complex is remarkable! It not only provides iron but also includes vitamin B12, vitamin C, and probiotics that enhance absorption. I noticed a significant reduction in chronic fatigue syndrome symptoms, with improved mood and energy levels. By the end of the course, my blood tests showed a considerable recovery in iron levels.
