Garden of Life Raw B Complex

Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991;14:414.

Vitamin B12 aids sleep disorders

We observed two adolescents struggling with severe sleep-wake schedule disorders respond positively to high doses of vitamin B12, specifically methylcobalamin. The 15-year-old girl with delayed sleep phase syndrome and the 17-year-old boy with hypernychthemeral syndrome showed immediate improvements after receiving 3,000 micrograms per day.

Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.

Magic pill effect

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15 people found this helpful

This product tackles psychological pressure, digestion difficulties, and insomnia effectively. Upon taking it, I felt no issues—like a magic pill! Its natural ingredients, probiotics, and digestive enzymes are easy for the body to tolerate.

Chest Pain details

Vitamin B complex's minor impact on health

Martí-Carvajal AJ, Solà I, Lathyris D, Dayer M. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2017;8:CD006612. doi:10.1002/14651858.CD006612.pub5

We evaluated the effects of vitamin B complex supplements on chest pain and heart health by reviewing 15 studies involving over 71,000 participants.

Our investigation revealed that while there were no significant differences in rates of heart attacks, overall deaths, or serious side effects between those receiving vitamin B complex and placebo, there was a slight reduction in stroke incidence.

However, the benefits were minimal and outcomes varied with dosages, indicating that more research is needed to draw firm conclusions about the effectiveness of these vitamin interventions on cardiovascular events.

Numbness resolved

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1 people found this helpful

The quality, ingredients, and quantity are excellent. I suffered from numbness on my right side, especially in my foot and hand at night, along with discomfort. After continuing with the vitamins, these issues disappeared entirely. The lack of B vitamins caused many problems, including stomach pain, which significantly eased.

We evaluated the effects of gabapentin combined with B vitamins (B1 and B12) against pregabalin for painful diabetic neuropathy. In this multicenter, randomized, and blind study, 270 patients participated over 12 weeks.

Both treatments reduced pain without a significant statistical difference. However, our findings indicated that the gabapentin plus B vitamin group experienced fewer cases of dizziness, highlighting a potential advantage in managing side effects compared to pregabalin. This could lead to a more comfortable treatment experience for patients.

Dizziness eliminated

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1 people found this helpful

Excellent vitamins! I love this company for its quality, which has been tested multiple times. A jar of capsules is packed securely with no damage. The vitamins are small, making them convenient to swallow, with no discomfort or aftertaste. I appreciate the raw composition. I purchased these vitamins for recovery after pregnancy, and after retaking my health indicators, they improved significantly! My health state has improved, and the dizziness has disappeared. Highly recommended!

Gastritis details

Effective gastritis relief

15 people found this helpful

Super-complex of B vitamins! I’m absolutely delighted! In spring, my hair began to fall out in large clumps, which was very distressing. After just one and a half weeks of taking these vitamins (along with organic MRM sulphur), the hair loss completely stopped. My sleep improved, and I found it easier to fall asleep. The signs of VSD that I experience every spring vanished. I took these vitamins during a gastritis flare-up, and thankfully, my stomach didn't hurt! I was somewhat concerned about the recommended dosage, so I opted for one capsule per day instead of two, and the effect has been quite noticeable!

Hypothyroidism details

Thiamine enhances memory in hypothyroidism

Based on 4 Researches

Saberi R, Mirazi N, Amirahmadi S, Darbandi ZK, Vafaee F, et al. Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase. Metab Brain Dis. 2023;38:2603. doi:10.1007/s11011-023-01317-0

We explored the impact of thiamine (Vitamin B1) on memory and learning in rats with hypothyroidism. In a study involving 50 young rats, we treated them with a hypothyroid-inducing agent and varying doses of thiamine over seven weeks.

The results were promising—thiamine improved memory in rats as evidenced by better performance in timed tests. Specifically, higher doses of thiamine led to increased memory retention and reduced oxidative stress. This suggests that thiamine could be a beneficial supplement for addressing memory issues related to hypothyroidism.

Skin cleansed quickly

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4 people found this helpful

Great working vitamin! I’ve taken it twice now, and I’ve noticed my skin is clearer within just a week. I have more energy, and my digestive system feels satisfied. With my AIT and hypothyroidism, this product is exactly what I needed. A finger wound healed in just a couple of hours, whereas it usually takes two days.

Allergies details

Pinitol may reduce allergy symptoms

You X, Sun X, Kong J, Tian J, Shi Y, et al. D-Pinitol Attenuated Ovalbumin-induced Allergic Rhinitis in Experimental Mice via Balancing Th1/Th2 Response. Iran J Allergy Asthma Immunol. 2021;20:672. doi:10.18502/ijaai.v20i6.8017

We evaluated how D-Pinitol affects allergic rhinitis (AR) in a controlled study using mice.

By sensitizing BALB/c mice with ovalbumin (OVA), we created an AR model. After giving treatment groups various doses of pinitol or montelukast, we found that higher doses of pinitol significantly reduced symptoms like sneezing and nasal discharge.

Notably, it also balanced specific immune responses typically seen in allergies. However, montelukast showed clearer results in some areas, indicating that while pinitol is promising, more research is necessary.

No allergies

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4 people found this helpful

It smells like dog food, but it does not cause allergies at all. It’s a consistent non-allergenic product.

Athlete’s Foot details

1 people found this helpful

The quality, ingredients and quantity are excellent. I suffered from numbness on my right side, especially in my foot and hand at bedtime, with annoying pain. After continuing this treatment, the numbness completely vanished. The lack of B vitamins caused many issues, including stomach pain, which has eased greatly since I began taking it with zinc and magnesium citrate.

Bruise details

Effective for dryness

7 people found this helpful

I was surprised to learn that the group of B vitamins is responsible for so many functions. Upon reflection, I realised I had issues with all of them. I began to bruise frequently, which was concerning, as well as experiencing a persistent dry sensation in my eyes, especially since I wear lenses. It was incredibly inconvenient. I had become dependent on expensive eye drops as a remedy. Now, I take this vitamin complex—one tablet each day on an empty stomach—and in just a month, everything has improved! The occurrence of bruises has decreased, and if they do appear, they fade rapidly. The dryness in my eyes is no longer an issue!

Cardiovascular Disease details

Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. doi:10.1016/j.ejphar.2025.177413

Vitamin B6 aids heart recovery

We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.

Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.

Energy boost

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36 people found this helpful

Thank you, iHerb. I am quite pleased with the complex! It genuinely provides strength and energy. I usually take one capsule, but after a stressful day, I took another one later, and it revitalised me. Everyone in my family has benefitted, especially with the easily digestible Vitamin B12. A lack of B12 can lead to significant issues, including nervous system disorders. Thus, this complex is crucial for maintaining health, particularly for combating cardiovascular disease.

Heart Attack details

Based on 7 Researches

Vitamin B6 aids heart recovery

We explored whether vitamin B6 can aid heart recovery after a heart attack. Our study showed that vitamin B6 promotes angiogenesis, the formation of new blood vessels, which plays a key role in heart function recovery.

We observed that vitamin B6 enhances cell migration and tube formation in laboratory settings, as well as improves heart function in mice after a heart attack. While it shows promise, we must remember that these results are based on animal studies, and more research is needed before drawing conclusions for humans.

Reduced heart rate

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29 people found this helpful

Thanks to the manufacturer, I've been saved from tachycardia. A friend introduced me to these vitamins after I was prescribed a sedative following a nervous system issue. Despite months on the sedative, I experienced internal tension and severe tachycardia. After taking these vitamins for a few days, my pulse returned to normal. I now take them during stress and they dissolve well in water.

High Cholesterol details

Niacin reduces cholesterol and oxidative stress

Based on 10 Researches

Hamoud S, Kaplan M, Meilin E, Hassan A, Torgovicky R, et al. Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol. Am J Med Sci. 2013;345:195. doi:10.1097/MAJ.0b013e3182548c28

We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.

The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.

Cholesterol improvement

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177 people found this helpful

I appreciate this complex! The dark glass jar with a protective membrane is commendable, as is the extra cardboard packaging. As someone with a folate cycle mutation (MTHFR), I find synthetic B vitamins hard to absorb. This product has a natural composition with probiotics and enzymes, which I store in the fridge for safety. After consuming one capsule, my analyses improved, and my high cholesterol levels have decreased. I highly recommend these vitamins and the packaging is lovely!

Migraine details

Vitamin B2 significantly reduces migraines

Based on 15 Researches

Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. doi:10.1080/1028415X.2021.1904542

In our review and meta-analysis, we sought to understand how Vitamin B2 supplementation influences migraines. By examining nine studies with over 670 participants, we found that taking 400 mg of Vitamin B2 daily for three months significantly reduced the frequency, duration, and pain intensity of migraine attacks.

Our analysis revealed that Vitamin B2 wasn't just a minor help; it truly made a difference in managing migraine symptoms. This suggests a potential alternative to traditional pharmaceuticals, offering hope for migraine sufferers looking for effective prevention options.

Blocks migraine attacks

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12 people found this helpful

Taking this supplement daily, I noticed my skin has improved, and notably, it has prevented my monthly migraine attacks linked to PMS. Normally, I suffer severe headaches that only vomiting alleviates, but after two months on this supplement, I was amazed to experience no migraines this time. I even gave a capsule to my mother when she had a headache, and after about an hour, she felt relief. Unlike painkillers, which only harm, this supplement appears to benefit the body and allow the mind some rest.

Sleep Apnea details

1 people found this helpful

I purchased these vitamins for my child on the advice of our paediatrician. After a month and a half, my 5-year-old now sleeps through the night without awakening! She has become more focused and her appetite has increased. I believe she was lacking B vitamins, and these have made a significant difference.

Blurred Vision details

Perfectly, B group vitamins (Riboflavin) enhance mental activity, boost work capacity, regulate carbohydrate metabolism and water balance, ensure the normal functioning of the nervous and cardiovascular systems, improve skin condition, and support vision.

Celiac details

This excellent natural product—herbal B-complex—has been fantastic for me. I take 2 capsules for at least 3 months due to my gluten intolerance. My hair has become thicker, my sleep has improved, my efficiency has increased, and my complexion looks better!

Heart Disease details

Tabei SM, Mazloom M, Shahriari M, Zareifar S, Azimi A, et al. Determining and surveying the role of carnitine and folic acid to decrease fatigue in β-thalassemia minor subjects. Pediatr Hematol Oncol. 2013;30:742. doi:10.3109/08880018.2013.771388

VB6 helps heart recovery post-AMI

We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.

Improves vitality

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24 people found this helpful

This vitamin complex has been a game-changer for me. After taking it for two months, I feel invigorated and energetic, better managing fatigue and stress. I only need one capsule daily, as it digests well. It's certainly the most effective vitamin B complex I've tried, helping me feel more balanced and enhancing my mood. I will continue to purchase this.

Bone Pain details

Carnitine aids bone pain relief

We examined the potential benefits of carnitine and folic acid in reducing bone pain and fatigue in patients with beta-thalassemia minor. Over three months, 73 participants received either carnitine alone, a combination of carnitine and folic acid, or folic acid alone, while a control group went without supplementation.

Our results showed that carnitine significantly improved plasma levels and reduced bone pain and muscle weakness for those affected by this condition. Although folic acid improved red blood cell levels, its impact on bone pain was not directly highlighted. Overall, our findings suggest that carnitine can be beneficial in addressing bone pain in these patients.

Calmness achieved

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2 people found this helpful

I was hesitant to take a vitamin B group due to potential side effects, but not with this one! These magical vitamins have provided relief from bone pain and stress. I recommend them for their visible benefits. It's a permanent purchase for me.

Chronic Fatigue Syndrome details

B12 and folic acid show variability

Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. doi:10.1371/journal.pone.0124648

We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.

Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.

However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.

Reduced fatigue

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247 people found this helpful

This is an exceptional vitamin B complex, derived from organic sources, notably reducing my chronic fatigue syndrome. I experience significantly fewer headaches now, which has been vital for my daily life. Highly recommended!

Rash details

Adie MA, Martes Gomez M, Yom J, Durand M, Wertheimer F, et al. Twin Premature Infants With Riboflavin and Biotin Deficiency Presenting With Refractory Lactic Acidosis, Rash, and Multiorgan Failure During Prolonged Parenteral Nutrition. J Investig Med High Impact Case Rep. 2023;11:23247096231168111. doi:10.1177/23247096231168111

Likely Very Effective

Based on 2 Researches

Vitamin B deficiency leads to rash

We explored the effects of riboflavin and biotin deficiencies in premature twins, who initially presented with skin rashes among other severe symptoms. After being diagnosed, one twin began supplementation with these vitamins.

Remarkably, this led to a quick improvement in clinical condition and laboratory findings within days. Though one twin experienced tragic complications resulting in death, the surviving twin went home in stable condition, highlighting the importance of addressing vitamin deficiencies early.

7.5

Boosts vitality

Most Useful Review

6 people found this helpful

Good. A jar of 60 capsules lasts, and I take 1 capsule daily in the morning. These capsules do not cause discomfort (unlike others that resulted in rashes and dermatitis). This complex certainly provides energy, lasting until the evening. I might consider taking 2, but honestly, I fear large dosages. I recommend it.

Ulcer details

Benfotiamine improves ulcer healing

Based on 7 Researches

Shokati Sayyad M, Khanjani MH, Amirbeik M, Seyedabadi M, Talebpour Amiri F, et al. The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study. J Mol Histol. 2024;55:863. doi:10.1007/s10735-024-10237-x

We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.

Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.

However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.

Quick relief achieved

Most Useful Review

1 people found this helpful

It's beneficial; I take out the contents and mix it with other superfoods for a drink. Using this when I have a mouth ulcer leads to a quick reduction in discomfort, proving to be quite helpful.

Anemia details

Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x

Based on 11 Researches

Case study: Vitamin B12 efficacy

We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.

Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.

Energy boost

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36 people found this helpful

I’m pleased with this complex, as it truly provides energy. On a stressful day, I doubled my intake and felt revitalised. The whole family uses it, and we all appreciate the wonderful results, especially regarding my husband's and my assistance in treating our anemia.

Bloating details

I have just started using it, taking one with a meal. It does not cause bloating as it contains no harmful chemicals.

Flu details

Boosts mental clarity

High-Quality B-Complex Supplement: Garden of Life consistently offers high-quality products, and this B-complex is outstanding. The capsules are well-made and contain essential B vitamins in raw forms, making it perfect for those after whole-food supplements. I’ve experienced a boost in energy and improved mental clarity without any stomach discomfort or niacin flush. An excellent choice for natural energy support. Highly recommended.

Anxiety details

Niacin helps alleviate anxiety symptoms

Based on 7 Researches

Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. doi:10.1016/j.exger.2024.112624

We examined the impact of Niacin on anxiety and memory loss caused by aging in a rat study. Rats were grouped and treated with various doses of Niacin and D-galactose for 14 days, followed by behavioral tests to assess anxiety and memory.

Our results showed that Niacin significantly reduced anxiety-like symptoms and improved memory deficits. Additionally, it mitigated factors like oxidative stress and inflammation, enhancing brain health. Overall, Niacin's antioxidant and neuro-modulatory properties suggest it may be beneficial in addressing aging-related psychiatric issues.

Enhanced stress handling

Most Useful Review

23 people found this helpful

I felt a noticeable difference with these vitamins. They provided me with energy and alleviated my stress and anxiety. I initially bought them due to articles indicating that stress can arise from a vitamin B deficiency. With these, I managed stress much better, even after a promotion that brought increased pressure. They proved to be miraculous pills, also positively affecting my acne. Although a bit pricey, they are worth it.

Common Cold details

Zinc reduces diarrhea, colds in infants

Likely Very Effective

McDonald CM, Manji KP, Kisenge R, Aboud S, Spiegelman D, et al. Daily Zinc but Not Multivitamin Supplementation Reduces Diarrhea and Upper Respiratory Infections in Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr. 2015;145:2153. doi:10.3945/jn.115.212308

We investigated the impact of daily multivitamin and zinc supplementation on the health of Tanzanian infants. In our randomized, double-blind study involving 2,400 infants, we compared the effects of these supplements against a placebo over 18 months.

Our findings revealed that while zinc significantly reduced occurrences of diarrhea and acute respiratory infections, multivitamins did not provide additional benefits. Ultimately, zinc supplementation starting at 6 weeks may be beneficial for reducing some common illnesses in infants, but multivitamins did not show any significant positive impact.

Strengthened immunity

Most Useful Review

5 people found this helpful

After pregnancy, childbirth, and two years of breastfeeding, I was exhausted and frequently suffered from colds. Upon taking these vitamins, I experienced a boost in energy and strength, and throughout the winter, I did not catch a common cold.

Depression details

Vitamin B may alleviate depression symptoms

Based on 12 Researches

Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. doi:10.12182/20250160608

Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.

We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.

The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.

Increased vitality

Most Useful Review

24 people found this helpful

I've been taking this B vitamin complex for two months. Even with a prophylactic dose of one capsule, I've noticed an increase in vitality, endurance against stress, and improved mood. These vitamins are highly effective for me, and I will continue to purchase them.

Tinnitus details

3 people found this helpful

The main reason I take vitamin B complex is my tinnitus. My ENT specialist advised me to take two tablets daily, affirming that vitamin B complex is beneficial for this condition. Many of my tinnitus acquaintances receive similar recommendations from their doctors. I've discovered that the vitamin B complex includes B1, B2, B6, and B12, with B6 particularly advantageous for bones.

Back Pain details

Vitamin B12 effectively reduces pain

Based on 14 Researches

Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4:53.

We sought to understand how intramuscular vitamin B12 could help alleviate low back pain in patients with mechanical lumbago. In a rigorous study involving 60 participants, we compared the effects of vitamin B12 to a placebo.

Our findings indicated that those receiving the vitamin reported significantly less pain and disability, as measured by a visual scale and disability questionnaire. Notably, those on vitamin B12 also used less paracetamol than the placebo group.

Overall, our study confirmed that vitamin B12 can be effective for treating low back pain without nutritional deficiency.

Pain alleviation

Most Useful Review

9 people found this helpful

Stunning vitamins! After childbirth, I suffered back pain for three years with no relief. Since taking these vitamins, I feel invigorated and my work capacity has greatly improved. However, once I stop, the pain returns.

Leg Cramps details

Vitamin B complex effective for cramps

Based on 2 Researches

Chan P, Huang TY, Chen YJ, Huang WP, Liu YC. Randomized, double-blind, placebo-controlled study of the safety and efficacy of vitamin B complex in the treatment of nocturnal leg cramps in elderly patients with hypertension. J Clin Pharmacol. 1998;38:1151.

We conducted a randomized, double-blind study to see if vitamin B complex could help older adults with nighttime leg cramps. Over three months, participants reported their cramp frequency and intensity.

The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.

Life improvement

Most Useful Review

13 people found this helpful

Excellent choice for B vitamins. After experiencing leg cramps from work stress, I noticed a significant improvement after I started taking this supplement. It has uplifted my mood and helped address my irritability. I've taken it with other vitamins, and I experienced no side effects. I highly recommend it!

Liver Disease details

Methylcobalamin protects against liver failure

Based on 4 Researches

Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. doi:10.1038/s41467-024-54826-6

We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.

In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.

Boosts energy levels

Most Useful Review

1 people found this helpful

These vitamins indeed do their job. I take one every second day, which is sufficient for me to notice enhanced skin and energy. Daily intake felt excessive for my body, particularly for my liver and kidneys to process.

Nausea details

Cariban effectively relieves pregnancy nausea

Based on 4 Researches

Saz-Leal P, Zamorano-Domínguez L, Frías J, Guerra P, Saura-Valls M, et al. Bioavailability of Cariban Capsules: A Modified-Release Fixed-Dose Combination of Doxylamine and Pyridoxine to Relieve Nausea and Vomiting During Pregnancy. Drugs R D. 2023;23:185. doi:10.1007/s40268-023-00425-7

We examined how Cariban, a combination of doxylamine and pyridoxine, helps alleviate nausea and vomiting during pregnancy. Using a controlled study involving 12 healthy women, we looked at how the modified-release capsules perform in the body compared to other forms.

Our findings showed that Cariban is absorbed quickly and maintains its effectiveness over an extended period. This makes it a reliable option for managing nausea in pregnant women, underscoring its value in clinical practice.

7.5

Helpful for sickness

Most Useful Review

5 people found this helpful

These vitamins have been a lifesaver! I've used them daily since about three months into my pregnancy and am nearing my due date. I've suffered from extreme nausea daily, and while these don’t eliminate it entirely, they've made it more manageable. They’re easy to swallow, though I dislike the taste due to my pregnancy. The difference in my energy levels is stark if I miss a morning dose. Despite my demanding retail job, these have been vital in helping me cope. I also explored raw B Complex and found it beneficial for many pregnant women. They worked wonders for me!

Acne details

Panthenol mask improves skin barrier

Likely Very Effective

Zhang X, Tao H, Deng Y, He X, Zhang Z, et al. Efficacy and safety of a panthenol-enriched mask for individuals with distinct impaired skin barrier subtypes. J Cosmet Dermatol. 2024;23:2109. doi:10.1111/jocd.16231

We aimed to evaluate how a panthenol-enriched mask, specifically La Roche-Posay Mask Pro, performs in improving skin barriers for different types, such as dry sensitive, oily sensitive, and oily acne-prone skin.

Over 177 participants used the mask under guidance, and we measured factors like hydration, sebum content, and redness at multiple intervals.

The results showed significant improvements across all skin types, particularly for oily acne skin, which saw reductions in sebum and redness. Importantly, there were no adverse effects reported, indicating that this mask can be a trusty companion for those with various skin concerns.

Effective acne treatment

Most Useful Review

12 people found this helpful

This B Complex cleared my acne! I began using this product in September 2015 after struggling with acne since I was 14. I always had painful cystic acne. Despite trying various supplements for my PCOS and thyroid, I continued to have acne. Upon taking this B complex, my pimples vanished, and I was acne-free for the first time in 16 years. After stopping for a while due to pregnancy, my acne returned, but resumed use of this product cleared it again. I believe the B5 is effective and prefer it over synthetic alternatives. If you have acne, give this a try.

Autoimmune Disorder details

Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4

Pernicious anemia case in Uganda

We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.

Boosted energy levels

Most Useful Review

36 people found this helpful

I appreciate iHerb for this complex. It genuinely enhances strength and energy. I usually take one capsule, but I had a busy day after waking at four in the morning. I took another capsule post-4 PM and felt revitalised, with no fatigue. My family's experiencing great results, especially with the easily digestible methylcobalamin form of B12. This vitamin supports various bodily processes, and I feel it's essential, especially for those with autoimmune disorders.

Cold details

Strengthened immunity

5 people found this helpful

For me, they were effective. I purchased vitamins to bolster my immunity after pregnancy and two years of breastfeeding. My body was exhausted, and I often suffered from colds. After taking these vitamins, I felt a surge of energy and strength, and throughout the winter, I didn't experience any ARI.

Diabetes details

Myo-inositol aids diabetes management

Based on 11 Researches

Long L, Huang Q, Song T, Dai Z. Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice. J Appl Biomed. 2024;22:74. doi:10.32725/jab.2024.009

We explored how Myo-inositol (MI) might help manage diabetes by studying its effects in db/db mice, a common model for type 2 diabetes. Findings showed that MI reduced high blood sugar and insulin levels, and it even improved insulin resistance, much like metformin does.

Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.

7.5

Calmer sleep quality

Most Useful Review

2 people found this helpful

Great B-complex! With type 1 diabetes, it fits perfectly. B vitamins restore metabolic processes in the body and help maintain correct blood sugar levels by improving carbohydrate metabolism. Results weren't immediate, but by the second week, my son's sleep improved, he became calmer, and his sugar indicators stabilised. We adhere to proper nutrition, and these vitamins have become ideal aids in supporting his health. There are no side effects. I give him one capsule daily, so this jar lasts for two courses with a break of five months.

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