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Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin)
5,000 mcg
208,330%
The product is found useful for the following medical conditions
Anemia
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.8
USERS' SCORE
Good
Based on 10 Reviews
8.9
9
Vitamin B12 effectively treats anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Most Relevant Research
We observed a compelling case surrounding the impact of vitamin B12 on anemia, particularly in a 62-year-old man facing severe deficiencies due to factors like drug use, hepatitis C, smoking, and alcoholism. Initially, this patient presented with symptoms such as fatigue, fever, and confusion, raising concerns about more critical conditions like thrombotic thrombocytopenic purpura (TTP). Laboratory tests indicated severe pancytopenia and signs of hemolysis, making the situation quite alarming.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
9.5
Bloodwork normalised
Most Useful Review
I could not find a source for my macrocytic anaemia, so I started taking the Jarrow formula before breakfast every day for better absorption. Six weeks later, my bloodwork was normal for the first time in years. I feel less irritable and have more energy. I take it whole for maximum effect since B12 isn't easily absorbed.
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.8
USERS' SCORE
Good
Based on 13 Reviews
8.8
9
Pernicious anemia treatment effectiveness
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
Most Relevant Research
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
9.5
Pain relief
Most Useful Review
I have rheumatoid arthritis and, in 2010, my pain worsened significantly. I discovered that a gluten-free diet alleviated most of my pain, but I still faced severe discomfort in my feet and hands. After researching B12 deficiency, I started taking Jarrow methyl B12 and I now experience minimal pain. I'm regaining my life.
Back Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 10 Reviews
8.8
9
Vitamin B12 aids low back pain
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Most Relevant Research
We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
9.5
Relieves chronic pain
Most Useful Review
Best product for chronic pain. I switched from expensive B12 shots for chronic fatigue and fibromyalgia to sublingual tablets at my doctor’s suggestion. I've experienced the same relief from pain, including back pain, from the tablets. My husband, who has severe back pain, has also found relief without any painkillers. He's much happier and able to help around the house—a true testament to this product’s effectiveness.
Insomnia
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 5 Reviews
8.8
8
Vitamin B12 promotes sleep in rats
Effects of intravenously administered vitamin B12 on sleep in the rat.
Most Relevant Research
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
10
Insomnia relief
Most Useful Review
Switch to methyl-B12 and never look back! If you’ve found methylcobalamin, you’ve likely done your research on its superiority over cyanocobalamin. This was a recent discovery for me, supported by research in medical journals. What a difference! Many women in my family have been low in B, and despite trying various supplements, I never felt the effects until now. I take a half-dose once or twice a day, and within minutes, I feel energetic again without jitteriness. I also sleep better. A friend tried it and found his insomnia is gone, sleeping through the night for the first time in years! If your body doesn’t respond to other B12 supplements, this one is well worth trying, especially with the trustworthy name of Jarrow Formulas behind it.
Hypothyroidism
SCIENTIFIC SCORE
Likely Ineffective
Based on 4 Researches
4.8
USERS' SCORE
Good
Based on 2 Reviews
8.8
7
Vitamin B12 and hypothyroid patients
A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital.
Most Relevant Research
We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
10
Life-enhancing product
Most Useful Review
Wonderful product. I have multiple medical conditions including B-12 deficiency and severe hypothyroidism. For years, I suffered with "shooting pain" in my limbs, and none of my medications worked. After discovering Jarrow Methyl B-12, I took it religiously. I reported to my doctor that without it, my health would have worsened. The pain has vanished, and I feel significantly better now. I would recommend discussing this with a healthcare provider if you suspect a B-12 deficiency.
Neuropathy
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.2
USERS' SCORE
Good
Based on 2 Reviews
8.8
9
Nitrous oxide affects B12 levels
Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report.
Most Relevant Research
We examined a remarkable case involving the effects of nitrous oxide (NO) on vitamin B12 levels and its neurological consequences. Nitrous oxide is not just a useful tool in medical and food industries; it is sometimes misused by young adults for recreational purposes. This misuse can lead to functional vitamin B12 deficiency, which in turn may result in serious neurological issues like peripheral neuropathy and subacute combined degeneration (SACD) of the spinal cord.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
10
Cured neuropathy pain
Most Useful Review
My friend, a type II Diabetic, had severe neuropathy pain caused by a B-12 deficiency due to statins and metformin. After his doctor removed him from these medications and administered B-12 shots, the neuropathy pain in his feet began to diminish temporarily. However, he found lasting relief through Methyl B-12 supplements and SERRAPEPTASE, which repaired his myelin sheathing and addressed the nerve damage caused by his previous medications. Now, he’s regaining his life without neuropathy and is also working on managing his diabetes.
Anxiety
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 10 Reviews
8.7
8
Vitamin B12 may reduce anxiety
Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach.
Most Relevant Research
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
9.5
Normalcy restored
Most Useful Review
This worked wonders for my anxiety! After switching to a vegan diet, my anxiety grew worse until I started taking Methyl-B12. Nearly immediately, my stress diminished, allowing me to sleep better and enjoy life again. I'm incredibly grateful for this supplement's impact on my daily motivation and general wellbeing.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 15 Reviews
8.7
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Most Relevant Research
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
8.8
Relieves brain fog
Most Useful Review
I have tried sublingual B-12s before but never saw much difference, until I tried this one. I had a huge relapse of my chronic fatigue syndrome and was desperate for something to help with my debilitating brain fog. The day after I started taking it, I noticed about a 90% reduction in my brain fog and a boost in morning energy. I plan to experiment with taking it in the afternoon too. Each individual reacts differently, but I am very pleased with my results. This B-12 is a solid choice; I will continue to use it.
Depression
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 7 Reviews
8.7
2
Vitamin B12 shows no benefit for depression
Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.
Most Relevant Research
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
9.5
Memory improvement
Most Useful Review
My husband had severe memory problems and depression, with low B12 levels. After taking two 5000 B12 a week, we saw a major improvement in his memory and energy levels.
Leg Cramps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Cramps alleviated
Most Useful Review
I am not diabetic, but since taking metformin, I believe my B12 levels have depleted, leading to constant burning in my feet. My restless leg syndrome was at its worst. After a few days of receiving Jarrow B12 5000, I experienced complete relief from the burning within two days of taking one or two tablets daily, and my restless legs improved significantly, allowing me to sleep peacefully. I am extremely grateful for this product—it’s the only thing that has worked!
Diabetes
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
Vitamin B12 improves eye movements
The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study.
Most Relevant Research
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
9.5
Cured neuropathy pain
Most Useful Review
My friend, a type II diabetic, suffered severe neuropathy due to a B-12 deficiency caused by statin and metformin use. After ceasing these medications and starting B-12 shots, his neuropathy improved, but it wasn't until he switched to Methyl B-12 and added Serrapeptase that he achieved permanent relief. He is now focusing on overcoming type II diabetes, which was induced by metabolic syndrome, with promising progress.
Arthritis
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.6
USERS' SCORE
Good
Based on 1 Review
8.6
9
Vitamin B12 may improve arthritis
Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice.
Most Relevant Research
We investigated the effects of vitamin B12 on rheumatoid arthritis, particularly focusing on its impact on peptidylarginine deiminase isoform 4 (PADI-4), an enzyme linked to the disease's progression. Our study revealed that vitamin B12 effectively inhibited this enzyme more than another related enzyme, PADI-2, highlighting its potential as a therapeutic agent.
We observed that vitamin B12 treatment led to lower overall levels of citrullination, which is important since unregulated citrullination is a common issue in rheumatoid arthritis. Additionally, when hydroxocobalamin, a form of vitamin B12, was administered to mice, it significantly reduced the severity of arthritis symptoms in those with collagen type II antibody induced arthritis (CAIA).
Importantly, we found that vitamin B12 also decreased the expression of various pro-inflammatory factors and cytokines often elevated in rheumatoid arthritis, including IL17A, TNFα, and IL-6. These findings suggest that vitamin B12 may have a beneficial role in managing rheumatoid arthritis, warranting further exploration of its therapeutic potential.
We observed that vitamin B12 treatment led to lower overall levels of citrullination, which is important since unregulated citrullination is a common issue in rheumatoid arthritis. Additionally, when hydroxocobalamin, a form of vitamin B12, was administered to mice, it significantly reduced the severity of arthritis symptoms in those with collagen type II antibody induced arthritis (CAIA).
Importantly, we found that vitamin B12 also decreased the expression of various pro-inflammatory factors and cytokines often elevated in rheumatoid arthritis, including IL17A, TNFα, and IL-6. These findings suggest that vitamin B12 may have a beneficial role in managing rheumatoid arthritis, warranting further exploration of its therapeutic potential.
9.5
Pain relief
Most Useful Review
I have suffered from rheumatoid arthritis for over ten years. After discovering that avoiding gluten significantly reduces my pain, I researched further and found a link between peripheral neuropathy, B12 deficiency, and arthritis. I started taking Jarrow methyl B12 from iHerb, and within days, my excruciating pain subsided, allowing me to walk almost pain-free. I've also identified intolerances to other foods, such as tomatoes and strawberries.
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Health improvement
Most Useful Review
This excellent product helps me stay healthy and fend off the common cold and illnesses. The price is fantastic, and even with delivery to Australia, they are cheaper than what we find here. Thank you so much for your service, providing such wonderful products at great prices.
Dizziness
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin B12 improves dizziness symptoms
Acute presentation of dizziness in vitamin B12 deficient old patient of cardiac disease: a case report.
Most Relevant Research
We observed a fascinating case involving an elderly patient who experienced acute dizziness, ataxia, and imbalance shortly after receiving a pacemaker. Upon investigation, we discovered that her symptoms were linked to a significant deficiency in vitamin B12.
The patient's vitamin B12 levels were notably low, accompanied by increased plasma homocysteine and methylmalonic acid levels. Despite her neurological symptoms suggesting peripheral neuropathy, her brain scan returned normal results. What stood out to us was the absence of the typical hematological signs often associated with vitamin B12 deficiency.
Importantly, the patient responded remarkably well to treatment with parenteral vitamin B12, leading to a resolution of her dizziness. This case underscores the importance of considering vitamin B12 deficiency, especially in elderly patients who present with neuropsychiatric symptoms. As we reflected on this, it became clear that proper recognition and treatment of vitamin B12 deficiency can significantly influence patient outcomes.
The patient's vitamin B12 levels were notably low, accompanied by increased plasma homocysteine and methylmalonic acid levels. Despite her neurological symptoms suggesting peripheral neuropathy, her brain scan returned normal results. What stood out to us was the absence of the typical hematological signs often associated with vitamin B12 deficiency.
Importantly, the patient responded remarkably well to treatment with parenteral vitamin B12, leading to a resolution of her dizziness. This case underscores the importance of considering vitamin B12 deficiency, especially in elderly patients who present with neuropsychiatric symptoms. As we reflected on this, it became clear that proper recognition and treatment of vitamin B12 deficiency can significantly influence patient outcomes.
8.8
Dizziness reduced
Most Useful Review
I've used this to treat my B12 deficiency, which caused dizziness and body sway. After taking it daily for three months, I've noticed a significant turnaround in my balance, which had affected me for years. I also take Migrelief for migraines and have been in physical therapy. Skipping this supplement revealed a return of my symptoms, confirming its effectiveness. My memory and focus have improved as well. I'm happy to report no allergic reactions experienced, despite my many allergies. My doctor has said I can reduce intake now, which indicates its positive impact!
Fibromyalgia
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin B12 aids fibromyalgia symptoms
Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study.
Most Relevant Research
We aimed to investigate how vitamin B12 can affect the symptoms and overall well-being of fibromyalgia patients. In our study, we worked with individuals diagnosed with fibromyalgia based on established criteria. Participants were given a daily dose of 1000 mcg of oral vitamin B12 to take for fifty days.
Before and after the treatment period, we assessed the patients' conditions using various questionnaires designed to measure pain severity, anxiety, and overall health. Our findings revealed that this short course of vitamin B12 significantly reduced the severity of fibromyalgia symptoms and improved anxiety levels.
Such results suggest that vitamin B12 could play an important role as an adjunctive therapy for managing fibromyalgia. We believe there is potential for further research in this area to enhance treatment options for individuals living with this condition.
Before and after the treatment period, we assessed the patients' conditions using various questionnaires designed to measure pain severity, anxiety, and overall health. Our findings revealed that this short course of vitamin B12 significantly reduced the severity of fibromyalgia symptoms and improved anxiety levels.
Such results suggest that vitamin B12 could play an important role as an adjunctive therapy for managing fibromyalgia. We believe there is potential for further research in this area to enhance treatment options for individuals living with this condition.
9.5
Vital supplement
Most Useful Review
Excellent product. It’s an essential supplement for managing my Chronic Fatigue and fibromyalgia. I can't live without it.
Ulcer
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.7
USERS' SCORE
Good
Based on 1 Review
8.6
9
Genetic insights into ulcer healing
Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations.
Most Relevant Research
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
9.5
Effective treatment
Most Useful Review
Very helpful for ulcers; after I used it, the ulcers improved significantly.
Autism
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 1 Review
8.6
4
Examining Vitamin B12 in Autism
Serum B12, homocysteine, and anti-parietal cell antibody levels in children with autism.
Most Relevant Research
We conducted a study that examined the levels of vitamin B12, homocysteine, and anti-parietal cell antibodies in children diagnosed with autism spectrum disorder (ASD) compared to a control group. Our research included 69 children, where 36 had ASD, and 33 were matched controls based on age, sex, and socioeconomic status. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS), while serum levels were measured using a common laboratory technique called enzyme-linked immunosorbent assay.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
9.5
Enhanced speech clarity
Most Useful Review
AUTISM aide!!!. This is fantastic. It beats getting injections for my son who has autism. The sublingual form takes a while to dissolve which he prefers. After two weeks, I've noticed a slight improvement in his speech clarity and fewer moments of “spacing out”. AUTISM is not a dead-end diagnosis! Knowledge is key for parents. I encourage biomedical treatments as many therapies can be self-administered. I believe in exploring different avenues for healing.
Cold
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.6
8
Vitamin B12 shows cold pain relief
The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats.
Most Relevant Research
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
9.5
Vanquished depression
Most Useful Review
This has significantly improved my mood. I had symptoms indicating low histamine, including fatigue and a lack of energy. After taking Vitamin B12, I now feel happy and energetic, as if a switch flipped. If you are low histamine like me, this could positively change your life.
Colitis
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 1 Review
8.6
9
Vitamin B12 aids colitis treatment
Vitamin B12 ameliorates gut epithelial injury via modulating the HIF-1 pathway and gut microbiota.
Most Relevant Research
We constructed a Drosophila model that simulates the recurrent intestinal injuries seen in inflammatory bowel diseases (IBDs) to explore the potential benefits of vitamin B12 (VB12) in treating colitis. Our findings showed that VB12 can effectively protect the intestinal barrier and reduce damage caused by factors like dextran sulfate sodium.
Additionally, we observed that VB12 helps restore balance in gut microbiota, reducing the growth of harmful gram-negative bacteria. This improvement in gut health appears to be linked to the activation of the hypoxia-inducible factor-1 (HIF-1) signaling pathway, which VB12 seems to influence during injury.
To further validate our results, we also tested VB12's protective effects in a murine acute colitis model, showing consistent beneficial impacts. Overall, we provide new insights on how vitamin B12 could play a supportive role in managing flare-ups of recurrent IBDs, particularly colitis.
Additionally, we observed that VB12 helps restore balance in gut microbiota, reducing the growth of harmful gram-negative bacteria. This improvement in gut health appears to be linked to the activation of the hypoxia-inducible factor-1 (HIF-1) signaling pathway, which VB12 seems to influence during injury.
To further validate our results, we also tested VB12's protective effects in a murine acute colitis model, showing consistent beneficial impacts. Overall, we provide new insights on how vitamin B12 could play a supportive role in managing flare-ups of recurrent IBDs, particularly colitis.
10
B12 levels normalised
Most Useful Review
It works – I have the numbers to prove it. I have ulcerative colitis, which prevents me from absorbing B12 properly. Last year my B12 was very low (136) and I received injections to bring it up to 1100. I didn't realise I needed to keep taking B12 and stopped, resulting in a level of 214 after nine months. Wanting to avoid injections again, I asked my doctor about oral supplements. He was sceptical but I decided to try these pills daily for three months. When tested again, my level was at 1350! I couldn’t believe it and intend to take these permanently. The injection therapy cost around $800, so I'm thrilled these work!
Diarrhea
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Vitamin B12 aids chronic diarrhea
CHRONIC DIARRHOEA: NOT A RARE PRESENTATION OF VITAMIN B 12 DEFICIENCY.
Most Relevant Research
We aimed to explore how vitamin B12 supplementation affects individuals suffering from chronic diarrhea. In our quasi-experimental study conducted at Pakistan Ordinance Factory Hospital, we focused on new patients aged between 12 and 65 years who exhibited low serum vitamin B12 levels and normal folate levels.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
9.5
Improved stomach issues
Most Useful Review
Works for me! I've been on several "prescription" grade B vitamin supplements because of specific health issues. The only thing that has made a difference is taking this product. After just three days, I noticed significant improvements in my sleep and gluten sensitivity. I'm even able to eat pizza without experiencing diarrhoea, which is a small miracle!
Hot Flashes
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Reduced hot flashes
Most Useful Review
Helped with my hot flashes! I've been taking this product for over a year now, and I’ve had great results! My energy levels feel stable, and my peri-menopausal symptoms have greatly reduced. Initially, I suffered from frequent hot flashes, especially at night, but after about two weeks, they significantly decreased in frequency and severity. When I skipped my vitamins for a couple of months, the hot flashes returned, particularly at night. After restarting my vitamins, they subsided within a few days again! I highly recommend these!
Psoriasis
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Vitamin B shows promise for psoriasis
Superiority of a vitamin B-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis.
Most Relevant Research
We conducted a study to examine the effectiveness of a vitamin B-containing ointment in treating mild-to-moderate plaque psoriasis compared to a standard glycerol-petrolatum-based emollient cream. The trial was designed thoughtfully, with 24 patients participating in a randomized, controlled, single-blind format. Each patient received the vitamin B ointment on one side of their body and the standard cream on the other side.
Over the duration of 12 weeks, we periodically measured the severity of psoriasis using the Psoriasis Area Severity Index (PASI). Our findings revealed that the vitamin B ointment significantly reduced the severity of psoriasis compared to the control cream at various times, particularly showing an impressive average reduction of 87.6% from baseline after 12 weeks.
This evidence suggests that vitamin B ointment not only offers a new treatment avenue for psoriasis but also should be considered in future treatment guidelines. We believe our research underscores the potential benefits of a vitamin B therapy approach in managing this chronic skin condition effectively.
Over the duration of 12 weeks, we periodically measured the severity of psoriasis using the Psoriasis Area Severity Index (PASI). Our findings revealed that the vitamin B ointment significantly reduced the severity of psoriasis compared to the control cream at various times, particularly showing an impressive average reduction of 87.6% from baseline after 12 weeks.
This evidence suggests that vitamin B ointment not only offers a new treatment avenue for psoriasis but also should be considered in future treatment guidelines. We believe our research underscores the potential benefits of a vitamin B therapy approach in managing this chronic skin condition effectively.
9.5
Improved psoriasis
Most Useful Review
This is the only type of B-12 I can take due to an MTHFR gene. Since using it, my psoriasis has begun to improve, and my antioxidant levels are finally normal. I had issues absorbing B12 and B6 before, leading to tremors, which have now resolved after two months of use.
Shingles
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 1 Review
8.6
8
Vitamin B12 aids shingles pain relief
Vitamin B12 for herpetic neuralgia: A meta-analysis of randomised controlled trials.
Most Relevant Research
We conducted a review of randomized controlled trials to determine the effectiveness of vitamin B12 in treating postherpetic neuralgia (PHN), a painful condition following shingles. Our analysis included data from databases such as PubMed and Cochrane Library, focusing specifically on trials that measured pain relief outcomes.
Our findings indicate that vitamin B12 supplementation has a significant positive effect on reducing pain levels in PHN patients. In fact, those who received vitamin B12 experienced a notable decrease in pain compared to those on placebo, with a reduction in the pain score of about four points. This result suggests that vitamin B12 not only helps with pain relief but also enhances overall quality of life for individuals suffering from this distressing condition.
Additionally, we observed a drop in the number of patients relying on analgesics, pointing to a potential alternative treatment avenue with vitamin B12. Although the evidence is moderate in quality, it presents a compelling case for the use of vitamin B12 as a complementary therapy for managing pain associated with shingles.
Our findings indicate that vitamin B12 supplementation has a significant positive effect on reducing pain levels in PHN patients. In fact, those who received vitamin B12 experienced a notable decrease in pain compared to those on placebo, with a reduction in the pain score of about four points. This result suggests that vitamin B12 not only helps with pain relief but also enhances overall quality of life for individuals suffering from this distressing condition.
Additionally, we observed a drop in the number of patients relying on analgesics, pointing to a potential alternative treatment avenue with vitamin B12. Although the evidence is moderate in quality, it presents a compelling case for the use of vitamin B12 as a complementary therapy for managing pain associated with shingles.
9.5
Minimal pain relief
Most Useful Review
I find this product invaluable. After having shingles twice, the last time caused severe nerve damage on my right rib area. Until I started this product, the pain was sharp and shocking. Now, after finishing one bottle and beginning my second, I have minimal pain and each day improves. It's a godsend and the taste is lovely!
Athlete’s Foot
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.3
Neuropathy relief
Most Useful Review
I ordered this to assist with neuropathy in my feet caused by chemotherapy. It has truly helped, and I plan to continue purchasing and using it.
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.5
7.5
Alleviates bone pain
Most Useful Review
I have consistently used this product. My legs hurt, making it hard to walk. However, since I started taking one tablet each morning and evening, my bone pain has eased significantly. I hope to continue using it for a long time, though a lower price would be great.
Breast Cancer
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.1
USERS' SCORE
Good
Based on 1 Review
8.5
7
Vitamin B12 may reduce breast cancer
Folic acid supplement use and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a case-control study.
Most Relevant Research
We explored the impact of vitamin B12 supplement use on breast cancer risk among women with BRCA mutations. In a case-control study involving 129 breast cancer patients and 271 healthy controls, we evaluated the relationship between dietary supplements, including folic acid and vitamin B12, and breast cancer incidence.
Our findings revealed that women who took vitamin B12 supplements showed a significant decrease in breast cancer risk when compared to those who did not use these supplements. Specifically, moderate B12 intake was linked to a 52% reduction in risk.
Importantly, this association was most pronounced in women carrying the BRCA1 mutation. These results suggest that vitamin B12, in conjunction with folic acid supplements, may contribute to a lower risk of developing breast cancer among those genetically predisposed to the disease.
However, we recommend further studies to confirm these findings, as more extensive research with larger participant groups would help solidify our understanding of vitamin B12's benefits in this context.
Our findings revealed that women who took vitamin B12 supplements showed a significant decrease in breast cancer risk when compared to those who did not use these supplements. Specifically, moderate B12 intake was linked to a 52% reduction in risk.
Importantly, this association was most pronounced in women carrying the BRCA1 mutation. These results suggest that vitamin B12, in conjunction with folic acid supplements, may contribute to a lower risk of developing breast cancer among those genetically predisposed to the disease.
However, we recommend further studies to confirm these findings, as more extensive research with larger participant groups would help solidify our understanding of vitamin B12's benefits in this context.
8
Vitamin B12 support
Most Useful Review
Recommended by my nutritionist to manage low vitamin B12 levels due to breast cancer, and also for my daughter who had bariatric surgery.
Cancer
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 1 Review
8.5
7
Vitamin B12 and lymphoma association
Circulating levels of vitamins and risk of lymphoma: insights from a two-sample Mendelian randomization.
Most Relevant Research
We aimed to understand how levels of vitamin B12 might influence the risk of developing lymphoma, a type of cancer that affects the lymphatic system. Using data from comprehensive genome-wide association studies, we assessed the potential genetic links between circulating vitamin levels and lymphoma.
Our analysis particularly focused on vitamin B12 along with other vitamins, utilizing robust methods to ensure reliable results. We discovered that higher levels of vitamin B12 showed a noticeable association with a lower risk of lymphoma, indicating that it might play a beneficial role in cancer prevention. Interestingly, we also found similar results for folic acid, suggesting that these vitamins could have important implications for lymphoma risk overall.
However, it's essential to note that while our findings are promising, the evidence isn't definitive. Further research is needed to explore these relationships in greater depth and to understand the mechanisms behind them. Understanding how vitamins like B12 affect cancer could lead to better preventive strategies in the future.
Our analysis particularly focused on vitamin B12 along with other vitamins, utilizing robust methods to ensure reliable results. We discovered that higher levels of vitamin B12 showed a noticeable association with a lower risk of lymphoma, indicating that it might play a beneficial role in cancer prevention. Interestingly, we also found similar results for folic acid, suggesting that these vitamins could have important implications for lymphoma risk overall.
However, it's essential to note that while our findings are promising, the evidence isn't definitive. Further research is needed to explore these relationships in greater depth and to understand the mechanisms behind them. Understanding how vitamins like B12 affect cancer could lead to better preventive strategies in the future.
8
Controls vitamin B12
Most Useful Review
Recommended by my nutritionist to manage low vitamin B12 levels due to cancer and also for my daughter following her bariatric surgery.
Heart Attack
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
3
USERS' SCORE
Good
Based on 2 Reviews
8.5
4
Vitamin B12 shows no heart attack benefit
Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial.
Most Relevant Research
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
8.8
Prevents heart attack
Most Useful Review
This high-quality supplement has a beneficial composition. The cherry flavour is pleasant, and it aids in improving red blood cell production and reducing homocysteine levels, which are linked to conditions like heart attack. Vitamin B12 is crucial as it eliminates pain and helps prevent pernicious anaemia, heart attack, stroke, and nervous diseases. I find the ingredients to be excellent.
Heart Disease
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 1 Review
8.5
9
Vitamin B12 helps heart recovery
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Most Relevant Research
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
8.8
Supports heart health
Most Useful Review
High-quality supplement with a good composition. The cherry flavour is pleasant. I find that it improves haematopoiesis and increases my red blood cell count. Vitamin B12 is crucial; it aids in converting homocysteine to methionine for DNA production and helps prevent heart disease. It also alleviates pain and reduces the risk of pernicious anaemia, heart attack, and stroke. Overall, it supports my treatment for various conditions, including heart disease, and I appreciate the quality of the ingredients.
Sciatica
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.5
9
Vitamin B12 helps alleviate sciatica
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Most Relevant Research
We conducted a double-blind, randomized, placebo-controlled study to explore the effectiveness of intramuscular vitamin B12 in treating low back pain, including cases of sciatica. A total of 60 patients between the ages of 18 and 65, all suffering from mechanical lumbago or sciatic neuritis, participated in the study over a period of time. Each patient had a solid medical history of back pain lasting from 6 months to 5 years, with significant pain intensity measured on a scale.
Throughout the study, both groups showed notable reductions in pain and disability. However, when we compared the active treatment with the placebo, the results favored vitamin B12 significantly; the differences were strikingly marked in measurement tools used for assessing pain and disability. Furthermore, the placebo group reported higher consumption of paracetamol compared to those receiving vitamin B12, indicating that this vitamin could effectively alleviate pain and the need for additional pain relief medications.
Overall, our findings support the potential of vitamin B12 injections in managing low back pain and sciatica for those without signs of nutritional deficiency.
Throughout the study, both groups showed notable reductions in pain and disability. However, when we compared the active treatment with the placebo, the results favored vitamin B12 significantly; the differences were strikingly marked in measurement tools used for assessing pain and disability. Furthermore, the placebo group reported higher consumption of paracetamol compared to those receiving vitamin B12, indicating that this vitamin could effectively alleviate pain and the need for additional pain relief medications.
Overall, our findings support the potential of vitamin B12 injections in managing low back pain and sciatica for those without signs of nutritional deficiency.
8.8
Helps with sciatica
Most Useful Review
I truly enjoy this brand of methylcobalamin. The taste is delightful, making it a hit with the kids. I experience twitchy toes due to my nerves, and this product significantly alleviates that discomfort. I also believe it aids with my sciatica.
Sinusitis
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Eases sinusitis symptoms
Most Useful Review
This product effectively alleviates my chronic rhinitis and sinusitis symptoms. I occasionally take one lozenge as needed, which also gives a subtle boost of clean energy. I've tried other brands but find this one the tastiest and reasonably priced for its high dose.
Stroke
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.5
9
Vitamin B12 alleviates stroke effects
Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice.
Most Relevant Research
We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
8.8
Reduced homocysteine levels
Most Useful Review
I found it great for lowering levels of an amino acid called homocysteine, which has been associated with chronic issues like heart disease, stroke, and Alzheimer's.
Migraine
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.7
USERS' SCORE
Good
Based on 1 Review
8.5
7
Vitamin B12 deficiency and migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Most Relevant Research
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
8.8
Migraine management aided
Most Useful Review
I take one of these daily after discovering my B12 deficiency caused dizziness and body sway. Alongside taking Migrelief for vestibular migraines, I have experienced significant improvements after years of balance issues. I stopped taking the B12 supplement to see if it made a difference, and my symptoms returned. Now, I take this regularly. While I'm not sure about increased energy, I noticed an improvement in memory and focus. Thankfully, I haven’t had any allergic reactions, even though I have many allergies.
Vertigo
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
9
Vitamin B12 enhances acupuncture effects
[Observation of therapeutic effects on cervical vertigo treated with different methods].
Most Relevant Research
We explored the effectiveness of various treatments for cervical vertigo, specifically focusing on different acupuncture methods and the inclusion of Vitamin B12 in one of the therapy combinations. In our study, ninety-one participants were divided into three groups: one receiving routine acupuncture, another using electroacupuncture, and a third receiving a combination of electroacupuncture and Vitamin B12 injections along with local anesthetics.
Each therapy was administered over twenty sessions within a month. We measured changes in blood flow in the vertebral and basilar arteries and evaluated the participants' symptoms and overall function related to their vertigo. While all treatment methods showed some positive effects, the combination therapy, which included Vitamin B12, stood out as being the most effective.
This suggests that Vitamin B12 might play a significant role alongside acupuncture methods in treating cervical vertigo. However, it’s important to note that the specific impact of Vitamin B12 alone wasn’t isolated in this study, leaving us to consider its effects within the broader context of combined therapies.
Each therapy was administered over twenty sessions within a month. We measured changes in blood flow in the vertebral and basilar arteries and evaluated the participants' symptoms and overall function related to their vertigo. While all treatment methods showed some positive effects, the combination therapy, which included Vitamin B12, stood out as being the most effective.
This suggests that Vitamin B12 might play a significant role alongside acupuncture methods in treating cervical vertigo. However, it’s important to note that the specific impact of Vitamin B12 alone wasn’t isolated in this study, leaving us to consider its effects within the broader context of combined therapies.
9
Significantly improved balance
Most Useful Review
I have been taking these daily for 3 months due to a B12 deficiency causing dizziness, vertigo spells, and body sway. With additional treatments, I’ve seen a considerable turnaround in my balance issues. My memory and focus have improved, and I’ve been allergy-free while taking them. My B12 levels have drastically improved to the point where I can reduce my intake.
Alzheimer
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6
USERS' SCORE
Good
Based on 4 Reviews
8.4
4
Vitamin B12's limited effect on Alzheimer's
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials.
Most Relevant Research
We explored the potential role of vitamin B12, alongside folic acid, in slowing the progression of Alzheimer's disease (AD) through a meta-analysis of randomized control trials. Our aim was to determine whether these supplements might improve cognitive function, daily life activities, and influence blood homocysteine levels in individuals diagnosed with AD.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
7.8
Quality recommendation
Most Useful Review
This is a very high-quality product. I recommend it for my patients who exhibit mild Alzheimer’s and neurological issues.
Tinnitus
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.3
8.8
Effective treatment
Most Useful Review
I take vitamin B12 for tinnitus. It is effective as it is hard to supplement through food.
Allergies
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 4 Reviews
8.2
7
Vitamin B12 hypersensitivity studied
Vitamin B Hypersensitivity: A Retrospective Multicenter Study.
Most Relevant Research
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
9.5
Effective ingredient choices
Most Useful Review
This is an excellent quality product. The carefully selected ingredients did not cause any allergies or negative reactions. The large package size lasts long, with average-sized capsules that have a neutral taste. I noticed improvements within a week; my intestinal function and metabolism have enhanced while my nervous system feels more stable. I have no doubts about its effectiveness in treating allergies.
Acne
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
USERS' SCORE
Good
Based on 2 Reviews
8.2
9.5
Vitamin B12 causes acne-like eruptions
Acneiform eruptions caused by vitamin B12: A report of five cases and review of the literature.
Most Relevant Research
We observed five notable cases of acneiform eruptions linked to vitamin B12 in women aged 21 to 62. These eruptions manifested between one week and five months after starting vitamin B12 therapy.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
6.5
Acne cleared significantly
Most Useful Review
I was experiencing severe acne on my face and back due to excessive B12 supplementation. After realising my mistake in dosage, I stopped taking it, and within a week, my acne has cleared by 80%. While the product itself is fine occasionally, it's crucial to avoid over-supplementation to prevent acne flare-ups.
Ear Infection
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.1
5.8
Energy support
Most Useful Review
Excellent for cellular energy and aiding in the formation of red blood cells. I bought this for my nerve and tinnitus issues from a while back. A mate suggested this supplement would assist with my tinnitus. After a month, I feel better; the ringing has reduced somewhat, but tinnitus still persists. I will carry on with the supplements.
Sleep Apnea
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 1 Review
7.9
2.3
Unsure effect
Most Useful Review
I mentioned it was good for sleep disorder, but it hasn't worked yet. The delivery was faster than expected, taking 2-3 days. I'm uncertain of its effects at this point, as I have been using it for about half a week now. I plan to continue for three months.
Headache
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.2
8
Vitamin B12 deficiency linked to migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Most Relevant Research
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
7.5
Positive effect
Most Useful Review
So far, so good. My husband and I are using these every 3 to 4 days and we both like them. They do take a while to dissolve, but overall, we’ve felt well, and I believe they have been helping my husband with his headaches. All in all, we like this product.
