'
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Magnesium (elemental) (from Magnesium Oxide, Magnesium Citrate and Magnesium Aspartate)
400 mg
95%

The product is found useful for the following medical conditions

Knee Pain

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 20 Reviews
9
9.5
Pain relief
Most Useful Review
It didn't run out of magnesium, and it helped alleviate my knee pain significantly. I appreciated that one capsule meets my daily needs. Excellent brand. Thank you, iHerb, for the fast delivery to Rio de Janeiro; it arrived in just 10 days.

Back Pain

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Good
Based on 42 Reviews
8.9
9.5
Magnesium reduces postoperative back pain
Effect of perioperative intravenous magnesium sulfate on postoperative pain after iliac venous stenting.
Most Relevant Research
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.

Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.

Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
9.5
Pain relief noted
Most Useful Review
The effect is noticeable from the very first capsule! I have a neurological disability and take magnesium regularly. This magnesium is excellent for alleviating spasticity, promoting sleep, and is perfect for irritable bowel syndrome as it quickly eases abdominal pain. I am very pleased with the purchase and will order more.

Headache

SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Good
Based on 42 Reviews
8.9
9
Magnesium aids migraine management
Magnesium and Migraine.
Most Relevant Research
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.

A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.

This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
9.5
Fewer headaches
Most Useful Review
I used to suffer from frequent headaches several times a week. After taking this supplement for two months, they have significantly decreased. I will purchase more!

Insomnia

SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.4
USERS' SCORE
Good
Based on 60 Reviews
8.9
9
Magnesium improves elderly insomnia
The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
Most Relevant Research
We conducted a double-blind, placebo-controlled clinical trial to investigate the effects of magnesium supplementation on insomnia in elderly individuals. Our study involved 46 participants who were assigned either to receive 500 mg of magnesium daily or a placebo for a duration of 8 weeks.

Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.

The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.

Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.
8.8
Reduced insomnia symptoms
Most Useful Review
This magnesium is excellent for its price. As a doctor, I recommend it for insomnia and sweet cravings. I noticed improvements in sleep and reduced anxiety after just one dose. My sweet cravings vanished within a week. The capsules are large yet easy to swallow. Given today’s pace of life, magnesium is essential. I will definitely order more for my family.

Anxiety

SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.9
USERS' SCORE
Good
Based on 57 Reviews
8.8
8
Magnesium treats anxiety in MS
Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
Most Relevant Research
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.

We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.

Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.

In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
9.5
Reduced anxiety
Most Useful Review
Taking magnesium improved my overall health and significantly reduced my muscle cramps and eyelid twitches. I no longer suffer from anxiety, and my general well-being has enhanced. If you find this review helpful, please like it!

Leg Cramps

SCIENTIFIC SCORE
Likely Ineffective
Based on 16 Researches
4.7
USERS' SCORE
Good
Based on 4 Reviews
8.8
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Most Relevant Research
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.

Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.

The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
9.5
Relieves restless legs
Most Useful Review
These magnesium capsules really do the trick! I’ve endured restless legs and leg cramps for years, and since starting magnesium, I've noticed a remarkable difference. I certainly feel it if I forget to take my magnesium at night. I appreciate that they don’t contain calcium, as I’ve learned that these supplements should be taken separately.

Athlete’s Foot

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Pain relief noted
Most Useful Review
I cannot live without this magnesium, and several family members use it too. I had pain in my left foot that made stepping difficult, especially at night. After researching, I realised it was inflammation of the tissue covering the bone. I started taking Magnesium Dimalate and within a week, the pain vanished. My friend had the same issue and found relief as well. It is very helpful for muscle pain, athlete’s foot, fibromyalgia, and tendonitis.

Depression

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 17 Reviews
8.7
9.5
Reduced anxiety
Most Useful Review
Every woman should consider magnesium, as deficiency can lead to heart issues and affect mental health, causing anxiety and depression. After taking one capsule daily, my leg cramps vanished, I became calmer, and my insomnia improved significantly. I find it a bargain for six months' supply.

Hypothyroidism

SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.7
USERS' SCORE
Good
Based on 7 Reviews
8.7
4
Magnesium shows promise in thyroid recovery
Proof of concept of the WOMED model of benign thyroid disease: Restitution of thyroid morphology after correction of physical and psychological stressors and magnesium supplementation.
Most Relevant Research
We set out to investigate how magnesium, along with selenium and coenzyme Q10, could influence hypothyroidism in patients with benign thyroid diseases. Our approach included a small group of eight patients—five with hyperthyroidism and three with hypothyroidism—who received additional treatment aimed at addressing both their thyroid condition and related physical and psychological stresses.

Over a period of 2 to 4 years, we observed some significant changes. Initially, we focused on correcting musculoskeletal issues, followed by addressing stress. As a result, we noted that thyroid morphology normalized in many cases, which was confirmed through ultrasound examinations. Interestingly, we also saw a reduction in thyroid antibody levels for most patients.

However, we must be transparent about our findings. While magnesium and the other supplements showed promise, there were two cases of chronic thyroiditis that did not respond positively to treatment, possibly due to long-standing fibrosis. This indicates that while magnesium may play a role in thyroid health, its effectiveness can vary significantly based on individual circumstances and the duration of the thyroid condition.
9.5
Improved thyroid function
Most Useful Review
I suffer from hypothyroidism and know magnesium is vital for thyroid function, converting inactive T4 to active T3. I take one capsule of magnesium glycinate nightly and have noticed my leg cramps are gone. It's important to ensure adequate intake, particularly for those with hypothyroidism, and I'm grateful for its benefits when combined with other vitamins.

Cardiovascular Disease

SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
USERS' SCORE
Good
Based on 25 Reviews
8.6
8
Magnesium's impact on heart health
The Role of Dietary Magnesium in Cardiovascular Disease.
Most Relevant Research
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.

Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.

Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
9.5
Effective for insomnia
Most Useful Review
Recommended for maintaining good health! I've heard that a lack of magnesium can increase the risk of insomnia and cardiovascular disease. Since I started taking it an hour before bed, I now fall asleep more quickly. It's been three weeks, and it helps my insomnia significantly. The supplement is large, so be cautious if you struggle to swallow. Magnesium is vital for health support, and I intend to continue taking it.

Chronic Cough

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Cough alleviated
Most Useful Review
Magnesium was essential for my recovery after COVID-19. I took one capsule daily for three months, alongside 15 mg of zinc. After a month, my health returned to normal, laboratory results improved, and the chronic cough that had been troubling me ceased.

Irritable Bowel Syndrome

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 62 Reviews
8.6
8
Magnesium boosts colonic activity
Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome.
Most Relevant Research
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.

Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.

Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
9.5
Effective soothing relief
Most Useful Review
The effect is noticeable from the very first capsule! I have a neurological disability and regularly take magnesium supplements. This magnesium is very good; it quickly relaxes my spasticity and helps me sleep better if taken in the evening. It also soothes my irritable bowel syndrome, with abdominal pains easing quickly. I'm very pleased with my purchase and shared it with my mum. I'll definitely order more.

Kidney Stones

SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Magnesium reduces kidney stone risk
Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.

After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.

Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
9.5
Kidney health improvement
Most Useful Review
I spent a long time searching for the right magnesium for my kidney health and found it with this product. I've tried various types over the years, and after learning of my weak kidney, I discovered magnesium oxide online. This supplement from NOW contains 400 mg of magnesium oxide, citrate, and aspartate, and I'm now very satisfied.

Vertigo

SCIENTIFIC SCORE
Likely Very Effective
Based on 3 Researches
9.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Effective magnesium treatment for vertigo
Successful treatment of a child with definite Meniere's disease with the migraine regimen.
Most Relevant Research
We explored the relationship between magnesium treatment and vertigo in a remarkable case involving a 5-year-old girl with Meniere's disease (MD). This young patient had been suffering from six months of left-sided hearing loss, followed by troubling daily episodes of vertigo, persistent headaches, and vomiting. She met the established criteria for definite MD, which made her situation particularly concerning for both her and her family.

After initiating a 6-week diet and lifestyle regimen aimed at migraine management, which included magnesium, we observed promising results. The patient reported being symptom-free and showed a significant improvement in her hearing, reaching near-normal levels. This outcome has led us to believe that the vertigo and other symptoms associated with MD may actually be linked to a vestibular migraine phenomenon, suggesting that magnesium and lifestyle changes could play a key role in alleviating these symptoms in pediatric patients.

Our findings suggest that children with MD might benefit from these migraine-oriented lifestyle modifications, highlighting the need for some researchers and caregivers to consider alternative approaches for treating children's vestibular symptoms.
9.5
Reduced eye twitches
Most Useful Review
Magnificent magnesium at a great price! I take it alongside vitamin B6 (100 mg) for a month, then have a break. Remarkably, I noticed my eye twitching ceased by the fifth day! I had suffered for 2-3 months before starting this. The price is much lower than at local pharmacies, and it’s sufficient for the whole family. A vital supplement for the body.

Neuropathy

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 1 Review
8.6
9
Magnesium's potential in neuropathy treatment
Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models.
Most Relevant Research
A recent study explored the connection between magnesium levels and diabetic sensorimotor polyneuropathy. We measured serum magnesium and plasma methylglyoxal levels in recently diagnosed type 2 diabetes patients—some with neuropathy and others without.

Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.

We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.

Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
9.3
Remarkable improvement
Most Useful Review
I've experienced peripheral neuropathy in both feet for over a decade without any specialist identifying the cause. After switching to NOW's 400mg magnesium supplement, I immediately noticed improvements in my neuropathy, particularly in reduced inflammation and enhanced blood flow to my extremities. Although my feet remain somewhat uncomfortable at night, they feel better overall. This progress encourages me, and I aim to discuss these positive results further with my doctors.

Autoimmune Disorder

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 20 Reviews
8.5
9.5
Quick relaxation
Most Useful Review
The effects were noticeable within my first capsule! With a neurological disability, I regularly take magnesium. This particular one works effectively; my spasticity relaxes quickly and aids my sleep, so it’s best taken in the evening. It alleviates my irritable bowel syndrome, and I’m very pleased with my purchase.

Brain Tumor

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.3
Notable recovery
Most Useful Review
I followed my doctor's advice due to my thyroid disease and used Bach’s extracts for my condition, inspired by others' recovery stories. I had a small brain tumour beside my neck, and after using the extract, I felt completely relieved. The doctor recommended Haldi, biotin, and magnesium. Now, I feel more active and have lost one and a half kilograms. I'm looking forward to my next test at the end of the month. Please pray for my recovery, Lord.

Chronic Fatigue Syndrome

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 61 Reviews
8.5
8.3
Reduced muscle tension
Most Useful Review
This supplement effectively alleviates various symptoms of chronic fatigue syndrome, including nervous and muscle tension, cravings, poor sleep, and headaches. I noticed improvements after two years of regular use, transforming me from a tired individual to a more balanced person.

Diabetes

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.3
USERS' SCORE
Good
Based on 11 Reviews
8.5
8
Magnesium deficiency affects diabetes control
Hypomagnesemia in adults with type 2 diabetes mellitus in Riyadh, Saudi Arabia: A cross-sectional study.
Most Relevant Research
We looked into how magnesium levels relate to diabetes, specifically focusing on adults with type 2 diabetes mellitus (T2DM) in Riyadh, Saudi Arabia. Conducted as a cross-sectional study, we analyzed data from 294 individuals, including T2DM patients, prediabetics, and nondiabetic controls. Our goal was to uncover the prevalence of magnesium deficiency and its potential effects on various metabolic factors.

The findings revealed a striking difference in magnesium levels across the groups. T2DM patients exhibited notably lower magnesium than those with prediabetes and nondiabetic controls. This deficiency was linked to worse metabolic outcomes, including higher fasting glucose and glycated hemoglobin (HbA1c) levels, as well as increased insulin resistance.

We noted a strong negative correlation between magnesium levels and both glucose and HbA1c, suggesting that as magnesium levels decrease, diabetes control worsens. Interestingly, our analysis indicated that magnesium levels could effectively predict higher HbA1c values, highlighting the need for regular monitoring of magnesium in diabetes management.

While our study emphasizes the significant impact of magnesium deficiency on the metabolic health of T2DM patients, it also opens the door for further exploration regarding the benefits of magnesium supplementation in diabetes care. Overall, these insights push us to consider the broader implications of maintaining proper magnesium levels for better diabetes management.
9.5
Diabetes balance
Most Useful Review
I found great benefits in balancing my diabetes.

Gout

SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.5
8
Magnesium may protect against bone erosion
Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study.
Most Relevant Research
We examined the relationship between magnesium levels and the occurrence of bone erosion in patients with gouty arthritis. In our analysis, we observed that 769 gout patients were studied, allowing us to classify them into groups based on their serum ionized magnesium levels.

The results were striking: those with lower magnesium levels had a significantly higher rate of bone erosion. Specifically, patients in the lowest magnesium group showed a bone erosion prevalence rate of over 60%, compared to less than 45% in those with higher magnesium levels.

Our findings suggest that maintaining adequate levels of magnesium might offer a protective effect against bone deterioration in gout arthritis. This points to the possibility that magnesium supplementation could be beneficial for preventing or slowing down bone erosion in these patients.
8.8
Reduces gout symptoms
Most Useful Review
Magnesium preparations are essential for nervous system health. They normalise my sleep and lessen irritability. Additionally, magnesium citrate aids in eliminating uric acid salts and alleviating gout symptoms. The packaging is generous and lasts a long time.

High Cholesterol

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
8.8
Lowers blood pressure
Most Useful Review
Reduces high blood pressure, relaxing my heart and muscles.

Migraine

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 39 Reviews
8.5
9
Magnesium reduces migraine symptoms
Magnesium and Migraine.
Most Relevant Research
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.

Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.

We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
9.5
Improved migraines
Most Useful Review
One of my favourite brands, with one minor downside: it may cause looseness of the stool due to citrate. I take magnesium for muscle cramps and headaches, using 10 mg per kg of body weight. I weigh roughly 50 kg, so the dosage works perfectly. Since using this supplement, I’ve had to take fewer capsules than various other brands. Overall, it's effective, especially for ensuring I maintain adequate magnesium levels for my health.

Osteoporosis

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.3
USERS' SCORE
Good
Based on 9 Reviews
8.5
9
Magnesium's role in osteoporosis therapy
Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism.
Most Relevant Research
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.

Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.

In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.

Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
9.5
Helps with osteoporosis
Most Useful Review
Magnesium helps alleviate insomnia, muscle cramps, and anxiety, and it’s essential for calcium absorption, which aids in preventing osteoporosis. I take a pill before bed and found my body adjusted well to it after initial relaxation effects.

Constipation

SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.6
USERS' SCORE
Good
Based on 159 Reviews
8.4
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
Most Relevant Research
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.

Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.

Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
8.8
Effective for constipation
Most Useful Review
I’ve been taking magnesium for a long time and am always pleased with the results. It calms and acts as a mild laxative, making it great for those suffering from constipation. My family and I all take one capsule a day and it keeps us happy!

Blood Clot

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
9.5
Improved digestion
Most Useful Review
My digestion was slow with significant constipation due to age and medication. After taking magnesium for 8 months, I experienced no constipation and improved digestion. An added benefit was that a blood test showed my cholesterol had increased good levels and decreased bad levels, bringing me within acceptable limits.

Heart Attack

SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.7
USERS' SCORE
Good
Based on 28 Reviews
8.3
9
Magnesium implantation improves heart recovery
Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.
Most Relevant Research
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.

Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.

Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
9
Normalised heart rhythm
Most Useful Review
This magnesium is easy to take and the dosage is good. I've observed positive effects, such as reduced seizures in an elderly person and calmer demeanour. It assists in normalising heart rhythm, but I recommend other sedative options for a better effect.

Heart Disease

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 56 Reviews
8.3
8.8
Stabilised heart
Most Useful Review
I consider these capsules essential for managing my atrial fibrillation because I need magnesium. Having taken this complex for two years, I've noticed my heart works more steadily and no longer goes out of rhythm with the slightest excitement. The capsules are small and easy to take, although my wife prefers to empty the powder into her food. The packaging confirms this is acceptable. I highly recommend this product!

Heartburn

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 12 Reviews
8.2
9.5
No heartburn experienced
Most Useful Review
I find this magnesium is fantastic as I experience no heartburn and feel relaxed shortly after taking it at night. It also helps with my menopausal palpitations. Thank you for offering such great value for money!

Common Cold

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.9
9.5
Restless legs improvement
Most Useful Review
I purchased this magnesium for my mother, who suffers from restless legs syndrome, particularly at night. After just three doses, she began to sleep peacefully, which is fantastic! It highlights the importance of maintaining proper magnesium levels in the body.

Sleep Apnea

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 55 Reviews
7.9
7
Magnesium's role in sleep apnea
Association between magnesium deficiency score and sleep quality in adults: A population-based cross-sectional study.
Most Relevant Research
We aimed to uncover the relationship between magnesium levels and sleep quality, particularly focusing on sleep apnea. Our study analyzed data from a large group of adults aged 20 and older, using a well-structured method to assess magnesium levels and the prevalence of sleep issues.

We found a notable connection between lower magnesium levels, measured as the magnesium depletion score (MDS), and the likelihood of experiencing sleep apnea. Specifically, individuals with higher MDS levels were significantly more likely to report sleep apnea, showing over three times the odds compared to those with adequate magnesium levels.

Interestingly, our research did not link magnesium deficiency to other sleep problems like insomnia or restless legs syndrome, suggesting a more complex relationship with sleep apnea alone. Additionally, we noticed that older adults with depressive symptoms showed a tendency toward excessive sleep rather than insufficient sleep.

While our findings highlight the association between magnesium deficiency and sleep apnea, they also point towards the potential of adequate magnesium intake in reducing this risk. This emphasizes the importance of maintaining proper magnesium levels for better sleep quality, especially in those at higher risk for sleep apnea.
7.5
Reduced tension
Most Useful Review
This magnesium offers excellent value for money. I take one capsule at night, and it significantly improves my sleep while reducing nervous tension. The capsules are large but easy to swallow.

Liver Disease

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.6
9.5
Migraine relief
Most Useful Review
I regularly purchase magnesium supplements, as many people are deficient, especially those under stress or with demanding lifestyles. After struggling with chronic migraines and using harsh medications that burdened my liver, I took 400 mg of magnesium with Vit D before bed. My migraines vanished, and my blood pressure normalised. A follow-up blood test revealed my magnesium levels were at the lower limit of normal. I highly recommend this product.

Chest Pain

SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.1
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.1
8
Magnesium supplementation aids chest pain
The prevalence of hypomagnesaemia in pediatric patients with mitral valve prolapse syndrome and the effect of mg therapy.
Most Relevant Research
We explored the effects of magnesium treatment on chest pain in pediatric patients suffering from mitral valve prolapse syndrome. In our study involving 230 young participants, we defined hypomagnesaemia as having a serum magnesium level below 1.5 mg/dl.

After identifying 19 patients with insufficient magnesium levels—representing about 8.2% of the group—we treated them with an oral magnesium chloride supplement for five weeks. We were eager to see whether this would help alleviate symptoms, particularly chest pain.

After the treatment period, we observed that magnesium therapy provided statistically significant relief of chest pain for these patients. However, we did not find substantial improvements in other symptoms like palpitations, fatigue, and dyspnea. This finding is vital, as it indicates that while magnesium may play a role in easing chest pain, its overall benefit to other symptoms remains uncertain.

Overall, our study highlights the relatively low prevalence of magnesium deficiency in pediatric patients with mitral valve prolapse compared to adults. Nevertheless, we concluded that magnesium supplementation could be a beneficial approach to address specific symptoms like chest pain in this population.
9.5
Miracle supplement
Most Useful Review
Magnesium supplementation is essential! It supports the nervous, cardiovascular, and cartilage systems. For those with joint pain, it's a miracle supplement. My aunt suffers from osteoarthritis, but since she began taking Magnesium daily, her pain has disappeared. I highly recommend it!

Pelvic Pain

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 16 Reviews
7
9.5
Pelvic pain relief
Most Useful Review
Low back pain has disappeared! My daughter suggested adding magnesium to balance the calcium I was taking, and I am now completely without low back pain. Thank you, iHerb!
image