Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Calcium (as Dibasic Calcium Phosphate)
65 mg
5%
Melatonin
3 mg
*
The product is found useful for the following medical conditions
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
USERS' SCORE
Good
Based on 18 Reviews
8.9
9
Melatonin delivery enhances sleep
Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.
Most Relevant Research
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
10
Life-changing relief
Most Useful Review
It is what it says it is. I suffered from moderate insomnia for nearly a decade due to anxiety. Falling asleep could take hours. Since starting Melatonin, it feels like my miracle pill. Despite my ongoing anxiety, the relief from insomnia has changed my life. I understand results vary, but for me, it truly works!
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Melatonin improves MS-related symptoms
12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial.
Most Relevant Research
We explored the impact of melatonin on patients with multiple sclerosis (MS), aiming to improve heart function and sleep. In a randomized controlled trial, participants received either melatonin or a placebo for 12 weeks.
We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.
This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.
We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.
This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.
9.5
Excellent sleep improvement
Most Useful Review
Excellent product for enhancing sleep. This is not my first purchase of melatonin at a 3 mg dosage, following my doctor's recommendation. I truly appreciate it, as I fall asleep swiftly and enjoy great sleep with no side effects. I definitely recommend it and will order more.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
Melatonin reduces pediatric anxiety, pain
The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
Most Relevant Research
We focused on the effects of oral melatonin on anxiety and pain in children during the stressful process of venipuncture. In a double-blind, randomized controlled trial, we found that administering 0.5 mg/kg of melatonin 30 minutes before the procedure significantly reduced both pain and anxiety levels compared to a placebo.
The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.
While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.
The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.
While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.
9.5
Improved sleep quality
Most Useful Review
Great! I have chronic anxiety and struggle to sleep soundly. After using this supplement, I no longer wake during the night!
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.6
USERS' SCORE
Good
Based on 17 Reviews
8.4
9.5
Melatonin improves sleep apnea outcomes
Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.
Most Relevant Research
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
9.5
Improved sleep quality
Most Useful Review
Long live melatonin! It, along with GABA, has been my foundation for half a year and has made me feel like a new person! Only those who have grappled with sleep issues for years will understand my joy. For nearly twenty years, I struggled to sleep as well as I do now! The price of "Melaxen", which contains melatonin, in our pharmacies is so high that it’s hard to feel relaxed about buying it. Do not enrich our pharmacy hucksters, buy here! I duplicated my review on Melatonin from Now because both work perfectly for me and provide excellent sleep.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.8
9.5
Agomelatine relieves hypnic headaches
Case report: Hypnic headache responds to agomelatine-a potential prophylactic treatment option.
Most Relevant Research
We explored how melatonin-based treatments, particularly agomelatine, can affect headaches, focusing on hypnic headaches (HH). This form of headache typically occurs during sleep, disrupting the rest of those affected. A fascinating case of a 58-year-old woman who experienced these nocturnal headaches for three years demonstrated the potential benefits of agomelatine.
After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.
This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.
After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.
This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.
3.5
Inconsistent effectiveness
Most Useful Review
Works half the time. Doesn't work with caffeine. They are very small pills, so should be easy to swallow. I've taken them on multiple occasions. Half the time, I sleep within 2 minutes and wake up refreshed; the other times, I either awake with a headache or feel sleepy. I discovered that taking this with caffeine doesn't work; after taking a caffeine pill, I struggled to sleep for another 2 hours.
