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Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%
Total Omega-3s♢
690 mg
†
EPA (Eicosapentaenoic Acid)
330 mg
†
DHA (Docosahexaenoic Acid)
220 mg
†
The product is found useful for the following medical conditions
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.6
USERS' SCORE
Good
Based on 7 Reviews
8.9
8
Eicosapentaenoic acid benefits MS
The therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils and its efficacy to attenuate inflammation in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial phase I.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore the effects of PEGlated nanoliposome of pistachio unsaturated oils on inflammation in multiple sclerosis (MS). During the study, we treated MS patients with these nanoliposomes enriched with eicosapentaenoic acid, a type of omega-3 fatty acid known for its potential health benefits.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
9.5
Mood improvement
Most Useful Review
This is my favourite so far. I received two cans and found the price quite reasonable for 120 capsules, lasting two months. I experienced a slight citrus burp instead of the usual fishy aftertaste, which is a plus. My hair and nails improved significantly, and it helped alleviate post-COVID depression. The capsules are large but easy to swallow.
Common Cold
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 10 Reviews
8.8
8
DHA reduces infant cold symptoms
Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial.
Most Relevant Research
We conducted a double-blind randomized controlled trial to understand how prenatal supplementation of docosahexaenoic acid (DHA) might influence infant health, particularly concerning the common cold. Pregnant women were given either a daily dose of 400 mg of DHA or a placebo starting at 18 to 22 weeks of gestation until childbirth.
Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.
While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.
Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.
This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.
Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.
While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.
Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.
This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.
9.5
Cold-free winter
Most Useful Review
I have been taking this product for months and it's the first time I've never had that horrible 'fishy' taste after swallowing the pills. I’ve remained cold and flu free during winter in New Zealand, and my hair, nails, and skin appear fantastic. I highly recommend this product to anyone.
Blood Clot
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.7
9
Eicosapentaenoic acid influences clotting
Emergence of omega-3 fatty acids in biomedical research.
Most Relevant Research
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences blood clotting processes. The interest in EPA grew substantially after the 1970s when researchers Dyerberg and Bang noted that Greenland Eskimos had lower rates of coronary disease linked to their diet rich in marine lipids.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
9.5
Helps lower cholesterol
Most Useful Review
Thanks to Nordic Naturals for such a fantastic product. This fish oil is in Triglyceride Form, which my body quickly accepts. Other brands mostly use the Ethyl Ester form, which takes longer to convert and can waste some of the omega-3 fatty acids. The TG form helps to lower bad cholesterol levels effectively without wasting nutrients, making it worthwhile despite the slightly higher price. I highly recommend Nordic Naturals or any reputable TG fish oil brand with the necessary certifications.
Heart Attack
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.7
9
Eicosapentaenoic acid aids heart recovery
Eicosapentaenoic Acid Preserves Mitochondrial Quality and Attenuates Cardiac Remodeling After Myocardial Infarction in Rats.
Most Relevant Research
We investigated how eicosapentaenoic acid (EPA) may help improve heart health after a heart attack. In our study, we induced myocardial infarction (MI) in male rats by ligating their coronary artery. Some of these rats received daily treatment with EPA, while others did not, allowing us to compare the effects.
Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.
Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.
Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
9.5
Reduces heart attack risk
Most Useful Review
After three weeks of taking this supplement, my hair has scarcely fallen out. My skin feels much less dry, even in the heating season. Omega-3 contributes to heart health by reducing “bad” cholesterol and lowering the risk of heart attack. It also aids in joint health, cognitive function, and managing stress. Additionally, vitamins A, E, and D enrich the skin and bones.
High Cholesterol
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.8
USERS' SCORE
Good
Based on 20 Reviews
8.7
9
Eicosapentaenoic acid benefits cholesterol
Omega-3 eicosapentaenoic polar-lipid rich extract from microalgae decreases plasma triglycerides and cholesterol in a real-world normolipidemic supplement consumer population.
Most Relevant Research
We explored the effects of eicosapentaenoic acid (EPA), a specific type of omega-3 fatty acid, on cholesterol levels in a recent study involving real-world supplement consumers. Participants took AlmegaPL capsules, which contain high amounts of EPA and are free of the other omega-3 fatty acid, DHA. This setup allowed us to gain insights from those who are already incorporating EPA into their diets.
Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.
These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.
These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
9
Meets safety standards
Most Useful Review
Choosing Omega-3 was important for me. Key factors include the composition of EPA and DHA, the source of ingredients, and the form of absorption. This product meets all safety standards and is beneficial, although it’s not cheap. High-quality products usually come with a higher price.
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Improved bone pain
Most Useful Review
After three weeks, my hair stopped falling out and my skin is less dry this winter, which is a relief. Omega-3 triglycerides have numerous benefits, including reducing bone pain, enhancing heart function, and improving joint flexibility. They help regulate hormones and reduce stress, which has positively impacted my overall wellbeing. Fish oil also contains vitamins A, E, and D, supporting skin condition, vision, and bone health. Thank you for this product.
Cold Sores
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
No sores experienced
Most Useful Review
I have tried various Omega-3 brands but often suffered from cold sores until now. With this one, there’s no fishy taste, and I've completely forgotten about my worries concerning cold sores. I highly recommend it!
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Reduced pelvic pain
Most Useful Review
After three weeks of taking this product, my hair stopped falling out and my skin has improved. Omega-3 triglycerides are essential nutrients that can help reduce pelvic pain and lower cholesterol, thus decreasing the risk of serious health issues. They also support joint health, improve cognitive functions, and enhance the immune system. Fish oil's vitamins A, E, and D contribute positively to skin condition and overall well-being.
Eczema
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Good
Based on 1 Review
8.6
9
Eicosapentaenoic Acid reduces eczema
Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.
Most Relevant Research
We embarked on a study to find out how dietary eicosapentaenoic acid (EPA) could help children suffering from atopic dermatitis, a common form of eczema. In a randomized triple-blind clinical trial, 48 children with this condition were divided into two groups—one received 250 mg of EPA twice daily, while the other received a placebo for four weeks.
Our observations showed noticeable improvements in those who took EPA. After just two weeks, participants in the EPA group reported a reduction in their SCORAD scores, which are used to measure the severity of atopic dermatitis. The scores went down significantly compared to the placebo group. After four weeks, the number of children needing corticosteroids to manage their symptoms was also lower in the EPA group.
Despite these positive results, both groups reported few adverse effects, indicating that EPA supplementation is generally well-received. Overall, we conclude that adding EPA to the diet may be an effective and safe strategy for reducing eczema severity in children.
Our observations showed noticeable improvements in those who took EPA. After just two weeks, participants in the EPA group reported a reduction in their SCORAD scores, which are used to measure the severity of atopic dermatitis. The scores went down significantly compared to the placebo group. After four weeks, the number of children needing corticosteroids to manage their symptoms was also lower in the EPA group.
Despite these positive results, both groups reported few adverse effects, indicating that EPA supplementation is generally well-received. Overall, we conclude that adding EPA to the diet may be an effective and safe strategy for reducing eczema severity in children.
10
Eczema elimination
Most Useful Review
I didn't realise just HOW good this is! I usually don't write reviews, but I had to for this. I originally bought this product for my pregnancy after thorough research. While I expected benefits for myself and my baby, after 2-3 weeks, the severe eczema on my face and neck disappeared completely. My skin became clear, smooth, and hydrated, a look I hadn't seen for years! I struggled with eczema for five years, trying an $180 cream that eventually stopped working. I discovered that fish oil is significantly more effective on eczema than any prescription cream. This was initially for my pregnancy, but I intend to use it for life!
Hot Flashes
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
10
Hot flashes stopped
Most Useful Review
Stopped the hot flashes! I was thrilled that these relieved my hot flashes. After finishing the bottle and switching to a drugstore brand, the hot flashes returned. There’s no substitute for quality, and the price is reasonable. The capsules are large but easy to swallow.
Food Poisoning
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.5
9
DHA promotes cadmium excretion
Docosahexaenoic Acid Promotes Cd Excretion by Restoring the Abundance of in Cd-Exposed Mice.
Most Relevant Research
We explored the effects of docosahexaenoic acid (DHA) on cadmium (Cd) exposure, a common pollutant that risks human health through the food chain. Our investigation focused on how DHA might help mitigate the harmful effects of Cd, particularly by looking at changes in gut microbiota.
The study involved examining mice that had been exposed to cadmium. We observed that DHA significantly boosted the amount of cadmium expelled in feces while reducing the levels of cadmium accumulated in various organs. Our findings highlighted a particularly encouraging increase in Parabacteroides, a beneficial bacteria in the gut that appeared to play a crucial role in this process.
We noted that the representative strain of Parabacteroides not only demonstrated the ability to reduce Cd toxicity but also helped repair gut damage inflicted by cadmium exposure. Furthermore, DHA effectively reduced cadmium levels in organs such as the liver, spleen, and kidneys, leading to a noticeable increase in cadmium excretion.
Overall, our results suggest that DHA may have significant potential in promoting the excretion of cadmium in instances of exposure. This insight offers a fascinating avenue for considering DHA as a supportive treatment option for handling heavy metal toxicity.
The study involved examining mice that had been exposed to cadmium. We observed that DHA significantly boosted the amount of cadmium expelled in feces while reducing the levels of cadmium accumulated in various organs. Our findings highlighted a particularly encouraging increase in Parabacteroides, a beneficial bacteria in the gut that appeared to play a crucial role in this process.
We noted that the representative strain of Parabacteroides not only demonstrated the ability to reduce Cd toxicity but also helped repair gut damage inflicted by cadmium exposure. Furthermore, DHA effectively reduced cadmium levels in organs such as the liver, spleen, and kidneys, leading to a noticeable increase in cadmium excretion.
Overall, our results suggest that DHA may have significant potential in promoting the excretion of cadmium in instances of exposure. This insight offers a fascinating avenue for considering DHA as a supportive treatment option for handling heavy metal toxicity.
8.3
Heart health improvement
Most Useful Review
I regularly give this omega to my nephew, who enjoys its taste. Although children can be quite selective with their food choices, this product is both flavourful and beneficial. A recent examination revealed improvements in the condition of his heart and blood vessels, which is encouraging, particularly in regard to any concerns about food poisoning.
Heart Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.3
USERS' SCORE
Good
Based on 17 Reviews
8.5
9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
Most Relevant Research
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
9.5
Improves child's heart
Most Useful Review
We only use this omega for my child, as it's regularly tested for toxins and heavy metals. The triglyceride form meets strict purity standards, and the capsules are easy to swallow with no fishy taste. I’ve noticed improvements in my child's activity and fatigue levels.
Cataract
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Aids dry eye recovery
Most Useful Review
Excellent for dry eyes. I'm very satisfied with the Omega 3 by Nordic. It's easy to swallow despite its large size and has helped with my left dry eye following cataract surgery. I highly recommend it for anyone suffering from dry eyes.
Hair Loss
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8
Notable benefits observed
Most Useful Review
Within just one week of taking this product, I saw significant benefits such as less dry skin, more body in my hair, and notably reduced hair loss. Additionally, I noticed improved blood sugar levels and energy.
Ulcer
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.5
9
Eicosapentaenoic acid aids ulcer healing
Eicosapentaenoic acid mitigates ulcerative colitis-induced by acetic acid through modulation of NF-κB and TGF-β/ EGFR signaling pathways.
Most Relevant Research
We examined how Eicosapentaenoic acid (EPA) could protect against ulcerative colitis (UC), a chronic condition that inflames the large intestine. In our research, we used acetic acid to induce UC in rats, administering oral EPA for 28 days in doses of 300 and 1000 mg/kg before the acetic acid treatment.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
9
Pain relief success
Most Useful Review
Best Omega-3 ever! I developed stomach ulcers from pain medication over 20 years. After taking Nordic Naturals, my knee swelling and pain vanished. I quickly reordered and highly recommend them for muscle soreness too.
Back Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
USERS' SCORE
Good
Based on 13 Reviews
8.4
9
Eicosapentaenoic acid alleviates back pain
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Most Relevant Research
We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
9.5
Pain relief achieved
Most Useful Review
After developing stomach ulcers from pain medications, I switched to Nordic Naturals and noticed a significant improvement. My knee swelling and pain disappeared shortly after starting them. I highly recommend this product as it works better than any other brands I've tried, plus it has no unpleasant aftertaste.
Leg Cramps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.1
9.5
Painful cramps relieved
Most Useful Review
My husband used to suffer from severe leg cramps which caused him considerable pain. Following a nutritionist's advice, he began taking Nordic Omega Fish Oil—three capsules daily. Remarkably, his cramps vanished within a week. I also decided to take one capsule daily and noticed relief from my painful leg cramps. I highly recommend this product.
Headache
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.2
USERS' SCORE
Moderately Good
Based on 1 Review
7.8
9.5
Eicosapentaenoic acid reduces migraines
A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.
Most Relevant Research
We conducted a 12-week study to explore how eicosapentaenoic acid (EPA) affects individuals suffering from episodic migraines. In our trial, 70 participants were randomly split into two groups—one received 2 grams of fish oil with 1.8 grams of pure EPA daily, while the other group got a placebo made of soybean oil.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
1.3
Chronic headaches experienced
Most Useful Review
Be aware of possible headache side-effect. I had a seemingly adverse reaction to these Omega-3 supplements. Shortly after starting them, I began experiencing terrible headaches that lasted all day and night. The usual headache medications only provided mild relief. After ten days of constant headaches, I realised they started after commencing the Omega-3.
