Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Vitamin C (as Ester-C® calcium ascorbate)
500 mg
556%
Citrus Bioflavonoid Complex
25 mg
**
Acerola Extract (Malpighia glabra) (fruit)
10 mg
**
Rose Hips (fruit)
10 mg
**
Rutin
5 mg
**

The product is found useful for the following medical conditions

Back Pain details

SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
We conducted a year-long study to investigate the effects of vitamin C on postoperative pain and recovery after a specific type of spine surgery known as posterior lumbar interbody fusion (PLIF). In this randomized, placebo-controlled trial, we worked with 123 patients, dividing them into two groups: one receiving vitamin C and the other a placebo.

Our main focus was to see how vitamin C influenced lower back pain measured by a visual analogue scale. While we found that there was no significant difference in pain levels at the one-year mark between the two groups, there was a silver lining. We observed that vitamin C appeared to enhance functional improvement, especially within the first three months after surgery.

So, while vitamin C didn’t seem to directly reduce pain intensity after surgery, it could play a role in supporting early recovery and everyday function. This finding may encourage further exploration into vitamin C's potential benefits in postoperative care for patients undergoing spine surgeries.
9
Eased gastrointestinal pain
Most Useful Review
These vitamins are excellent throughout the year, especially during epidemics. They are perfect for sensitive stomachs, and I have not suffered from heartburn or gastrointestinal pain after taking them. When I feel unwell, I take two 500 mg tablets, and the next morning, I feel much better. I'm on my second can and will continue to use them!
Updated: Apr 2025

Heartburn details

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 28 Reviews
8.6
We investigated how vitamin C, specifically in the form of a 2% vitamin C solution spray, could help alleviate heartburn symptoms following Lugol chromoendoscopy, a procedure that involves staining the esophagus to better visualize abnormalities. In a well-structured study with 240 participants, we used a randomized, double-blind approach to compare the effectiveness of vitamin C to normal saline and sodium thiosulfate solutions.

Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.

Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
9
No heartburn issues
Most Useful Review
196 people found this helpful
This is the best vitamin C. Unlike others, it is easily absorbed, and I have no heartburn after taking it.
Updated: Mar 2026

Tonsillitis details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.6
9
Effective for tonsillitis
Most Useful Review
1 people found this helpful
I paid close attention! I drank the whole jar last winter and, for the entire season from autumn to spring, I didn't experience a single cold or serious illness. For the first time in years, even my chronic tonsillitis was not aggravated! Despite facing great psychological and physical stress from living in a poorly built dacha and encountering cold conditions, I was very satisfied. I saw results as per the instructions and will definitely purchase again. I recommend it to others. Stay healthy, positive, and beautiful! PS I have bought a second jar currently.
Updated: Apr 2026

Blood Clot details

SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.7
USERS' SCORE
Good
Based on 2 Reviews
8.5
We sought to understand how ascorbic acid, commonly known as vitamin C, impacts blood clotting during living donor liver transplantation (LDLT). In our study, we analyzed blood samples from 21 recipients before and after their surgeries.

We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.

Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.

This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
9
Aids blood clot
Most Useful Review
I've found that vitamin C with bioflavonoids is absorbed 35% better than regular ascorbic acid and is gentler on the stomach. It aids in thinning the blood, preventing blood clots and reducing heart strain. This improvement helps with varicose veins and overall blood circulation. If my review was helpful, please give it a thumbs up.
Updated: Apr 2025

Celiac details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.5
9
Immunity improvement
Most Useful Review
8 people found this helpful
The Solgar company is one I approve of, as their products are halal, free from dairy, gluten, and wheat, and non-GMO. I've noticed an improvement in my immunity, hair, nails, and skin since using their supplements. The quality is excellent, and I strongly recommend it. I take one pill daily before breakfast, alongside collagen, on an empty stomach. As the capsules have no taste, they are easy to swallow. You will notice a difference after consulting your doctor, God willing.
Updated: Mar 2026

Cough details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Cough disappeared
Most Useful Review
A great product! The cough was gone by the second day of use. I will buy more.
Updated: Mar 2026

Heart Disease details

SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
We aimed to understand the role of vitamin C in heart disease and its potential cardioprotective effects. Vitamin C is renowned for its antioxidant properties, which means it fights off harmful substances in our body, potentially reducing the risk of heart issues.

Our analysis revealed that vitamin C could play a meaningful role in supporting cardiovascular health. While the evidence is promising, it is important to be cautious, as clinical studies have shown mixed results regarding its effectiveness.

So, while vitamin C might contribute positively to heart health, more solid evidence is required to fully confirm these effects. Overall, we learned that while there are positive indicators, we should be careful about over-relying on vitamin C as a sole preventive measure for heart disease.
9
Supports body during attack
Most Useful Review
1 people found this helpful
I took vitamin C during a heart attack, and it provided excellent support for my body.
Updated: Mar 2026

Knee Pain details

SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
We observed an intriguing case involving a 4.5-year-old boy who developed significant knee pain due to a rare nutritional deficiency, scurvy. This condition stemmed from his exclusive intake of meat over the past two years, resulting in skeletal issues and inflammation in multiple joints, including his knees.

Upon examination, the child exhibited several symptoms, including pain, swelling, and an inability to walk. Standard blood tests primarily indicated anemia, but X-rays revealed alarming conditions related to scurvy, such as delayed bone age and severe osteopenia. This alarming picture led us to the conclusion that vitamin C deficiency was the underlying culprit behind his knee pain and skeletal issues.

After initiating vitamin C therapy, we noted a remarkable reduction in pain and swelling over the next two months. The child’s condition improved significantly, allowing him to walk again, and follow-up X-rays confirmed the positive changes in his bone health. This case clearly illustrates how vitamin C can effectively alleviate knee pain related to scurvy and reinforces the importance of proper nutrition for overall skeletal health.
9
Reduced knee pain
Most Useful Review
1 people found this helpful
I've been taking Ester-S Plus Vitamin C each morning after breakfast for three months. I really like it; it has alleviated my fatigue, and my joints no longer hurt, especially my knee pain. I never thought I could improve my health this way. I used to get colds frequently, but after taking 500 mg twice a day, my cold symptoms subsided quickly.
Updated: Apr 2026

Pneumonia details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Restores strength
Most Useful Review
Following bilateral pneumonia caused by coronavirus, I began taking fish oil concentrate and Vitamin Ester-C on my doctor's advice. I quickly felt revitalised, regaining my energy and strength. My doctor recommended long-term use of these supplements for Covid recovery.
Updated: Mar 2026

Allergies details

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 10 Reviews
8.4
We conducted a thorough evaluation of how vitamin C, when combined with pleuran, impacts asthma control and respiratory issues in children suffering from perennial asthma. The study was meticulously designed as a double-blind, placebo-controlled trial involving 230 children aged 7 to 17 years. This means that neither the participants nor the researchers knew who was receiving the active treatment or the placebo, ensuring the findings were reliable.

The results were promising, especially for children under 12 years. They showed significant improvements in asthma control compared to those receiving only the placebo treatment. Meanwhile, older children (12 years and above) experienced fewer respiratory infections with the combination treatment. Overall, by the end of the 48 weeks, a majority of children on the pleuran and vitamin C treatment reported better asthma control compared to those on the placebo.

While the combination of pleuran and vitamin C was indeed beneficial for managing asthma, we must note that the study did not specifically isolate the effect of vitamin C alone on allergies or asthma. Thus, it is hard to draw definitive conclusions about vitamin C's effectiveness independently from pleuran. However, the approach suggested that using these supplements together could offer a helpful boost in managing asthma symptoms.
10
No allergy
Most Useful Review
4 people found this helpful
Excellent vitamins; I can't do without them, and I have no allergies to this vitamin C, unlike others.
Updated: Mar 2026

Indigestion details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Great absorption effect
Most Useful Review
Excellent product! The ester form is one of the best for absorption and does not cause indigestion for me at all, unlike regular vitamin C. It’s great for those of us who struggle with gastritis or ulcers. I feel much more comfortable taking it.
Updated: Mar 2026

Leg Cramps details

SCIENTIFIC SCORE
Questionable
Based on 1 Research
5
USERS' SCORE
Good
Based on 4 Reviews
8.4
We explored the effects of vitamin C on leg cramps in a group of 60 pregnant women through a double-blind trial. Participants received either calcium or vitamin C (1 g twice daily) as treatment. Our observations revealed that there was no significant difference in clinical improvement between the two treatment groups.

Notably, 14 patients experienced complete relief from symptoms, while 27 reported significant improvement regardless of which treatment they received. Unfortunately, 17 participants found their symptoms unchanged, and only two noticed an increase in leg cramps during the treatment period.

Throughout the study, we measured serum levels of total and ionized calcium, total magnesium, and albumin, but these parameters did not show significant changes in either treatment group. We also didn’t identify any biochemical differences when comparing the effectiveness of vitamin C and calcium for alleviating cramps.

Ultimately, our findings suggest that vitamin C may not be an effective solution for leg cramps in pregnant women, as both treatments yielded similar results with minimal biochemical changes.
9
Invigoration noticed
Most Useful Review
1 people found this helpful
Reacta C has truly invigorated me and alleviated my leg fatigue.
Updated: Apr 2025

Acne Rosacea details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.3
7.5
Effective against redness
Most Useful Review
1 people found this helpful
Fabulous! There is little I can say to praise this vitamin C. It does not induce heartburn, which I often experience with other vitamin C products, making it particularly effective in combating acne rosacea. During the autumn-winter period, I noticed fewer capillary bursts and less facial redness. In short, I highly recommend it. However, it's best to consult a doctor regarding the dosage.
Updated: Mar 2026

Anemia details

SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.9
USERS' SCORE
Good
Based on 15 Reviews
8.3
We observed a fascinating phenomenon related to vitamin C and anemia during a series of cases in a prison setting in Ethiopia. Specifically, we examined how scurvy, a disease caused by a lack of vitamin C, contributed to anemia among prisoners.

Our study focused on ten patients who were admitted for treatment, all of whom presented with some form of leg swelling or pain. After administering vitamin C in the form of ascorbic acid, we noted a significant increase in hemoglobin levels, rising from an average of 4.6 to 7.1 g/dL. This improvement indicates that vitamin C may play a crucial role in alleviating some anemia symptoms when the underlying cause is related to dietary deficiencies.

Additionally, through an observational study involving 67 other patients in the same prison, we confirmed that leg swelling and pain were common symptoms among those affected. With consistent therapeutic doses of vitamin C, all patients showed considerable improvement in their conditions.

Thus, we can conclude that vitamin C does seem to have a valuable effect on anemia caused by dietary deficiencies, particularly in high-risk environments like prisons. This finding encourages healthcare providers to remain vigilant about such nutritional deficiencies and highlights the importance of vitamin C in treatment.
9
Improves absorption
Most Useful Review
2 people found this helpful
Excellent vitamin C! I've been dealing with anaemia, so the doctor recommended an iron supplement. I purchased both iron and vitamin C to enhance iron absorption. This Ester-C form is easily tolerated, even on an empty stomach. Very satisfied with the results!
Updated: Mar 2026

Diarrhea details

SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Good
Based on 6 Reviews
8.3
We investigated how adding vitamin C to milk influences the growth and health of young calves, particularly those experiencing diarrhea. The study involved 48 Holstein calves, which were sorted into two groups based on their health status: healthy calves and those with diarrhea. Each calf was fed the same amount of pasteurized milk and monitored until they reached 74 days of age.

Calves that received vitamin C showed an impressive increase in weight by weaning—74.3 kg compared to 72.2 kg for those without vitamin C. Additionally, calves treated with vitamin C demonstrated improved blood antioxidant levels, suggesting better overall health. Notably, calves suffering from diarrhea benefitted significantly from the vitamin C, needing fewer days of medication for treatment compared to those who did not receive the supplement.

The research highlights that vitamin C can play a critical role in supporting the health of calves during episodes of diarrhea. This is especially relevant for those that faced even mild cases early in life, as they seemed to gain the most benefits from the supplementation. Overall, it appears that vitamin C can positively impact both growth and health in calves suffering from diarrhea.
9
Easily tolerated
Most Useful Review
This vitamin C is excellent as it is easily tolerated and does not cause diarrhoea. Together with bioflavonoids, it enhances absorption, and I've been taking it daily without any problems.
Updated: Mar 2026

Herpes details

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 6 Reviews
8.3
We explored the effects of ascorbic acid and its derivatives on the replication of Herpes simplex virus type I using human muscle cancer cells.

The study revealed that a specific form of vitamin C, known as 2-O-glycoside of ascorbic acid, showed promising antiviral properties.

Interestingly, while this derivative can inhibit certain chemical reactions involving carbon-centered radicals, it does not impact reactions with oxygen-centered radicals.

However, despite these findings, the overall benefits of vitamin C treatment for herpes remain inconclusive.
9
Forget about herpes
Most Useful Review
I buy this constantly. It has allowed me to forget about the herpes that tormented me for years.
Updated: Mar 2026

High Cholesterol details

SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.3
We explored how vitamin C supplementation affects cholesterol levels in broiler chickens, particularly under heat stress conditions. Through a thorough meta-analysis of 35 studies conducted between 1985 and 2023, we assessed various performance metrics, including blood parameters, carcass characteristics, and overall meat quality.

Our findings revealed that vitamin C significantly reduced cholesterol levels in the broiler chickens subjected to heat stress. Specifically, the study reported a notable decrease in cholesterol concentrations, with a standard mean difference of -0.976, indicating a strong beneficial effect of vitamin C in managing high cholesterol.

Additionally, we noticed improvements in body weight and average daily gain among chickens receiving vitamin C when compared to those that did not. While vitamin C did not significantly impact feed intake or breast meat quality, it emerged as a valuable antioxidant that can help lower blood triglycerides and reduce cholesterol, thus promoting better overall health and growth in broilers during stressful conditions.

Ultimately, this meta-analysis supports the use of vitamin C at a recommended dosage of 250 mg/kg as an effective growth promoter and antioxidant in broiler diets under heat stress, directly influencing cholesterol management.
7.5
Stomach comfort
Most Useful Review
1 people found this helpful
This product is non-acidic, which means it doesn't upset my stomach unlike other products, and I've noticed improved results regarding my high cholesterol levels.
Updated: Mar 2026

Sore Throat details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 20 Reviews
8.3
9
Fast cold recovery
Most Useful Review
4 people found this helpful
I experienced cold symptoms during a summer trip and found vitamin C to be a tremendous aid. Upon feeling ill with a sore throat and fever, I took a large dose of vitamin C. Within a day, I nearly returned to normal. Now, I rely on Ester-C Plus, which is gentle on the stomach, and once again, it provides quick results for my family during colder months.
Updated: Apr 2025

Bacterial Infection details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.2
9
Helpful for infections
Most Useful Review
Vitamin C is fantastic! It significantly assisted with a viral infection. I consume 1000 mg at the onset of illness!
Updated: Mar 2026

Bruise details

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.2
USERS' SCORE
Good
Based on 5 Reviews
8.2
We explored how vitamin C can impact bruising, particularly in individuals experiencing a deficiency. The research highlighted a case involving an elderly woman who faced challenges such as weakness, easy bruising, and fatigue due to a lack of this vital nutrient.

After beginning treatment with vitamin C supplements, we observed significant improvements in her symptoms, emphasizing the importance of this vitamin in healthier skin and tissue repair. It showcased that scurvy, a condition rooted in vitamin C deficiency, can still occur today, especially in certain at-risk populations.

This case reminds us that while scurvy might seem like a relic of the past, it can still affect modern individuals. Skin issues like easy bruising can sometimes signal deeper dietary concerns that need addressing, especially in older adults.
9
Strengthens vessels
Most Useful Review
This supplement successfully strengthens my weak blood vessels. I take 500 ml every morning, resulting in healthier gums and the absence of small bruises.
Updated: Apr 2026

Chronic Fatigue Syndrome details

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7
USERS' SCORE
Good
Based on 4 Reviews
8.2
We examined how a combination of megadose vitamin C infusions and other treatments might help manage chronic fatigue syndrome, particularly in the context of interstitial pneumonia. Our findings were based on nearly a decade of treating patients, allowing us to gather valuable insights.

We observed that the long-term use of this treatment system significantly reduced the risk of pneumonia recurrence. It also appeared to help prevent the emergence of certain cancers in older patients suffering from interstitial pneumonia. Surprisingly, we found a link between interstitial pneumonia and an increased risk of depression, likely driven by prolonged glucocorticoid use.

While some patients showed promise under this treatment, those battling both interstitial pneumonia and depression responded less favorably. We suggested that increasing the amount of dehydroepiandrosterone in the treatment could be beneficial. Throughout our experience, we noted that the characteristics of chronic fatigue syndrome align closely with those of interstitial pneumonia, arguing against the notion that they should be viewed as separate conditions.

Overall, our approach not only alleviated inflammation but did not suppress the fibrotic processes in the long run. We made modifications to the treatment to lower the risks of vascular complications. The main strength of our treatment lies in creating a hormonal environment that helps tackle immune deficiencies using vitamin C, which faces lower resistance in the body compared to steroid treatments.
7.5
Reduced fatigue
Most Useful Review
20 people found this helpful
Wonderful! I take one tablet daily with a meal and feel more refreshed. My fatigue has diminished, and my skin appears clearer. I truly love this brand for its quality. If you find my review helpful, please give it a thumbs up!
Updated: Mar 2026

Cold details

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 1300 Reviews
8.2
We explored the effects of vitamin C on the common cold and pneumonia by examining a range of studies. Interestingly, research on animals suggests that vitamin C may have protective effects against infections. However, when it comes to preventing colds in the general population, taking more than 1 gram of vitamin C per day didn’t show significant benefits.

But there's a twist! Participants engaged in heavy physical activities saw their cold incidence reduced by half with vitamin C supplementation. Additionally, regular intake of 1 gram or more daily was linked to a 15% decrease in cold severity. While some therapeutic trials showed inconsistent results when vitamin C was taken after cold symptoms appeared, two studies did indicate that larger doses (6-8 grams per day) could effectively shorten the duration of colds compared to lower doses.

Our investigation also looked into pneumonia, but the studies were conducted in unique settings, such as a boarding school and military recruits. This makes it hard to generalize the findings to the wider population. Yet, some trials suggested benefits for pneumonia patients. Finally, the role of vitamin C in treating COVID-19 and sepsis remains unclear, with mixed results.

Given that vitamin C seems to alleviate symptoms and shorten the duration of colds, while being safe and affordable, it might be worth considering a dose of 6-8 grams per day to see if it helps at an individual level.
9
Immune support
Most Useful Review
780 people found this helpful
This is what I drink constantly, and during a cold, I increase the dosage to 2-3 capsules per day. It helps a lot and the results are almost immediate. My immune system feels strengthened.
Updated: Mar 2026

Flu details

SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
USERS' SCORE
Good
Based on 62 Reviews
8.2
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.

However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.

Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.

Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
7.5
Prevented flu effectively
Most Useful Review
25 people found this helpful
Helps my immune system. I use this product to boost my immune health with natural ingredients. It helps keep bladder infections at bay. I take it to avoid getting the flu. Typically, I suffer from a severe flu every winter, but this year I did not get the flu. I usually buy this locally, but I appreciate the convenience of delivery. We could all benefit from stronger immune systems.
Updated: Mar 2026

Bone Pain details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.1
9
Collagen production support
Most Useful Review
1 people found this helpful
I highly recommend this for its role in collagen and bone production as well as strength; it's truly exceptional.
Updated: Mar 2026

Cold Sores details

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 18 Reviews
8.1
We investigated how an ascorbic acid-based solution could help treat recurrent cold sores, also known as mucocutaneous herpes. This study was carefully designed as a randomized, double-blind, placebo-controlled trial, which helps ensure the results are reliable and trustworthy.

Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.

Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.

In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.
9
Immunity boost
Most Useful Review
3 people found this helpful
An excellent tool for boosting immunity! I took two capsules each morning and evening, which did wonders for my cold symptoms.
Updated: Apr 2025

Gastritis details

SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.7
USERS' SCORE
Good
Based on 16 Reviews
8.1
We aimed to discover how vitamin C supplementation affects oxidative stress in individuals diagnosed with chronic gastritis. In this study, we looked at 244 Japanese patients suffering from atrophic gastritis. They were randomly assigned to receive either 50 mg or 500 mg of vitamin C every day for five years.

After analyzing the results, we found notable differences between the two groups. The high-dose group experienced a significant decrease in reactive oxygen species (ROS), suggesting that vitamin C may help reduce oxidative stress associated with chronic gastritis. In contrast, the low-dose group reported an increase in ROS levels. These findings prompt further interest in how vitamin C can protect against oxidative stress in similar conditions.

Overall, our study supports the idea that higher doses of vitamin C could have a beneficial effect on oxidative stress, particularly in those dealing with gastritis. This insight opens avenues for considering vitamin C as a potential supportive treatment for managing oxidative stress-related issues in digestive health.
9
No stomach issues
Most Useful Review
24 people found this helpful
I was prescribed vitamin C, but many made my gastritis worse. Solgar’s vitamin C works well for me; I take it without any stomach issues. The packaging is reliable, especially during the pandemic, which I value.
Updated: Mar 2026

Nausea details

SCIENTIFIC SCORE
Very Likely Ineffective
Based on 1 Research
2
USERS' SCORE
Good
Based on 13 Reviews
8.1
We explored the effects of vitamin C as a treatment for nausea and vomiting in pregnancy, also known as emesis gravidarum. Our study involved 111 participants, who were given either vitamin C-containing chewing gum, a placebo, or no treatment at all. We monitored them over two follow-up visits in early pregnancy to assess their symptoms.

While we measured various factors that could influence nausea—including hormone levels like hCG and DAO—our findings showed that the chewing gum did not effectively reduce nausea symptoms compared to the placebo or no treatment. Specifically, the vitamin C gum was not associated with any significant alleviation of nausea or vomiting.

Interestingly, we found that elevated levels of hCG were linked to increased nausea severity. In contrast, higher levels of DAO appeared to have a protective effect against symptoms. Additionally, elevated thyroxine and pyridoxine levels correlated with worsened nausea.

Overall, while vitamin C is often highlighted for its health benefits, our results suggest it does not play a significant role in treating nausea during pregnancy. This study highlights the complexities behind nausea in pregnancy, indicating that further research is necessary to uncover effective treatment options.
9
Supports immunity well
Most Useful Review
3 people found this helpful
A wonderful product that promotes activity and boosts immunity. Despite having a sensitive stomach, I experienced no acidity or nausea while taking this vitamin.
Updated: Apr 2025

Adrenal Gland Disorder details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 12 Reviews
8
9
Maintains adrenal health
Most Useful Review
I've been taking Ester-C for about three years now. This non-irritating form has higher bioavailability than regular vitamin C. I rely on it daily to maintain adrenal function, increasing dosage during respiratory infections for better outcomes.
Updated: Mar 2026

Chest Pain details

SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.3
USERS' SCORE
Good
Based on 4 Reviews
8
We explored the effects of vitamin C on chest pain in chronic smokers experiencing endothelial dysfunction. In our study, 31 patients, who were undergoing diagnostic catheterization without significant coronary artery issues, participated in a controlled trial. They were given either an IV infusion of 3 grams of ascorbic acid (vitamin C) or a placebo saline solution before undergoing a cold pressor test to assess their coronary artery response.

The results were telling. Smokers typically showed a decrease in luminal area—an indicator of blood flow—during the cold pressor test. However, after infusing vitamin C, this response shifted positively, demonstrating improved blood flow through a vasodilation effect. On the other hand, those who received the placebo did not experience significant changes.

This means that for chronic smokers, acute administration of vitamin C appears to enhance the function of the endothelium, which is vital for proper blood vessel health and managing chest pain. Ultimately, we observed that vitamin C may help prevent the inactivation of nitric oxide, a compound that supports healthy blood flow, and this effect could be crucial for managing cardiovascular health in smokers.
7.5
Chest pain alleviated
Most Useful Review
64 people found this helpful
Solgar Ester-C Plus is a staple for me. It doesn’t irritate my stomach, even when taken on an empty stomach, which is crucial as I have gastritis. This product has proven effective for dealing with colds; it alleviates symptoms, including chest pain, and can even lower my temperature. I appreciate the 500 mg dosage, and I take 1000 mg during illness. I've never encountered an overdose or allergy. I highly recommend this quality product from Solgar.
Updated: Apr 2025

Common Cold details

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.4
USERS' SCORE
Good
Based on 4 Reviews
8
We explored how vitamin C affects the severity of common colds through a comprehensive review of available studies. By including only randomized, placebo-controlled trials where participants received at least 1 gram of vitamin C daily, we aimed to investigate both the overall duration of colds and the intensity of symptoms experienced.

Our analysis found that vitamin C significantly reduced the severity of cold symptoms by about 15%. Interestingly, it appears that the benefits are more pronounced for those experiencing severe symptoms compared to mild ones. In specific comparisons, vitamin C didn’t substantially affect the duration of mild symptoms but had a notable impact on how long severe symptoms lasted.

This insight is crucial, as the common cold often leads to absenteeism at work and school, with more severe symptoms playing a key role in this setback. By highlighting vitamin C's greater effectiveness against intense cold symptoms, we suggest that future research should continue to look into how this vitamin can be utilized in managing cold severity.
9
Improves recovery
Most Useful Review
2 people found this helpful
The vitamin C content of 500mg is perfect for me. I have atopic dermatitis, and while I sometimes experience scratches, I find my skin regenerates quickly. I feel it has played a part in my stability during cold temperatures, helping us recover during the initial symptoms, and my family has escaped the common cold for several years.
Updated: Mar 2026

Adenoiditis details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.8
9
Prevented flu completely
Most Useful Review
1 people found this helpful
Excellent and, as Solgar's Vitamin C, it has absolutely helped me a lot! I was great all winter without flu and any respiratory problems - such as bronchitis or sore throat!
Updated: Mar 2026

Rash details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.8
7.5
No allergy rash
Most Useful Review
9 people found this helpful
Wonderful! I am not allergic to it! My body did not respond poorly to vitamin C from various manufacturers, as I usually develop a red rash on my elbow that itches. This particular vitamin C did not cause any allergies, which has made me very happy. I recommend it to anyone with similar issues; it may suit you too.
Updated: Mar 2026

Ulcer details

SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.1
USERS' SCORE
Moderately Good
Based on 29 Reviews
7.8
We conducted a double-blind trial involving sixteen individuals with chronic foot ulcers to see how vitamin C impacts their healing. Half of the participants received 500 mg of vitamin C, while the others got a placebo.

After eight weeks, those taking vitamin C showed significant improvement—ulcer healing was much better compared to the placebo group. Notably, everyone who received vitamin C healed without needing amputation, while 44% of the control group did not see any healing.

Our findings suggest vitamin C may be a beneficial treatment for chronic foot ulcers, given its accessibility and low cost.
7
Does not corrode stomach
Most Useful Review
85 people found this helpful
Super Vitamin C in ester form. It doesn’t corrode the stomach and can be taken by those suffering from an ulcer. We definitely use it in the fall.
Updated: Apr 2026

Headache details

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.7
We aimed to understand how dietary vitamin C affects migraines by analyzing data from the National Health and Nutrition Examination Survey, conducted from 1999 to 2004. In this survey, we identified adults who reported experiencing severe headaches or migraines over the past three months.

Our findings were quite revealing. Out of 4,101 participants, 702 individuals reported having a migraine, which represents about 17% of the group. We discovered an interesting trend: higher dietary vitamin C intake seemed to correlate with a lower likelihood of experiencing migraines. Specifically, participants with the highest vitamin C intake had a 36% reduced odds of suffering from migraines compared to those with the lowest intake.

We employed various statistical methods to confirm our results, including logistic regression and restricted cubic spline regression, which showed a clear linear relationship between vitamin C intake and the frequency of migraines.

Overall, this study suggests that increasing our dietary vitamin C might help minimize migraines, which is promising news for those who suffer from these intense headaches. However, as with all studies, further research is necessary to solidify these findings and fully understand the relationship between vitamin C and headache relief.
9
Eliminates headaches quickly
Most Useful Review
6 people found this helpful
This super vitamin allows me to remain well through winter. If I feel itching or discomfort, I take a double dose and the ailment vanishes. I've noticed that my headaches dissipate after taking it. It's a product I intend to use indefinitely!
Updated: Apr 2026

Kidney Stones details

SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.9
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.3
We examined the relationship between vitamin C intake and the risk of developing kidney stones in a large cohort. This study included a significant number of participants: 156,735 women from the Nurses' Health Studies and 40,536 men from the Health Professionals Follow-up Study.

Our findings revealed that total and supplemental vitamin C intake was linked to a higher risk of kidney stones in men, but there was no such association evident in women. Specifically, among men, those who consumed higher amounts of vitamin C had greater likelihoods of developing stones when compared to those with lower intakes.

However, dietary vitamin C did not show a connection with kidney stones in either men or women. This suggests that while supplements may pose risks for men, dietary sources of vitamin C might not have the same impact. Overall, the study indicates that we should be cautious about high vitamin C supplement consumption, especially for men, while highlighting that dietary intake appears safe.
9
Gentle on stomach
Most Useful Review
1 people found this helpful
Ester-C is a superb Vitamin C, not acidic and gentle on the stomach and kidneys. It provides benefits over 24 hours, allowing a single dose daily, which I find highly effective.
Updated: Mar 2026

Pelvic Pain details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.1
9
Joint pain relief
Most Useful Review
1 people found this helpful
I’ve been taking Esther-S Plus Vitamin C each morning after breakfast for three months. I really like it; my fatigue symptoms have improved, and my joint pain, especially in my knees, has diminished. Surprisingly, it has made dealing with colds easier. I took 500 mg twice daily, and the likelihood of catching a cold noticeably decreased.
Updated: Mar 2025
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