Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3
25 mcg (1,000 IU)
125%
The product is found useful for the following medical conditions
Asthma details
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
We're delving into the potential effects of vitamin D on asthma management. The focus of this study is whether vitamin D supplementation can help asthmatic patients reduce their flare-ups and enhance their lung function.
To answer this question, we analyzed several randomized controlled trials that scrutinized the impact of vitamin D on patients with asthma. The findings were promising, as we observed that vitamin D supplementation not only improved lung function, measured through the predicted FEV1 value, but also successfully elevated the levels of serum 25-hydroxyvitamin D in participants.
Overall, this study supports the idea that vitamin D may play a beneficial role in asthma care by potentially reducing the frequency of asthma attacks and improving lung health. It's an exciting area for further research, especially considering the varying results from asthma studies worldwide.
To answer this question, we analyzed several randomized controlled trials that scrutinized the impact of vitamin D on patients with asthma. The findings were promising, as we observed that vitamin D supplementation not only improved lung function, measured through the predicted FEV1 value, but also successfully elevated the levels of serum 25-hydroxyvitamin D in participants.
Overall, this study supports the idea that vitamin D may play a beneficial role in asthma care by potentially reducing the frequency of asthma attacks and improving lung health. It's an exciting area for further research, especially considering the varying results from asthma studies worldwide.
9
Significant asthma improvement
Most Useful Review
4 people found this helpful
Helped my asthma! I've struggled with allergic asthma due to grass for years. Skeptical at first, I tried increasing my vitamin D intake after reading studies on its effects on asthma. To my astonishment, I began feeling relief after just weeks! My asthma has decreased significantly. After consulting my doctor, we've adjusted my dosage, and I'm hopeful for even more improvement!
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.4
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
9
Improves health
Most Useful Review
4 people found this helpful
This high-quality dietary supplement has worked wonders for my hair loss and bone pain. Recommended by my doctor to improve immunity, I noticed health improvements within days, including better skin and hair. It's miraculous, and I plan to continue taking it.
Arthritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
9
Reduces arthritis signs
Most Useful Review
Removes signs of early arthritis in three to four weeks. It has been tested repeatedly!
Blood Clot details
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.7
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Our research focused on understanding how Vitamin D (VitD) might influence blood clotting, especially in the context of COVID-19. We found that when human endothelial cells were exposed to IL-6—an inflammatory cytokine associated with severe COVID-19—it led to dysfunction in these cells. This dysfunction was marked by increased levels of Tissue Factor (TF) and cell adhesion molecules (CAMs), which promote blood clotting.
Remarkably, when we treated these endothelial cells with VitD, we observed a reversal of these harmful effects. VitD appeared to inhibit the expression of TF and CAMs and even modulated the levels of the ACE2 receptor, which is crucial for the entry of the virus into cells. Our findings suggest that VitD could play a protective role against the blood clotting complications associated with COVID-19 by counteracting IL-6's effects on endothelial cells.
Overall, this study paves the way for further research into VitD as a potential therapeutic option for mitigating thrombotic risks in COVID-19 patients.
Remarkably, when we treated these endothelial cells with VitD, we observed a reversal of these harmful effects. VitD appeared to inhibit the expression of TF and CAMs and even modulated the levels of the ACE2 receptor, which is crucial for the entry of the virus into cells. Our findings suggest that VitD could play a protective role against the blood clotting complications associated with COVID-19 by counteracting IL-6's effects on endothelial cells.
Overall, this study paves the way for further research into VitD as a potential therapeutic option for mitigating thrombotic risks in COVID-19 patients.
9
Boosted blood circulation
Most Useful Review
142 people found this helpful
Vitamin D3 helps improve blood clotting and enhances cell sensitivity to insulin. It supports nerve fibre regeneration, boosts immune function, and reduces cholesterol build-up in blood vessels.
Heartburn details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Improved blood counts
Most Useful Review
Super vitamin D3 has been excellent for me. I’ve taken two packs and experienced no heartburn, and my blood counts have improved. I highly recommend this product.
Leg Cramps details
SCIENTIFIC SCORE
Very Likely Ineffective
Based on 2 Researches
2
USERS' SCORE
Good
Based on 3 Reviews
8.5
4
We assessed the impact of vitamin D on leg cramps experienced during pregnancy, referring to data from various studies. One of the key findings was that vitamin D treatment showed little to no difference when it came to reducing the frequency of leg cramps.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
9
Cramps alleviated
Most Useful Review
3 people found this helpful
Vitamin D is fantastic! After taking it for about 5 or 6 months, my leg cramps and discomfort disappeared. Now, I take it not only for myself but also for all the children.
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
9
No more migraines
Most Useful Review
This dietary supplement has significantly improved my life, especially regarding migraine relief during PMS. I've also noticed quicker recovery from illnesses and rapid healing of skin lesions. My nails are stronger, and my back pain has reduced. Overall, I feel more energetic and my mood swings have disappeared.
Adenoiditis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.4
7.5
Improved mood
Most Useful Review
3 people found this helpful
In order not to hurt, I had problems with my immunity, frequently experiencing colds, sore throats, and conjunctivitis. I discovered vitamin D3 online and, after testing low levels, ordered it, finding Moscow prices exorbitant. I've been taking it for six months. I did experience a slight temperature and cough, but I managed well without being bedridden for a week as before. My mood has improved, and my nails have stopped flaking. Once I finish the jar, I’ll get tested again, and if results are normal, I’ll continue taking it in lower doses for prevention. The results take about a week or two to notice. Overall, I recommend this!
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Good
Based on 6 Reviews
8.4
8
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
9
No side effects
Most Useful Review
11 people found this helpful
This vitamin D is the first that has worked for me! Previously, I had tried three different brands that either caused allergies or were ineffective. With my confirmed deficiency, I required over 3000 IU, which caused skin issues. My children have similar reactions. Only Solgar has been suitable with no side effects. I can take 5000 IU comfortably, and throughout autumn, I didn’t catch any colds or allergies. It’s a powerful remedy for immunity, and I plan to continue using it in winter.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.4
9
We explored the effect of vitamin D3 supplementation on anxiety levels among elderly individuals diagnosed with prediabetes. In our study, we randomly assigned participants to receive either a weekly dose of 25,000 IU of vitamin D3 or a placebo, alongside general lifestyle recommendations. Over the course of 12 months, we measured anxiety levels using standardized assessments.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
9
Life-changing vitamins
Most Useful Review
3 people found this helpful
Excellent Quality. I highly recommend these vitamins to anyone struggling with anxiety. After discovering my deficiencies in vitamins D3 and B12, which contributed to my anxiety and depression, I started taking them. Within a few months, I felt my life transform and was able to engage with society again.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.4
USERS' SCORE
Good
Based on 19 Reviews
8.4
0
We conducted a study to see if high-dose vitamin D3 could improve vascular health and reduce fatigue in individuals suffering from chronic fatigue syndrome (CFS). This was a well-structured trial involving 50 participants, all of whom met specific diagnostic criteria for CFS. Participants were divided into two groups: one received 100,000 units of vitamin D3 every two months, while the other received a placebo over a period of six months.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
9
Fatigue reduction noted
Most Useful Review
42 people found this helpful
I recommend this concentration of D3 for children. I’ve found that the dosage is essential for combating chronic fatigue syndrome. Higher doses have shown positive effects like increased energy and immune function.
Common Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 17 Reviews
8.4
8
We explored the connection between vitamin D levels and the frequency of upper respiratory tract infections (URTI) in physically active individuals throughout different seasons. In our research, we observed over 1,600 military recruits during their basic training, noting that only 21% were vitamin D sufficient during winter. Alarmingly, those who had sufficient vitamin D levels were found to be 40% less likely to experience URTIs compared to their deficient counterparts, suggesting that maintaining adequate vitamin D may be crucial for better respiratory health during demanding training periods.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
10
Energy boost
Most Useful Review
7 people found this helpful
This is brilliant! After a month of taking it for a serious deficiency, I feel energised, my mood has improved, and my general health has enhanced. My immunity is much stronger now, and I recommend it to everyone. I'm amazed by the results and will keep ordering for my family.
Flu details
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.7
USERS' SCORE
Good
Based on 11 Reviews
8.4
8
We explored the potential benefits of vitamin D supplementation for reducing the risk of influenza infections. Through a comprehensive analysis of multiple Randomized Controlled Trials (RCTs), we aimed to clarify whether taking vitamin D can help prevent the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
9
Energy boost
Most Useful Review
7 people found this helpful
This is absolutely incredible! After a month of taking it, I discovered a severe deficiency (level 14) but now feel energised and ready for anything. My mood has improved immensely, and I believe my immunity benefited, especially through the cold and flu season. I plan to continue taking it and will order it for my entire family. I'm truly astonished by the results and wholeheartedly recommend it to everyone!
Hair Loss details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
USERS' SCORE
Good
Based on 8 Reviews
8.4
9
This study dives into how 1,25-(OH)D, a potent form of vitamin D, influences hair growth. Through a combination of experiments in live mice, hair follicle organ culture, and detailed cellular investigations, we uncovered that this vitamin enhances hair regeneration.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
9
Noticeable effect
Most Useful Review
9 people found this helpful
Jamil Voronin This is something incredible! I've just started taking these vitamins recently, and the effect is already noticeable! I can say that this is simply miraculous - ideal for those suffering from hair loss, I recommend them for autumn.
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8.4
8
Vitamin D benefits for insomnia
We set out to explore the relationship between vitamin D and insomnia by examining how low-fat milk and yogurt fortified with 1,500 IU of nano-encapsulated vitamin D could improve sleep issues and overall quality of life.
In our analysis, we included adults with abdominal obesity and a history of insomnia, identifying twenty-nine participants through insomnia severity questionnaires. They were split into four groups: one receiving fortified low-fat milk, another with unfortified milk, a third group consuming fortified yogurt, and a fourth with unfortified yogurt. Over a ten-week period, we tracked changes in insomnia symptoms and quality of life.
Our findings revealed that those drinking the vitamin D fortified milk experienced significant improvements in insomnia scores compared to those consuming regular milk. Additionally, quality of life assessments showed positive changes for both fortified and unfortified milk groups. However, the yogurt groups did not demonstrate significant benefits, indicating that while fortified dairy has potential, yogurt may not be as effective in this context.
In conclusion, incorporating fortified low-fat milk into our diets could help ease insomnia symptoms and enhance life satisfaction, although yogurt did not show the same promise.
In our analysis, we included adults with abdominal obesity and a history of insomnia, identifying twenty-nine participants through insomnia severity questionnaires. They were split into four groups: one receiving fortified low-fat milk, another with unfortified milk, a third group consuming fortified yogurt, and a fourth with unfortified yogurt. Over a ten-week period, we tracked changes in insomnia symptoms and quality of life.
Our findings revealed that those drinking the vitamin D fortified milk experienced significant improvements in insomnia scores compared to those consuming regular milk. Additionally, quality of life assessments showed positive changes for both fortified and unfortified milk groups. However, the yogurt groups did not demonstrate significant benefits, indicating that while fortified dairy has potential, yogurt may not be as effective in this context.
In conclusion, incorporating fortified low-fat milk into our diets could help ease insomnia symptoms and enhance life satisfaction, although yogurt did not show the same promise.
9
Resolved insomnia
Most Useful Review
4 people found this helpful
I started taking vitamin D3 in Moscow without testing my levels, as I knew there was a deficiency here. After a week or two of taking 50 mcg daily, my insomnia improved significantly; I no longer needed sleeping pills. My monthly cycle also stabilised. Within three months, my herpes outbreaks decreased considerably.
Psoriasis details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.4
8
Vitamin D3 ethosomal gel for psoriasis
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
9
Improved psoriasis treatment
Most Useful Review
2 people found this helpful
I took 2000 units during pregnancy for my psoriasis, and the difference was noticeable; my psoriatic plaques improved, and my hair hardly fell out. There is a clear distinction between this vitamin D3 and others from NOW.
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
No sun allergies
Most Useful Review
Wonderful vitamins. I purchased these on the recommendation of a gynaecologist in November 2019, as I live in an area with very few sunny days each year. Prior to taking VitD, I experienced constant fatigue and drowsiness. After two weeks, the drowsiness disappeared, and I gained more energy. This summer, for the first time in seven years, I had no allergies to the sun (usually after sunbathing, I would develop rashes and itching). My tan also became brighter and more lasting. I believe this occurred because my body received VitD during winter and autumn, so it did not react adversely to the sun's sudden appearance. Overall, I am pleased with Solgar vitamins, hence my purchase of two packs, sufficient until summer.
Acne details
SCIENTIFIC SCORE
Questionable
Based on 22 Researches
6.9
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
We examined how vitamin D levels relate to acne and the potential connection with acne severity. By analyzing data from various studies, we found that 1,362 individuals with acne were compared against 1,081 healthy controls.
Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.
This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.
Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.
This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.
7.5
No side effects
Most Useful Review
11 people found this helpful
Solgar is the first vitamin D that worked for me! Previously, I tried three different brands, but they either caused allergies or had no effect. I needed to take more than 3000 IU, but with others, I broke out with acne. My children have a similar reaction. Only Solgar had no side effects, and I can take 5000 IU easily. It has significantly boosted my immunity, and I managed to avoid ARVI and Kovid despite exposure. I'll continue taking it through winter!
Bacterial Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.3
9
Significant health improvements
Most Useful Review
I have been taking Solgar D3 for over six months, and my immune system has significantly improved. At 68, I noticed my immune system declining, especially after an ear infection I couldn’t shake off. I bought Solgar D3 gelcaps at 1000 IU to increase my intake until I felt a difference. I’m doing remarkably well, with many improvements in my overall health.
Breast Cancer details
SCIENTIFIC SCORE
Questionable
Based on 29 Researches
6.8
USERS' SCORE
Good
Based on 3 Reviews
8.3
8
We examined the relationship between vitamin D intake and breast cancer, delving into how this vitamin may play a role in prevention and management. The findings suggest that vitamin D may have a protective effect, potentially lowering the risk of developing breast cancer.
While we found a notable connection, it’s important to recognize that most of the existing evidence comes from observational studies. This means we can identify associations but cannot definitively say that vitamin D causes these effects.
Additionally, there are several complexities in studying vitamin D, such as varying metabolism and differences in study designs, which make drawing firm conclusions challenging.
Although the research provides intriguing insights, more rigorous studies are necessary to truly clarify how vitamin D could be integrated into breast cancer care moving forward.
While we found a notable connection, it’s important to recognize that most of the existing evidence comes from observational studies. This means we can identify associations but cannot definitively say that vitamin D causes these effects.
Additionally, there are several complexities in studying vitamin D, such as varying metabolism and differences in study designs, which make drawing firm conclusions challenging.
Although the research provides intriguing insights, more rigorous studies are necessary to truly clarify how vitamin D could be integrated into breast cancer care moving forward.
7.5
Health benefits noted
Most Useful Review
8 people found this helpful
No vitamin promotes health like vitamin D (D3/cholecalciferol). Research suggests it may help prevent SARS and upper respiratory infections. Studies show those with higher vitamin D levels have a lower risk of heart attack, breast cancer, colon cancer, and diabetes. I purchased vitamin D3 during the pandemic. The capsules are small and easy to swallow, ideally consumed with fatty foods. If you find my review helpful, please click Yes. Thank you!
Ear Infection details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
USERS' SCORE
Good
Based on 3 Reviews
8.3
8
We explored the relationship between vitamin D (VD) supplementation and the risk of ear infections, specifically in children who frequently suffer from acute otitis media (AOM). The study involved 116 children with a history of recurrent ear infections, who were randomly assigned to receive either a daily dose of 1000 IU of vitamin D or a placebo for four months. Their number of AOM episodes was monitored for six months after the treatment period.
Our findings were quite revealing: the children who received vitamin D supplements had a significantly lower incidence of AOM compared to those who were given the placebo. Specifically, only 26 children in the vitamin D group experienced at least one episode of AOM, versus 38 in the placebo group—a notable difference that became even more pronounced when looking specifically at uncomplicated AOM cases.
We concluded that vitamin D deficiency is common among children who frequently experience ear infections. By restoring serum vitamin D levels to above 30 ng/mL through supplementation, we observed a significant reduction in the risk of uncomplicated AOM. This suggests that vitamin D could play a beneficial role in managing ear infections in children prone to these issues.
Our findings were quite revealing: the children who received vitamin D supplements had a significantly lower incidence of AOM compared to those who were given the placebo. Specifically, only 26 children in the vitamin D group experienced at least one episode of AOM, versus 38 in the placebo group—a notable difference that became even more pronounced when looking specifically at uncomplicated AOM cases.
We concluded that vitamin D deficiency is common among children who frequently experience ear infections. By restoring serum vitamin D levels to above 30 ng/mL through supplementation, we observed a significant reduction in the risk of uncomplicated AOM. This suggests that vitamin D could play a beneficial role in managing ear infections in children prone to these issues.
7.5
Notable improvement
Most Useful Review
7 people found this helpful
Excellent results from this product! My husband and I took it alongside Omega 3 based on our doctor's recommendation. We didn’t expect noticeable improvements in our general condition and mood until three weeks in. After four months, we both experienced increased working capacity and noticed a reduction in weight. We plan to continue at a therapeutic dose in the cold season, and everyone we've recommended this to has also reported improvements. Solgar consistently delivers high-quality products, and this one is no exception.
Hypertension details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.3
9
We explored the role of calcitriol, the active form of vitamin D, in addressing age-related hypertension. The study involved young and aged male mice, where we administered calcitriol daily for eight weeks. Our goal was to determine if this vitamin could effectively lower high blood pressure that often comes with aging.
Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.
Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.
Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.
Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.
Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.
Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.
7.5
Health benefits noted
Most Useful Review
8 people found this helpful
No vitamin enhances health or well-being like vitamin D (vitamin D3 or cholecalciferol). Research indicates that it may play a vital role in preventing SARS and upper respiratory infections. Studies show that individuals with higher levels of vitamin D have a reduced risk of heart attack, breast cancer, colon cancer, multiple sclerosis, type 1 and type 2 diabetes, and hypertension. I bought vitamin D3 during the pandemic; the capsules are small and easy to swallow, ideally taken with fatty foods.
Menopause details
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.9
USERS' SCORE
Good
Based on 8 Reviews
8.3
8
Vitamin D supports bone health
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
9
Supports menopause symptoms
Most Useful Review
I take one capsule daily with meals, prescribed for those over 18. It includes 15 mg of vitamin D3, which helps regulate insulin and thyroid hormones, and balances blood sugar. It alleviates menopausal symptoms and promotes conception, pregnancy, and fetal immunity. It also aids recovery post-childbirth and helps with PMS. This vitamin benefits vision, concentration, and memory.
Nausea details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Good
Based on 8 Reviews
8.3
8
Vitamin D and nausea in gastroparesis
We delved into an intriguing question: how do low vitamin D levels affect nausea in people experiencing gastroparesis, a condition that slows gastric emptying? By measuring the vitamin D levels of patients from the Gastroparesis Clinical Consortium Registry, we aimed to uncover the relationships between vitamin D, nausea, and gastric function.
Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
9
No nausea experienced
Most Useful Review
1 people found this helpful
It is excellent and does not cause nausea. I consume it every morning or after a substantial meal, taking a grain daily.
Premenstrual Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.3
10
Eliminated PMS symptoms
Most Useful Review
I love this dietary supplement and will take it regularly, especially in winter. There are several reasons: speeds recovery from illnesses, heals skin quickly, completely eliminates PMS and its symptoms including migraines and mood swings, strengthens nails, and improves my back's condition. My back has become stronger and I feel much better, which has increased my performance significantly, showing real results since using this vitamin.
Tonsillitis details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
We aimed to understand the link between vitamin D deficiency and recurrent acute tonsillitis in children. In our study, we gathered data from 242 children suffering from repeated bouts of tonsillitis and compared it with a control group of 262 healthy children.
Our findings revealed that the average vitamin D levels were significantly lower in those with recurrent tonsillitis. Through detailed statistical analysis, we discovered that as vitamin D levels increased, the number of tonsillitis episodes decreased. Specifically, for every increase of one unit in vitamin D, we saw a 3.1% reduction in occurrences of tonsillitis each year.
These results strongly suggest that vitamin D deficiency may contribute to more frequent episodes of tonsillitis in children. To further enhance our understanding, we recommend future trials to explore the potential benefits of vitamin D supplementation for those frequently affected by this condition.
Our findings revealed that the average vitamin D levels were significantly lower in those with recurrent tonsillitis. Through detailed statistical analysis, we discovered that as vitamin D levels increased, the number of tonsillitis episodes decreased. Specifically, for every increase of one unit in vitamin D, we saw a 3.1% reduction in occurrences of tonsillitis each year.
These results strongly suggest that vitamin D deficiency may contribute to more frequent episodes of tonsillitis in children. To further enhance our understanding, we recommend future trials to explore the potential benefits of vitamin D supplementation for those frequently affected by this condition.
9
Effective treatment
Most Useful Review
This is my favourite vitamin from my preferred brand. As a student-pharmacist, I truly appreciated Solgar. I take D3 to support my immunity due to chronic tonsillitis, which has not troubled me for over two years. I believe this vitamin D3 has greatly contributed to that improvement.
Blurred Vision details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.2
7.5
Vision improvement
Most Useful Review
The quality is evident from the first use; the natural ingredients have noticeably improved my vision. There are no side effects, and the taste is pleasant and easy to consume. I feel calmer with tangible benefits for my nervous system. The capsules are small and easy to swallow, with a flavour reminiscent of berries, much like candy. The quality is exceptional, and I can confirm the vitamins are effective.
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.5
USERS' SCORE
Good
Based on 10 Reviews
8.2
8
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
9
Effective for bone density
Most Useful Review
4 people found this helpful
This product is great! It's easy to swallow and has no aftertaste. Due to lower bone density from radiation treatment for cancer, I take these alongside calcium supplements, ensuring my Vitamin D intake stays healthy.
Back Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.6
USERS' SCORE
Good
Based on 14 Reviews
8.1
9
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
9
Relieved back pain
Most Useful Review
4 people found this helpful
After childbirth, I had pubic area pain. My doctor prescribed calcium with vitamin D, but I realised I consumed enough calcium. It was vitamin D that corrected my deficiency and helped with calcium absorption. After two weeks, I felt relief, and the pain disappeared. Now I take one capsule daily for prevention. This vitamin also supports the immune system.
Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
USERS' SCORE
Good
Based on 51 Reviews
8.1
8
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
9
Impressive results
Most Useful Review
5 people found this helpful
Very effective D3! After long-term use from September to May, my husband and I took 1 capsule in the morning and evening with meals. The result: convenient 1000 dosage maintained prevention; I didn't get sick, just a runny nose occasionally. My lower back pain vanished! Thus, we will stock up for the cold period, ensuring we have Solgar D3. I’m very pleased with the quality, convenient dosages, and pricing! Thanks.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7
USERS' SCORE
Good
Based on 9 Reviews
8.1
9
Vitamin D3 improves depressive symptoms
We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
7.5
Emotional support
Most Useful Review
4 people found this helpful
I believe it assisted our family during a challenging period. We took one capsule twice daily from December to mid-March. We initially felt drained and emotionally exhausted due to a significant family crisis. After starting the Solgar D3 and Omega California, I was surprised by the boost in my energy and mood by February, allowing me to return to work.
Diabetes details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.1
2
Vitamin D3 shows no diabetes benefit
We conducted a thorough investigation to understand how vitamin D3 supplementation influences the risk of developing type 2 diabetes in healthy older adults. Over the course of five years, we carried out a randomized, placebo-controlled trial involving 2,271 participants aged 60 and over. This diverse group of adults was free from cardiovascular disease and cancer, ensuring a focus on individuals not at high risk for diabetes.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
7.5
Cancer risk reduction
Most Useful Review
Vitamin D, particularly D3, is unparalleled in improving health. Research indicates its role in preventing respiratory infections and reducing risks of conditions like diabetes and several cancers. I started taking it during the pandemic with a daily dosage of 1000 units. It’s easy to swallow and should be taken with fatty foods for better absorption.
Cold Sores details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 5 Reviews
8
8
We explored how a specific genetic variant associated with vitamin D might influence the occurrence of cold sores, also known as Herpes Simplex Labialis (HSL). Our research involved nearly 1,800 participants from the TwinsUK registry, with a focus on a group of 595 that completed both blood tests and questionnaires regarding their cold sore experiences.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
9
Immunity improvement
Most Useful Review
7 people found this helpful
This product is fantastic! After a month of use, I noticed a significant boost in my mood and energy levels. My general health has improved dramatically, and I believe my immunity is much stronger, especially during this flu season. I’ll continue using it and have recommended it to my family and friends. The results are genuinely stunning!
Knee Pain details
SCIENTIFIC SCORE
Questionable
Based on 26 Researches
6.7
USERS' SCORE
Good
Based on 4 Reviews
8
8
We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
9
Pain relief
Most Useful Review
3 people found this helpful
Vitamin D is fantastic! I've been taking it for about 5 or 6 months. My leg bones ached and crunched before, but now Vitamin D has alleviated the pain and crunching. I take it myself and also give it to all the children!
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.6
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.9
9
We conducted a rigorous study to explore how vitamin D3 supplementation might influence headaches in people suffering from migraines. By utilizing a well-structured, placebo-controlled, double-blind design, we included 80 participants with episodic migraines, assigning them either a daily dose of vitamin D3 or a placebo for 12 weeks.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
9
No headache side effect
Most Useful Review
1 people found this helpful
Simply the best quality vitamin D I can find that isn't sourced from lanolin. This product is of high quality and does not induce a headache like Lanolin-sourced vitamin D.
Heart Disease details
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.7
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
7
Vitamin D's role in heart health
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
9
Improved immunity
Most Useful Review
1 people found this helpful
VITAMIN D3 is essential for immunity and bone health! After discovering low levels of vitamin D3, I took this for three months. My results normalised, and I felt a boost in energy and mood. Solgar's quality is reliable, and studies confirm D3's role in reducing risks of heart disease and other ailments. It works with K2 and fatty foods for optimal absorption. With winter sun exposure lacking, I find supplementation vital, especially for those facing heart disease risks. I genuinely recommend this product!
Osteoporosis details
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.9
8
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
9
Stronger immunity
Most Useful Review
1 people found this helpful
Vitamin D3 is essential for immunity and bone health. After three months of use, my levels normalised, and my health improved significantly. I felt energised and positive, and I firmly believe that this vitamin helps prevent osteoporosis and boosts overall bodily functions, especially during the winter months when sunlight is scarce.
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.9
9
Pelvic pain relief
Most Useful Review
4 people found this helpful
After childbirth, I experienced pelvic pain. My gynaecologist recommended calcium with vitamin D. I realised my diet was sufficient in calcium, but vitamin D corrected my deficiency. After two weeks, I felt considerable relief, and the pain completely disappeared. I now take one capsule daily for prevention, maintaining the 1000 units recommended. The capsules are small, and it’s best to take them with plenty of water. This vitamin also supports the immune system.
Cardiovascular Disease details
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.9
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.8
9
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
9
Improved immunity
Most Useful Review
1 people found this helpful
Vitamin D3 is essential for immunity and bone health. After discovering I had low levels, I took this supplement for three months, and my levels normalised. My energy and mood improved significantly, and I felt more vibrant. This vitamin D3 from Solgar has proven benefits for cardiovascular disease and overall health. It aids calcium absorption and prevents bone-related issues. Sunshine helps produce vitamin D3, but supplementation is often necessary, especially in winter. For optimal results, it's wise to take it together with vitamin K2.
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.1
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
9
We set out to evaluate what effect vitamin D3 supplementation might have on patients suffering from mild obstructive sleep apnea syndrome (OSAS). In this study, 19 adult men who were diagnosed with mild OSAS and had low vitamin D levels participated over an 8-week period. Each week, they took a sizable dose of 50,000 IU of vitamin D3 while undergoing various health assessments. We measured important factors like blood glucose, lipid profiles, and inflammation markers, along with repeated sleep monitoring through polysomnography.
By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.
Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.
By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.
Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.
6
Muscle cramping relief
Most Useful Review
No cramps or spasms; I take two to three capsules daily. It aids my sleep, especially when taken with calcium and magnesium tablets. I noticed that my muscles no longer cramp during the night, and my calves are free from cramping, which is beneficial for managing sleep apnea.
Prostate Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.7
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.5
8
Vitamin D may reduce prostate cancer mortality
We set out to understand how vitamin D signaling within prostate cancer tumors might impact patient outcomes, particularly the risk of developing lethal forms of the disease. In our exploration, we analyzed data from 404 men with primary prostate cancer over a long follow-up period, assessing specific gene expressions linked to vitamin D in their tumor tissues.
Our findings revealed a noteworthy trend: the activation of vitamin D signaling in tumors was associated with a lower chance of progressing to lethal prostate cancer. Specifically, men with higher scores indicating active vitamin D signaling had a significantly reduced risk of metastasis or prostate cancer-related death compared to those with lower scores.
Interestingly, this protective association appeared to be stronger in individuals with predicted higher levels of vitamin D in their blood and those who had a body mass index of 25 or higher. With our research providing a clearer picture of how vitamin D functions within tumors, we believe there’s a solid basis for considering vitamin D interventions as potential strategies to enhance survival outcomes for prostate cancer patients.
Our findings revealed a noteworthy trend: the activation of vitamin D signaling in tumors was associated with a lower chance of progressing to lethal prostate cancer. Specifically, men with higher scores indicating active vitamin D signaling had a significantly reduced risk of metastasis or prostate cancer-related death compared to those with lower scores.
Interestingly, this protective association appeared to be stronger in individuals with predicted higher levels of vitamin D in their blood and those who had a body mass index of 25 or higher. With our research providing a clearer picture of how vitamin D functions within tumors, we believe there’s a solid basis for considering vitamin D interventions as potential strategies to enhance survival outcomes for prostate cancer patients.
6
Good for cancer
Most Useful Review
I bought it as it's beneficial for cancer patients.
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.4
9
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
9
Bone pain relief
Most Useful Review
14 people found this helpful
Vitamin D3 is an excellent antioxidant and a good bone pain relief supplement. After taking it for three weeks, I felt more energetic and less anxious. The results are impressive, and the quality is excellent! I highly recommend it.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.3
USERS' SCORE
Medium or Average
Based on 25 Reviews
6.4
9
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
9
Effective treatment plan
Most Useful Review
53 people found this helpful
After three months of taking vitamin D-3 due to low levels, I saw an increase from 17 to 39 ng/ml. My endocrinologist suggested this dosage approach, combining natural and synthetic forms. It’s crucial to monitor levels regularly to stay within limits. Vitamin D-3 serves as an immunomodulator, highlighting its importance for my autoimmune disorder management. I trust Solgar for its quality in cleaning cod liver oil.
