Solgar Vitamin D3 25 mcg (1000 IU)

CYP11A1, Autism Symptoms, Vitamin D3

Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention.

Most Relevant Research

We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.

Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.

Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.

9.5

Life-changing vitamins

Most Useful Review

Excellent Quality. I highly recommend these vitamins to anyone struggling with anxiety. After discovering my deficiencies in vitamins D3 and B12, which contributed to my anxiety and depression, I started taking them. Within a few months, I felt my life transform and was able to engage with society again.

Asthma

Vitamin D3 improves asthma control

Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials.

Most Relevant Research

We explored the effectiveness of vitamin D3 in reducing asthma exacerbations among children through a systematic review and meta-analysis of randomized controlled trials. In our investigation, we analyzed data from ten studies, which included a total of 1,243 children with asthma. Among these, 631 received vitamin D3 supplementation while 612 were given a placebo.

Our pooled analysis revealed promising results: vitamin D3 supplementation significantly reduced the overall number of asthma exacerbations. Specifically, we found a risk ratio of 0.62, indicating a notable decrease in attacks. Notably, a subgroup analysis showed that children receiving the standard daily dose of vitamin D experienced an even more significant improvement, with a risk ratio of 0.41.

Overall, we concluded that vitamin D3 supplementation holds the potential to lower asthma exacerbations in children. This is particularly encouraging as it also correlates with improved lung function, measured through FEV1. Hence, vitamin D3 could be a valuable addition to asthma management for young patients.

9.5

Significant asthma improvement

Most Useful Review

Helped my asthma! I've struggled with allergic asthma due to grass for years. Skeptical at first, I tried increasing my vitamin D intake after reading studies on its effects on asthma. To my astonishment, I began feeling relief after just weeks! My asthma has decreased significantly. After consulting my doctor, we've adjusted my dosage, and I'm hopeful for even more improvement!

Blood Clot

Vitamin D may influence blood clotting

Based on 9 Researches

Relationship between vitamin D deficiency and thrombus load in patients with ST-elevation myocardial infarction.

Most Relevant Research

We explored the connection between vitamin D levels and coronary thrombus load in patients who experienced ST-elevation myocardial infarction (STEMI). The study included 77 patients where we measured serum vitamin D levels, thrombus degree, and other relevant factors.

Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.

Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.

Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.

9.5

Boosted blood circulation

Most Useful Review

Vitamin D3 helps improve blood clotting and enhances cell sensitivity to insulin. It supports nerve fibre regeneration, boosts immune function, and reduces cholesterol build-up in blood vessels.

High Cholesterol

Vitamin D3 lowers cholesterol levels

Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity.

Most Relevant Research

We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.

After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.

Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.

Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.

9.5

Improves health

Most Useful Review

This high-quality dietary supplement has worked wonders for my hair loss and bone pain. Recommended by my doctor to improve immunity, I noticed health improvements within days, including better skin and hair. It's miraculous, and I plan to continue taking it.

Insomnia

Vitamin D3 improves adolescent insomnia

Based on 3 Researches

High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls.

Most Relevant Research

We studied how high-dose vitamin D3 supplementation might affect insomnia in adolescent girls. Over nine weeks, 940 participants received a weekly dose of 50,000 IU of vitamin D3 while we tracked changes in their sleep patterns.

Interestingly, we observed a notable reduction in insomnia rates after the treatment. The number of girls reporting insomnia dropped from 15.0% to 11.3%, indicating that this vitamin can potentially improve sleep quality.

We also noticed a slight decrease in daytime sleepiness, with cases falling from 15.6% to 14.7%. Furthermore, those experiencing both insomnia and sleepiness saw a decline from 8.0% to 6.1%.

These findings suggest that high-dose vitamin D can play a significant role in alleviating sleep issues among adolescent girls. However, further studies are needed to see if these effects are consistent across diverse age and gender groups.

9.5

Resolved insomnia

Most Useful Review

I started taking vitamin D3 in Moscow without testing my levels, as I knew there was a deficiency here. After a week or two of taking 50 mcg daily, my insomnia improved significantly; I no longer needed sleeping pills. My monthly cycle also stabilised. Within three months, my herpes outbreaks decreased considerably.

Acne

Vitamin D analogs reduce acne effectively

Based on 10 Researches

Identification of a unique subset of 2-methylene-19-nor analogs of vitamin D with comedolytic activity in the rhino mouse.

Most Relevant Research

We explored the effects of vitamin D and its analogs on acne, primarily focusing on their ability to reduce the size of comedones (or acne lesions) in a rhino mouse model. This study evaluated the active form of vitamin D, known as 1,25-dihydroxyvitamin D(3), along with several modified analogs.

All analogs tested, including the natural hormone, increased the thickness of skin. However, only a particular group of analogs without a full side chain and 25-hydroxyl group were effective in actually reducing comedone size. Notably, this reduction in acne did not negatively impact serum calcium levels, which is a common concern with vitamin D treatments.

Interestingly, while all compounds featuring a side chain of 2 to 5 carbons worked similarly in terms of comedolytic activity, longer chains tended to increase calcemic risk. Moreover, our findings indicated that increasing the epidermal thickness required a lower dose compared to what was needed for comedolysis. This identifies a distinct set of vitamin D analogs that can help manage acne without the side effects of hypercalcemia.

Overall, we highlighted how certain vitamin D analogs can combat acne effectively while minimizing potential risks related to calcium levels.

8.8

No side effects

Most Useful Review

Solgar is the first vitamin D that worked for me! Previously, I tried three different brands, but they either caused allergies or had no effect. I needed to take more than 3000 IU, but with others, I broke out with acne. My children have a similar reaction. Only Solgar had no side effects, and I can take 5000 IU easily. It has significantly boosted my immunity, and I managed to avoid ARVI and Kovid despite exposure. I'll continue taking it through winter!

Arthritis

Vitamin D3's role in OA prevention

Based on 10 Researches

1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.

Most Relevant Research

We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.

When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.

Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.

9.5

Reduces arthritis signs

Most Useful Review

Removes signs of early arthritis in three to four weeks. It has been tested repeatedly!

Heartburn

Improved blood counts

Most Useful Review

Super vitamin D3 has been excellent for me. I’ve taken two packs and experienced no heartburn, and my blood counts have improved. I highly recommend this product.

Hives

Vitamin D3 aids chronic hives

Resolution of chronic urticaria coincident with vitamin D supplementation.

Most Relevant Research

We explored the potential benefits of vitamin D3 supplementation specifically for individuals experiencing chronic hives. This study focused on the direct impact of vitamin D3, allowing us to isolate its effects from other treatments.

Over the course of the study, we observed significant improvements in symptoms among participants who received vitamin D3. Many reported a noticeable reduction in hives, suggesting that vitamin D3 may help alleviate this bothersome condition.

The findings point towards vitamin D3 as an effective treatment option for managing chronic urticaria. This could offer new hope for those who have struggled with persistent hives, emphasizing the importance of considering vitamin D levels in treatment strategies.

9.5

Hives relief

Most Useful Review

Good, I take these every day. The dosage is just right – not too much or too little. I usually experience hives when taking vitamin D, but these vitamins do not cause that reaction. I highly recommend them.

Leg Cramps

Vitamin D is fantastic! After taking it for about 5 or 6 months, my leg cramps and discomfort disappeared. Now, I take it not only for myself but also for all the children.

Migraine

Vitamin D3 improves migraine symptoms

Based on 13 Researches

Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.

Most Relevant Research

We explored the potential benefits of vitamin D3 supplementation for people suffering from migraines. In a carefully designed study, 80 individuals with episodic migraines participated in a 12-week trial where they were randomly assigned to receive either 2000 IU (50 μg) of vitamin D3 daily or a placebo.

Throughout the study, we closely monitored headache characteristics using diaries and measured various serum inflammatory markers before and after the trial. Our findings showed that those taking vitamin D3 experienced significant improvements. They reported fewer headache days each month, shorter headache durations, and less severe pain overall when compared to the placebo group.

Interestingly, while the levels of some inflammatory markers didn't change much, we did notice a striking reduction in a certain enzyme linked to inflammation in the vitamin D3 group. Additionally, there was a trend toward lower levels of another inflammation marker, suggesting that vitamin D3 might offer a protective effect against neuro-inflammation in migraine sufferers.

In essence, our study indicates that vitamin D3 could be a promising supplemental treatment to help improve the quality of life for those battling episodic migraines.

9.5

No more migraines

Most Useful Review

This dietary supplement has significantly improved my life, especially regarding migraine relief during PMS. I've also noticed quicker recovery from illnesses and rapid healing of skin lesions. My nails are stronger, and my back pain has reduced. Overall, I feel more energetic and my mood swings have disappeared.

Osteoporosis

Vitamin D derivatives enhance bone health

Based on 14 Researches

Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.

Most Relevant Research

We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.

One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.

We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.

9.5

Stronger immunity

Most Useful Review

Vitamin D3 is essential for immunity and bone health. After three months of use, my levels normalised, and my health improved significantly. I felt energised and positive, and I firmly believe that this vitamin helps prevent osteoporosis and boosts overall bodily functions, especially during the winter months when sunlight is scarce.

Psoriasis

Vitamin D3 ethosomes for psoriasis

Based on 7 Researches

Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.

Most Relevant Research

We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.

In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.

Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.

9.5

Improved psoriasis treatment

Most Useful Review

I took 2000 units during pregnancy for my psoriasis, and the difference was noticeable; my psoriatic plaques improved, and my hair hardly fell out. There is a clear distinction between this vitamin D3 and others from NOW.

Tonsillitis

Vitamin D3 improves tonsillitis outcomes

Likely Very Effective

Impact of vitamin D in children with chronic tonsillitis (immunohistochemical study of CD68 polarisation and proinflammatory cytokines estimation).

Most Relevant Research

We conducted a study to explore the impact of vitamin D3 on children suffering from chronic tonsillitis, particularly those with low vitamin D levels. Our research involved 80 children, dividing them into two groups—one received vitamin D3 and the other received a placebo. This setup allowed us to compare the effects of the treatment effectively and observe any significant changes in their condition.

After administering vitamin D3 weekly for 3 to 6 months, we saw a noticeable improvement compared to those on the placebo. The vitamin D group had significantly higher serum levels of vitamin D, while the children on placebo showed elevated levels of inflammatory markers, indicating a more severe state of illness. Interestingly, those taking vitamin D3 had better histological results, with fewer pro-inflammatory cells present in their tonsils.

Overall, our findings suggest that vitamin D3 can have a beneficial effect on chronic tonsillitis in children, potentially reducing inflammation and improving overall tonsil health. This opens up new avenues for considering vitamin D as a supportive treatment for children fighting this condition.

9.5

Effective treatment

Most Useful Review

This is my favourite vitamin from my preferred brand. As a student-pharmacist, I truly appreciated Solgar. I take D3 to support my immunity due to chronic tonsillitis, which has not troubled me for over two years. I believe this vitamin D3 has greatly contributed to that improvement.

Allergies

Vitamin D3 impacts allergy severity

Based on 5 Researches

Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis.

Most Relevant Research

We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.

Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.

Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.

9.5

No side effects

Most Useful Review

This vitamin D is the first that has worked for me! Previously, I had tried three different brands that either caused allergies or were ineffective. With my confirmed deficiency, I required over 3000 IU, which caused skin issues. My children have similar reactions. Only Solgar has been suitable with no side effects. I can take 5000 IU comfortably, and throughout autumn, I didn’t catch any colds or allergies. It’s a powerful remedy for immunity, and I plan to continue using it in winter.

Back Pain

Vitamin D3 improves back pain

Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial.

Most Relevant Research

We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.

Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.

The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.

Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.

9.5

Relieved back pain

Most Useful Review

After childbirth, I had pubic area pain. My doctor prescribed calcium with vitamin D, but I realised I consumed enough calcium. It was vitamin D that corrected my deficiency and helped with calcium absorption. After two weeks, I felt relief, and the pain disappeared. Now I take one capsule daily for prevention. This vitamin also supports the immune system.

Cancer

Vitamin D3 offers anti-cancer benefits

Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.

Most Relevant Research

We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.

We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.

Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.

We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.

9.5

Effective for bone density

Most Useful Review

This product is great! It's easy to swallow and has no aftertaste. Due to lower bone density from radiation treatment for cancer, I take these alongside calcium supplements, ensuring my Vitamin D intake stays healthy.

Chronic Cough

I had issues with immunity, suffering from various ailments like chronic cough and sore throats. I discovered vitamin D3 online and tested low levels. After six months of taking it, I noticed fewer symptoms; I experienced a slight rise in temperature and chronic cough, but I recovered quickly. My mood has improved, and my nails no longer flake. Once I finish my current jar, I plan to retest and possibly continue a lower dose for prevention. The results took time to show but are definitely worth it.

Depression

Vitamin D3 improves depressive symptoms

Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial.

Most Relevant Research

We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.

After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.

This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.

8.8

Emotional support

Most Useful Review

I believe it assisted our family during a challenging period. We took one capsule twice daily from December to mid-March. We initially felt drained and emotionally exhausted due to a significant family crisis. After starting the Solgar D3 and Omega California, I was surprised by the boost in my energy and mood by February, allowing me to return to work.

Dizziness

Vitamin D treatment reduces BPPV

Based on 7 Researches

Reduction of recurrence rate of benign paroxysmal positional vertigo by treatment of severe vitamin D deficiency.

Most Relevant Research

We sought to understand the impact of severe vitamin D deficiency on benign paroxysmal positional vertigo (BPPV), a common cause of dizziness. Previous studies showed a connection between low vitamin D levels and both the onset and recurrence of BPPV, but none had conclusively demonstrated that addressing this deficiency could lessen the recurrence of symptoms.

To examine this further, we included patients diagnosed with unilateral, idiopathic posterior canal BPPV and severe vitamin D deficiency, indicated by levels of 25-hydroxyvitamin D3 at or below 10 ng/ml. After thorough evaluations including hearing tests and balance assessments, we prescribed vitamin D therapy to our participants.

Over the following months, we monitored the changes in their vitamin D levels and followed up with them for 18 months to observe any recurrence of dizziness. Our findings revealed that patients who showed an improvement in their vitamin D levels experienced a significant reduction in the recurrence of BPPV symptoms.

This suggests that by addressing vitamin D deficiency, we can potentially offer a more effective approach to managing BPPV—lessening those troublesome dizzy spells that can really impact quality of life.

8.8

Dizziness improvement

Most Useful Review

I took Solgar D3 1000ME for severe vitamin D deficiency for two weeks. While I didn't notice drastic changes, some improvements occurred. The dizziness vanished, and I found it easier to sleep and wake up. My weakness has lessened, and I've regained strength, although some issues persist. Overall, my life feels brighter and my hair quality has improved. The quality of the product is excellent.

Eczema

Vitamin D3 improves eczema symptoms

Assessment of the Effectiveness of Vitamin Supplement in Treating Eczema: A Systematic Review and Meta-Analysis.

Most Relevant Research

We explored the potential benefits of vitamin D3 as a treatment for eczema, a condition that has been increasingly prevalent in recent years. By examining several randomized controlled trials, we were able to focus on how effective vitamin D3 might be in alleviating the symptoms of eczema, as measured by established severity indexes.

Our analysis included ten studies, with eight of them providing sufficient data for a quantitative comparison. In comparing the vitamin D3 group to control groups, we observed a significant reduction in eczema severity, evidenced by lower scores on the SCORAD and EASI scales. Specifically, participants taking vitamin D3 had a mean difference of -5.96, indicating a meaningful improvement in their symptoms.

This evidence suggests that incorporating vitamin D3 into eczema management could be beneficial. We believe this finding is important as it highlights a potential therapeutic avenue for eczema sufferers looking for effective solutions.

8.8

Effective for eczema

Most Useful Review

I purchased this product for my son who suffers from eczema, and I believe it works effectively.

Frozen Shoulder

Reduced pain significantly

Most Useful Review

Excellent! It’s lovely to see an improvement, especially with the easing of lethargy and pain in my shoulders. Previously, even after a full night’s sleep, I would still feel discomfort due to my frozen shoulder.

Hashimoto

Vitamin D3 shows limited effect

Alterations in CD4 T Cell Cytokines Profile in Female Patients with Hashimoto's Thyroiditis Following Vitamin D Supplementation: A Double-blind, Randomized Clinical Trial.

Most Relevant Research

We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 supplementation affects Hashimoto's thyroiditis (HT) in female patients. Over three months, participants received either 50,000 IU of vitamin D3 or a placebo. Our focus was on measuring changes in serum cytokine levels and gene expression in CD4+ T cells, which play a critical role in the immune response associated with autoimmune diseases like HT.

Following vitamin D3 supplementation, we observed a significant increase in serum levels of 25-hydroxyvitamin D, while serum calcium levels also rose compared to where they started. However, when checking for changes related to immune response, we noted that supplementation led to a decrease in interleukin-17 (IL-17) levels, but this change didn't differ significantly from those in the placebo group.

On the other hand, the transforming growth factor-beta (TGFβ) gene expression rose significantly with vitamin D3 treatment, yet once again, we didn't see a noticeable difference between the two groups. Importantly, there was no marked effect on other key immune markers, such as interferon-gamma and IL-4 levels. Although we did see some increase in T-bet and GATA3 transcription factors, the overall impact of vitamin D3 on Hashimoto's thyroiditis in our study suggests limited benefits.

This trial sheds light on the complex relationship between vitamin D supplementation and autoimmune conditions like Hashimoto's thyroiditis. While vitamin D3 shows some promise, further long-term studies are essential to truly understand its role and effectiveness in managing HT.

8.8

Improved symptoms

Most Useful Review

Excellent! Solgar is my favourite supplement brand due to its century-long reputation for quality. After incorporating various supplements on my doctor's advice, my symptoms related to Hashimoto's, such as fatigue and hair loss, began to improve significantly. I realised the importance of vitamin D3 and its fat-soluble nature, so I included healthy fats in my diet for better absorption. Staying hydrated throughout the day is also essential for optimising the supplements' effects.

Menopause

Vitamin D3 in menopause management

Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats.

Most Relevant Research

In this study, we explored how vitamin D3, among other supplements, affects metabolic health during menopause. The research utilized a group of ovariectomized female rats, which serve as a model for menopausal conditions in women. These rats were divided into several groups, including a control group and various groups that received different treatments, including vitamin D3.

The findings indicated that administering vitamin D3, along with boric acid, magnesium, and extra virgin olive oil, led to notable improvements in metabolic parameters. We observed benefits in areas such as inflammation and oxidative stress, which are crucial for managing health during menopause. However, while vitamin D3 showed positive effects, the study highlighted that the combination of all supplements had a more significant impact than vitamin D3 alone.

Ultimately, while vitamin D3 contributes positively to metabolic health in menopause, the full extent of its isolated benefits remains unclear without further studies. Thus, we recognize the need for additional research to fully understand how effective vitamin D3 can be independently in this context.

9.5

Supports menopause symptoms

Most Useful Review

I take one capsule daily with meals, prescribed for those over 18. It includes 15 mg of vitamin D3, which helps regulate insulin and thyroid hormones, and balances blood sugar. It alleviates menopausal symptoms and promotes conception, pregnancy, and fetal immunity. It also aids recovery post-childbirth and helps with PMS. This vitamin benefits vision, concentration, and memory.

Nausea

No nausea experienced

Most Useful Review

It is excellent and does not cause nausea. I consume it every morning or after a substantial meal, taking a grain daily.

Obesity

Vitamin D reduces triglycerides effectively

Based on 9 Researches

Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials.

Most Relevant Research

We explored the effects of vitamin D supplementation on lipid profiles in overweight and obese women. Our investigation included data from various randomized controlled trials (RCTs) that specifically examined how vitamin D might influence cholesterol and triglyceride levels in this population.

Our analysis revealed that vitamin D had a significant impact on lowering triglycerides and total cholesterol levels. We found reductions of about 6.13 mg/dL for triglycerides and 4.45 mg/dL for total cholesterol. Additionally, there was a noteworthy increase in HDL cholesterol, the “good” cholesterol, by an average of 1.54 mg/dL.

Interestingly, we noticed that those with higher baseline triglyceride levels saw even greater benefits, particularly with a significant reduction in triglycerides when vitamin D was supplemented for 26 weeks or less. However, it’s important to mention that vitamin D supplementation did not have a significant effect on LDL cholesterol levels in this group.

Overall, our findings suggest that vitamin D can be an effective option for managing certain aspects of lipid profiles in overweight or obese women, particularly in addressing high triglycerides.

Improved well-being

Most Useful Review

I decided to try this vitamin D from the liver of deep-sea fish, which contains a dosage of 25 mcg (1000 IU). Symptoms of deficiency include fatigue, frequent colds, sleep disturbances, and muscle pain. Such a deficiency can also exacerbate various diseases, including obesity. I find this supplement beneficial for enhancing my overall health and addressing these issues effectively.

Colitis

Vitamin D3 shows comparable effects

Based on 3 Researches

Daily Vitamin D3 Versus Stoss Vitamin D3 for Correction of 25OHD Deficiency in Children with Inflammatory Bowel Disease, a Randomised Controlled Trial.

Most Relevant Research

We conducted a randomized controlled trial to investigate how vitamin D3 impacts children with inflammatory bowel disease (IBD), specifically aiming to address vitamin D deficiency in those suffering from colitis.

The study compared two different treatment approaches: a low daily dose of 2000 IU of vitamin D3 and a one-time high dose of the 'stoss' therapy, where children received a significantly larger dose of 400,000 IU or 800,000 IU, depending on their age. Children in both treatment groups were monitored over 12 months for various health indicators, including 25OHD levels and clinical disease activity.

Our findings revealed that the stoss therapy was non-inferior to the daily dosing regimen in raising vitamin D levels over the study period. Importantly, there were no significant differences in vitamin D levels at any of the checkpoints—3, 6, 9, or 12 months.

This indicates that both supplementation methods can effectively address vitamin D deficiency in children with colitis. However, the study emphasizes the absence of any superior benefits from one treatment over the other.

8.8

Consistent results

Most Useful Review

Excellent quality! I need to take vitamin D, 1000 IU daily due to my ulcerative colitis. I notice a direct impact on my health and mood with Solgar, which consistently delivers positive results reflected in my blood work. It's the only brand I trust, as I’ve experienced negative effects from trying others. My colon worsens, and I feel down; however, returning to Solgar improves my condition within days. Please heed caution if taking higher doses of vitamin D, as it can lead to elevated calcium levels in the blood.

Neuropathy

Vitamin D3's protective effects on neuropathy

The therapeutic potential of 1, 25-dihydroxy vitamin D3 on cisplatin-affected neurological functions is associated with the regulation of oxidative stress and inflammatory markers as well as levels of MMP2/9.

Most Relevant Research

We examined the effects of calcitriol, the active form of vitamin D3, on neuropathy induced by the chemotherapy drug cisplatin. By administering cisplatin to male Wistar rats over a five-week period, we aimed to observe how vitamin D3 might protect against the nerve damage typically associated with cancer treatments.

Our findings revealed that cisplatin treatment led to cognitive impairments and reduced levels of brain-derived neurotrophic factor (BDNF), which is essential for nerve health. Additionally, we noted an increase in oxidative stress and inflammation, characterized by elevated levels of harmful molecules and decreased antioxidant defenses. However, when we introduced calcitriol supplementation, the detrimental effects seemed to lessen. It improved memory function and partially restored nerve function, evidenced by enhanced sensory nerve conduction.

Furthermore, we found that calcitriol helped to balance oxidative stress and inflammation, reducing markers associated with nerve damage. Overall, our study suggests that vitamin D3 could be a promising option for mitigating nerve damage caused by chemotherapy, highlighting its potential as a neuroprotective agent worth further exploration.

8.8

Easy to take

Most Useful Review

My husband has diabetic neuropathy in his feet, and these are easy for him to swallow, particularly as he has difficulty swallowing (dysphagia). They are part of his regimen, along with other supplements.

Ulcer

Vitamin D3 improves ulcer healing

Based on 15 Researches

Improved Healing of Diabetic Foot Ulcers After High-dose Vitamin D: A Randomized Double-blinded Clinical Trial.

Most Relevant Research

We set out to explore how different doses of vitamin D3, specifically Cholecalciferol, impact the healing of chronic diabetic foot ulcers. Our study included patients with diabetes who had one or more foot ulcers present for longer than six weeks. We assigned participants at random to receive either a high dose of 170 micrograms or a low dose of 20 micrograms daily. Throughout the experiment, both patients and assessors were kept unaware of who was receiving which treatment to ensure unbiased results.

Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.

In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.

8.8

Consistent results

Most Useful Review

Excellent quality. I take vitamin D, 1000 IU daily due to my ulcerative colitis. I notice a significant improvement in my health and mood with Solgar. When I switch to other brands, I can feel a decline in my condition quickly. Once back on Solgar, I feel better within days.

Chronic Fatigue Syndrome

Vitamin D3 ineffective for CFS

Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.

Most Relevant Research

We conducted a thorough investigation into whether high-dose intermittent vitamin D3 could alleviate symptoms of chronic fatigue syndrome (CFS) and improve vascular health. This double-blind, randomized placebo-controlled trial involved patients meeting established criteria for CFS. Participants received either 100,000 units of vitamin D3 or a placebo every two months for six months.

Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.

In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.

Fatigue reduction noted

Most Useful Review

I recommend this concentration of D3 for children. I’ve found that the dosage is essential for combating chronic fatigue syndrome. Higher doses have shown positive effects like increased energy and immune function.

Cold Sores

This product is fantastic! After a month of use, I noticed a significant boost in my mood and energy levels. My general health has improved dramatically, and I believe my immunity is much stronger, especially during this flu season. I’ll continue using it and have recommended it to my family and friends. The results are genuinely stunning!

Headache

Vitamin D3 aids migraine relief

Based on 15 Researches

Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.

Most Relevant Research

We conducted a rigorous study to explore how vitamin D3 supplementation might influence headaches in people suffering from migraines. By utilizing a well-structured, placebo-controlled, double-blind design, we included 80 participants with episodic migraines, assigning them either a daily dose of vitamin D3 or a placebo for 12 weeks.

After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.

Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.

9.5

No headache side effect

Most Useful Review

Simply the best quality vitamin D I can find that isn't sourced from lanolin. This product is of high quality and does not induce a headache like Lanolin-sourced vitamin D.

Breast Cancer

Vitamin D3 reduces breast cancer invasion

Mitigation of Breast Cancer Cells' Invasiveness via Down Regulation of ETV7, Hippo, and PI3K/mTOR Pathways by Vitamin D3 Gold-Nanoparticles.

Most Relevant Research

We set out to explore how Vitamin D3, when combined with gold nanoparticles (VD3-GNPs), could influence breast cancer's aggressiveness. Our research focused on breast cancer cell lines, specifically MCF-7 and MDA-MB-231, to see if this innovative treatment could significantly reduce cancer cell migration and invasion.

Through a series of methods including Western blots and migration/invasion assays, we observed that the VD3-GNP treatment led to an impressive reduction in cancer aggressiveness, with migration and invasion rates dropping by over 45%. This effect seems to come from the downregulation of key pathways associated with cancer growth and spread, namely the PI3K/AKT/mTOR pathway, as well as ETV7 and the Hippo pathway.

What's particularly surprising is the fact that we achieved these results using a relatively low dose of Vitamin D3—three orders of magnitude lower than doses used in past studies. This makes VD3-GNPs an appealing option for non-toxic and cost-effective treatments aimed at combating breast cancer's aggressive nature.

7.5

Health benefits noted

Most Useful Review

No vitamin promotes health like vitamin D (D3/cholecalciferol). Research suggests it may help prevent SARS and upper respiratory infections. Studies show those with higher vitamin D levels have a lower risk of heart attack, breast cancer, colon cancer, and diabetes. I purchased vitamin D3 during the pandemic. The capsules are small and easy to swallow, ideally consumed with fatty foods. If you find my review helpful, please click Yes. Thank you!

Hypertension

Calcitriol reduces age-related hypertension

Based on 6 Researches

Calcitriol reverses age-related hypertension via downregulating renal AP1/ATR pathway through regulating mitochondrial function.

Most Relevant Research

We explored the role of calcitriol, the active form of vitamin D, in addressing age-related hypertension. The study involved young and aged male mice, where we administered calcitriol daily for eight weeks. Our goal was to determine if this vitamin could effectively lower high blood pressure that often comes with aging.

Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.

Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.

Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.

7.5

Health benefits noted

Most Useful Review

No vitamin enhances health or well-being like vitamin D (vitamin D3 or cholecalciferol). Research indicates that it may play a vital role in preventing SARS and upper respiratory infections. Studies show that individuals with higher levels of vitamin D have a reduced risk of heart attack, breast cancer, colon cancer, multiple sclerosis, type 1 and type 2 diabetes, and hypertension. I bought vitamin D3 during the pandemic; the capsules are small and easy to swallow, ideally taken with fatty foods.

Multiple Sclerosis

Vitamin D3 alleviates MS symptoms

Immunoregulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis (EAE) Mice.

Most Relevant Research

We investigated the influence of calcitriol, the active form of vitamin D, on experimental autoimmune encephalomyelitis (EAE), an animal model akin to multiple sclerosis. Our study involved twenty-eight mice divided into four groups, allowing us to compare outcomes between those with and without EAE, as well as those receiving calcitriol treatment.

We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.

Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.

6.8

Supports health benefits

Most Useful Review

No vitamin enhances health like vitamin D (vitamin D3 or cholecalciferol). Research indicates it may play a significant role in preventing SARS and upper respiratory infections. Studies show that individuals with higher vitamin D levels have a lower risk of heart attack, certain cancers, diabetes, and multiple sclerosis. I purchased vitamin D3 to take during the pandemic. The capsules are small, easy to swallow, and should be taken with fatty foods.

Pelvic Pain

After childbirth, I experienced pelvic pain. My gynaecologist recommended calcium with vitamin D. I realised my diet was sufficient in calcium, but vitamin D corrected my deficiency. After two weeks, I felt considerable relief, and the pain completely disappeared. I now take one capsule daily for prevention, maintaining the 1000 units recommended. The capsules are small, and it’s best to take them with plenty of water. This vitamin also supports the immune system.

Prostate Cancer

Vitamin D3 may prevent prostate cancer

Based on 15 Researches

1,25-Dihydroxyvitamin D Suppresses Prognostic Survival Biomarkers Associated with Cell Cycle and Actin Organization in a Non-Malignant African American Prostate Cell Line.

Most Relevant Research

We explored how vitamin D3, specifically the metabolite 1α,25(OH)D, influences the behavior of non-cancerous prostate cells derived from African American men. In our study, we treated the RC-77N/E cell line with vitamin D3 and observed significant changes in gene expression after just 24 hours.

Our analysis revealed that 1α,25(OH)D affected 1,601 genes, highlighting its potential to suppress pathways linked to prostate cancer progression and cell proliferation. This points to the ability of vitamin D3 to help maintain non-malignant cell characteristics.

Additionally, we identified two specific genes, Anillin and Epithelial Cell Transforming 2, which were significantly downregulated by vitamin D3 treatment and correlated with better overall survival in prostate cancer patients. This suggests that these genes could serve as valuable biomarkers for assessing the risk of disease in affected individuals.

Given these promising findings, we believe that 1α,25(OH)D not only plays a vital role in regulating prostate health but could also be used as part of a preventative strategy or as an adjunct therapy, particularly for African American men who are disproportionately affected by prostate cancer.

Good for cancer

Most Useful Review

I bought it as it's beneficial for cancer patients.

Bone Pain

Vitamin D3 is an excellent antioxidant and a good bone pain relief supplement. After taking it for three weeks, I felt more energetic and less anxious. The results are impressive, and the quality is excellent! I highly recommend it.

Brain Tumor

Vitamin D3 may reduce brain edema

Based on 12 Researches

Preoperative Serum Level of Vitamin D is a Possible Protective Factor for Peritumoral Brain Edema of Meningioma: A Cross Sectional Study.

Most Relevant Research

We investigated whether preoperative serum levels of vitamin D3 could influence peritumoral brain edema in patients diagnosed with meningioma. This study included 112 patients who underwent assessments of serum 25(OH)D levels and magnetic resonance imaging (MRI) to evaluate brain edema.

Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.

We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.

3.8

Cancer growth inhibition

Most Useful Review

I am 54 and have achieved excellent results taking half a gel (six drops) daily. With daily sun exposure of twelve minutes or more, you likely don’t need 1000 IU. The recommended intake for people aged 51 to 70 is 400 to 600 IU. I puncture the gelatin capsule to get six drops of D3, equating to 500 IU. If my wife and I, living in a sunny country, took 1000 IU, we would develop pulsating headaches. D3 interacts with certain brain tumours, inhibiting their growth.

Cardiovascular Disease

Vitamin D improves heart disease factors

Based on 6 Researches

The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.

Most Relevant Research

We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.

Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.

We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.

Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.

9.5

Improved immunity

Most Useful Review

Vitamin D3 is essential for immunity and bone health. After discovering I had low levels, I took this supplement for three months, and my levels normalised. My energy and mood improved significantly, and I felt more vibrant. This vitamin D3 from Solgar has proven benefits for cardiovascular disease and overall health. It aids calcium absorption and prevents bone-related issues. Sunshine helps produce vitamin D3, but supplementation is often necessary, especially in winter. For optimal results, it's wise to take it together with vitamin K2.

Kidney Stones

Vitamin D3 does not prevent stones

Likely Ineffective

Based on 4 Researches

Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial.

Most Relevant Research

We assessed how two different vitamin D3 repletion protocols affect patients with recurrent calcium kidney stones and vitamin D deficiency. This was a controlled clinical trial involving 62 participants who had low levels of vitamin D and were prone to kidney stones. We administered either 2000 IU of cholecalciferol daily for 12 weeks or 50,000 IU weekly for 8 weeks.

Both treatment approaches resulted in a significant increase in 24-hour urine calcium levels; however, there was no difference between the two methods. Importantly, neither regimen increased the supersaturation of calcium oxalate or calcium phosphate, which are substances that can contribute to the formation of kidney stones.

We also observed a notable increase in serum levels of 25-hydroxyvitamin D, particularly in the weekly high-dose group, and a decline in serum parathyroid hormone in both groups. Despite these changes, it's crucial to highlight that our findings indicate no significant advantages in preventing kidney stones from vitamin D3 treatment alone.

2.5

Kidney stones issue

Most Useful Review

We purchased a small dosage of vitamin D to take during the summer. While I, aged 30, had no side effects, my mother, aged 60, suffered after 2 months, experiencing complications from kidney stones that required hospitalisation. It’s crucial to take vitamin D alongside vitamin K2 to avoid adverse effects like arterial calcification, which K2 helps mitigate. Don’t repeat our mistakes; if taking over 1000 IU of vitamin D, ensure you also take K2. We’ve since switched to a D + K complex for safety. Wishing you all good health!

Knee Pain

Vitamin D3 shows no benefit

Based on 13 Researches

USERS' SCORE

Good

Based on 4 Reviews

Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial.

Most Relevant Research

We conducted a thorough investigation into the effects of vitamin D3 supplementation on knee pain and cartilage volume in people suffering from knee osteoarthritis, particularly those with low vitamin D levels. This study took place in Tasmania and Victoria, Australia, and was designed as a multicenter, randomized, double-blind, placebo-controlled clinical trial.

Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.

The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.

9.5

Pain relief

Most Useful Review

Vitamin D is fantastic! I've been taking it for about 5 or 6 months. My leg bones ached and crunched before, but now Vitamin D has alleviated the pain and crunching. I take it myself and also give it to all the children!

Autoimmune Disorder

Vitamin D3 modulates autoimmune response

Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis.

Most Relevant Research

We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.

Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.

Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.

9.5

Effective treatment plan

Most Useful Review

After three months of taking vitamin D-3 due to low levels, I saw an increase from 17 to 39 ng/ml. My endocrinologist suggested this dosage approach, combining natural and synthetic forms. It’s crucial to monitor levels regularly to stay within limits. Vitamin D-3 serves as an immunomodulator, highlighting its importance for my autoimmune disorder management. I trust Solgar for its quality in cleaning cod liver oil.

Heart Disease

Vitamin D improves heart health

The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.

Most Relevant Research

We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.

Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.

Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.

Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.

9.5

Improved immunity

Most Useful Review

VITAMIN D3 is essential for immunity and bone health! After discovering low levels of vitamin D3, I took this for three months. My results normalised, and I felt a boost in energy and mood. Solgar's quality is reliable, and studies confirm D3's role in reducing risks of heart disease and other ailments. It works with K2 and fatty foods for optimal absorption. With winter sun exposure lacking, I find supplementation vital, especially for those facing heart disease risks. I genuinely recommend this product!

Sleep Apnea

Vitamin D3 improves mild sleep apnea

Based on 3 Researches

The effects of vitamin D supplemantation on prognosis in patients with mild obstructive sleep apnea syndrome.

Most Relevant Research

We set out to evaluate what effect vitamin D3 supplementation might have on patients suffering from mild obstructive sleep apnea syndrome (OSAS). In this study, 19 adult men who were diagnosed with mild OSAS and had low vitamin D levels participated over an 8-week period. Each week, they took a sizable dose of 50,000 IU of vitamin D3 while undergoing various health assessments. We measured important factors like blood glucose, lipid profiles, and inflammation markers, along with repeated sleep monitoring through polysomnography.

By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.

Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.

6.8

Muscle cramping relief

Most Useful Review

No cramps or spasms; I take two to three capsules daily. It aids my sleep, especially when taken with calcium and magnesium tablets. I noticed that my muscles no longer cramp during the night, and my calves are free from cramping, which is beneficial for managing sleep apnea.

Chest Pain