Best Naturals Alpha Lipoic Acid 200 Mg

We aimed to understand how alpha-lipoic acid (LA) affects wound healing in diabetic conditions. The study involved five groups of mice: healthy controls, wounded healthy mice, wounded diabetic mice, and two groups of wounded diabetic mice treated with different doses of LA for 14 days.

Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.

This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.

9.5

Manages neuropathy

Most Useful Review

I purchased this for my 87-year-old mother with diabetes. Doctors recommended alpha-lipoic acid to help her manage diabetic neuropathy. I found it much cheaper to buy online. It significantly alleviates her symptoms and helps lower her blood sugar levels, which may require adjustment of her medications.

Liver Disease

SCIENTIFIC SCORE

Moderately Effective

Based on 2 Researches

Alpha-lipoic acid protects liver health

α-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal β-Oxidation and Reducing Lipophagy in Chicken Hepatocyte.

Most Relevant Research

We explored the protective effects of alpha-lipoic acid (LA) against liver damage caused by arsenic, a well-known environmental toxin. In our examination, we uncovered the mechanisms through which arsenic harms the liver, including its ability to induce autophagy, apoptosis, and oxidative stress, as well as disrupt lipid metabolism.

Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.

This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.

9.5

Improves liver health

Most Useful Review

Great price! I would choose alpha-lipoic acid for health. Its effects benefit the nerves, liver, and blood sugar levels. This quality product is offered at a great price—highly recommended!

Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials.

Most Relevant Research

We assessed the effects of alpha-lipoic acid on migraines, focusing on its potential benefits backed by evidence from several trials. These trials provided insights into how alpha-lipoic acid influences migraine characteristics such as attack frequency and severity.

Our analysis indicated that supplementation with alpha-lipoic acid led to a reduction in the number of migraine attacks, with an average decrease of about 1.24 attacks compared to control groups. Although the impact on severity was less pronounced, the decrease in attack frequency is promising for individuals seeking relief from migraines.

It’s important to note that while alpha-lipoic acid showed some positive outcomes, it did not significantly affect all measured aspects of migraines, particularly compared to other dietary supplements. This points to the need for additional research to confirm its benefits and understand its effectiveness in isolation from other treatments.

8.8

Helps prevent migraines

Most Useful Review

This product alleviated nerve pain and tingling in my legs. I take it alongside other vitamins to prevent migraines, and firmly believe it has helped stave them off. Do keep it away from pets!

Stroke

SCIENTIFIC SCORE

Moderately Effective

Based on 3 Researches

Alpha-Lipoic Acid Shows Stroke Potential

Ischemic Microenvironment-Targeted Bioinspired Lipoprotein Sequentially Penetrates Cerebral Ischemic Lesions to Rescue Ischemic Stroke.

Most Relevant Research

We examined how alpha-lipoic acid (ALA) impacts stroke recovery, particularly through a newly developed delivery system designed to target ischemic brain lesions. This system uses bioinspired lipoproteins to carry ALA, allowing it to reach the areas most affected by stroke more effectively than standard methods.

In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.

Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.

8.8

Energy boost post-stroke

Most Useful Review

These supplements are aiding my husband, who experienced a severe stroke. After taking this, he has noticeably more energy, which his stroke had taken away. His physician has approved this, confirming it has not harmed him at all.

Neuropathy

SCIENTIFIC SCORE

Possibly Effective

Based on 3 Researches

Alpha-lipoic acid reduces AGEs

Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.

Most Relevant Research

We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.

Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.

Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.

7.8

Reduced pain medication use

Most Useful Review

My neurologist recommended this for peripheral neuropathy. After a month, I was able to cut my pain medication use by over half. I switched brands and had a reaction, but returned to this one with no problems. It’s not a miracle cure, but it has helped me more than any prescription meds I've tried over 20 years. Major decrease in symptoms.