Doctor&#039;s Best Alpha-Lipoic Acid

Alpha-lipoic acid is an antioxidant with proven benefits that alleviate various diseases such as diabetes, Alzheimer's, oncology, cardiovascular issues, and obesity. The capsules are economical for a six-month supply. After a week of use, I want to eat less often, my mind is clearer, and pancreatic pain has diminished. The capsules are pleasant-smelling, pale yellow, and easy to swallow. The quality is excellent; I recommend it!

Carpal Tunnel Syndrome details

4 people found this helpful

Alpha Lipoic Acid for polyneuropathy and Carpal Tunnel Syndrome. I took it alongside phosphatidylserine; I experienced severe pain in my wrist joint and hand due to nerve entrapment and swelling caused by the nerve being clamped in the bone canal. After using it for approximately six months, the pain has dissipated. Alpha Lipoic Acid at 600 mg is a suitable dosage. I am pleased with the purchase.

Chemotherapy details

ALA mitigates chemotherapy-related cognitive decline

Moderately Effective

Based on 16 Researches

Lal R, Dharavath RN, Chopra K. Alpha-Lipoic Acid Ameliorates Doxorubicin-Induced Cognitive Impairments by Modulating Neuroinflammation and Oxidative Stress via NRF-2/HO-1 Signaling Pathway in the Rat Hippocampus. Neurochem Res. 2023;48:2476. doi:10.1007/s11064-023-03914-y

We investigated the effects of alpha-lipoic acid (ALA) in protecting against cognitive impairments caused by the chemotherapy drug doxoruibicin (DOX). In a study involving Sprague-Dawley rats, we treated them with ALA for four weeks while administering DOX to evaluate memory function through specific tasks.

Our findings indicated that ALA not only improved memory performance but also reduced oxidative stress and inflammation in the brain. This suggests that ALA may offer significant neuroprotective benefits in the context of chemotherapy-induced cognitive issues, primarily through its antioxidant properties.

7.5

Aid post-chemotherapy

Most Useful Review

7 people found this helpful

Alpha-lipoic acid was recommended to me after chemotherapy. I've used it for four years without complaints. I tried another brand once but disliked the side effects. Doctor's Best is great, and I highly recommend it!

Cholecystitis details

Effective for gallbladder

I love this product; it works exceptionally well for my liver and gallbladder. The price is also great.

Heart Disease details

Heart health improvement

Excellent! This product is crucial for cardiovascular health and should be used consistently to prevent heart disease.

Osteoporosis details

Pain minimised quickly

I am a 66-year-old woman with Osteoporosis and chronic pain in my right arm. After taking it alongside B12, I found the quality to be excellent and the packaging nice. My pain was minimised, and I noticed a difference within just 20 days. The size is convenient, and I will definitely order again ❤️.

Rash details

Alpha Lipoic Acid is an effective antioxidant and detoxifies the body while aiding glucose metabolism and energy production. It is both grease and water-soluble. While taking it, I felt more relaxed, and both my sleep and memory improved. I experienced increased energy. My skin condition improved, with no more rashes, acne, dryness, or peeling. Hair loss decreased, and my hair became thicker. Blood sugar levels are normal. Headaches ceased. This product has a cumulative effect, and I recommend it for health and longevity.

Swollen Lymph Nodes details

5 people found this helpful

This remedy is my secret to maintaining weight. When I take it, I don’t experience weight gain, and surprisingly, I don’t swell, even after indulging in a pack of chips at night. Previously, I would wake up with swollen eyes. I pair it with zinc and selenium due to thyroid issues advised by my doctor.

Allergies details

2 people found this helpful

Tried on a friend's advice and have no regrets! After completing the course, I now drink it again. This tool significantly helped me, eliminating constant rashes on my hands due to allergies, and I feel my body has been cleansed. I highly recommend it!

Arthritis details

6 people found this helpful

I started taking this supplement about two months ago to assist with arthritis in my fingers and sciatica pain. I can't pinpoint when the pain subsided; one day I just realised, “wow, I haven’t had pain in a while!” ALA, combined with specific exercises for my sciatica, has provided me with considerable relief. The arthritis in my fingers is nearly gone.

Back Pain details

2 people found this helpful

I began taking Alpha-Lipoic Acid alongside turmeric for lumbar back issues, which significantly improved my discomfort. I would recommend it for similar problems, as the quality is good and the capsules are easy to swallow.

Bulimia details

Improved insulin resistance

7 people found this helpful

He seems to be doing quite well. The trial supply is substantial and should last six months. After a month using this, I've noticed improvements in insulin resistance and binge eating, and expect the effects to last for three months.

Cancer details

Sgaramella LI, Pasculli A, Moschetta M, Puntillo F, Dicillo P, et al. Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery. Sci Rep. 2025;15:4899. doi:10.1038/s41598-025-86651-2

Likely Very Effective

Alpha-lipoic acid aids recovery

We conducted a thorough analysis to determine how alpha-lipoic acid, in combination with other supplements, affects early complications like edema and seroma following breast-conserving surgery (BCS). Our study was structured as a double-blind, randomized, placebo-controlled trial involving 114 participants over a span of three years.

Participants were divided into three groups, with one group receiving a mix of Casperome™-Boswellia Phytosome and bromelain along with alpha-lipoic acid, while the other groups received either bromelain with a placebo or just a placebo. Over a period of 30 days, we gathered data on the effectiveness of these treatments.

Our findings revealed that the combination of bromelain and alpha-lipoic acid significantly reduced the incidence of edema and seroma compared to the placebo. Specifically, after one month, we observed marked improvements in patients who received the active treatment. This research highlights the potential therapeutic benefits of alpha-lipoic acid, especially when used with other agents, in managing early complications that can follow breast surgery. Although it’s important to note that the specific isolating effects of alpha-lipoic acid on its own were challenging to determine, the results offer a promising glimpse into its use in surgical recovery.

Promotes recovery

Most Useful Review

8 people found this helpful

I brought this for my dad who has cancer. It offers powerful antioxidants and aids in cell renewal. I pray for my father's recovery.

Kidney Stones details

ALA is great! It significantly benefits diabetics. I take one capsule morning and night, and it helps alleviate my kidney pain. I've heard a smell during urination, which is normal with ALA. I’ll continue buying it as part of my daily routine.

Polycystic Ovary Syndrome details

A good antioxidant. After finishing my first bottle, I can confidently say it’s effective. I find it should be taken early in the morning to prevent insomnia later in the day. Initially, I took it to detox heavy metals, but after a month, I believe I am ovulating normally despite my Polycystic ovary syndrome condition, which usually makes it difficult for me to ovulate properly. I read that it can enhance egg quality and improve fertility.

Autoimmune Disorder details

Balanced glucose levels

78 people found this helpful

The result is great! I ordered it for myself on a friend’s recommendation after struggling with my weight and a sluggish metabolism. I was surprised by the immediate effect; it evened out my glucose levels and significantly cut my sugar intake from 100% to 5-10%. I recommend monitoring dosage carefully; I took 600 mg initially and suffered from severe heartburn. People with gastritis should take a smaller dosage and consult a doctor.

Bone Pain details

Reduced pancreas pain

77 people found this helpful

Alpha-Lipoic Acid is an antioxidant with beneficial properties for various ailments, including diabetes and obesity. The daily dosage is convenient, lasting six months, and I’ve noticed reduced hunger, improved clarity, and my pancreas pain has disappeared. The capsules are medium-sized, pleasant smelling, pale yellow, and easy to swallow. I recommend it wholeheartedly.

Cardiovascular Disease details

Cardiovascular system restoration

4 people found this helpful

Very good! This alpha-lipoic acid aids nutrient transport, cleanses the vessels, and restores the cardiovascular system. I've taken it periodically for over five years without side effects.

Cold details

61 people found this helpful

I take this alpha lipoic acid two times a day on an empty stomach (1200mg/day). It's been two years since then, but my skin has become lustrous, my hair has regained its lively black colour, and I don't catch colds at all. The rejuvenation is significant, especially after ensuring I take all the basic nutrients. Japan is known for its additives, and I feel I need to protect my body myself since we can't rely on decent food alone. α-Lipoic acid is vital for men and women of all ages, and I believe it should be a regular purchase, even at a higher price, as it truly improves health.

Food Poisoning details

30 people found this helpful

Unexpectedly, I experienced a pleasant effect! After three days of taking 600 mg of alpha-lipoic acid daily before meals, I realised I was genuinely full. As a lover of food, I usually eat large portions, yet on the third day, I found myself indifferent to sweets—a remarkable shift for me, especially as I hadn't previously known about this effect. I had initially purchased ALA for different reasons.

Mild Cognitive Impairment details

Must-have health product

This health product is essential for me as it protects the heart, prevents strokes, helps with the aftereffects of strokes, combats senile dementia, and stabilises my blood sugar levels.

Neuropathy details

Alpha-lipoic acid improves neuropathy symptoms

Based on 16 Researches

Pingali U, Kammila S, Mekala P, Yareeda S, Penugonda S. A Study to Evaluate the Effect of Alpha-Lipoic Acid on Neuropathic Symptoms in Diabetic Neuropathy Patients on Gabapentin or Pregabalin. Cureus. 2024;16:e70299. doi:10.7759/cureus.70299

We conducted a double-blind, placebo-controlled study involving 52 patients with diabetic neuropathy on gabapentin or pregabalin to explore the effects of alpha-lipoic acid (ALA). Over 12 weeks, we found that ALA significantly improved vibration perception threshold and secondary symptoms like overall quality of life, oxidative, and inflammatory markers.

Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.

Good dosage

Most Useful Review

33 people found this helpful

I bought this for my wife, and it helps her significantly with polyneuropathy. The dosage is commendable, and it works well.

Premenstrual Syndrome details

I ordered this two months ago and shared it with my family. Upon starting the pills, I noticed a positive change: I had diminished appetite compared to before due to severe PMS. The quality is excellent, the capsule size is good, and it's easy to use, benefiting my diet well.

Hair Loss details

1 people found this helpful

If you are struggling with hair loss, poor skin, or nails, Biotin is essential, as it effectively addresses these concerns. This supplement significantly improved my hair loss and overall body condition, proving its quality and efficacy.

Irritable Bowel Syndrome details

Resolved bowel issues

20 people found this helpful

I appreciated the supplement, which my husband and I decided to try based on its indications. I took a capsule on an empty stomach to address my irritated bowels. Initially, my stools became better formed, but I later experienced some constipation, which is unusual for me. I began taking the capsule with meals, and the problems have since disappeared. I shared these personal details as others' transparency about their supplement experiences greatly aided my decision-making. I believe it’s beneficial to take this supplement in courses. I recommend it.

Migraine details

Kelishadi MR, Naeini AA, Khorvash F, Askari G, Heidari Z. The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines. Sci Rep. 2022;12:271. doi:10.1038/s41598-021-04397-z

Based on 8 Researches

ALA shows promise for migraines

We evaluated how alpha-lipoic acid (ALA) supplementation impacts women suffering from episodic migraines. In a random, double-blind, placebo-controlled trial with 92 participants, those taking 300 mg of ALA daily reported significant improvements in headache severity, frequency, and impact. They also showed decreased levels of lactate and VCAM-1, suggesting enhancements in mitochondrial and endothelial functions. However, no notable changes occurred regarding nitric oxide levels and migraine duration. Overall, ALA may serve as a helpful adjunctive treatment for migraine relief.

Improved migraine symptoms

Most Useful Review

1 people found this helpful

After taking thiocarnitine for three days, I felt my brain reacted quicker, and my migraine decreased. After three weeks, the recent migraines improved significantly and I felt more refreshed. I will continue taking one tablet a day to help repair damaged nerves and prevent brain degeneration.

Candidiasis details

The Doctor's Best Alpha Lipoic Acid is an excellent product. I take it daily to manage toxins in my body while addressing Candidiasis, and I find it works remarkably well.

Hypothyroidism details

Baki AM, Aydın AF, Vural P, Olgaç V, Doğru Abbasoğlu S, et al. α-Lipoic Acid Ameliorates The Changes in Prooxidant-Antioxidant Balance in Liver and Brain Tissues of Propylthiouracil-Induced Hypothyroid Rats. Cell J. 2020;22:117. doi:10.22074/cellj.2020.7049

Based on 8 Researches

ALA reduces oxidative stress

We explored the effects of alpha-lipoic acid (ALA) on hypothyroidism, particularly focusing on oxidative stress in the body. In a controlled experiment, rats were given propylthiouracil (PTU) to induce hypothyroidism, followed by treatment with ALA and thyroxine (T4) to assess the outcomes over a 10-week period.

Our findings revealed increased oxidative stress markers, particularly in the brain, in hypothyroid rats. ALA treatment alone significantly reduced these markers, suggesting it can help counteract oxidative damage linked to hypothyroidism. Moreover, ALA also improved conditions arising from T4 therapy.

Overall, our study indicates that ALA may offer a valuable approach to manage oxidative stress in thyroid dysfunctions, both on its own and when combined with traditional hormone replacement therapies.

7.5

Weight loss support

Most Useful Review

7 people found this helpful

I have autoimmune thyroiditis, which has led to insulin resistance and hypothyroidism. Alpha lipoic acid has aided my weight loss, as many with AIT, like myself, face challenges in controlling their weight. Recommended by my doctor, I used it to manage insulin resistance. After three months, I lost 9 kg, despite not being strict with my diet and having decreased physical activity. I recommend it to anyone with a similar diagnosis who is struggling with weight loss.

Athlete’s Foot details

6 people found this helpful

After using it, the results were remarkable; the numbness and tingling in my hands and feet due to sugar ended. It's strong on the stomach, so I prefer to take it after eating.

Gastritis details

Effective weight control

78 people found this helpful

The result was impressive! I ordered it based on a friend's recommendation, as I struggled to lose weight due to a sluggish metabolism. Remarkably, it worked instantly, balancing my glucose levels, and I reduced my sweet intake drastically. However, I caution those with gastritis to stick to a lower dosage and consult a doctor.

Knee Pain details

Pain significantly reduced

I opted for this instead of Berlition, which my neurologist prescribed for a cervical spine hernia. I find this more effective; my knee pain is nearly gone and I hope to avoid surgery. It was also more affordable than Berlition, with enough for the course, and no allergic reactions. I’ll continue to take it due to its various benefits.

Flu details

This product effectively reduces inflammation! The flu has been severe recently. I occasionally have throat discomfort, especially after spicy meals. Taking the pill before bed provides me relief by the next day. It combats oxidation and removes free radicals without any strange taste. I've always found the quality of the Doctor Best brand to be excellent, and I’ll continue repurchasing it.

Liver Disease details

Alpha-lipoic acid protects liver health

Moderately Effective

Based on 2 Researches

Zhao Y, Guo M, Pei T, Shang C, Chen Y, et al. α-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal β-Oxidation and Reducing Lipophagy in Chicken Hepatocyte. Adv Sci (Weinh). 2025. doi:10.1002/advs.202413255

We explored the protective effects of alpha-lipoic acid (LA) against liver damage caused by arsenic, a well-known environmental toxin. In our examination, we uncovered the mechanisms through which arsenic harms the liver, including its ability to induce autophagy, apoptosis, and oxidative stress, as well as disrupt lipid metabolism.

Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.

This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.

7.5

Cleanses toxins

Most Useful Review

188 people found this helpful

This product is indispensable for managing insulin resistance, with impressive results in helping me lose weight while on a diet. It effectively detoxifies the liver, allowing it to eliminate toxins and cleanse the body. I take it before meals, twice daily, and recommend it to others.

Chronic Fatigue Syndrome details

Fatigue greatly improved

After taking alpha-lipoic acid for about a month, I believe much of my fatigue has diminished. My skin feels brighter, and it seems to have a whitening effect as I continue using it. I will keep purchasing.

High Cholesterol details

99 people found this helpful

A great remedy for lowering both sugar and cholesterol. The dosage is high, but the results are evident.

Sleep Apnea details

Great product! I chose it for its price, taste, quality, and results. It has numerous useful ingredients and great health and sleep benefits. I recommend it to everyone; it meets all expectations with no issues noted.

Weight Loss details

Effective in hunger reduction

212 people found this helpful

Alpha lipoic acid is beneficial for weight loss; it targets the brain areas regulating appetite, which decreases hunger. It lessens fat storage in the liver and promotes glucose absorption, leading to reduced blood levels. It also stimulates energy expenditure, crucial for weight loss.

Brain Tumor details

4 people found this helpful

Excellent for mental clarity! It has significantly helped with my brain fog.

Diabetes details