Jarrow Formulas Milk Thistle 150 mg

Curcumin reduces cold symptoms

Effects of Highly Bioavailable Curcumin Supplementation on Common Cold Symptoms and Immune and Inflammatory Functions in Healthy Japanese Subjects: A Randomized Controlled Study.

Most Relevant Research

We embarked on an engaging investigation into how highly bioavailable curcumin, a key component of turmeric, affects common cold symptoms. Our study spanned 12 weeks, involving 99 healthy Japanese adults who were randomly divided into three groups. Two groups received different formulations of curcumin while the third group was given a placebo.

Each participant took four capsules daily, and we measured the cumulative days participants experienced cold symptoms. Interestingly, we discovered that those taking either curcumin formulation reported significantly fewer days with cold symptoms compared to the placebo group.

Additionally, we monitored various immune function markers, inflammatory parameters, and overall safety throughout the study. Notably, we observed no adverse effects from curcumin supplementation, making it a promising option for those looking to mitigate cold symptoms naturally.

9.5

Effective for colds

Most Useful Review

Curcumin is excellent for inflammation and pain relief. I find it effective against the common cold, especially when I double the dose at the first signs of illness. I take it with meals, ideally with fat and black pepper for better absorption. It's essential for my joint pain and even helps with headaches. A great supplement overall.

Heart Disease

Nano-curcumin improves heart health

Effect of nano-curcumin supplementation on angina status, and traditional and novel cardiovascular risk factors in overweight or obese patients with coronary slow flow phenomenon: a randomized double-blind placebo-controlled clinical trial.

Most Relevant Research

We conducted a double-blind, placebo-controlled trial to see how nano-curcumin, a supplement derived from turmeric, affects heart health in overweight or obese patients with a condition known as coronary slow flow phenomenon (CSFP). Our study involved 42 participants who received either 80 mg of nano-curcumin or a placebo daily for 12 weeks.

To measure how angina—a type of chest pain—improved, we used the Seattle angina questionnaire among other cardiovascular risk factors, including endocan, adropin, homocysteine levels, and various lipid profiles.

At the end of the study, we observed that those taking nano-curcumin reported significant improvements in their angina status and some cardiovascular factors, compared to their baseline measures. While some improvements were also seen in traditional and novel risk factors, more research will be needed to understand these changes in depth and whether they offer any real-world benefits for heart health.

9.5

Eliminated pain relief

Most Useful Review

This is a fantastic product. I use it for its anti-inflammatory properties, which have allowed me to nearly stop using Ibuprofen. My cardiologist considers me his most boring patient after having two heart stents for almost six years. I also take nattokinase and serrapeptase to maintain excellent cardiovascular health.

Liver Disease

Turmeric shows promise for NAFLD

"Evaluation of Curcuma zedoaria Rosc. in the management of non-alcoholic fatty liver Disease: A Randomized, single blind, controlled trial".

Most Relevant Research

In a recent clinical trial, we explored the effectiveness of Curcuma zedoaria Rosc., commonly known as turmeric, in treating non-alcoholic fatty liver disease (NAFLD). This condition is alarmingly widespread, affecting a significant portion of the global population. Over the course of 60 days, we compared turmeric with vitamin E, a standard treatment, to see which had better results.

Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.

The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.

Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.

Breast cancer remission

Most Useful Review

Elizabeth B, curcumin has anti-cancer properties. I’ve taken 2 grams daily since my stage 4 breast cancer diagnosis. I went into remission within three months, and there hasn't been any evidence of disease for eight months now.

Pelvic Pain

Effective pain relief

Jarrow Curcumin 500 mg is fantastic for managing joint pain associated with rheumatoid arthritis. I'm very pleased with it and highly recommend it.

Prostate Cancer

Curcumin's potential in prostate cancer

The Association Between Anti-Neoplastic Effects of Curcumin and Urogenital Cancers: A Systematic Review.

Most Relevant Research

We evaluated the anti-cancer effects of turmeric, specifically focusing on how it influences prostate cancer. Our systematic review examined various studies that investigated the relationship between curcumin, a component of turmeric, and the regulation of microRNA expressions linked to prostate cancer.

Among the studies we analyzed, we found that curcumin appears to play a significant role in combating prostate cancer by modulating specific microRNAs. This compound seems to promote tumor suppression by increasing beneficial microRNAs while simultaneously decreasing those associated with cancer progression.

By effectively altering the balance of these molecules, curcumin is thought to inhibit cell proliferation and encourage apoptosis, or programmed cell death, in prostate cancer cells. Overall, the evidence suggests that turmeric may serve as a valuable complementary approach in the fight against prostate cancer.

Stronger antioxidant

Most Useful Review

Curcumin is known for its powerful anti-cancer actions and strong antioxidant properties. I prefer the Drs. Best 1000 mg caplets over the Jarrow formula for affordability and take it twice daily.

Alzheimer

Curcumin derivative shows Alzheimer's promise

Based on 12 Researches

New low-dose curcumin derivative with therapeutic potential in Alzheimer's disease: Results from an in vitro and in vivo study in mice.

Most Relevant Research

We examined the potential of a curcumin derivative, known as Derivative 27, to treat Alzheimer's disease (AD). Curcumin, a compound found in turmeric, has previously been recognized for its ability to interfere with amyloid-β (Aβ) peptide aggregates, a hallmark of AD. The study focused on enhancing curcumin's effectiveness at lower doses, aiming to make treatment more accessible for patients.

Through rigorous testing, both in vitro and in vivo, we evaluated the anti-inflammatory, antioxidant, and anti-amyloidogenic properties of Derivative 27. In laboratory settings, the compound showed impressive results by significantly reducing the production of nitric oxide and various pro-inflammatory proteins. Additionally, it activated a key protective transcription factor known as Nrf2, illustrating its potential to combat neuroinflammation.

In a more practical application, we tested Derivative 27 on one-year-old APP/PS1 mice, a model for Alzheimer's. After administering the treatment daily for 28 days, we observed improvements in the mice's short-term spatial memory. Significant reductions in hippocampal pro-inflammatory markers and Aβ levels were also noted, supporting the idea that this new curcumin derivative could be beneficial in the fight against Alzheimer’s.

Overall, this research opens the door to developing modified curcumin compounds that could lead to effective low-dose treatments for Alzheimer's disease, all while highlighting the therapeutic potential of turmeric derivatives in neurodegenerative conditions.

9.5

Alzheimer prevention

Most Useful Review

A highly recommended product! This well-known brand provides quality ingredients, offering a capsule a day that potentially helps prevent Alzheimer's and cancer.

Arthritis

Curcumin reduces osteoarthritis severity

Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway.

Most Relevant Research

We investigated how curcumin, the active compound in turmeric, impacts osteoarthritis (OA) by focusing on its role in reducing the formation of bone-destroying cells called osteoclasts. In our research, we used a mouse model designed to mimic OA by destabilizing the medial meniscus, allowing us to measure the effects of curcumin on joint health.

Our study included three groups of male mice: those who received a vehicle treatment after their surgery, those with OA but also receiving the vehicle, and those with OA that were treated with curcumin. Over the course of eight weeks, we monitored the mice's cartilage and bone structure, looking for any changes.

We found that curcumin significantly suppressed osteoclast formation and bone resorption without harming the cells, suggesting it may be a promising treatment to alleviate arthritis symptoms. Specifically, curcumin inhibited the activation of important signaling pathways that promote osteoclast formation and cartilage degradation. This suggests a new and exciting approach for treating osteoarthritis, offering hope for better management of this chronic condition.

9.5

Relieves joint pain

Most Useful Review

This curcumin product is excellent for managing joint pain from arthritis. I wholeheartedly recommend it.

Back Pain

Turmeric-Boswellia improves back pain

Based on 3 Researches

The effect of turmeric-Boswellia formulation (Rhuleave-K) in posture-related low back soreness and discomfort: A randomized double blinded placebo controlled trial.

Most Relevant Research

We investigated how a turmeric and Boswellia formulation, known as Rhuleave-K, helps manage low back pain related to poor posture. This study involved 52 participants, equally divided by gender, who had been experiencing discomfort for at least two to three weeks.

Using a randomized, placebo-controlled, and double-blinded approach, we carefully measured the pain intensity at the beginning and again at the end of the 15-day trial. The findings were promising; those taking Rhuleave-K experienced a dramatic reduction in pain—showing a reduction of up to 98.5% by the end of the trial. In comparison, the placebo group reported minimal improvement.

We also noted significant decreases in the Oswestry disability index, indicating that participants not only had less pain but also felt increasingly able to carry out daily activities. Overall, this study supports the idea that Rhuleave-K can be a safe and effective option for those looking to alleviate low back discomfort, specifically due to poor posture.

9.5

Significant improvement

Most Useful Review

I have been taking curcumin for six months for back pain and found it effective. Initially, my joints were very painful, and I struggled to walk. After three months, I noticed a significant improvement and could manage my back pain better. Although it’s not a panacea, it has had a positive effect alongside my strict diet.

Brain Tumor

Curcumin reduces glioma tumor growth

Based on 9 Researches

Action of Curcumin on Glioblastoma Growth: A Systematic Review with Meta-Analysis of Animal Model Studies.

Most Relevant Research

We conducted a thorough investigation into how curcumin, a compound found in turmeric, affects brain tumors, particularly gliomas. Our research involved a systematic review and meta-analysis of 24 studies from 15 different articles. Each study utilized murine xenograft models to observe the effects of curcumin on tumor growth.

Through our analysis, we discovered that curcumin significantly reduced tumor volume compared to control groups. The overall results showed a notable decrease, with a standardized mean difference of -2.079, suggesting a strong therapeutic effect.

We explored various conditions under which curcumin was tested, including different animal models and administration methods. While we did identify some publication bias in the existing studies, this did not negate the effectiveness of curcumin. Overall, our findings strongly advocate for further research into curcumin as a potential treatment for gliomas.

9.5

Effective treatment

Most Useful Review

I have been taking 2 gms (four capsules) of curcumin daily since my stage 4 breast cancer diagnosis a year ago. Remarkably, I entered remission within three months, and all tumours have disappeared. I have now been in remission with no evidence of disease for eight months.

Depression

Curcumin reduces depression severity

Based on 11 Researches

Curcumin Reduces Depression in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial.

Most Relevant Research

We conducted a study to explore the effects of curcumin, a natural supplement found in turmeric, on depression among obese patients with type 2 diabetes. Using a randomized, double-blind, placebo-controlled approach, we engaged 227 participants to assess how curcumin might help alleviate symptoms of depression.

Over the course of 12 months, we monitored changes in depression severity using a standard questionnaire, the Patient Health Questionnaire-9. Additionally, we evaluated various biomarkers such as serotonin levels, inflammatory markers, and antioxidant activity to better understand curcumin's potential benefits.

Our findings were quite promising. By the end of the study, those taking curcumin reported significantly lower depression severity. We also observed that curcumin increased serotonin levels while reducing markers associated with inflammation. Improvements in antioxidant activity were noted in the curcumin group too.

Overall, these results suggest that curcumin could be a beneficial addition to the treatment plan for individuals dealing with depression, particularly for those who are also managing obesity and type 2 diabetes. This research not only highlights the antidepressant effects of curcumin but also emphasizes the importance of holistic approaches in healthcare.

9.5

Fights depression effectively

Most Useful Review

Curcumin demonstrates powerful antioxidant properties that enhance heart health and may aid in preventing cancer. It also helps combat depression by blocking inflammatory signals. It has proven effective compared to some anti-inflammatory drugs in certain studies.

Eczema

Herbal remedies show promise for eczema

Formulation and clinical evaluation of topical dosage forms of Indian Penny Wort, walnut and turmeric in eczema.

Most Relevant Research

We conducted a study that explored the effectiveness of topical treatments using herbal ingredients, specifically focusing on Indian pennywort, walnut, and turmeric, for managing eczema. Our research included three different formulations—a micro emulsion, gel, and ointment—derived from these extracts. We treated 360 eczema patients in a controlled clinical trial, comparing the results of our formulations with placebo treatments.

Throughout the study, we observed various clinical signs of eczema, including erythema (redness), oedema (swelling), scaling, itching, and lichenification (thickened skin). Interestingly, while each formulation showed benefits, the micro emulsion was particularly effective in reducing redness and swelling. The gel formulation stood out for relieving itching more effectively, whereas the ointment proved to be the best option for managing scaling and lichenification.

It’s important to note that while turmeric was included in our formulations, we couldn't isolate its specific effect due to its combination with other ingredients. However, the overall results suggest that these herbal treatments could serve as promising alternatives for eczema care.

9.5

Eczema cured

Most Useful Review

I was suffering from eczema, but it was cured by taking a combination of curcumin and silymarin complex.

Fibromyalgia

Significant pain reduction

Best Curcumin! This formula has significantly reduced my fibromyalgia pain—more effectively than many pain medications—and decreased inflammation. After using Jarrows Curcumin for a few weeks, my massage therapist noticed less swelling in my limbs. I wouldn't want to go a day without this supplement!

Irritable Bowel Syndrome

Questionable

Turmeric may alleviate IBS symptoms

Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study.

Most Relevant Research

We undertook an investigation to understand how turmeric, scientifically known as Curcuma longa, might affect symptoms of irritable bowel syndrome (IBS) in healthy adults. In a well-structured pilot study, we screened 500 volunteers for IBS and ultimately randomized 207 suitable candidates to assess the impact of taking one or two tablets of a standardized turmeric extract daily for eight weeks.

Throughout the study, we observed significant improvements in IBS symptoms. The prevalence of IBS symptoms decreased notably in both dosage groups, and after treatment, those taking one tablet saw a 53% reduction in symptoms, while the two-tablet group experienced a 60% decline. We also noted a meaningful reduction in abdominal pain and discomfort, with scores dropping by 22% and 25% respectively.

Furthermore, most participants reported improved overall quality of life related to their IBS symptoms. Approximately two-thirds of individuals noted a positive change in their symptoms post-treatment, indicating a favorable response to turmeric. While there were no significant differences between the two dosage groups, the findings confirm that turmeric may offer a helpful option for managing IBS symptoms.

Given these encouraging results, we believe that further placebo-controlled trials are necessary to validate the effectiveness of turmeric in treating IBS.

9.5

Improved bowel condition

Most Useful Review

I recommend everything for Crohn's disease! I've struggled with bowel issues for over 10 years and tried various medications. I discovered curcumin online, impressed by its natural composition, and decided to order it. It has anti-inflammatory and antimicrobial effects and is gentle on my stomach. By the second week, my irritable bowel syndrome symptoms improved, and my overall well-being enhanced. It's essential to maintain the correct diet for those with Crohn's. Best of health!

Lung Cancer

Curcumin promotes cancer cell death

Curcumin inhibits the activity of ubiquitin ligase Smurf2 to promote NLRP3‑dependent pyroptosis in non‑small cell lung cancer cells.

Most Relevant Research

We explored the impact of curcumin, a natural compound found in turmeric, on non-small cell lung cancer (NSCLC). Our investigation utilized two models: laboratory-based NSCLC cell lines (A549 and NCI-H1299) and a mouse tumor model. By applying curcumin treatment, we aimed to understand how it influences cell growth and induces a specific form of cell death known as pyroptosis.

Our findings revealed that curcumin effectively slowed down the growth of NSCLC cells and triggered pyroptosis. This process is mediated through interactions with a protein called Smurf2, which regulates the ubiquitination of another protein, NLRP3. We observed that when Smurf2 activity was inhibited by curcumin, NLRP3 was stabilized, leading to increased levels of pyroptosis-associated factors.

In the animal study, curcumin treatment also resulted in smaller tumor sizes and decreased expression of Ki67, a marker for cell proliferation. Furthermore, this treatment increased NLRP3 and the factors linked to pyroptosis. Overall, our work illustrates how curcumin may hold therapeutic promise for lung cancer treatment by promoting destruction of cancer cells through pyroptosis.

9.5

In remission

Most Useful Review

Elizabeth B: Curcumin is known for its anti-cancer properties. I have been taking 2g (4 capsules) daily since shortly after my stage 4 lung cancer diagnosis a year ago. I went into remission within three months, and all my tumours have since disappeared. I have been in remission with no evidence of disease for eight months now.

Ulcer

Curcumin alleviates ulcerative colitis

Effect of curcumin regulated memory Th7 cells in mice with DSS-induced colitis.

Most Relevant Research

Our exploration focused on how curcumin, a key ingredient in turmeric, affects ulcerative colitis (UC), particularly its impact on memory helper T (mTh) cells. Through a carefully designed experiment using dextran sulfate sodium (DSS) to create a colitis model in mice, we aimed to understand curcumin’s role as a potential treatment.

We found that curcumin significantly improved various symptoms of colitis in the mice, including a reduction in disease activity levels and overall inflammation. Notably, curcumin helped in decreasing the structural damage within the colon and led to a restoration of colon length. Furthermore, the treatment adjusted cytokine levels, promoting beneficial ones like IL-2, IL-4, and IL-10 while suppressing IL-7 and IL-21, which are linked to inflammation.

Importantly, our study demonstrated that curcumin influences mTh7 cells and their activity. The findings from advanced techniques, such as molecular docking and Surface Plasmon Resonance (SPR), reinforced that curcumin interacts effectively with both IL-7 and its receptor, ultimately reducing their expression. This suggests that curcumin helps heal DSS-induced colitis by curbing the activity of mTh7 cells and blocking the pro-inflammatory IL-7/IL-7R signaling pathway.

9.5

Effective for ulcers

Most Useful Review

The main active ingredient in turmeric is curcumin, which is known for its antioxidant and anti-inflammatory properties. Adding curcumin to anti-Helicobacter pylori therapy enhances its effectiveness. This opens new options for using turmeric to treat ulcers. Good results have also been reported for curcumin in conditions like ulcerative colitis and Crohn's disease. Moreover, it has therapeutic effects on inflammatory processes in the intestines and the pancreas, and it prevents fatty liver disease. Overall, turmeric holds promise for treating ulcers and various inflammatory conditions.

Anemia

Curcumin reduces iron overload effectively

The Effect of Curcumin on Iron Overload in Patients with Beta-Thalassemia Intermedia.

Most Relevant Research

We set out to understand how curcumin, a compound found in turmeric, affects people with beta-thalassemia intermedia, particularly focusing on iron overload, a common issue in this condition. Our study was carefully designed as a randomized, controlled, double-blind trial. This means that neither the participants nor the researchers knew who was receiving the curcumin treatment or the placebo, which helps ensure the results are reliable.

We conducted blood tests before and after the treatment to measure various iron-related indicators like serum iron, ferritin, and transferrin levels. To our delight, we observed that participants receiving curcumin showed significant reductions in serum iron and ferritin levels compared to those on placebo. Specifically, serum iron levels decreased with a p-value of less than 0.001, and ferritin levels dropped with a p-value of 0.002. Additionally, transferrin saturation also significantly improved in the group taking curcumin.

Overall, our findings suggest that curcumin can be an effective option for managing iron overload in patients dealing with beta-thalassemia intermedia. This provides hope for new strategies in treating this challenging aspect of the disease.

8.8

Improved condition

Most Useful Review

Curcumin did not cause any side effects and effectively helped with my iron deficiency anaemia and other issues. I noticed a significant improvement in my condition. This polyphenol works at the cellular level.

Anxiety

Curcumin shows promise for anxiety

Based on 10 Researches

Effect of curcumin supplementation on symptoms of anxiety: A systematic review and meta-analysis of randomized controlled trials.

Most Relevant Research

We explored the potential of curcumin, a natural compound found in turmeric, as a treatment for anxiety. Through a thorough analysis of eight randomized controlled trials that included 567 participants, we aimed to determine whether curcumin could effectively alleviate anxiety symptoms.

The results were promising. The analysis indicated a significant improvement in anxiety symptoms among those who took curcumin, with a standardized mean difference of -1.56. This suggests that curcumin may lead to a noticeable reduction in anxiety levels. However, it’s important to note that the studies included were limited in number, and the variety in their designs contributed to considerable variation in outcomes.

While we found indications that curcumin may offer benefits for individuals dealing with anxiety, we also recognize the need for further high-quality research to solidify these findings. Until more comprehensive studies are conducted, it's crucial to approach curcumin as a potential supplementary treatment, rather than a standalone solution for anxiety disorders.

9.5

Reduces anxiety effectively

Most Useful Review

If you suffer from inflammation or pain, this supplement is essential. Curcumin, shown to be as effective as ibuprofen, is a key addition for my joint pain and headaches. It may also alleviate anxiety if linked to inflammation. I double my dose when feeling unwell, and it noticeably speeds up recovery from infections.

Asthma

Curcumin nanoparticles reduce asthma effects

Based on 11 Researches

Effect of curcumin nanoparticles on proliferation and migration of mouse airway smooth muscle cells and airway inflammatory infiltration.

Most Relevant Research

We set out to understand how turmeric, specifically its active component curcumin, can affect asthma-related issues in airway smooth muscle cells. To do this, we leveraged curcumin-loaded nanoparticles (CUR-NPs) which enhance the delivery and effectiveness of curcumin, overcoming its natural hurdles like hydrophobicity and instability.

In our study, we isolated airway smooth muscle cells from mice and subjected them to a process that mimics conditions present during asthma attacks, specifically looking at how these cells proliferate and migrate under the influence of a growth factor called TGF-β1. Our observations revealed that CUR-NPs significantly reduced the excessive cell growth and movement that TGF-β1 induces.

Not only did CUR-NPs appear to regulate curcumin’s release effectively, but they also inhibited key pathways involved in inflammation and remodeling of the airways. We also validated our findings using an asthma model in mice, where CUR-NPs treatment visibly reduced inflammatory markers in lung tissue compared to untreated control groups.

Overall, our research suggests that turmeric, through its nanoparticles form, may hold promise as a therapeutic approach for managing asthma by preventing the excessive growth and migration of airway smooth muscle cells.

9.5

Potential asthma aid

Most Useful Review

Curcumin is utilised in creating drugs for chronic inflammatory diseases in the body, including asthma. It may help alleviate pain and enhance joint mobility for those with arthritis.

Autoimmune Disorder

Curcumin improves rheumatoid arthritis symptoms

The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial.

Most Relevant Research

We conducted a clinical trial to explore how curcumin, a compound found in turmeric, affects women with rheumatoid arthritis (RA). Over the course of eight weeks, 48 participants took either a daily curcumin capsule or a placebo. This double-blind, placebo-controlled design ensured that neither the participants nor the researchers knew who was receiving the actual treatment, which adds credibility to our findings.

At the end of the study, we observed some encouraging results. Women who took curcumin showed a significant increase in their serum total antioxidant capacity (TAC), indicating improved antioxidant levels in their bodies. Additionally, these participants experienced a notable decrease in symptoms like tender and swollen joints, pain intensity, and overall disease activity, as measured by the Disease Activity Score in 28 joints (DAS-28).

While levels of malondialdehyde (MDA)—a marker of oxidative stress—decreased in the curcumin group, the change wasn't significantly different when compared to the placebo group. Overall, our findings support the idea that curcumin can be beneficial for women with RA, particularly in reducing disease activity and enhancing antioxidant levels.

Normalised bowel function

Most Useful Review

I highly recommend curcumin for managing my autoimmune disorder, Crohn's disease. After over 10 years of battling bowel problems and trying various ineffective medications, I discovered curcumin online. Its natural composition and anti-inflammatory properties caught my attention. Within two weeks, my stool returned to normal, and my overall condition improved. Following a strict diet is crucial for those with Crohn's. Wishing everyone good health!

Bloating

I took this on my nutritionist's recommendation. Combined with other supplements, it worked wonders for my cat, and I no longer experience bloating. Additionally, I regularly take apple cider vinegar and artichoke. These are beneficial supplements that are not addictive and significantly aid my digestion and liver detox.

Bursitis

I love this product. Curcumin is an effective anti-inflammatory, and this high-dose source offers great value. My dad used it for his bursitis, and after a consistent three-month period, he no longer suffers from it.

Cardiovascular Disease

Curcumin protects heart cells effectively

Based on 8 Researches

Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1.

Most Relevant Research

We explored how curcumin, a natural compound found in turmeric, can protect heart cells during events like myocardial ischemia/reperfusion injury (I/RI). This type of injury occurs when blood supply returns to the heart after a period of low oxygen, often leading to additional damage to heart tissue.

Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.

Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.

Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.

9.5

Powerful anti-inflammatory

Most Useful Review

Curcumin is a concentrated extract of turmeric root with a strong anti-inflammatory effect, beneficial in various conditions including cardiovascular disease. It reduces inflammatory markers and is an effective COX-2 inhibitor, similar to many modern NSAIDs, providing pain relief in arthritis. A typical effective dosage is 1-1.5 grams daily, and it can be combined with Boswellia. It's important to note that curcumin is contraindicated in cases of gallstones.

Chronic Cough

After hearing about Curcumin's effectiveness, I began taking it with my husband. He experienced a severe chronic cough and sputum production every morning, while I also took Pycnogenol. My cough and sputum resolved within a day, and I felt much better. I intend to continue taking it.

Cold Sores

Curcumin and blue light therapy

Photodynamic Therapy Mediated by Curcumin and Blue Light for Recurrent Herpes Labialis: A Case Report.

Most Relevant Research

We explored the effectiveness of photodynamic therapy (PDT) using curcumin and blue light for treating recurrent cold sores, specifically herpes labialis. This innovative treatment approach was assessed based on its ability to accelerate the healing of lesions and reduce their recurrence.

Our findings suggest that PDT shows promise as a safe and cost-effective option for managing this troublesome condition. However, it is important to note that the study was primarily focused on the combined effect of curcumin with PDT, making it difficult to determine the isolated benefits of curcumin on its own for cold sore treatment.

Overall, our research highlights an exciting potential pathway for alleviating the symptoms associated with recurring herpes labialis, paving the way for future studies to further investigate its components and their individual effects.

9.5

Treats cold sores

Most Useful Review

Curcumin is essential if you suffer from pain or inflammation. It's proven to be as effective as ibuprofen for symptoms like joint pain, headaches, and possibly even anxiety linked to inflammation. I double the dose when I sense a flu or cold approaching, which helps me recover quicker.

Diabetes

Great curcumin. A sister I know took curcumin alongside her diabetes medication and saw her blood sugar levels finally drop to a safe level. The doctor may lower her medication at her next appointment if she continues with curcumin. Thank goodness!

Erectile Dysfunction

Curcumin nanoparticles improve erectile function

Based on 5 Researches

Topically Applied Curcumin-Loaded Nanoparticles Treat Erectile Dysfunction in a Rat Model of Type-2 Diabetes.

Most Relevant Research

We explored the potential benefits of curcumin, a compound found in turmeric, for treating erectile dysfunction (ED) in a rat model of type-2 diabetes. To assess its effectiveness, we applied curcumin-loaded nanoparticles directly to the skin of diabetic rats every two days for two weeks. This method was chosen to bypass the poor absorption of curcumin when taken orally, which limits its effectiveness.

The findings revealed that applying these curcumin nanoparticles did improve erectile function in the treated rats, particularly at lower stimulation levels. We measured the erectile response by assessing pressure changes in the rats' bodies after nerve stimulation. Alongside this, we also noted changes in inflammatory markers within the corporal tissue, suggesting a potential therapeutic mechanism.

However, while the response was promising, it was significant only under certain conditions and not overwhelmingly strong. This indicates that further research is necessary to refine treatment protocols and understand any possible side effects. Overall, our study highlights the possibility of using topical curcumin as a novel treatment option for ED in patients with type-2 diabetes.

9.5

Improved erectile dysfunction

Most Useful Review

Magic! The anti-inflammatory and vasodilatory effects are superb, significantly aiding in addressing my erectile dysfunction—a remarkable outcome!

Frozen Shoulder

Eased shoulder inflammation

Great help with my severe frozen shoulder. I took three pills, three times a day for three weeks. Delivery to Israel took just three days. Excellent service from iHerb!!

Gout

Curcumin nanoparticles effectively combat gout

Based on 6 Researches

Anti-gouty arthritis and anti-inflammatory effects of curcumin nanoparticles in monosodium urate crystals induced Balb/C mice.

Most Relevant Research

We explored the potential of curcumin nanoparticles (CNPs) as a treatment for gout, a condition caused by the buildup of urate crystals in the joints. To investigate this, researchers induced gout-like symptoms in mice by injecting monosodium urate crystals. This led to joint swelling and increased levels of uric acid in the bloodstream.

The study involved administering various concentrations of CNPs, alongside a commonly used medication, allopurinol. The results were promising, showing that CNPs not only lowered uric acid levels and reduced swelling but also decreased inflammation in the affected mice. Interestingly, the application of CNPs increased beneficial substances like high-density lipoprotein and interleukin-10, further supporting their potential health benefits.

Overall, our findings indicate that curcumin nanoparticles present a viable and effective anti-gout treatment with minimal side effects compared to traditional pharmaceuticals. This opens exciting possibilities for developing natural therapies to manage gout and improve patient quality of life.

8.8

Helps with gout

Most Useful Review

I bought this for my dad, who suffers from gout, and it has been helpful for him!

High Cholesterol

Turmeric improves cholesterol levels

Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.

Most Relevant Research

We aimed to understand how turmeric, specifically its active compound curcumin, affects cholesterol levels in the body. After searching several online databases and analyzing 64 randomized clinical trials, we found that turmeric supplementation can lead to noticeable improvements in key cholesterol metrics.

Specifically, we observed significant reductions in total cholesterol, triglycerides, and low-density lipoprotein cholesterol (often referred to as "bad" cholesterol). Additionally, there was an increase in high-density lipoprotein cholesterol, known as "good" cholesterol. However, it's important to note that turmeric did not show considerable effects on related apolipoproteins, which are proteins that help carry cholesterol in the blood.

Although these results are promising, we must approach them with caution. The quality of evidence was assessed to be low and very low regarding these outcomes. This means that while turmeric supplementation does seem to help with certain cholesterol levels, more rigorous studies are needed to confirm these benefits and properly evaluate the overall efficacy.

8.3

Cholesterol treatment

Most Useful Review

Curcumin reduces bad cholesterol levels and slows blood clot formation. It inhibits the production of inflammatory substances. Turmeric also aids in preventing and alleviating atherosclerosis. It has proven effective in reducing and preventing metabolic syndrome.

Hypertension

Turmeric supports blood pressure management

Based on 8 Researches

Curcumin/turmeric supplementation could improve blood pressure and endothelial function: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials.

Most Relevant Research

We explored the potential benefits of turmeric, particularly curcumin, in managing hypertension through a systematic review and meta-analysis of randomized controlled trials. This rigorous examination pulled together findings from several studies to better understand how turmeric could influence blood pressure and related heart health factors.

Our focus was on key indicators such as systolic and diastolic blood pressure, flow-mediated vasodilation, and the levels of certain adhesion molecules that could predict vascular health. By using various reputable online databases, we gathered a wide range of data to offer a comprehensive view of turmeric's effectiveness.

The findings suggest that turmeric supplementation could indeed play a supportive role in improving blood pressure and endothelial function. However, it's essential to note that more research is required to fully understand its impact on inflammatory adhesion molecules in the bloodstream.

9.5

Significant improvement

Most Useful Review

I bought this for my father, who has type 2 diabetes mellitus and hypertension. After two weeks of taking it, he reported feeling much better.

Nausea

Turmeric aids nausea relief

Based on 2 Researches

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta-analyses of randomized controlled trials in humans.

Most Relevant Research

We delved into the myriad ways that turmeric, particularly in the form of ginger supplements, can help mitigate nausea. Our exploration involved synthesizing the findings from 161 different meta-analyses of randomized controlled trials, which ultimately revealed that turmeric is associated with various health benefits.

Specifically, ginger has shown effectiveness in reducing nausea, especially in pregnant women and those undergoing chemotherapy or surgery. Each of these situations often comes with its own set of challenges, prompting individuals to seek effective relief. The ability of turmeric to alleviate these symptoms highlights its potential as a natural remedy.

While the evidence suggests a favorable impact of turmeric on nausea, we also noted that the study’s context—such as the combination of turmeric with other treatments—might complicate how we view its effectiveness. It’s important to consider that while the data is promising, high-quality research is still needed to further confirm these beneficial associations and dissect turmeric’s impact when used in isolation.

8.8

Improved digestion

Most Useful Review

I purchased this medication for my mother, who was experiencing issues with her digestion, including poor appetite and nausea. After taking this medication, her appetite returned, and her digestion improved significantly.

Psoriasis

Curcumin nanogels show psoriasis promise

Curcumin Nanogel Preparations: A Promising Alternative for Psoriasis Treatment.

Most Relevant Research

We explored the potential of curcumin, a natural compound derived from turmeric, as a treatment for psoriasis. Known for its anti-inflammatory properties, curcumin has been used in traditional medicine for centuries and is now being recognized for its role in modern therapeutic approaches. Psoriasis, a chronic skin condition marked by red, scaly patches, can be challenging to manage, making the search for effective treatments crucial.

The study highlighted curcumin's ability to inhibit specific enzymes and proteins that contribute to the inflammation and proliferation of skin cells associated with psoriasis. Interestingly, curcumin is being formulated into nanogels—small, crosslinked hydrogels that enhance the delivery of the compound. This nanogel preparation not only boosts the solubility and stability of curcumin but also increases its bioavailability, meaning we may need lower doses to achieve the desired results.

Ultimately, we found that curcumin nanogels present a promising alternative to traditional psoriasis treatments. They offer a potential pathway to more effective and safer treatment options. However, it's essential to emphasize that more research is necessary to fully understand how well these curcumin nanogels work in humans before they become a standard part of psoriasis care.

9.5

Good for psoriasis

Most Useful Review

Curcumin is essential in one’s diet for its antiseptic qualities and ability to relieve inflammation. It speeds up healing, manages arthritis, and effectively addresses psoriasis, eczema, and other skin conditions. It also enhances metabolism, detoxifies the body, and helps combat depression and chronic fatigue.

Stroke

Curcumin aids stroke recovery

Curcumin protects against cerebral ischemia-reperfusion injury in rats by attenuating oxidative stress and inflammation: A meta-analysis and mechanism exploration.

Most Relevant Research

We explored how curcumin, a compound found in turmeric, may help protect the brain from damage caused by stroke. The study we reviewed involved an in-depth analysis, aggregating data from various experiments on rats that experienced cerebral ischemia-reperfusion injury (CIRI), which mimics the conditions of a stroke.

Our findings indicated that curcumin significantly improved neurological outcomes in these animals. We observed a marked reduction in neurological deficit scores, infarct volumes, and brain water content after curcumin treatment. This suggests that curcumin not only helps the brain recover but might also reduce damage during a stroke.

Additionally, the analysis revealed that curcumin enhances the body’s antioxidant defenses while decreasing harmful inflammatory markers. We found increases in beneficial substances like superoxide dismutase and glutathione, alongside decreases in reactive oxygen species and pro-inflammatory cytokines.

Subgroup analyses hinted that the effectiveness of curcumin could vary based on the dosage used. Overall, our exploration supports the potential of curcumin as a neuroprotective agent in stroke treatment, though further research is needed to solidify its practical applications in stroke therapy.

8.8

Improved bowel regularity

Most Useful Review

It is a fantastic product! I initially purchased this for my husband, as I learned that turmeric may assist stroke patients. Afterward, I began taking it too and found it helps me detox. I have regular bowel movements after every meal, which makes me feel great. It has also benefited my husband, who had constipation issues, becoming more regular up to twice daily.

Tendonitis

Curcumin enhances tendon healing effectively

Based on 9 Researches

Curcumin improves tendon healing in rats: a histological, biochemical, and functional evaluation.

Most Relevant Research

We evaluated how curcumin, a compound found in turmeric, affects tendon healing, particularly in the context of tendon injuries. To do this, we created a controlled study using Sprague-Dawley rats, dividing them into two groups: one that received curcumin and a control group that did not. The curcumin treatment involved administering 100 mg per kg of body weight via oral gavage.

Throughout the experiments, we looked at various indicators of tendon healing, including the organization of collagen fibers, levels of oxidative stress markers, and overall biomechanical properties of the tendons. What we observed was quite promising—curcumin-treated tendons exhibited well-structured collagen, lower levels of malondialdehyde, and enhanced strength, which suggests improved healing.

Our findings indicate that curcumin can be a valuable addition to treatments aimed at promoting the healing of tendon injuries. While we didn’t study tendonitis directly, the positive impact we noted suggests that turmeric might hold potential for managing various tendon-related issues.

9.5

Effective for tendonitis

Most Useful Review

Forget pharmaceuticals! This stuff is fantastic. It works just as effectively as steroids, without the unpleasant side effects. I found it particularly helpful for bowel inflammation and tendonitis, and I felt 90% better the very next day. It's well worth trying before spending money on the pharmaceutical companies.

Tinnitus

Effective against tinnitus

Works well for tinnitus. I have found it truly beneficial in alleviating the symptoms.

Acne

Curcumin shows promise for acne

Based on 7 Researches

In vitro anti-propionibacterium activity by curcumin containing vesicle system.

Most Relevant Research

We investigated the potential of curcumin, a natural compound from turmeric, as an effective treatment for acne caused by Propionibacterium acnes. This bacterium can contribute to the development of inflammatory acne, especially when it grows excessively in hair follicles. Our goal was to create lipid-based vehicles to effectively deliver curcumin and see if it could inhibit the growth of this troublesome bacteria.

Using innovative testing methods, including bioluminescence assays, we evaluated how well our curcumin-infused vehicles performed against P. acnes. Additionally, we studied how much curcumin could accumulate in the skin using specialized diffusion cells and high-tech microscopy. The results were promising: we found that our lipid vehicles could accumulate an impressive amount of curcumin in the skin while significantly reducing the bacteria's growth.

Notably, curcumin showed discernible inhibitory effects at a concentration of just 0.43 µg/mL. Moreover, we confirmed through microscopy that the curcumin effectively formed a reservoir in the skin, enabling longer-lasting effects against acne. Overall, these findings suggest that curcumin-based vehicles, particularly when mixed with lauric acid, could serve as a promising new option for treating acne vulgaris.

Improved skin quality

Most Useful Review

Friendly for women during menstruation, curcumin positively impacts skin quality. After using it for over a year, I've noticed improvements in my acne and faster muscle recovery. It also helps lessen discomfort and abdominal pain during my cycle. This brand is reliable.

Breast Cancer

Curcumin reduces breast cancer aggressiveness

Curcumin alleviates the aggressiveness of breast cancer through inhibiting cell adhesion mediated by TEAD4-fibronectin axis.

Most Relevant Research

We explored how curcumin, a compound found in turmeric, can influence breast cancer by targeting specific cellular pathways. The study focused on understanding the role of TEAD4, a transcription factor known to affect cancer cells’ abilities to adhere and invade other tissues.

Our findings revealed that curcumin significantly decreased the migration and invasion capabilities of breast cancer cells. This was particularly important since these qualities contribute to tumor metastasis, which is the leading cause of death in breast cancer patients. In experiments with mice, curcumin also showed the potential to inhibit lung metastasis of breast cancer.

We discovered that TEAD4 promotes the expression of fibronectin, an important protein that helps cancer cells stick to each other and spread. Curcumin was found to disrupt the interaction between TEAD4 and the fibronectin gene, limiting its ability to encourage tumor spread. Interestingly, removing fibronectin from the cancer cells reversed the aggressive behavior induced by TEAD4 overexpression.

Overall, our investigation suggests that the TEAD4-fibronectin pathway could be targeted in breast cancer therapies. Curcumin demonstrates promise in reducing the aggressive nature of breast cancer and could pave the way for new treatment strategies.

9.5

Remission achieved

Most Useful Review

I have been taking 2 grams (4 capsules) of curcumin daily since my stage 4 breast cancer diagnosis a year ago. Remarkably, I went into remission within three months, and all tumours have disappeared. I’ve been in remission for eight months with no evidence of disease.

Constipation

Curcumin improves IBS-C symptoms

Based on 3 Researches

Therapeutic effects of curcumin on constipation-predominant irritable bowel syndrome is associated with modulating gut microbiota and neurotransmitters.

Most Relevant Research

We set out to explore the effects of curcumin, a compound found in turmeric, on constipation-predominant irritable bowel syndrome (IBS-C). This condition affects a significant portion of the global population, making it essential to investigate potential treatments.

In our assessment, we compared the effectiveness of curcumin to mosapride, a known treatment, by observing changes in gut microbiota and neurotransmitter levels in rat models of IBS-C. Through analysis, we found that the rats receiving curcumin experienced improved bowel movements, characterized by increased fecal weight and water content compared to those with IBS.

Furthermore, our investigations revealed that curcumin treatment led to a reduction in certain neurotransmitters in the serum of the rats. This suggests that curcumin may not only help regulate gut health but also impact the signals that influence bowel function.

Overall, these findings indicate that curcumin could be a promising natural option for managing IBS-C by modifying gut microbiota and balancing neurotransmitter levels.

9.5

Symptom relief

Most Useful Review

Curcumin works similarly to ibuprofen, relieving symptoms of constipation, gastrointestinal pain, and effectively helping with colds. It also aids joint pain and acts as a natural tonic.

Leg Cramps

This turmeric product has significantly improved my menstrual cramps. I used to struggle with leg cramps, but now they are much easier to manage.

Menopause

Curcumin may mitigate menopause effects

Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats.

Most Relevant Research

We focused on how curcumin, a natural compound found in turmeric, could help address menopause-related challenges, particularly oxidative stress and lipid profile issues. Our study utilized female Wistar rats, dividing them into two main groups: those who underwent ovariectomy (OVX)—a model for menopause—and those that were sham-operated.

We gave the OVX rats either a vehicle or varying doses of curcumin over 30 days and observed significant findings. The OVX rats showed increased intestinal fat and higher levels of harmful substances like IL-6 and LDL cholesterol compared to the sham group, highlighting the negative impact of menopause on health. However, curcumin supplementation appeared to notably reduce these adverse effects, bringing many parameters back to levels similar to those seen in the sham-operated rats.

Our findings suggest that curcumin may serve as a promising option for managing changes in lipid metabolism and reducing oxidative damage that often accompany menopause. This study indicates a potential path for further exploration into natural treatments for menopause-related health issues.

8.8

Menopause symptom relief

Most Useful Review

Excellent! Curcumin is a promising ingredient for supporting a healthy inflammatory response. It's proven to have numerous healing properties, including benefits for women during menopause, by reducing symptoms such as PMS and hot flashes. Additionally, turmeric positively affects skin condition by supporting collagen synthesis. I take one capsule daily with meals and highly recommend it!

Migraine

Nano-curcumin reduces IL-17 levels

The effects of nano-curcumin supplementation on Th1/Th17 balance in migraine patients: A randomized controlled clinical trial.

Most Relevant Research

We conducted a study to explore how nano-curcumin, a special formulation of turmeric, influences the balance of immune proteins associated with migraines. By randomly assigning forty participants with episodic migraines to receive either an 80 mg dose of nano-curcumin or a placebo for two months, we ensured that our findings would be robust and reliable.

Our primary focus was on two key proteins: interferon gamma (IFN-γ) and interleukin-17 (IL-17). These proteins play significant roles in immune responses and are implicated in migraine pathophysiology. Using advanced techniques like real-time PCR and ELISA, we measured the levels of these proteins in our participants' blood.

The results were promising; we noted a significant decrease in the levels and gene expression of IL-17 in the group taking nano-curcumin compared to the placebo group. However, it’s important to mention that we found no significant differences in the levels of IFN-γ between the groups.

Overall, our findings suggest that nano-curcumin supplementation may provide beneficial effects for migraine patients by specifically targeting IL-17, which could lead to new approaches for managing migraine symptoms going forward.

9.5

Migraine benefits

Most Useful Review

Curcumin acts as a tonic, analgesic, and hemostatic. Its regular use increases antimicrobial proteins, bolstering immune support against fungi and viruses. I benefit from it for migraines, gallstones, and more. It also lowers cholesterol, preventing thrombosis and atherosclerosis. I take one capsule daily with food.

Obesity

Turmeric nanovesicles aid obesity treatment

Based on 15 Researches

Development and Evaluation of Reconstructed Nanovesicles from Turmeric for Multifaceted Obesity Intervention.

Most Relevant Research

We explored the potential of turmeric in challenging obesity, driven by its natural properties and numerous health benefits. Our focus was on a newly developed formulation called "Reconstructed Turmeric-derived Nanovesicles" (Rec-tNVs), which aimed to enhance the effects of curcumin, the active component of turmeric.

By using advanced techniques, we increased the curcumin content significantly in these nanovesicles, allowing us to measure their impact more effectively. The Rec-tNVs showed a remarkable capacity to promote fat breakdown and prevent fat creation in fat cells, while also encouraging the conversion of fat cells to a more metabolically active form.

In rigorous tests involving high-fat diet mouse models, we observed weight reductions of about 18.68% and 14.56% with intragastric and subcutaneous delivery of the Rec-tNVs, respectively, over four weeks. Importantly, these results were better than what we saw with free curcumin treatment alone, suggesting that these nanovesicles could target fat tissues effectively and influence overall metabolism and gut health.

This study highlights the multi-dimensional benefits of turmeric and opens doors for new plant-based treatments for obesity. It's an exciting step forward in the quest for safer weight management solutions.

8.8

Reduces inflammation

Most Useful Review

The benefit of curcumin is its ability to reduce chronic inflammation, which can lead to metabolic disorders, including obesity. It also positively affects arthritis patients by alleviating joint swelling. Regular use of curcumin notably decreases the risk of liver diseases and mitigates symptoms of conditions like hepatitis, diabetes, and periodontitis.

Pneumonia

Reduced blood pressure

Since contracting pneumonia, my blood pressure has risen, and my examination revealed inflammation in my cells. After consuming curcumin, I noticed a significant anti-inflammatory effect, and my blood pressure has now returned to normal.

Sleep Apnea

Curcumin protects neurons in sleep apnea

Based on 3 Researches

Curcumin triggers the Wnt/β-catenin pathway and shields neurons from injury caused by intermittent hypoxia.

Most Relevant Research

We investigated how Curcumin, a compound found in turmeric, may help reduce neuronal damage linked to obstructive sleep apnea (OSA). Using a cell model that simulates intermittent hypoxia, we assessed various factors such as cell health, toxicity, apoptosis (cell death), and the activity of a specific signaling pathway known as Wnt/β-catenin.

Our findings revealed that intermittent hypoxia increases cell death and harmful toxicity while suppressing cell growth and the Wnt/β-catenin pathway. However, when we introduced Curcumin, we noted significant improvements. Cell viability rose, apoptosis rates fell, and cell proliferation was promoted. Additionally, Curcumin helped activate the Wnt/β-catenin pathway, which is crucial for cell survival and function.

To further test our results, we created an animal model of intermittent hypoxia. In this model, Curcumin treatment managed to reduce damage to the hippocampus and restore Wnt/β-catenin pathway activity, validating our cell-based findings. Overall, these promising results suggest that Curcumin might be an innovative approach to battling neurological impairments caused by sleep apnea.

9.5

Joint pain relief

Most Useful Review

I took it to my father, who has arthritis. I read that curcumin is a good anti-inflammatory for such a diagnosis. After a few days of taking it, the pain diminished, and I began to sleep normally. I ordered it alongside other vitamins, so we shall see what happens next, but at present, we notice an improvement, as his joints hurt less.

Urinary Tract Infection

Curcumin inhibits UTI bacteria

Based on 5 Researches

Inhibition of biofilm development of uropathogens by curcumin - an anti-quorum sensing agent from Curcuma longa.

Most Relevant Research

We examined the potential of curcumin, the active ingredient in turmeric, to combat urinary tract infections (UTIs), which are often caused by bacteria forming biofilms. This study specifically looked at how curcumin could interfere with the quorum sensing (QS) systems of uropathogens like Escherichia coli and Pseudomonas aeruginosa.

Our research found that curcumin effectively inhibited the formation of biofilms by these bacteria and was even able to disrupt existing mature biofilms. Using light and confocal laser scanning microscopy, we observed these effects firsthand.

Additionally, we noted that treatment with curcumin reduced important QS-dependent activities in these bacteria, such as exopolysaccharide and alginate production, as well as their swimming and swarming abilities. Remarkably, curcumin also increased the effectiveness of standard antibiotics against these uropathogens, making it a promising option for enhancing current UTI treatments.

8.3

Really good effect

Most Useful Review

I ordered it for my father, and he said it was great! It’s truly effective for treating urinary tract infection and inflammation.

Whooping Cough

After hearing about the effects of Curcumin, I began taking it with my husband for his severe morning cough and sputum. Although he experienced symptoms, I also took Pycnogenol, which stopped my cough and sputum within a day. I felt significantly better and plan to continue.

Ear Infection

Curcumin prevents ear infection biofilm

Based on 6 Researches

[Can curcumin prevent the formation of Pseudomonas aeruginosa biofi lm on the surface of tympanostomy tubes?].

Most Relevant Research

We aimed to find out if curcumin, the active ingredient in turmeric, could help prevent the formation of harmful biofilms from Pseudomonas aeruginosa on tympanostomy tubes. Biofilms can lead to ear infections, particularly after surgeries that involve these tubes.

Our study involved a systematic approach where we tested curcumin at different concentrations in a controlled laboratory environment. The results were promising; we observed that a concentration of 100 µg/mL of curcumin was effective in stopping the biofilm formation completely. In contrast, lower concentrations did not prevent the growth of bacteria, which is critical for keeping ears healthy post-surgery.

These findings suggest that using curcumin could play a significant role in managing ear infections related to tympanostomy tubes. However, further studies in real-life settings are needed to confirm these results. If successful, this treatment could lead to better outcomes for patients undergoing ear surgeries.

7.5

Effective treatment

Most Useful Review

I ordered this for my father, who said it was great! He found it particularly helpful for his ear infection and inflammation.

Gastritis

Curcumin reduces H. pylori-induced gastritis

Based on 6 Researches

Curcumin inhibits gastric inflammation induced by Helicobacter pylori infection in a mouse model.

Most Relevant Research

We recently investigated how curcumin, a natural compound found in turmeric, affects gastritis caused by Helicobacter pylori (H. pylori) infection. This study used twenty-eight C57BL/6 mice infected with the H. pylori strain and compared their results to ten non-infected control mice.

By the conclusion of the study, we found that 42% of the infected mice who did not receive treatment developed gastritis, which was confirmed through histological examination. These mice showed heightened levels of inflammatory markers. However, curcumin treatment led to a significant reduction in these inflammatory responses. Notably, no inflammation was observed in the mice that received curcumin.

Our findings suggest that curcumin may be a beneficial nutritional approach to mitigate the detrimental gastric inflammation triggered by H. pylori infections, particularly in the absence of effective vaccines or eradication strategies. This points to the potential of dietary interventions in managing gastric health amid ongoing challenges in treating H. pylori.

9.5

Helpful for gastritis

Most Useful Review

This curcumin is free from pepper, making it suitable for my gastritis. It does not upset my stomach and has significantly helped with body replenishment, allergies, and pain in my spine and joints. While taking it, I experienced no discomfort. I consumed two cans, taking one capsule a day. I plan to repeat the course soon.

Heartburn

The functioning of my gastrointestinal tract has certainly improved! My heartburn has decreased, and my stool is now regular, though I did notice that this was only the case when I took it regularly.

Chest Pain

Effective for swelling

Very effective for my swelling. I have rheumatoid arthritis, and this product really helps with the pain and swelling; however, please drink plenty of water as it can cause mild constipation.

Chronic Fatigue Syndrome

Curcumin alleviates fatigue symptoms

Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model.

Most Relevant Research

We examined the connection between curcumin, a natural compound found in turmeric, and chronic fatigue syndrome in a mouse model. This model used purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigens to induce symptoms of fatigue.

The study involved a water-immersion stress test conducted for 10 minutes each day over 19 days. Notably, the mice treated with LPS or BA showed increased immobility time and heightened sensitivity to pain, which are markers for fatigue. As expected, these mice also exhibited elevated levels of tumor necrosis factor-alpha (TNF-alpha), a sign of inflammation.

Upon administering curcumin during this period, we observed significant improvements. The treatment reduced both the immobility time and pain sensitivity in the mice. Additionally, curcumin helped to lower oxidative stress and the levels of TNF-alpha.

These findings suggest that curcumin could be a promising option for addressing chronic fatigue syndrome, especially related to inflammation and oxidative stress. As we continue to explore this natural remedy, we may uncover more about its potential role in managing this challenging condition.

7.5

Supports autoimmune issues

Most Useful Review

This has been helpful for my chronic pain and my chronic fatigue syndrome related to autoimmune issues.

Heart Attack

Curcumin shows promise for heart health

Cardioprotective effect of curcumin on myocardial ischemia/reperfusion injury: a meta-analysis of preclinical animal studies.

Most Relevant Research

We explored how curcumin, a natural compound found in turmeric, might help protect the heart during episodes of myocardial ischemia/reperfusion (I/R) injury. In a comprehensive analysis of 37 animal studies, we looked at the effects of curcumin on heart damage caused by interrupted blood flow, which is a common issue during heart attacks.

Our findings showed that curcumin seemed to have a significant positive impact on reducing the size of heart damage, improving heart function, and lowering harmful enzymes and oxidative stress in the heart muscle. We noted that these effects were consistent across various animal models and dosages used in the studies we reviewed. However, we also discovered some indications of publication bias in the reporting of certain results, which is something to consider in interpreting the data.

While the evidence from animal studies is promising, we must be cautious. It's essential to validate these findings through research in larger animal models and, ultimately, in human clinical trials before we can confidently recommend curcumin as a treatment for heart attack injuries.

9.5

Supports heart health

Most Useful Review

This is an excellent product. I take this curcumin twice daily with meals. It’s great for heart health, reduces cholesterol, combats cancer cells, and is anti-inflammatory.

Headache

Curcumin improves migraine symptoms

Based on 8 Researches

Effects of Curcumin Supplementation on Clinical Features and Inflammation, in Migraine Patients: A Double-Blind Controlled, Placebo Randomized Clinical Trial.

Most Relevant Research

We conducted a thoughtful investigation into the effects of curcumin, a natural compound found in turmeric, on migraine sufferers. This study involved 44 women with migraines, who were randomly assigned to receive either 500 mg of curcumin twice a day or a placebo for eight weeks. The team measured various factors, including the severity, duration, and frequency of headaches, as well as specific inflammation markers in the body.

After the eight-week period, we observed noticeable improvements in the group receiving curcumin. Compared to the placebo, participants taking curcumin reported significant reductions in pain severity and headache duration. While there was a slight improvement in how often headaches struck, it didn't reach a level of statistical significance.

Moreover, curcumin supplementation also appeared to lower levels of two important inflammatory markers related to migraines: calcitonin gene-related peptide (CGRP) and interleukin-6 (IL-6). We didn't see any significant changes in body weight or composition between the groups, indicating that the effects were primarily linked to curcumin's properties rather than any other lifestyle changes.

Overall, our findings suggest that curcumin may serve as an effective, natural remedy for managing migraine symptoms, largely due to its anti-inflammatory benefits.

9.5

Relieves detox headaches

Most Useful Review

This product effectively alleviates my detox headaches. I found that other supplements caused mild headaches, but this one does not have any side effects.

Pancreatitis

Mum took it to reduce inflammation but experienced unwanted symptoms in the form of pancreatitis, likely because she lacks a gallbladder. Curcumin is fat-soluble, requiring fats and bile acids for absorption, which may explain her issues.

Reflux

Curcuma extract improves reflux symptoms

Based on 5 Researches

Protective Effects of Inflammation of Curcumae Longae Rhizoma 30% EtOH Extract on Acute Reflux Esophagitis Rats.

Most Relevant Research

We evaluated how Curcumae Longae Rhizoma extract, which contains the well-known compound curcumin, influences reflux conditions in rats suffering from acute reflux esophagitis (ARE). Through a series of experiments, we were able to measure various antioxidant and inflammatory markers, providing insight into how this natural treatment helps manage reflux symptoms.

To investigate the protective effects of this turmeric extract, we induced ARE in Sprague-Dawley rats and administered the extract prior to the onset of reflux. Remarkably, we found that the inclusion of the turmeric extract significantly reduced tissue damage in the esophagus of the treated rats. Moreover, the levels of harmful substances typically associated with inflammation and oxidative stress, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were notably decreased.

Additionally, our results indicated that the turmeric extract helped promote antioxidant activity while suppressing pro-inflammatory proteins. This suggests that Curcumae Longae Rhizoma may be a promising therapeutic option for managing reflux-related conditions effectively. Overall, we were encouraged by the findings that indicate its potential role in both prevention and treatment of acute reflux esophagitis.

4.8

Limited reflux relief

Most Useful Review

So far so good; it might be helping with general inflammation. However, it hasn't yet alleviated my reflux as I hoped. It can stain clothing yellow, yet it has had no negative effects.

Allergies

Curcumin shows no allergy test effects

Based on 10 Researches

Curcumin does not significantly affect immediate skin tests.

Most Relevant Research

We focused on how turmeric, specifically curcumin, might influence allergies. Our study involved 34 participants who were allergic to certain antigens. To assess the effect of curcumin, we randomly assigned participants to receive either curcumin or a placebo for one week, all while keeping the study double-blind to eliminate bias.

After this week, we conducted skin-prick tests to measure reactions before and after the treatment. We compared the size of the skin test reactions, or wheals and flares, to see if there were any significant changes.

The results were clear: curcumin did not show a statistically significant impact on the size of these reactions. Although earlier studies suggested that curcumin may help reduce allergic symptoms, our findings indicate that it does not change the immediate response measured through skin tests. Thus, there's no need to stop using curcumin before allergy testing since it doesn't interfere with the results.

6.8

Slight improvement

Most Useful Review

When allergy symptoms arise, I give this to my child when they have a runny nose. I believe it helps alleviate the issue somewhat.

Multiple Sclerosis

Curcumin reduces MS-related inflammation

Based on 15 Researches

Curcumin and Its Semisynthetic Derivative F-Curcumin Ameliorate the Expression of Cytokines in Autoimmune Encephalomyelitis Mouse Models of Multiple Sclerosis.

Most Relevant Research

We set out to understand how curcumin, a compound found in turmeric, and its modified version, F-curcumin, impact cytokine levels in mouse models of multiple sclerosis (MS). In our research, we focused on autoimmune encephalomyelitis (EAE), a model that closely mimics MS, examining how these compounds affect various cytokines that play key roles in inflammation and immune responses in the central nervous system.

Our findings revealed that both curcumin and F-curcumin significantly reduced the severity and onset of EAE. Notably, these compounds led to a marked drop in the expression of several pro-inflammatory cytokines, such as IL-1, IFN-γ, and IL-17, while boosting the levels of anti-inflammatory cytokines like TGF-β and IL-10. This shift suggests a potential for curcumin and F-curcumin to balance the immune response, which is crucial in managing MS.

Interestingly, the effects were more pronounced with F-curcumin, indicating that our modified version may offer enhanced benefits for inflammatory conditions like MS. Overall, this study highlights the promise of curcumin and its derivatives as potential therapeutic agents in mitigating inflammation associated with multiple sclerosis.

3.5

No effect noted

Most Useful Review

Not suitable for everyone. I have multiple sclerosis and gastrointestinal issues. After an exacerbation, I experienced muscle pain and frequent headaches. I began taking curcumin, starting with one tablet. After two weeks with no effect, I increased to two tablets and no longer needed NSAIDs, but I developed diarrhoea. They also mention potential side effects such as kidney stones and iron deficiency. Unfortunately, the drug did not suit me.

Blood Clot

Curcumin inhibits platelet activation

Based on 7 Researches

Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer's Disease Patients.

Most Relevant Research

We explored how curcumin, a natural compound found in turmeric, affects platelet activation specifically when stimulated by amyloid peptides associated with Alzheimer’s disease. The research aimed to determine if curcumin could help modulate these potentially harmful blood clotting responses.

Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.

Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.

Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.

9.5

Cholesterol reduction

Most Useful Review

Super!!! Curcumin lowers bad cholesterol and slows blood clot formation while blocking inflammatory substances. It helps prevent and alleviate atherosclerosis.

Diarrhea