NOW Supplements 5-HTP

I ordered 5-HTP, potassium, and melatonin (from Now and Swanson). The delivery was prompt and very fast, and the prices are the most competitive I’ve found. With 5-HTP, my sleep has improved significantly. Importantly, since taking Potassium Aspartate, my muscle cramps in my calves and feet have vanished. I previously struggled with certain yoga poses due to this issue. It’s commonly attributed to magnesium deficiency, but I believe it relates to potassium. I highly recommend giving it a try; it's cost-effective and the relief from leg cramps is invaluable.

Low Libido details

Enhanced mood reported

What is 5-HTP? It’s a naturally occurring amino acid converted into serotonin in the body. Sourced from Griffonia Seed Extract, it enhances mood and sleep quality, improves genital organ function, and, as a bonus, increases libido. When I experienced a low mood and decreased interest in the opposite sex, I decided to try 5-HTP. Taking it in the morning worked wonders for me, with noticeable improvements by the second day. My energy surged, and I found myself eager to engage in life again.

Autism details

It is my second purchase. The 5HTP in VDD provides numerous benefits, not only for serotonin production but also for alleviating anxiety, depression, and stress. It has greatly assisted my daughter with autism.

Multiple Sclerosis details

5-HTP helps me manage fatigue associated with multiple sclerosis. I suffer from significant fatigue due to my condition, and 5-HTP is essential for maintaining my performance at work without feeling excessively tired. I wholeheartedly recommend it.

Premenstrual Syndrome details

Significant mood improvement

541 people found this helpful

I have been taking this supplement for a month and I feel like I am finally living! I didn't initially realise why I no longer craved sweets; my appetite simply vanished. It dawned on me after I researched the effects of this supplement. I've had two cycles without PMS—my husband even remarked on the lack of mood swings. My sleep has improved, and my emotional state is so much better. The effectiveness of this 5-HTP is clear, especially as Now Foods uses top-notch ingredients. I would highly recommend it. If this review was helpful, please give it a thumbs up! Wishing you all health and happiness!

Rash details

Worth trying—super instant effect, as mentioned in reviews, so don’t watch out! However, I definitely began to sleep better. If you take it before bedtime, you can feel it immediately. After taking it, I had no allergies or any rash.

Anxiety details

Gao K, Farzi A, Ke X, Yu Y, Chen C, et al. Oral administration of WHH2078 alleviates depressive and anxiety symptoms in mice with induced chronic stress. Food Funct. 2022;13:957. doi:10.1039/d1fo03723d

Based on 4 Researches

WHH2078 reduces anxiety in mice

This study explored how the strain WHH2078 can affect anxiety and depression in mice impacted by chronic stress. By administering WHH2078, researchers observed a significant reduction in anxiety-like behaviors over five weeks.

The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.

Life-changing supplements

Most Useful Review

499 people found this helpful

Life changer! I started this in November 2017 with GABA and L-Phenylalanine for mental wellness. I can't pinpoint one specific supplement, but 5-HTP has helped a lot! I take one at night for sleep and another in the morning for energy and mood. These supplements transformed my life. After weeks of use, I felt significant changes, leading me to even take a second job on weekends that aids my mental health.

Atrial Septal Defect details

77 people found this helpful

This tryptophan was purchased for my son, who has a diagnosis of atrial septal defect and severe sleep issues, including not sleeping for two days at a time. Previously, I tried melatonin from the same manufacturer, which helped me but was ineffective for him. I first tested it on my wife with no noticeable effects. I took it before bed and felt a subtle change; my sleep became calmer, and my dreams were notably vivid but not distressing. However, the hypnotic effect is quite weak compared to Novopassit. Despite this, I noticed statistically positive effects on my son; he began sleeping better and seemed calmer during the day. It seems this drug has varying effects on individuals without causing allergies. I recommend trying l-tryptophan for comparison.

Cardiovascular Disease details

182 people found this helpful

During this season of illness, I started taking the treatment for VSD, and it has remarkably alleviated all my symptoms. I am now able to sleep better without negative thoughts.

Flu details

Mood and anxiety improvement

21 people found this helpful

5 HTP is known to be a precursor of serotonin, associated with well-being. It has properties that help with depression, anxiety reduction, appetite control, and sleep. A rich source of serotonin, it alleviates depressive symptoms. Serotonin also helps balance mood and tension. Anxiety can often stem from Serotonin Deficiency Syndrome (SDS), where below-normal serotonin levels disrupt mood and appetite regulation. Overall, this supplement looks promising for mood enhancement and anxiety alleviation.

Insomnia details

Gao L, Gu L, Li W, Wang G, Zhao J, et al. Construction of composite nanoparticles of β-cyclodextrin and corn starch encapsulating 5-hydroxytryptophan for sustained release and sleep improvement in vivo. Int J Biol Macromol. 2025;303:140831. doi:10.1016/j.ijbiomac.2025.140831

Based on 3 Researches

5-HTP nanoparticles improve sleep

We investigated how a new composite nanoparticle system can enhance the sleep-promoting effects of 5-hydroxytryptophan (5-HTP).

By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.

Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.

This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.

Quickly aids sleep

Most Useful Review

465 people found this helpful

I’ve been taking this nightly for over two years and love it. I have insomnia and take 1 or 2 at bedtime, and within minutes I’m asleep. It alleviates my anxiety for the next day. Previously, I was prescribed medications that dulled my senses. This, however, makes me feel like myself again. I truly appreciate it.

Adhd details

Cord blood metabolites and ADHD

Raghavan R, Anand NS, Wang G, Hong X, Pearson C, et al. Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder. Transl Psychiatry. 2022;12:270. doi:10.1038/s41398-022-01992-0

We examined how levels of 5-hydroxytryptophan (5-HTP) in cord blood relate to the risk of developing ADHD and other developmental disorders. This study followed nearly 1,000 children from birth, looking for connections between cord plasma metabolites and diagnoses later on.

Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.

Enhanced positive thinking

Most Useful Review

31 people found this helpful

5-HTP has remarkably changed my life. Living with six subtypes of ADHD, it greatly aids in alleviating negative thought patterns and mental stress. I can confidently say that my thinking has turned more positive, allowing me to process my thoughts effortlessly. The obsessiveness associated with ADHD has significantly decreased. Thank you, IHERB!

Adrenal Gland Disorder details

My husband was suffering from low energy in the afternoons due to adrenal fatigue. He started taking this supplement at night along with 7-Keto DHEA in the morning and evening, and he noticed a remarkable improvement quickly.

Back Pain details

9 people found this helpful

Perfect! This has saved my life! No more synthetic, side-effect-ridden prescriptions for me! My serotonin is balanced, my energy and zest for life have returned, and I couldn't be more pleased that it's significantly cheaper than prescribed medications!

Cold details

5-HTP inhibits thyroid cold response

Likely Very Effective

Hashizume K. Effects of drugs that modify brain biogenic amine concentrations on thyroid activation induced by exposure to cold. Neuroendocrinology. 1976;20:47.

We delved into the effects of 5-hydroxytryptophan (5-HTP) on the thyroid's response to cold exposure. Our observations indicated that 5-HTP markedly inhibited the thyroid's reaction to cold, highlighting its potential impact. The study showed that other substances influenced this response in various ways, but 5-HTP stood out in its effectiveness. Despite the promising results, it’s important to note that alterations in the thyroid’s responses were closely linked to changes in brain chemistry, rather than direct hormonal influences.

Stress relief

Most Useful Review

This winter has been stressful, and with frequent colds, I started taking 5-HTP. My emotional state, sleep, and appetite improved remarkably. The illness vanished quickly.

Depression details

Javelle F, Lampit A, Bloch W, Häussermann P, Johnson SL, et al. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis. Nutr Rev. 2020;78:77. doi:10.1093/nutrit/nuz039

Based on 11 Researches

5-HTP shows limited effectiveness

We explored the impact of 5-hydroxytryptophan (5-HTP) as a treatment for depression through a systematic review and meta-analysis.

Our analysis included 13 studies, revealing a depression remission rate of 65%. While this sounds promising, the research shows considerable variability in factors like treatment duration and types of depression tackled.

Additionally, the overall quality of the studies was weak, with many lacking proper control groups. To truly understand 5-HTP's effectiveness, more rigorous, placebo-controlled trials are essential.

Seasonal blues alleviated

Most Useful Review

197 people found this helpful

It effectively helps combat the seasonal blues, relieves depression, and calms shattered nerves.

Knee Pain details

It's effective! I take HTP-5 twice daily, one capsule. Instantly, my worries about knee pain lessen. My dreams have intensified, and if I wake during the night, I find it easy to return to sleep. It genuinely helps! If you find my review useful, please indicate 'YES'.

Stroke details

Mental well-being improvement

The 5-HTP dietary supplement from NOW is a real stroke of luck! It has helped me manage insomnia and improve my mood significantly. I felt the effect after just a few days. The quality is excellent and the price is affordable. I recommend it to anyone seeking a natural solution for better mental well-being.

Acne details

Cleans skin effectively

Superb! It's great for women as it regulates appetite while improving both emotional and physical conditions. I no longer feel cravings for sweets, giving me an immediate sense of normalcy. My skin has cleared up from acne, and my nails have become stronger. I take 1-2 tablets daily, and they are enjoyable and natural, making them ideal for our modern lifestyle. Highly recommended!

Blurred Vision details

The best remedy for depression! I've taken it three times, and the effects are instantly noticeable the next morning. Colours appear brighter, and both my mood and vision have improved significantly. My sleep has also enhanced, though I find there are rather too many dreams for my taste. I’m considering starting the third pack in the morning. This is my number one choice for excellent well-being, and I wholeheartedly recommend it to my friends as I have experienced its powerful effects firsthand.

Common Cold details

Family immunity booster

This vitamin is excellent; my family takes it throughout the cold season to boost our immunity.

Ear Infection details

16 people found this helpful

My little saviour!!! Most of my supplements are from the Now brand, so I decided to try this one. I've felt depressed and tired for some time, and my sleep was disturbed, affecting my daily life. I opted for 5HTP without consulting a professional. Starting with 100mg at night, I experienced no side effects, which was a relief. While I can't say for certain if it's effective yet, I've noticed feeling calmer and a bit happier during the day. After a month, I’ve not experienced low moods, and my PMS is under control. I'm managing daily responsibilities better now, and it's just nice to feel normal for a change :)

Fibromyalgia details

Increases energy remarkably

This supplement is fantastic. I began to truly live again, no longer just existing. I suffered from constant muscle pain (fibromyalgia), fatigue, and apathy. Now, I feel revitalised, the muscle pain has diminished, headaches are less frequent; it’s a remarkable effect. I take one daily, and the quality is excellent. The ingredients include hydroxytryptophan. The packaging is a plastic jar of 120 pieces, and I certainly advise anyone who has low serotonin levels or suffers from depression or apathy to try it.

Obesity details

Indications for use - insomnia, chronic headache, obesity, narcolepsy, sleep disturbances! 5-HTP is not placebo! In treating depression, it increases the release of beta-endorphins. 5-HTP consumption reduces appetite, resulting in weight loss! I tested it myself, and there are no side effects. The capsules are easy to use. An extremely effective supplement that deserves 5 out of 5. I will order more and recommend it.

Autoimmune Disorder details

133 people found this helpful

Seven years ago, I was diagnosed with panic disorder and faced numerous side effects from various medications. After starting this supplement, I discovered that the side effect migraines disappeared completely. I’m amazed at the reduction in medication necessity.

Constipation details

Versatile digestive aid

The 5-HTP, 100 mg supplement, packaged in 120 vegetable capsules, boasts high quality and convenience. While primarily enhancing serotonin production for mood support, it also improves digestion and nutrient absorption, contributing to a healthier gut. Users have noted a reduction in constipation due to enhanced digestive function. Overall, it is a beneficial supplement for well-being.

Food Poisoning details

18 people found this helpful

I've used these pills for weight loss, and they have significantly reduced my appetite. After a week, I lost the desire for meat and only feel inclined to eat vegetables and fish.

Menopause details

Freedman RR. Treatment of menopausal hot flashes with 5-hydroxytryptophan. Maturitas. 2010;65:383. doi:10.1016/j.maturitas.2009.11.025

Very Likely Ineffective

5-HTP ineffective for hot flashes

We aimed to find out how effective 5-hydroxytryptophan (5-HTP) is for reducing hot flashes in menopausal women.

In a double-blind study involving 24 postmenopausal participants, we divided the group to receive either 5-HTP or a placebo.

Unfortunately, our results showed no significant difference in hot flash frequency between the two groups after treatment.

Thus, it appears that 5-HTP at the tested dose does not effectively alleviate hot flashes, making further research necessary.

Normal sleep restored

Most Useful Review

1 people found this helpful

It greatly alleviates anxious sleep; I used to awaken several times during the night due to menopause. With 5-HTP, my sleep has gradually returned to normal, and now I rest undisturbed until morning.

Parkinson details

5-HTP shows potential sleep benefits

Based on 8 Researches

Meloni M, Figorilli M, Carta M, Tamburrino L, Cannas A, et al. Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson's disease. Sleep Breath. 2022;26:1023. doi:10.1007/s11325-021-02417-w

We explored the impact of 5-hydroxytryptophan (5-HTP) on REM sleep behavior disorder in patients with Parkinson's disease. In a small, randomized, double-blind trial with 18 participants, we compared daily doses of 5-HTP to a placebo over four weeks. The results suggested that 5-HTP can improve sleep quality and stability without increasing REM sleep disorder episodes. However, the overall benefits were marginal and further research with larger groups and longer durations is essential to confirm these findings.

Improved emotional health

Most Useful Review

8 people found this helpful

Following the intake of 5-HTP, symptoms of depression, apathy, and anxiety diminish; sleep becomes regular, and overall mood improves significantly. Notably, it alleviates symptoms of migraine and Parkinson's disease while enhancing concentration and overall productivity. A dosage of 50 to 300 mg per day is recommended.

Bone Pain details

Positive mood enhancement

354 people found this helpful

SUPER !!!!!!!!!!!!! MY CHOICE ⬇⬇⬇ TESTED PRESS “YES”, YOU ARE NOT HARD, AND IT IS PLEASANT TO KNOW ME THAT I HELPED YOU!!! Now Foods, 5-HTP, 100 mg, 60 capsules. This natural amino acid effectively affects the body's biochemistry, relieving anxiety, stress, and even depression without causing drowsiness. It improves mood, sleep quality, and appetite control. Importantly, this drug is not an antidepressant and doesn’t result in addiction. The effects include mood elevation, decreased anxiety and aggression, increased pain threshold and alleviation of various symptoms. This remedy works wonders!

Chronic Cough details

Improved sleep quality

6 people found this helpful

I wake up feeling cheerful. Since pregnancy, I've dealt with chronic fatigue, exacerbated by sleepless nights following my child's birth, leading to apathy and irritation. Initially, I thought my fatigue was due to osteonia and tried several supplements, including B vitamins and melatonin. My journey to normal sleep was long, and I realised my cortisol levels were high. To alleviate my condition, I opted for serotonin tablets without much hope but decided to try. After two days of taking them at night, I experienced restful sleep for the first time in ages. I felt calmer and had vivid dreams, although I still wake up slightly fatigued. I remain hopeful for continued improvement.

High Cholesterol details

Stress and insomnia reduced

4 people found this helpful

Menopause has brought insomnia and stress, limiting me to a mere 3–5 hours of sleep nightly. After taking one pill for a few days, I noticed my sleep duration improved to six or seven hours! Now, I’m sharing this and highly recommending it as I even managed to sleep for a record eight hours. My nerves have calmed, and stress has notably decreased!

Reflux details

Effectively reduces reflux

I've been using NOW Supplements Probiotic for about two months and have struggled with acid reflux for a year, particularly at night. I've tried various over-the-counter medicines and natural aids, but nothing has worked as well as this. I take one tablet on an empty stomach each morning. After testing it with some spicy Tex-Mex for dinner instead of using over-the-counter meds, I found it effective. I haven’t had any issues with acid reflux since. Although the product isn't shipped cool, I refrigerate it after opening, as advised. Interestingly, it's also helped regulate my digestion. My wife has begun taking it for her constipation and is pleased with the results. I've learned that supplements often take time to work, and their effectiveness can vary between individuals.

Sleep Apnea details

885 people found this helpful

Since using this product, I noticeably sleep better, falling asleep faster and staying asleep without awakening. Although I’m unsure about my mood improvement, the better sleep alone makes me appreciate this natural remedy. I highly recommend it!

Adenoiditis details

Early positive effects

4 people found this helpful

Having suffered from insomnia for many years, I decided to try this supplement. I had not heard of 5-HTP before, but it was said that the effects would be felt from about two weeks later. In my case, I realised the effects early on; I slept soundly and began waking up in the morning. My partner, who has been drinking for years due to panic disorder, found that if you do not drink enough water when taking the capsule, it may linger around your throat and chest. Thus, I highly recommend drinking plenty of water.

Tinnitus details

Reduced tinnitus symptoms

6 people found this helpful

For relief of tinnitus and remission. Initially, I had good hearing, but due to poor blood circulation in my inner ear, my hearing temporarily deteriorated. Despite trying various prescription drugs, supplements, Chinese medicine, acupuncture, and moxibustion, my hearing returned after a few months, yet the aftereffects of tinnitus persisted. When the ringing became painful, I managed it with sleep-inducing and anti-anxiety medications from the psychosomatic department. Over a few months, my tinnitus became less frequent. By taking this supplement nightly, I slept well without interruptions. Mental relaxation alleviates tinnitus. Combined with a small amount of melatonin, my sleep improved remarkably. I now feel hopeful about reducing my reliance on prescription sleeping pills and am closer to overcoming my tinnitus.

Frozen Shoulder details

Reduced shoulder tension

8 people found this helpful

My autonomic nervous system has been out of balance for a long time, with the sympathetic nervous system dominating, making it difficult to relax. I frequently tense my shoulders, which affects my sleep and makes me easily fatigued. This treatment has helped stabilise my mental health and relieve my tension.

Heart Disease details

This unique product has helped me improve my psycho-emotional state during PMS and anxiety due to the pandemic. L-tryptophan is crucial for serotonin and dopamine production. 5-HTP is a mild, non-addictive natural antidepressant that enhances brain function and contributes positively to overall emotional well-being. I recommend using it with magnesium at night for better results.

Weight Loss details

Cangiano C, Ceci F, Cascino A, Del Ben M, Laviano A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr. 1992;56:863.

Questionable

Based on 4 Researches

5-HTP aids in weight loss

We looked into how 5-hydroxytryptophan (5-HTP) functions in aiding weight loss among obese individuals. In a well-structured study, 20 participants were split into two groups—one received 5-HTP and the other a placebo. Notably, over two 6-week phases, those taking 5-HTP reported significant weight loss, reduced carb intake, and felt fuller quicker.

These findings suggest that 5-HTP could be a safe option for supporting weight management without the immediate need for dietary restrictions.

Suppresses hunger

Most Useful Review

190 people found this helpful

After the first dose, my hunger disappeared for a day! Initially, it helped my diet and weight loss, though the appetite did partially return after a few weeks. I've also felt calmer and less stressed.

Gastritis details

I am suffering from gastritis, and this excellent remedy relieved me of my stomach pain! Additionally, after taking it, my mood improved. I recommend it to everyone.

Chronic Fatigue Syndrome details

8 people found this helpful

All good! I followed my psychologist’s advice and took one capsule each morning and evening for three months. After suffering from panic attacks for two years, I am now completely free from them. This is a fantastic drug with no withdrawal symptoms, unlike antidepressants. I felt great throughout the course, without any side effects. I recommend it to everyone!

Blood Clot details

Effective anti-stress

13 people found this helpful

Initially, I felt depressed due to stress and PMS despite prescription antidepressants. However, after incorporating 5-HTP, my ability to manage stress improved significantly. A month later, I noticed I was calmer and could handle stress without overeating or feeling out of control. The doctor informed me that my issues with a previous liver test had improved, and I finally felt like I was addressing the underlining serotonin deficiency related to stress. Healthily, I lost weight and regained a more balanced mood without the adverse effects previously experienced.

Urinary Tract Infection details

Useless with side effects

I can’t understand the good reviews at all. Firstly, I experienced side effects in my digestive tract, and secondly, headaches. It didn’t help calm my nerves or affect my appetite. To me, this product did nothing beneficial, yet it came with side effects.

Liver Disease details

Detoxification support

This drug was recommended at a nutrition school for liver support and detoxification. I take 100 mg on an empty stomach, ideally 2-3 hours after dinner.

Brain Tumor details

Reduced anxiety and appetite

12 people found this helpful

I have been taking 5-HTP for a little over a month, and it pleasantly surprised me. My sleep normalised, and anxiety nearly vanished! My mood improved, and I am no longer easily irritated. The drug isn’t addictive and is well absorbed, crucial for me. It can also decrease appetite and aid in weight loss. 5-HTP alleviated panic attacks and anxiety, making it a fantastic choice for improvement in mood and behaviour.

Heart Attack details

Stress relief effective

This medication is effective for stress, panic attacks, anxiety, irritability, and overfatigue. I highly recommend it.

Hypertension details

Overcomes hypertension

My mum has seen remarkable results. She used 5-hydroxytryptophan for her depression, and within one capsule, she felt better—sleep improved and her stress resistance increased. Previously, her hypertension fluctuated frequently, even with daily medication. Now, the pressure spikes much less often, and she only requires light daily pills for hypertension. Thanks to "Mr. Tryptophan"!

Kidney Stones details

Muscle relief experienced

I take 5-HTP along with GABA before bed, which results in sound sleep and a stable mood. To my surprise, since starting this combination, I've noticed that my legs no longer hurt and feel much softer after training. It effectively relaxes my body, which has been a remarkable change for me.

Heartburn details

I recommend this product for its good volume and composition. It didn’t cause any unpleasant sensations or heartburn for me, which was refreshing.

Irritable Bowel Syndrome details

Keszthelyi D, Troost FJ, Jonkers DM, van Eijk HM, Dekker J, et al. Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism--a preliminary study. Neurogastroenterol Motil. 2015;27:1127. doi:10.1111/nmo.12600

Questionable

Based on 2 Researches

5-HTP alters serotonin metabolism

In our investigation, we examined the impact of 5-hydroxytryptophan (5-HTP) on individuals with irritable bowel syndrome (IBS) compared to healthy volunteers.

Using a randomized double-blind placebo-controlled approach, we found that while 5-HTP led to increased pain perception in hypersensitive IBS patients, it also caused similar effects in some healthy controls.

Notably, IBS patients showed significant changes in serotonin metabolites alongside altered pain thresholds. However, these changes weren't beneficial across the board, as non-hypersensitive IBS patients did not experience the same response.

7.5

Stress relief

Most Useful Review

8 people found this helpful

This supplement has been a super remedy for stress. I noticed positive effects from the very first day. Previously, I struggled with irritability and had insomnia for two years, but now I wake up in a good mood and enjoy life. I definitely recommend it for anyone feeling depressed!

Diarrhea details

Severe diarrhea experienced

I hoped it would help with my depression, but I suffered severe diarrhoea. A doctor advised that 100mg was excessive and advised to reduce my dosage to 50mg daily.

Headache details