Solgar Methylcobalamin

Laird EJ, O'Halloran AM, Molloy AM, Healy M, Hernandez B, et al. Low vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. Br J Nutr. 2023;130:268. doi:10.1017/S0007114521004748

Based on 21 Researches

Vitamin B affects depression risk

We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.

However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.

Depression alleviated

Most Useful Review

23 people found this helpful

A beautiful product! To be brief, my depression has passed, and I have experienced less hair loss.

Headache details

Vitamin B12 deficiency linked to migraines

Based on 8 Researches

Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. doi:10.1080/01616412.2025.2462735

We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.

We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.

Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.

Disappeared headache

Most Useful Review

I've been using this B12 methylcobalamin for two months and am very pleased. I've experienced more energy, and my headache has disappeared. I've tried others, but this is far superior.

Anemia details

Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x

Based on 21 Researches

Effectiveness of B12 in IGS

We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.

This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.

Positive lab results

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3 people found this helpful

This is great for pernicious anemia. It effectively improved my husband’s condition, as evidenced by before and after lab tests.

Cardiovascular Disease details

Vitamin B status correlates with mortality

Based on 9 Researches

Li Y, Wang H, Chen S, Wei Q, Liu Y, et al. The combined indicator of vitamin B status calculated using 3-parameters (3cB) is negatively associated with mortality among US adults: NHANES 1999 to 2004. Nutr Res. 2025;136:53. doi:10.1016/j.nutres.2025.02.008

We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.

Lowered homocysteine levels

Most Useful Review

42 people found this helpful

I tested this product myself, taking one tablet daily under the tongue. Alongside it, I took Solgar B9 and other cheap vitamins. After a course of 1.5 months, my homocysteine levels dropped from 10.6 to 5.6. I'm thrilled, as a lower level indicates healthier blood vessels and a considerably reduced risk of cardiovascular disease. My parents also experienced similar results with their homocysteine levels. I highly recommend this.

We observed a case involving a 20-year-old woman with Type 1 diabetes experiencing persistent gastrointestinal issues, including diarrhea and nausea. Her medical journey led her to be diagnosed with autoimmune gastritis, an uncommon but important condition.

In the course of her treatment, we noticed her Vitamin B12 levels were not deficient, which is traditionally expected with autoimmune gastritis. Despite this, she was given parenteral Vitamin B12 therapy due to her neurological symptoms.

This case highlights that even when Vitamin B12 deficiency isn’t present, administration of Vitamin B12 can still provide significant relief from symptoms related to autoimmune gastritis. We learned that prompt treatment can prevent further neurological damage and improve overall quality of life for patients with autoimmune conditions.

Effective treatment

Most Useful Review

Works! I have chronic gastritis, which affects my Vitamin B12 absorption. When I get seizures in the corners of my mouth, I take one tablet of this vitamin and the next day, the seizure vanishes. No ointments or creams can assist.

Menopause details

Vitamin B12 may aid menopause relief

Likely Very Effective

Based on 2 Researches

Palacios S, Mustata C, Rizo JM, Regidor PA. Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9. Eur Rev Med Pharmacol Sci. 2023;27:8180. doi:10.26355/eurrev_202309_33578

We observed the effects of a nutritional product that combined various ingredients, including vitamin B12, on menopausal symptoms. This study involved 156 menopausal women who took the product daily for 12 weeks and reported their symptoms using a validated scale.

After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.

However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.

Skin improvement

Most Useful Review

13 people found this helpful

A very good product! I had been feeling quite anemic for a long time, relying on regular vitamin B12 (Natures own brand) to keep me afloat. I switched to these due to information I found online about active B12. I had been experiencing very dry and aged skin; as a beauty therapist, I couldn't understand how I'd aged so much in just a year. Despite using various creams, I struggled to retain moisture. At 36, I thought I might be going through menopause early. However, after just two days on this supplement, my skin regained its normal glow, fine lines vanished, and it looked like it used to. I absolutely love this product, and it tastes delightful!

Allergies details

Vitamin B12 microneedles reduce inflammation

Based on 3 Researches

Guillot AJ, Martínez-Navarrete M, Giner RM, Recio MC, Santos HA, et al. Cyanocobalamin-loaded dissolving microneedles diminish skin inflammation in vivo. J Control Release. 2024;375:537. doi:10.1016/j.jconrel.2024.09.032

We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.

Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.

However, it's important to note that while the results are promising, further studies are needed for broader applications.

Child-friendly product

Most Useful Review

This product is delicious, sweet, and cherry-scented. It did not trigger any allergic reactions in my child.

Blood Clot details

Khaliq L, Kabir KF, Pyai K, Hadid T, Collins-Hamel B. A Simple Vitamin Deficiency With Life-Threatening Complications: A Case of B12 Deficiency and Hyperhomocysteinemia-Induced Thrombosis. Cureus. 2023;15:e42908. doi:10.7759/cureus.42908

Based on 14 Researches

B12 deficiency linked to clots

We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.

The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.

Quick absorption

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5 people found this helpful

A great product! I highly recommend it! The tablets are quickly absorbed, and within a week of use, my blood test indicated a significant improvement! They are small, chewable, and quite tasty. My child (6 years old) enjoys taking them without any fuss.

Blurred Vision details

Improved vision clarity

7 people found this helpful

Methyl cobalamin is essential for the nervous system and vision, especially for those frequently using computers. This form of B12 significantly enhances accommodation, allowing the eyes to clarify objects at varying distances. In contrast, cyanocobalamin is less effective. It is advisable to take it alongside methylolate from Solgar or similar brands, which offers a more easily absorbed B9 form.

Dizziness details

B12 treatment improved dizziness symptoms

Based on 17 Researches

Cittolin-Santos GF, Khalil S, Bakos JK, Baker K. Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia. Case Rep Hematol. 2020;2020:8697493. doi:10.1155/2020/8697493

We examined a unique case involving a 28-year-old male who experienced dizziness related to severe anemia from low vitamin B12 levels.

After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.

Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.

Affordable recommendation

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2 people found this helpful

I am aware of the benefits of Mechiko and its necessity, so I regularly purchase it. While it’s a recommended supplement, its price has increased significantly. I bought this to help my husband avoid dizziness; the quality seems good, although the size is ample while the amount in the container is small. I wish for a lower price. I’m nearing completion of the bottle, and since starting, I haven’t experienced any dizziness.

Heart Attack details

Vitamin B12 shows no heart attack benefit

Likely Ineffective

Based on 2 Researches

Borowczyk K, Piechocka J, Głowacki R, Dhar I, Midtun Ø, et al. Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial. J Intern Med. 2019;285:232. doi:10.1111/joim.12834

In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.

Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.

Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.

Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.

Supports heart health

Most Useful Review

Very good for the heart and arteries.

Rash details

Works best B I've tasted, with a nice sweet flavour. I take it in the morning. It does not provoke rashes, unlike alternatives.

Athlete’s Foot details

Best Vitamin B12! Within two months of taking this, I noticed that signs of vitamin B12 deficiency disappeared: frequent chills and poor coordination improved, and my feet stopped being cold. I highly recommend it!

Cancer details

Vitamin B12 and lymphoma association

Rong YY, Liu PC, Huang XB, Chen GA. Circulating levels of vitamins and risk of lymphoma: insights from a two-sample Mendelian randomization. Expert Rev Hematol. 2024;17:833. doi:10.1080/17474086.2024.2410009

We aimed to understand how levels of vitamin B12 might influence the risk of developing lymphoma, a type of cancer that affects the lymphatic system. Using data from comprehensive genome-wide association studies, we assessed the potential genetic links between circulating vitamin levels and lymphoma.

Our analysis particularly focused on vitamin B12 along with other vitamins, utilizing robust methods to ensure reliable results. We discovered that higher levels of vitamin B12 showed a noticeable association with a lower risk of lymphoma, indicating that it might play a beneficial role in cancer prevention. Interestingly, we also found similar results for folic acid, suggesting that these vitamins could have important implications for lymphoma risk overall.

However, it's essential to note that while our findings are promising, the evidence isn't definitive. Further research is needed to explore these relationships in greater depth and to understand the mechanisms behind them. Understanding how vitamins like B12 affect cancer could lead to better preventive strategies in the future.

Fights cancer effectively

Most Useful Review

Excellent dosage and improved absorption. It is also beneficial in combating cancer, halting the growth of harmful cells and aiding in recovery! There are additional benefits too.

Cold details

Tamaddonfard E, Samadi F, Egdami K. The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats. Vet Res Forum. 2013;4:19.

Based on 3 Researches

Vitamin B12 shows cold pain relief

We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.

In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.

As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.

Cold symptoms alleviated

Most Useful Review

The best Vitamin B-12! Within two months of taking this supplement, signs of vitamin B-12 deficiency, including frequent chills, impaired coordination, and memory issues, improved. My feet no longer feel cold. Highly recommend!

Irritable Bowel Syndrome details

Dietary guidance aids IBS management

Mazzawi T, Hausken T, Gundersen D, El-Salhy M. Effects of dietary guidance on the symptoms, quality of life and habitual dietary intake of patients with irritable bowel syndrome. Mol Med Rep. 2013;8:845. doi:10.3892/mmr.2013.1565

We examined how dietary guidance affects irritable bowel syndrome (IBS) symptoms and quality of life, particularly focusing on vitamin B12 intake. Our study involved 46 patients diagnosed with IBS based on established criteria, with 17 completing the entire program.

Through three sessions of personalized dietary advice, each lasting about 45 minutes, we found a significant reduction in IBS symptoms after the patients implemented the dietary changes. Their quality of life scores also improved notably. Although we noted an increase in vitamin B12 intake, it's important to emphasize that we did not isolate its effects from those of other dietary changes.

Interestingly, while our guidance helped patients enhance their overall nutrient intake, including vitamins and minerals, the increase in vitamin B12 specifically was the only change that reached statistical significance. However, we found no substantial differences in overall caloric or macronutrient intake among the participants.

In conclusion, while dietary guidance showed promising benefits for managing IBS symptoms and overall life quality, the impact of vitamin B12 alone remains unclear, as other dietary modifications may have played a role. Our findings suggest that individualized dietary counseling is a viable option in IBS management.

7.5

Effective treatment

Most Useful Review

12 people found this helpful

I have utilised this B12 supplement for carpal tunnel syndrome over many years, and it has been very beneficial.

Neuropathy details

B12 treatment improves neuropathy symptoms

Based on 15 Researches

Dekker MJHJ, Heerdink GC, Plattel CHM. Vitamin B12 Deficiency-Induced Neuropathy and Cognitive and Motor Impairment in the Elderly: A Case Study. Food Nutr Bull. 2024;45:S53. doi:10.1177/03795721241226886

We explored the effects of vitamin B12 deficiency on neurological health in elderly patients. In a case study involving two patients, we observed that even with normal B12 levels, symptoms like fatigue and cognitive impairment persisted, especially in those with significant medical histories.

Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.

7.5

Significant improvement

Most Useful Review

16 people found this helpful

Methyl B12 nuggets have been recommended to me by my GP in Sydney and are far superior to the messy and costly oral spray I previously used. Both my husband and I find them much more convenient and economical. Although I'm unsure of our current levels, mine was 495. I have noticed an improvement in my feet (neuropathy) and my energy levels. My husband no longer feels drowsy after meals and has experienced an uplift in his mood and memory. Thank you for creating such an exceptional product.

Sleep Apnea details

4 people found this helpful

Vitamin B12 is vital for nerve function. Since last summer, I struggled with sleep. After taking Solgar Methylcobalamin for three months, I feel less fatigued and, importantly, I’ve noticed a remarkable improvement in my sleep. It’s affordable, and I believe it’s worth trying if you're facing similar issues.

Stroke details

Ge Y, Yang C, Zadeh M, Sprague SM, Lin YD, et al. Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice. iScience. 2024;27:109480. doi:10.1016/j.isci.2024.109480

Based on 16 Researches

Vitamin B12 aids stroke recovery

We explored the role of vitamin B12 in managing neuroinflammation after an ischemic stroke. Through preclinical studies, we observed that vitamin B12 effectively influenced microglial cells, which are key to the brain's immune response. This treatment promoted important cellular processes, leading to reduced brain damage and better neurological outcomes. However, when microglia were depleted before stroke, the positive effects of vitamin B12 disappeared. Overall, while vitamin B12 shows promise in enhancing recovery post-stroke, its impact hinges on these immune cells.

Supports recovery

Most Useful Review

1 people found this helpful

One of the best vitamins for those who have suffered a stroke or have brain-related issues. My husband, who had a cerebellar stroke in 2019, was advised by his neurologist to take it due to its importance for brain neurotransmitters. His blood levels of vitamin B12 were low, and I highly recommend this brand as it has proven effective.

Ulcer details

Genetic insights into ulcer healing

Shah A, Khuba S, Kumar C S, Shanmukhaiah C, George M, et al. Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations. J Hum Genet. 2025;70:207. doi:10.1038/s10038-025-01320-6

We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.

Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.

Effective against ulcer

Most Useful Review

I’ve been using these for a while now, and they are excellent. The tiny tablets are easy to take and have little taste. I’ve been taking these to prevent mouth ulcers, and thus far, they’ve been working well.

Vertigo details

Vitamin B12 enhances acupuncture effects

Li JP, Cai J, Gan XM. [Observation of therapeutic effects on cervical vertigo treated with different methods]. Zhongguo Zhen Jiu. 2011;31:405.

We explored the effectiveness of various treatments for cervical vertigo, specifically focusing on different acupuncture methods and the inclusion of Vitamin B12 in one of the therapy combinations. In our study, ninety-one participants were divided into three groups: one receiving routine acupuncture, another using electroacupuncture, and a third receiving a combination of electroacupuncture and Vitamin B12 injections along with local anesthetics.

Each therapy was administered over twenty sessions within a month. We measured changes in blood flow in the vertebral and basilar arteries and evaluated the participants' symptoms and overall function related to their vertigo. While all treatment methods showed some positive effects, the combination therapy, which included Vitamin B12, stood out as being the most effective.

This suggests that Vitamin B12 might play a significant role alongside acupuncture methods in treating cervical vertigo. However, it’s important to note that the specific impact of Vitamin B12 alone wasn’t isolated in this study, leaving us to consider its effects within the broader context of combined therapies.

Symptom relief

Most Useful Review

1 people found this helpful

It significantly reduces the symptoms of Meniere's vertigo.

Bone Pain details

Feeling better overall

I use it every two days and am beginning to feel an improvement in my bone pain and leg joints.

Flu details

Effective energy boost

A high-quality product from this brand that performs exceptionally well. The tablets are small, the packaging is convenient with a glass jar, and I felt a noticeable increase in energy.

Multiple Sclerosis details

Pan L, Yin Y, Chen J, Ma Z, Chen Y, et al. Homocysteine, vitamin B12, and folate levels in patients with multiple sclerosis in Chinese population: A case-control study and meta-analysis. Mult Scler Relat Disord. 2019;36:101395. doi:10.1016/j.msard.2019.101395

Vitamin B12 affects MS patients

We explored the relationship between vitamin B12 levels and multiple sclerosis (MS) in a focused study involving 80 Chinese patients with MS and 166 control participants. By measuring the serum levels of homocysteine (Hcy), vitamin B12 (VB12), and folate, we aimed to unravel how these nutrients might relate to MS.

Our findings indicated that MS patients generally had elevated levels of homocysteine compared to control groups, suggesting a potential risk factor in their condition. On the other hand, we noted that individuals with MS, particularly those experiencing relapses, showed lower levels of vitamin B12. This points toward a potential connection between low vitamin B12 and the exacerbation of MS symptoms. However, it’s worth noting that we didn't find significant differences in folate levels among the groups, implying that folate may not play the same role in MS as Hcy and VB12.

In summary, while the study highlights concerns regarding elevated homocysteine and decreased vitamin B12 levels in MS patients, it also suggests that vitamin B12 may correlate with the frequency of relapses, offering some insight into how dietary factors could influence MS management. Therefore, this research underscores the importance of monitoring vitamin B12 levels in MS patients as part of a comprehensive treatment strategy.

7.5

Neurological damage prevention

Most Useful Review

A deficiency of vitamin B12 leads to ineffective hematopoiesis, resulting in the formation of large, dysfunctional erythrocytes and ultimately megaloblastic anaemia. Insufficient B12 causes changes in the neurons of the brain and spinal cord, which can lead to various disorders. In medicine, cyanocobalamin treats anaemia, polyneuritis, multiple sclerosis, and sciatica. High doses are crucial in reducing the progression of atherosclerosis early. It's also essential for monitoring vitamin levels in several medical contexts, especially for patients over 50 or those needing post-surgical care.

Alzheimer details

Vitamin B12's limited effect on Alzheimer's

Lee CY, Chan L, Hu CJ, Hong CT, Chen JH. Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials. Aging (Albany NY). 2024;16:7856. doi:10.18632/aging.205788

We explored the potential role of vitamin B12, alongside folic acid, in slowing the progression of Alzheimer's disease (AD) through a meta-analysis of randomized control trials. Our aim was to determine whether these supplements might improve cognitive function, daily life activities, and influence blood homocysteine levels in individuals diagnosed with AD.

After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.

The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.

Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.

7.5

Supports neurological function

Most Useful Review

6 people found this helpful

A tablet under the tongue after breakfast provides essential Vitamin B12, which is crucial for hormonal and metabolic functions. This vitamin is necessary for energy production, normal neurological function, and blood formation. It aids in the transport of nutrients and protects vascular walls, preventing cardiovascular issues, Alzheimer's, and dementia. The B12 synergy is vital for over 100 functions daily.

Chronic Cough details

6 people found this helpful

I experience post-encephalitic chronic fatigue, and taking a couple of these daily really helps provide a noticeable energy boost and alleviates some of the brain fog I've been dealing with for years. The low dosage allows for easy adjustment, and B12 is generally safe as any excess is excreted. This is essential for anyone suffering from chronic fatigue and brain fog, but ensure you fulfil your cofactors, especially folate.

Chronic Fatigue Syndrome details

Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214.

Vitamin B12 ineffective for CFS

We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.

In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.

These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.

7.5

Alleviates fatigue

Most Useful Review

2 people found this helpful

I have been using these daily for several years alongside B12 injections. My doctor mentioned that this form of medication offers the next best availability for the body. I find they help lessen my fatigue, although I wish they were packaged in a more compact container; a large one doesn't offer any extra benefits.

Migraine details

Vitamin B12 deficiency and migraines

Based on 11 Researches

We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).

Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.

This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.

Effective migraine relief

Most Useful Review

I heard it is very useful for migraine, so I bought it and tried it. The result was very good! The pain was relieved that night! I recommend it.

Sciatica details

Horasanli B, Hasturk AE, Arikan M, Togral G, Helvacioglu F, et al. Comparative evaluation of the electrophysiological, functional and ultrastructural effects of alpha lipoic acid and cyanocobalamin administration in a rat model of sciatic nerve injury. J Back Musculoskelet Rehabil. 2017;30:967. doi:10.3233/BMR-150386

Based on 4 Researches

B12 and ALA assist nerve recovery

We explored the effects of Vitamin B12 and alpha lipoic acid (ALA) on nerve recovery in a rat model of sciatic nerve injury.

Through a rigorous study design involving 40 rats divided into different treatment groups, we assessed functional recovery using various analyses.

Interestingly, while both treatments yielded positive results, ALA showed greater functional improvements compared to B12.

Overall, B12 was effective in enhancing myelination and reducing edema, highlighting its unique benefits alongside ALA’s advantages.

7.5

Reduced sciatica pain

Most Useful Review

6 people found this helpful

I discovered that B12 is beneficial for sciatica, which led me to this product. After experiencing a hernia, I was suddenly afflicted with sciatica, leaving me unable to walk. I found it amusing to read numerous reviews and felt fortunate to have found this solution. However, the amount in the bottle seemed quite small, almost laughable. Sublingual therapy appears to have a high absorption rate, so I expect it to be effective. Though I have to drink it with water, I believe I’m experiencing its benefits. I feel much better, and I anticipate continuing this treatment. Thank you!

Diabetes details

Zhou J, Ma H, Guan M, Feng J, Dong X, et al. Anti-inflammatory Fucoidan-ConA oral insulin nanosystems for smart blood glucose regulation. Int J Pharm. 2024;659:124250. doi:10.1016/j.ijpharm.2024.124250

Based on 11 Researches

Novel system lowers blood sugar

We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.

Supports diabetic health

Most Useful Review

2 people found this helpful

Very excellent for metabolism and very necessary for diabetics. It protects nerves from diabetes waste. I wish everyone wellness and safety.

Hair Loss details

8 people found this helpful

This works well. I take it with other supplements for my hair and have noticed improvement, with a noticeable reduction in hair loss.

High Cholesterol details

White button mushrooms reduce cholesterol

Based on 10 Researches

Jeong SC, Jeong YT, Yang BK, Islam R, Koyyalamudi SR, et al. White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res. 2010;30:49. doi:10.1016/j.nutres.2009.12.003

We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.

Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.

Boosts overall well-being

Most Useful Review

1 people found this helpful

I suffer from pernicious anaemia. After using a sublingual B12 spray, I still felt terrible, but I switched to this brand without cyanide and had excellent results. I feel amazing now and highly recommend this product. I wish they offered Methylcobalamin and Adenosylcobalamin, which I am now trying.

Mild Cognitive Impairment details

Boosted energy levels

2 people found this helpful

Methylcobalamin for nervous system health and prevention of anemia is fantastic. I've felt a surge of energy and vitality since I started taking B12, and my physical health has improved significantly. It’s essential for myelin production, which protects nerve fibers, ensuring normal nervous system functioning. B12 also helps lower homocysteine levels, protecting against heart disease and dementia, while supporting various bodily processes.

Nausea details

B12 treatment effective for pancytopenia

Choi E, Galicia Garcia G, Kishore Anna K, Albuja Altamirano MF, Yip L, et al. Vitamin B12 Deficiency Manifesting As Pancytopenia, Lymphadenopathy, and Fever: A Clinical Mimic of Hematologic Malignancies. Cureus. 2024;16:e64676. doi:10.7759/cureus.64676

We observed how vitamin B12 deficiency can masquerade as serious conditions like hematologic malignancies, causing symptoms such as dizziness, nausea, and leukopenia. In our evaluation of a 39-year-old male, we found that treating severe B12 deficiency led to significant improvement in his blood counts.

After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.

No nausea

Most Useful Review

I was prescribed this during my pregnancy and it worked well. My deficiency was addressed quickly, and thankfully, I experienced no nausea. I would recommend consulting your doctor before use.

Pelvic Pain details

Eliminated severe pain

14 people found this helpful

I was going crazy from the intense pain and numbness extending from my shoulder to my fingers, utterly exhausting and preventing me from sleeping. After using it, the pain entirely vanished. I'm now requesting it for the third time!

Anxiety details

Nahar M, Rai R, Jat D. Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach. Int J Neurosci. 2024. doi:10.1080/00207454.2024.2398564

Based on 12 Researches

Vitamin B12 may reduce anxiety

We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.

The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.

Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.

Anxiety diminished

Most Useful Review

4 people found this helpful

Excellent! My endocrinologist prescribed a vitamin complex based on my analyses. Since I started, I now wake up feeling energetic and no longer require an alarm. My feelings of anxiety and apathy have disappeared, demonstrating the importance of nourishing my body with essential vitamins. Thanks to ayherb and my doctor!

Brain Tumor details

Vitamin B12's unclear impact on glioblastoma

Martínez-Mendiola CA, Estrada JA, Zapi-Colín LÁ, Contreras-Chávez GG, Contreras I. Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line. Int J Neurosci. 2024;134:1320. doi:10.1080/00207454.2023.2263815

We explored the effects of vitamin B12 (cobalamin) supplementation on a human glioblastoma cell line known as U-87 MG. Our main goal was to understand how cobalamin, particularly in combination with pyridoxine (vitamin B6), influences cell viability and the process of cell death, known as apoptosis.

Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.

We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.

In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.

Energising recovery

Most Useful Review

33 people found this helpful

Miraculously, after trying various brands without success for stress relief and brain recovery, this product proved transformative. Immediate effects were evident once I resumed taking the sweet pink tablet; I was very sleepy, which seemed necessary for my recovery. A weekend of rest led to a refreshing revitalisation thereafter. I'm continually impressed by the high quality of Solgar products compared to others.

Reflux details

Effective reflux relief

Take with care. Initially, I deleted my previous reservation because I believed this product caused a side effect. However, it turned out to be related to another medical condition. This product is excellent; it relaxes me and, for some reason, alleviates my reflux, which even omeprazole fails to do.

Autoimmune Disorder details

Pernicious anemia diagnosis and treatment

Based on 15 Researches

Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4

We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.

Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.

Fast delivery

Most Useful Review

1 people found this helpful

I was impressed with the super fast delivery time, receiving my order within nine days. The packaging was perfect in a sturdy cardboard box. The product container is excellent as well— a glass bottle with an aluminium screw cap. The sublingual tablets are robust and dissolve easily. The quality is high, and after finishing the bottle, my lab test results for vitamin B12 levels were excellent.

Cold Sores details

Productivity increase

The supplement raised my B12 levels from critically low to normal, enhancing my productivity and overall quality of life. However, I've noticed that after three applications, I developed internal sore acne around my cheekbones, a side effect experienced by many of my friends as well.

Tinnitus details

Dadgarnia M, Mandegari M, Zand V, Vaziribozorg S, Zare-Zardini H, et al. The effect of vitamin B12 on idiopathic tinnitus. Am J Otolaryngol. 2024;45:104028. doi:10.1016/j.amjoto.2023.104028

No significant benefit from B12

We conducted a double-blind clinical trial with 140 patients suffering from idiopathic tinnitus to gauge the effectiveness of vitamin B12. Participants were divided into two groups, one receiving vitamin B12 and the other a placebo over a month.

We evaluated tinnitus severity through questionnaires at multiple intervals. However, our findings revealed that vitamin B12 did not significantly reduce tinnitus severity compared to the placebo.

Ultimately, our study suggests that vitamin B12 may not be a beneficial treatment for tinnitus, as the results showed no noteworthy improvements.

Cured my tinnitus

Most Useful Review

8 people found this helpful

Though my tinnitus was mild and didn't interfere with life, it no longer disturbs me before bed. There's a noticeable reduction in my usual tiredness too.

Acne details