NOW Supplements Vitamin C

I'm thrilled with this product! Previously, I suffered from frequent colds, often with a red sore throat. I was terrified of catching a chill at night or even drinking something cool, but I’m delighted that these days are behind me! I drink vitamin C, alongside a complex with Echinacea, and occasionally some brandy, leading to significant improvement. I previously doubted long-term use, but seeing positive foreign reviews reassured me. Overall, my experience has been very positive.

Common Cold details

Hemilä H, Chalker E. Vitamin C reduces the severity of common colds: a meta-analysis. BMC Public Health. 2023;23:2468. doi:10.1186/s12889-023-17229-8

Based on 7 Researches

Vitamin C reduces cold severity

We explored how vitamin C affects the severity of common colds through a comprehensive review of available studies. By including only randomized, placebo-controlled trials where participants received at least 1 gram of vitamin C daily, we aimed to investigate both the overall duration of colds and the intensity of symptoms experienced.

Our analysis found that vitamin C significantly reduced the severity of cold symptoms by about 15%. Interestingly, it appears that the benefits are more pronounced for those experiencing severe symptoms compared to mild ones. In specific comparisons, vitamin C didn’t substantially affect the duration of mild symptoms but had a notable impact on how long severe symptoms lasted.

This insight is crucial, as the common cold often leads to absenteeism at work and school, with more severe symptoms playing a key role in this setback. By highlighting vitamin C's greater effectiveness against intense cold symptoms, we suggest that future research should continue to look into how this vitamin can be utilized in managing cold severity.

9.5

Supports recovery

Most Useful Review

It’s essential for connective tissue and immunity! Due to the coronavirus pandemic, I bought this supplement to support my immune system and improve collagen absorption. This vitamin is well-known for its crucial role in combatting the common cold.

Autoimmune Disorder details

Vitamin C impacts autoimmune response

Yin Y, Wu S. Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies. Cell Commun Signal. 2024;22:373. doi:10.1186/s12964-024-01756-x

We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.

Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.

Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.

Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.

9.5

Nails improved

Most Useful Review

Vitamin D3 significantly helped me. After my second birth, I experienced problems with my nails and a lack of energy. Following my sister's advice, I started taking this vitamin (one tablet every two days), and within a week, I felt energised. I was able to clean my whole flat and engage with my children more. Even with sun exposure, I wasn't feeling well, but after a month of taking Vitamin D3, the improvements were noticeable. My nails are now smoother!

Bacterial Infection details

Fights infections well

If you seek a quality vitamin C, look no further. The large packaging lasts well for two adults. My wife and I noticed improved energy and reduced fatigue shortly after we started taking it. She's convinced that high doses of vitamin C are excellent against "bacterial infection". Remarkably, we didn’t fall ill that spring. I highly recommend this product!

Cold Sores details

Hovi T, Hirvimies A, Stenvik M, Vuola E, Pippuri R. Topical treatment of recurrent mucocutaneous herpes with ascorbic acid-containing solution. Antiviral Res. 1995;27:263.

Based on 3 Researches

Vitamin C alleviates cold sores

We investigated how an ascorbic acid-based solution could help treat recurrent cold sores, also known as mucocutaneous herpes. This study was carefully designed as a randomized, double-blind, placebo-controlled trial, which helps ensure the results are reliable and trustworthy.

Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.

Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.

In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.

9.5

Quick recovery

Most Useful Review

This helps enormously with colds. I take it at the first signs, and it’s an excellent remedy!

Cold details

Effectiveness of Vitamin C on Colds

Hemilä H, Chalker E. Vitamin C for the common cold and pneumonia. Pol Arch Intern Med. 2025;135. doi:10.20452/pamw.16926

We explored the effects of vitamin C on the common cold and pneumonia by examining a range of studies. Interestingly, research on animals suggests that vitamin C may have protective effects against infections. However, when it comes to preventing colds in the general population, taking more than 1 gram of vitamin C per day didn’t show significant benefits.

But there's a twist! Participants engaged in heavy physical activities saw their cold incidence reduced by half with vitamin C supplementation. Additionally, regular intake of 1 gram or more daily was linked to a 15% decrease in cold severity. While some therapeutic trials showed inconsistent results when vitamin C was taken after cold symptoms appeared, two studies did indicate that larger doses (6-8 grams per day) could effectively shorten the duration of colds compared to lower doses.

Our investigation also looked into pneumonia, but the studies were conducted in unique settings, such as a boarding school and military recruits. This makes it hard to generalize the findings to the wider population. Yet, some trials suggested benefits for pneumonia patients. Finally, the role of vitamin C in treating COVID-19 and sepsis remains unclear, with mixed results.

Given that vitamin C seems to alleviate symptoms and shorten the duration of colds, while being safe and affordable, it might be worth considering a dose of 6-8 grams per day to see if it helps at an individual level.

8.8

Helps with cold

Most Useful Review

The quality is excellent. The best antioxidant, it supports immunity. For colds, it works effectively with zinc for a quick recovery.

We aimed to understand how Vitamin C could help with the toxicity caused by omeprazole, a common treatment for conditions like gastroesophageal reflux disease (GERD) and gastritis. During our study, we examined gastric cells from rabbits to see how Vitamin C, alongside other antioxidants, could protect these cells from damage caused by omeprazole.

We found that both omeprazole and another thiol-oxidant, monochloramine, significantly reduced cell viability. Interestingly, the toxicity from omeprazole occurred independently from monochloramine. However, we observed that using Vitamin C effectively protected the gastric cells from this injury, maintaining their function without interfering with omeprazole's intended effects.

This suggests that incorporating Vitamin C into treatment plans for people using proton pump inhibitors (PPIs) like omeprazole could be beneficial. Ultimately, our research highlights the potential of using antioxidants to mitigate the adverse effects often associated with medication for reflux and related conditions.

No acidic reflux

Most Useful Review

This supplement contains a high dose, which is fantastic, and it doesn’t cause any acid reflux like some other vitamin C supplements do.

Allergies details

Pleuran and Vitamin C aid asthma

Jesenak M, Hrubisko M, Chudek J, Bystron J, Rennerova Z, et al. Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma. Sci Rep. 2025;15:7146. doi:10.1038/s41598-025-91830-2

We conducted a thorough evaluation of how vitamin C, when combined with pleuran, impacts asthma control and respiratory issues in children suffering from perennial asthma. The study was meticulously designed as a double-blind, placebo-controlled trial involving 230 children aged 7 to 17 years. This means that neither the participants nor the researchers knew who was receiving the active treatment or the placebo, ensuring the findings were reliable.

The results were promising, especially for children under 12 years. They showed significant improvements in asthma control compared to those receiving only the placebo treatment. Meanwhile, older children (12 years and above) experienced fewer respiratory infections with the combination treatment. Overall, by the end of the 48 weeks, a majority of children on the pleuran and vitamin C treatment reported better asthma control compared to those on the placebo.

While the combination of pleuran and vitamin C was indeed beneficial for managing asthma, we must note that the study did not specifically isolate the effect of vitamin C alone on allergies or asthma. Thus, it is hard to draw definitive conclusions about vitamin C's effectiveness independently from pleuran. However, the approach suggested that using these supplements together could offer a helpful boost in managing asthma symptoms.

9.5

Cold prevention

Most Useful Review

High dosage of vitamin C as ascorbic acid (1000 mg) with added citrus bioflavonoids and rutin enhances its effect. I usually purchase this before the cold season and take 1000 mg daily at the first signs of illness. This dosage helps alleviate cold symptoms but should not be taken daily for more than 2-3 weeks. A continuous dosage should be between 250-500 mg to avoid issues.

Blood Clot details

Kwon JH, Kim D, Cho H, Shin BS. Ascorbic acid improves thrombotic function of platelets during living donor liver transplantation by modulating the function of the E3 ubiquitin ligases c-Cbl and Cbl-b. J Int Med Res. 2019;47:1856. doi:10.1177/0300060518817408

Based on 6 Researches

Vitamin C enhances blood clotting

We sought to understand how ascorbic acid, commonly known as vitamin C, impacts blood clotting during living donor liver transplantation (LDLT). In our study, we analyzed blood samples from 21 recipients before and after their surgeries.

We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.

Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.

This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.

9.5

Improved blood vessels

Most Useful Review

These vitamins are excellent for collagen formation, which benefits the skin, ligaments, and blood vessels. My facial inflammation has subsided, and my complexion improved. My mother's leg pain has stopped, and vitamin C has strengthened my bleeding gums. Healing of wounds and bruises has accelerated too.

Bruise details

Vitamin C improves bruising symptoms

Based on 9 Researches

Amisha F, Ghanta SN, Kumar A, Fugere T, Malik P, et al. Scurvy in the Modern World: Extinct or Not?. Cureus. 2022;14:e22622. doi:10.7759/cureus.22622

We explored how vitamin C can impact bruising, particularly in individuals experiencing a deficiency. The research highlighted a case involving an elderly woman who faced challenges such as weakness, easy bruising, and fatigue due to a lack of this vital nutrient.

After beginning treatment with vitamin C supplements, we observed significant improvements in her symptoms, emphasizing the importance of this vitamin in healthier skin and tissue repair. It showcased that scurvy, a condition rooted in vitamin C deficiency, can still occur today, especially in certain at-risk populations.

This case reminds us that while scurvy might seem like a relic of the past, it can still affect modern individuals. Skin issues like easy bruising can sometimes signal deeper dietary concerns that need addressing, especially in older adults.

9.5

Strengthens blood vessels

Most Useful Review

I take different vitamins of this brand. They are affordable and effective! I combined vitamin C with a routine of the same brand. I really liked the action of these vitamins. They work well together, and I've noticed the strengthening of blood vessels since I started taking them. The nosebleeds have ceased, and bruises on my legs no longer occur spontaneously. I recommend these vitamins, particularly for strengthening blood vessels.

Depression details

Vitamin C intake linked to depression

Based on 10 Researches

Zhao D, Long X, Wang J. Association of dietary vitamin C intake with depression in adults: A cross-sectional study of NHANES from 2005 to 2020. J Affect Disord. 2024;358:113. doi:10.1016/j.jad.2024.05.032

This study aimed to understand how dietary vitamin C affects depression in adults. By analyzing data from the National Health and Nutrition Examination Survey spanning from 2005 to 2020, we focused on the relationship between vitamin C intake and depression levels among 38,157 participants.

Our findings revealed that individuals who consumed higher amounts of vitamin C had lower odds of experiencing depression. Specifically, those in the higher intake quartiles showed significantly reduced odds compared to those with the lowest intake. Interestingly, we discovered an L-shaped curve representing the relationship between vitamin C and depression, suggesting that while increased intake was beneficial up to a certain point (around 93.61 mg), higher consumption did not yield additional benefits.

While our results are promising, it's crucial to note that this was a cross-sectional study, meaning we cannot definitively claim that vitamin C intake causes changes in depression. Additionally, other factors might have influenced these associations, which we couldn't fully control for.

Overall, this research provides intriguing evidence of the potential role that dietary vitamin C might play in alleviating depressive symptoms, especially for those consuming lower amounts.

9.5

Reduced depression significantly

Most Useful Review

Drinking this helped to reduce my depression and hair loss. In my experience, taking B vitamins, vitamin E, niacin, carnosine, and vitamin C together has a synergistic effect on depression, making it even more effective. For hair loss, combining vitamin E and niacin with vitamin C further lessened the problem. I didn't notice any difference in effectiveness compared to vitamin C without bioflavonoids.

Herpes details

Love! Saved from herpes! I take 2g of vitamin C daily and plan to increase to 3g by winter. In the past year, I haven't caught colds, despite regular stress and lack of sleep. It astonishingly stopped herpes one evening! After an unfortunate sunburn, I felt the onset of herpes on my lips, which I usually treat with acyclovir for over a week. However, after taking 4 capsules before bed, I woke up with no sign of it! I truly didn’t expect such results. I hope others benefit too! 🙏🏼⚠️

High Cholesterol details

Vitamin C reduces cholesterol levels

Based on 6 Researches

Tavakolinasab F, Hashemi M. Effect of Using Vitamin C Supplementation on Performance, Blood Parameters, Carcass Characteristics and Meat Quality of Broiler Chickens Under Heat Stress Condition: A Meta-Analysis. J Anim Physiol Anim Nutr (Berl). 2025. doi:10.1111/jpn.14091

We explored how vitamin C supplementation affects cholesterol levels in broiler chickens, particularly under heat stress conditions. Through a thorough meta-analysis of 35 studies conducted between 1985 and 2023, we assessed various performance metrics, including blood parameters, carcass characteristics, and overall meat quality.

Our findings revealed that vitamin C significantly reduced cholesterol levels in the broiler chickens subjected to heat stress. Specifically, the study reported a notable decrease in cholesterol concentrations, with a standard mean difference of -0.976, indicating a strong beneficial effect of vitamin C in managing high cholesterol.

Additionally, we noticed improvements in body weight and average daily gain among chickens receiving vitamin C when compared to those that did not. While vitamin C did not significantly impact feed intake or breast meat quality, it emerged as a valuable antioxidant that can help lower blood triglycerides and reduce cholesterol, thus promoting better overall health and growth in broilers during stressful conditions.

Ultimately, this meta-analysis supports the use of vitamin C at a recommended dosage of 250 mg/kg as an effective growth promoter and antioxidant in broiler diets under heat stress, directly influencing cholesterol management.

9.5

Eliminates herpes symptoms

Most Useful Review

Love this! I've been taking 2g of vitamin C daily and plan to increase it this winter. I've had no colds even with stress and irregular sleep. Remarkably, it stopped a herpes outbreak overnight. I took four capsules before bed when I felt it coming on, and by morning, the symptoms were gone! This unexpected effect was incredible. I hope it works for others, too!

Hypothyroidism details

Vitamin C may lower hypothyroidism risk

Based on 12 Researches

Chen L, Mao Y, Chen G. Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012. Br J Nutr. 2024;132:1575. doi:10.1017/S0007114524001715

We set out to examine how total vitamin C intake might influence hypothyroidism in individuals with Hashimoto thyroiditis, using data from the National Health and Nutrition Examination Survey conducted between 2007 and 2012. Our study utilized multivariate logistic regression and restricted cubic spline analyses to uncover possible associations.

What we found was quite intriguing. There was a clear negative linear relationship between total vitamin C intake and hypothyroidism. Specifically, participants who consumed higher amounts of vitamin C had a significantly lower likelihood of developing hypothyroidism. Those in the top quartile of vitamin C intake were about 60% less likely to have hypothyroidism compared to those in the lowest quartile.

This pattern remained consistent across different age groups and sexes, further emphasizing the potential benefits of vitamin C for individuals with Hashimoto's. Our findings suggest that increasing vitamin C intake may be a simple and effective strategy for reducing the risk of hypothyroidism in those affected. The data indicates that consuming between 4.57 and 1258.9 mg/day of vitamin C could be beneficial.

Overall, our research adds to the understanding of how antioxidants like vitamin C can play a role in thyroid health, encouraging us to consider dietary sources of this vital vitamin for those managing Hashimoto's thyroiditis.

9.5

Increased energy

Most Useful Review

Excellent! I really liked the vitamin D from this manufacturer; I feel energised and active from early morning to late evening, and sometimes even at night. The apathy associated with hypothyroidism has vanished! I have a large jar that will last me a long time, and the small gelatin capsules are convenient to take. I highly recommend it! 👍

Indigestion details

No indigestion issues

Excellent! This effective vitamin C for adults aids in maintaining good health. The ingredients are straightforward and beneficial: vitamin C, bioflavonoids, and rutin. The latter two enhance the effectiveness of vitamin C. Each capsule contains 1000 mg, with a jar holding 100 capsules. Taking two capsules is sufficient for almost a season, as we don't always drink them daily—sometimes they are forgotten. Not only does this vitamin C support the immune system well, but it is also gentle on the stomach — though there are occasional indigestion, everything remains fine with this product. Therefore, I wholeheartedly recommend it!

Influenza details

Vitamin C's unclear influenza impact

Based on 6 Researches

Park JH, Lee Y, Choi M, Park E. The Role of Some Vitamins in Respiratory-related Viral Infections: A Narrative Review. Clin Nutr Res. 2023;12:77. doi:10.7762/cnr.2023.12.1.77

We explored the relationship between vitamin C and influenza, delving into various studies conducted from 2000 to June 2021. In our analysis of the research, we found eleven studies that specifically examined the effects of vitamin C on influenza.

While some of these studies reported positive outcomes, we should note that the isolated benefits of vitamin C can be hard to determine. This is primarily because some studies included additional treatments, making it difficult to draw definitive conclusions about vitamin C alone.

Overall, we observed that while there is some interest and preliminary evidence regarding the efficacy of vitamin C in preventing or treating influenza, its stand-alone effectiveness remains somewhat unclear.

Continued research should help clarify how much vitamin C can truly contribute to combating influenza.

9.5

Highly recommended supplement

Most Useful Review

You absolutely need this! It’s an amazing product, excellent for immunity; the pill size is manageable and the taste is just fine. I've used it for quite some time with consistent quality. I believe it’s among the best Vitamin C supplements available. I never experienced stomach issues even while taking 5-6 pills daily during my bouts with influenza/Covid.

Nausea details

Vitamin C ineffective against nausea

Very Likely Ineffective

Foessleitner P, Rager L, Mikula F, Hager M, Granser S, et al. The Role of hCG and Histamine in Emesis Gravidarum and Use of a Chewing Gum Containing Vitamin C as a Treatment Option: A Double-Blinded, Randomized, Controlled Trial. J Clin Med. 2024;13. doi:10.3390/jcm13175099

We explored the effects of vitamin C as a treatment for nausea and vomiting in pregnancy, also known as emesis gravidarum. Our study involved 111 participants, who were given either vitamin C-containing chewing gum, a placebo, or no treatment at all. We monitored them over two follow-up visits in early pregnancy to assess their symptoms.

While we measured various factors that could influence nausea—including hormone levels like hCG and DAO—our findings showed that the chewing gum did not effectively reduce nausea symptoms compared to the placebo or no treatment. Specifically, the vitamin C gum was not associated with any significant alleviation of nausea or vomiting.

Interestingly, we found that elevated levels of hCG were linked to increased nausea severity. In contrast, higher levels of DAO appeared to have a protective effect against symptoms. Additionally, elevated thyroxine and pyridoxine levels correlated with worsened nausea.

Overall, while vitamin C is often highlighted for its health benefits, our results suggest it does not play a significant role in treating nausea during pregnancy. This study highlights the complexities behind nausea in pregnancy, indicating that further research is necessary to uncover effective treatment options.

Prevents nausea

Most Useful Review

Good product that I consume in winter to prevent vitamin deficiency. It does not induce nausea or allergies.

Pneumonia details

Improved recovery speed

After my dad became seriously ill with pneumonia, he was hospitalised. The doctor recommended vitamin D, C, and zinc, but we couldn't find the correct dosage locally, so I ordered it here. Within three days of taking the vitamins, my dad began to improve — his temperature fell, he regained his colour, and his breathing became easier. The doctor was astonished at his rapid recovery for his age and acknowledged that the vitamins certainly played a role.

Tonsillitis details

Prevented tonsillitis

A quick way to combat a virus, rating 10/10. During my illness, my seasonal cold often develops into acute tonsillitis, with all its consequences. This time, at the initial stages of the illness, I took a substantial dose—two tablets of 1000mg each. To my amazement, the temperature did not rise, and I did not experience a sore throat. Previously, this treatment helped me easily cope with an exacerbation of tonsillitis.

Whooping Cough details

Due to the pandemic, finding good vitamin C is quite challenging, but this product is fantastic. I started to sneeze and cough, so I took one capsule, and by morning, everything had cleared up. The quality is exceptional and budget-friendly. I am very grateful for this product—thank you. I highly recommend it.

Acne Rosacea details

Clear skin improvement

Works effectively 👌🏽 Great product! Both quality and efficacy are high! The large packaging lasted me more than three months, making it very cost-effective. I purchased it to maintain my health during the autumn-winter period, taking one capsule daily. I experienced no gastrointestinal side effects, even with my increased stomach acidity. I noticed a significant improvement in my health; my immunity strengthened, I stopped catching colds, and the nasal congestion that troubled me for weeks disappeared. Additionally, there was a positive effect on my skin, as I had red blood vessels in the nose area due to acne rosacea. After a course of this vitamin C, my skin became clear and perfectly smooth. Excellent result!

Acne details

Vitamin C shows effectiveness for acne

Based on 16 Researches

Woolery-Lloyd H, Baumann L, Ikeno H. Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: a randomized, double-blind, controlled trial. J Cosmet Dermatol. 2010;9:22. doi:10.1111/j.1473-2165.2010.00480.x

In our recent study, we set out to explore the effectiveness of a 5% sodium L-ascorbyl-2-phosphate lotion, a stable form of vitamin C, for treating acne. We conducted a double-blind, controlled trial with 50 participants over 12 weeks, where half used the vitamin C lotion and the other half received a placebo.

Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.

The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.

Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.

9.5

Acne improvement noted

Most Useful Review

The capsules are large and have a sour taste. I take them after breakfast with water; taking them on an empty stomach caused me pain. The quantity is excellent, and they've wonderfully helped with chest disease symptoms. After getting the Corona vaccine and falling ill, fatigue lasted only a day. My skin has improved significantly, and the red spots of acne are beginning to disappear. I recommend storing them in the refrigerator.

Adrenal Gland Disorder details

Supports overall well-being

Vitamin C is important not only during colds but also for general well-being. It is essential in collagen formation and is not produced by the body, so must be ingested externally. Vitamin C improves insulin resistance, supports the adrenal glands, and is vital during stress, as the body’s needs increase. A lack of vitamin C is linked to numerous health issues. Therefore, it’s crucial to replenish it, especially during periods of illness or stress.

Anxiety details

Vitamin C alleviates anxiety in autism

Tarahomi P, Arab M, Seyedinia SA, Rahmani M, Rashidy-Pour A, et al. Vitamin C and Gallic Acid Ameliorate Motor Dysfunction, Cognitive Deficits, and Brain Oxidative Stress in a Valproic Acid-Induced Model of Autism. Brain Behav. 2025;15:e70262. doi:10.1002/brb3.70262

We set out to explore how vitamin C influences anxiety-like behaviors in a model of autism caused by valproic acid (VPA). In our study, we used fourteen female rats that underwent specific treatments to induce autism in their offspring. After a period of observation, we treated male pups with daily injections of vitamin C for four weeks. Then, we assessed their behavior to see if there were any changes in anxiety levels.

Our findings suggested that vitamin C significantly reduced anxiety-like behaviors in these rats. This outcome is particularly promising considering that autism often brings associated anxiety. By measuring various brain oxidative stress markers, we also noted improvements in mental functioning and motor skills after vitamin C treatment. Overall, our work underscores the potential benefits of vitamin C as a supportive treatment for anxiety-related issues in autism, indicating a pathway for future research and therapeutic strategies.

9.5

Significant relief

Most Useful Review

Fast-acting vitamin C is truly effective for boosting my energy. As someone with bipolar type 2, it has been a lifesaver during my depressive episodes and extreme fatigue. It notably alleviates my anxiety attacks—something that no other remedy has achieved apart from medication.

Arthritis details

Vitamin C's role in arthritis management

Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9

We explored the role of vitamin C in addressing arthritis symptoms, particularly its effect on joint inflammation. Vitamin C is known for its antioxidant properties, and we found that it plays a crucial role in collagen synthesis. This feature is important as collagen forms the structural basis of our joints.

What excited us was the possibility that vitamin C could help reduce inflammation in patients with rheumatoid arthritis. Given that inflammation is a major factor in the discomfort and damage associated with this condition, any reduction could significantly enhance the quality of life for those affected.

However, while vitamin C shows promise due to its supportive functions, we must remember that the evidence concerning its direct effectiveness on arthritis specifically is still evolving. The correlation between vitamin C intake and reduced joint inflammation points to a beneficial role, but more detailed studies are necessary to solidify these findings and determine optimal dosages.

Overall, our review highlights that while vitamin C may indeed support joint health and aid in managing inflammation, further research is essential to fully understand its impact and to evaluate how it can be integrated into arthritis management strategies effectively.

9.5

Joint pain relief

Most Useful Review

In one capsule, not only essential vitamin C, but also rutin and bioflavonoids. Rutin is known for its protective role for ascorbic acid (vitamin C) due to its antioxidant properties, which fend off excessive oxidation. Preparations from sophora are recommended for strengthening blood vessels. I have arthritis and can definitely say that my joints have become much less painful. This vitamin is particularly useful during heightened virus activity. My whole family takes it as an additional source of body protection, and we rarely suffer from respiratory illnesses. I appreciate the convenient dosage and reasonable pricing of this company's products, and I wholeheartedly recommend it.

Chronic Fatigue Syndrome details

Kodama M, Kodama T. The clinical course of interstitial pneumonia alias chronic fatigue syndrome under the control of megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex. Int J Mol Med. 2005;15:109.

Based on 5 Researches

Vitamin C aids immune function

We examined how a combination of megadose vitamin C infusions and other treatments might help manage chronic fatigue syndrome, particularly in the context of interstitial pneumonia. Our findings were based on nearly a decade of treating patients, allowing us to gather valuable insights.

We observed that the long-term use of this treatment system significantly reduced the risk of pneumonia recurrence. It also appeared to help prevent the emergence of certain cancers in older patients suffering from interstitial pneumonia. Surprisingly, we found a link between interstitial pneumonia and an increased risk of depression, likely driven by prolonged glucocorticoid use.

While some patients showed promise under this treatment, those battling both interstitial pneumonia and depression responded less favorably. We suggested that increasing the amount of dehydroepiandrosterone in the treatment could be beneficial. Throughout our experience, we noted that the characteristics of chronic fatigue syndrome align closely with those of interstitial pneumonia, arguing against the notion that they should be viewed as separate conditions.

Overall, our approach not only alleviated inflammation but did not suppress the fibrotic processes in the long run. We made modifications to the treatment to lower the risks of vascular complications. The main strength of our treatment lies in creating a hormonal environment that helps tackle immune deficiencies using vitamin C, which faces lower resistance in the body compared to steroid treatments.

9.5

Alleviates withdrawal symptoms

Most Useful Review

I love that this product includes bioflavonoids, as they enhance the benefits of vitamin C. I'm using it to manage withdrawal symptoms from benzodiazepines, improve adrenal fatigue, and provide an antioxidant effect. It has helped me immensely. I take 5g a day in divided doses.

Dizziness details

Zhang N, Liu JX, Ma FR, Yu LS, Lin YQ, et al. Change of extracellular ascorbic acid in the brain cortex following ice water vestibular stimulation: an on-line electrochemical detection coupled with in vivo microdialysis sampling. Chin Med J (Engl). 2008;121:1120.

Based on 3 Researches

Ascorbic Acid and Dizziness Study

We explored how ice water vestibular stimulation affects ascorbic acid (AA) levels in the brain, particularly in relation to dizziness. Using a method called in vivo microdialysis coupled with electrochemical detection, we monitored changes in extracellular AA in the primary somatosensory area of guinea pigs. Our study included 16 guinea pigs divided into three groups: one group received ice water stimulation, while the other two were exposed to warm water and ice water without vestibular input.

The results revealed that the concentration of extracellular AA increased in the brain following the ice water stimulation. This finding suggests that there may be neurochemical responses associated with AA that play a role in managing conditions like vertigo. However, while the study shows an intriguing relationship between AA levels and vestibular stimulation, it does not establish a direct link between vitamin C's effectiveness in treating dizziness specifically.

Overall, the insights gained from this research could help pave the way for further investigations into the role of vitamin C in vertigo-related treatments, adding a layer of understanding to its neurochemical functions.

9.5

Reduced dizziness

Most Useful Review

Drinking it four times a day has helped alleviate fatigue! I previously suffered from throat inflammation and dizziness after work, but since I began taking Now's c1000, both issues have markedly improved. I take 4000mg divided throughout the day to eliminate the symptoms. I hope to enhance the effect by combining it with whey protein and multivitamins in the morning and evening. Consequently, I am recovering from fatigue much quicker.

Headache details

Zhao D, Long X, Wang J. Association between dietary vitamin C intake and migraine in adults: A cross-sectional study of the National Health and Nutrition Examination Survey. J Hum Nutr Diet. 2024;37:1454. doi:10.1111/jhn.13366

Vitamin C intake reduces migraines

We aimed to understand how dietary vitamin C affects migraines by analyzing data from the National Health and Nutrition Examination Survey, conducted from 1999 to 2004. In this survey, we identified adults who reported experiencing severe headaches or migraines over the past three months.

Our findings were quite revealing. Out of 4,101 participants, 702 individuals reported having a migraine, which represents about 17% of the group. We discovered an interesting trend: higher dietary vitamin C intake seemed to correlate with a lower likelihood of experiencing migraines. Specifically, participants with the highest vitamin C intake had a 36% reduced odds of suffering from migraines compared to those with the lowest intake.

We employed various statistical methods to confirm our results, including logistic regression and restricted cubic spline regression, which showed a clear linear relationship between vitamin C intake and the frequency of migraines.

Overall, this study suggests that increasing our dietary vitamin C might help minimize migraines, which is promising news for those who suffer from these intense headaches. However, as with all studies, further research is necessary to solidify these findings and fully understand the relationship between vitamin C and headache relief.

8.8

Headache reduction

Most Useful Review

I very often suffered from headaches and started taking a vitamin with bioflavonoids to strengthen my blood vessels. Initially, I drank it every three hours for a week, then switched to morning and evening doses. Surprisingly, my headaches have stopped, despite having previously taken numerous nootropics.

Insomnia details

Vitamin C alleviates chemotherapy insomnia

Carr AC, Vissers MC, Cook J. Relief from cancer chemotherapy side effects with pharmacologic vitamin C. N Z Med J. 2014;127:66.

We explored the effects of pharmacologic vitamin C on insomnia related to cancer chemotherapy. In our case study, we worked with a woman battling recurrent breast cancer who was experiencing significant fatigue and lethargy as she underwent weekly chemotherapy sessions.

To combat her sleep disturbances, we administered high doses of vitamin C, 50 grams per session, twice a week. We also employed quality of life and fatigue questionnaires to monitor changes over time.

The results were promising! We observed marked improvements in her insomnia and overall fatigue levels. Furthermore, there was a notable enhancement in her cognitive functioning, without any adverse side effects from the vitamin C treatment.

This case highlights how vitamin C may offer relief from insomnia associated with chemotherapy, providing a new avenue for improving quality of life during cancer treatment.

8.8

Improved sleep effects

Most Useful Review

Immunity has a stabilising effect on insomnia, depression, autonomic disorders, and similar conditions, particularly during menopause or old age. High-quality ingredients are natural, providing stress relief, stimulating brain function, improving concentration, increasing performance, and normalising sleep and mood. The capsules are of medium size. GABA, a central nervous system neurotransmitter, enhances sleep quality, as the highest growth hormone release occurs at night. This component limits stress factors, leading to significantly deeper and more effective sleep. The dosage is optimal.

Lung Cancer details

Vitamin C reduces lung cancer spread

Based on 8 Researches

Man S, Bi J, Liu F, Xie W, Ma L. Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway. Mol Nutr Food Res. 2024;68:e2300706. doi:10.1002/mnfr.202300706

We explored the effects of vitamin C on lung cancer, particularly its ability to inhibit pulmonary metastasis—meaning the spread of cancer to the lungs. Using an H22 pulmonary metastasis mouse model, we observed that vitamin C administration, both intraperitoneally and orally, showed promising results.

Through the research, we found that intraperitoneal injections of vitamin C led to an increase in crucial proteins like Nrf2 and HO-1, which are known to help combat cancer. This process resulted in increased cell death in cancer cells through DNA damage and apoptosis, mimicking the effects seen when using pro-oxidant treatments in cells lacking the p53 protein—a critical tumor suppressor.

Furthermore, oral vitamin C not only activated these protective pathways but also spurred the expression of p53 in healthy tumor cells, showcasing its potential as an antimetastatic agent. We noted that vitamin C reduced the proliferation and migration of lung cancer cells while being gentler on normal cells, suggesting a safer therapeutic profile.

Overall, this study highlights vitamin C's dual role in both bolstering the body's defenses against cancer and directly inhibiting the spread of lung cancer, paving the way for its consideration in clinical treatments for pulmonary metastasis.

9.5

Effective against cancer

Most Useful Review

Affordable and highly effective, particularly for lung cancer therapy. Vitamin C is ineffective without bioflavonoids, which many people overlook, and producers often exploit. However, these capsules have proven very beneficial in combating lung cancer, effectively disrupting cancer cells.

Rosacea details

Tsiskarishvili NV, Katsitadze A, Tsiskarishvili Ts, Tchitanava L, Tsiskarishvili NI. [Angioprotectors in the treatment of rosacea]. Georgian Med News. 2014.

Rosacea treatment with vitamin C

We explored the effectiveness of Rutin Forte, a treatment that includes long-acting vitamin C along with zinc and selenium, in managing rosacea, particularly in its erythematous stage. Our study included 30 patients—20 women and 10 men, aged 25 to 50—who were divided into two groups. One group received standard treatments like antibiotics and topical therapies, while the other group received the same treatments along with Rutin Forte for 2 to 3 months.

Over a 12-month observation period, we observed significant improvements in the group that received Rutin Forte. This group showed a notable reduction in erythema, the redness associated with rosacea, and intriguingly, there were no relapses of the condition. Conversely, the standard treatment group experienced recurrences of rosacea by the third month of follow-up, and their reduction in erythema was less pronounced.

This indicates that Rutin Forte, likely due to the vitamin C it contains, might play a beneficial role in treating and preventing rosacea symptoms, particularly in stubborn cases. Overall, our findings suggest that incorporating vitamin C into rosacea treatment can be quite effective.

9.5

Improved skin clarity

Most Useful Review

Works effectively! It's a great product with high quality and efficiency. The large packaging lasted me over three months, making it very economical. I purchased it to maintain my health during autumn and winter, taking one capsule daily with no gastrointestinal side effects despite my high stomach acidity. I noticed significant benefits; my immunity improved, I stopped catching colds, and my nasal congestion vanished after weeks. Importantly, I observed a positive impact on my skin. I had red blood vessels on my nose from rosacea, but after a course of this vitamin C, my skin became clear and perfectly even. Excellent result!

Sinusitis details

Cho DY, Hwang PH, Illek B. Effect of L-ascorbate on chloride transport in freshly excised sinonasal epithelia. Am J Rhinol Allergy. 2009;23:294. doi:10.2500/ajra.2009.23.3316

Vitamin C aids chloride transport

We explored the effects of L-ascorbate, commonly known as Vitamin C, on chloride transport in sinonasal epithelial tissues. This research is particularly significant as it addresses the common condition of chronic rhinosinusitis (CRS) and its potential link to the function of the cystic fibrosis transmembrane conductance regulator (CFTR) — a key chloride ion channel.

During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.

This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.

Sinusitis-free life

Most Useful Review

Very effective for sinusitis, I had it on and off for five years. I used to visit my doctor whenever my allergies flared; however, since I started taking this supplement—recommended by a friend—I've not had to return to the doctor. It's been two years now, and I'm free from sinusitis.

Stroke details

Vitamin C aids stroke rehabilitation

Based on 4 Researches

Wang J, Chang E, Jiang Y. Effects of vitamin C stimulation on rehabilitation of dysphagia after stroke: a randomized trial. Eur J Phys Rehabil Med. 2022;58:558. doi:10.23736/S1973-9087.22.07337-3

We explored how vitamin C stimulation affects the recovery of stroke patients suffering from dysphagia, a condition that makes swallowing difficult. In a carefully designed study involving 120 stroke patients, we divided them into two groups: one received traditional swallowing training, while the other group was given vitamin C stimulation alongside their training.

Our findings highlighted that those who received vitamin C showed marked improvements in their ability to swallow, as reflected in assessments such as the water swallow test and video fluoroscopic swallowing study. Additionally, we observed enhancements in their nutritional status and immune function, measured by indices like serum albumin and immunoglobulins.

Overall, it seems that vitamin C isn’t just a vitamin; it may play a vital role in helping stroke patients recover more effectively from dysphagia. This evidence supports using vitamin C as a beneficial component in stroke rehabilitation plans.

9.5

Protects against strokes

Most Useful Review

Excellent! Vitamin C is vital for the body’s normal functioning, particularly in children. Ascorbic acid reduces the risk of chronic diseases and offers protection against strokes and heart attacks; it heals wounds, strengthens bones, and enhances brain function, among other benefits. This supplement includes bioflavonoids that assist in the absorption of vitamin C. I highly recommend it.

Swollen Lymph Nodes details

Fantastic vitamin C! It contains bioflavonoids, which enhance its absorption. After taking it, I experience no swelling or heartburn and feel more energised. Highly recommended.

Toothache details

Good for inflammation

This nutrient is my top choice. I took 3,000 mg of vitamin C daily to tackle all sorts of inflammation, including colds and toothaches. At times, I boosted my intake to 4,000 mg five times a day, and it worked exceptionally well!

Back Pain details

Lee GW, Yang HS, Yeom JS, Ahn MW. The Efficacy of Vitamin C on Postoperative Outcomes after Posterior Lumbar Interbody Fusion: A Randomized, Placebo-Controlled Trial. Clin Orthop Surg. 2017;9:317. doi:10.4055/cios.2017.9.3.317

Based on 4 Researches

Vitamin C's limited impact on pain

We conducted a year-long study to investigate the effects of vitamin C on postoperative pain and recovery after a specific type of spine surgery known as posterior lumbar interbody fusion (PLIF). In this randomized, placebo-controlled trial, we worked with 123 patients, dividing them into two groups: one receiving vitamin C and the other a placebo.

Our main focus was to see how vitamin C influenced lower back pain measured by a visual analogue scale. While we found that there was no significant difference in pain levels at the one-year mark between the two groups, there was a silver lining. We observed that vitamin C appeared to enhance functional improvement, especially within the first three months after surgery.

So, while vitamin C didn’t seem to directly reduce pain intensity after surgery, it could play a role in supporting early recovery and everyday function. This finding may encourage further exploration into vitamin C's potential benefits in postoperative care for patients undergoing spine surgeries.

9.5

Effective treatment noted

Most Useful Review

During the epidemic, I avoided visiting the dentist. When I experienced bleeding gums or mouth sores, I took high doses of Vitamin C every hour or two. Within a day or two, the pain subsided significantly. For over three years, I’ve been taking around seven high-dose Vitamin C capsules daily and my overall health is excellent. I rarely need any medication and haven’t caught the flu.

Brain Tumor details

Vitamin C impacts glioblastoma progression

Based on 12 Researches

Jara N, Ramirez E, Ferrada L, Salazar K, Espinoza F, et al. Vitamin C deficient reduces proliferation in a human periventricular tumor stem cell-derived glioblastoma model. J Cell Physiol. 2021;236:5801. doi:10.1002/jcp.30264

We aimed to understand how a lack of vitamin C influences the growth of glioblastoma, one of the most aggressive types of brain tumors. Using guinea pigs, we tested the effects of a vitamin C-deficient diet on tumor growth caused by two different human glioblastoma cell lines, U87-MG and HSVT-C3.

Through this study, we observed that the absence of vitamin C significantly hindered tumor proliferation in both models. Notably, we found that vitamin C deficiency reduced factors associated with tumor growth, such as vasculature and immune cell infiltration, particularly in the HSVT-C3 cells, which are known for their stem cell-like properties.

Our findings suggest that vitamin C plays a crucial role in supporting tumor growth, and when absent, it can lead to a notable reduction in glioblastoma progression. This emphasizes the potential importance of maintaining adequate vitamin C levels for patient outcomes in brain tumor scenarios.

8.8

Improved mood

Most Useful Review

The capsules last for three months, and the vitamin C within them does not cause heartburn, making them suitable for older individuals or those with stomach issues. The dose is quite large, so the effects are noticeable. Since I began taking them, I feel cheerful, with an unshakeable good mood and enhanced productivity. Lethargy and fatigue have disappeared, and my memory seems to be sharper, enabling quicker thought processes. My appearance has also improved; my eyes are brighter, and my skin looks fresher.

Cancer details

He X, Wang Q, Cheng X, Wang W, Li Y, et al. Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response. Cell. 2025. doi:10.1016/j.cell.2025.01.043

Likely Very Effective

Vitamin C enhances immune response

We delved into how vitamin C might influence cancer treatment, focusing on its effects on the immune system. Our findings revealed that vitamin C directly modifies certain proteins, leading to a new type of protein change called vitcylation. This process specifically affects a protein known as STAT1.

By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.

Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.

9.5

Essential for therapy

Most Useful Review

Vitamin C is remarkably effective, especially in cancer therapy. Many people underestimate the importance of bioflavonoids which are essential for its effectiveness. These capsules have proven beneficial, showing significant efficacy in combating cancer cells.

Irritable Bowel Syndrome details

Great bowel cleanse. Very good delivery, and after long waits, I saw the xhs sisters sharing stock while I was fishing in the beautiful morning. I quickly placed my order, finding it to be very cost-effective. Presently, I believe it is quite useful for me; I've noted improvements in my sleep.

Knee Pain details

Noordin S, Baloch N, Salat MS, Rashid Memon A, Ahmad T. Skeletal manifestations of scurvy: a case report from dubai. Case Rep Orthop. 2012;2012:624628. doi:10.1155/2012/624628

Vitamin C for knee pain relief

We observed an intriguing case involving a 4.5-year-old boy who developed significant knee pain due to a rare nutritional deficiency, scurvy. This condition stemmed from his exclusive intake of meat over the past two years, resulting in skeletal issues and inflammation in multiple joints, including his knees.

Upon examination, the child exhibited several symptoms, including pain, swelling, and an inability to walk. Standard blood tests primarily indicated anemia, but X-rays revealed alarming conditions related to scurvy, such as delayed bone age and severe osteopenia. This alarming picture led us to the conclusion that vitamin C deficiency was the underlying culprit behind his knee pain and skeletal issues.

After initiating vitamin C therapy, we noted a remarkable reduction in pain and swelling over the next two months. The child’s condition improved significantly, allowing him to walk again, and follow-up X-rays confirmed the positive changes in his bone health. This case clearly illustrates how vitamin C can effectively alleviate knee pain related to scurvy and reinforces the importance of proper nutrition for overall skeletal health.

8.8

Pain relief achieved

Most Useful Review

During the epidemic, I did not visit the dentist. When I experienced bleeding gums or mouth sores, I took high doses of vitamin C every couple of hours. Within one or two days, the pain subsided. I have been taking around seven capsules of high-dose vitamin C daily for over three years, and I feel well. I do not require any other medication and have not had the flu.

Leg Cramps details

Leg cramps treatment comparison

Hammar M, Berg G, Solheim F, Larsson L. Calcium and magnesium status in pregnant women. A comparison between treatment with calcium and vitamin C in pregnant women with leg cramps. Int J Vitam Nutr Res. 1987;57:179.

We explored the effects of vitamin C on leg cramps in a group of 60 pregnant women through a double-blind trial. Participants received either calcium or vitamin C (1 g twice daily) as treatment. Our observations revealed that there was no significant difference in clinical improvement between the two treatment groups.

Notably, 14 patients experienced complete relief from symptoms, while 27 reported significant improvement regardless of which treatment they received. Unfortunately, 17 participants found their symptoms unchanged, and only two noticed an increase in leg cramps during the treatment period.

Throughout the study, we measured serum levels of total and ionized calcium, total magnesium, and albumin, but these parameters did not show significant changes in either treatment group. We also didn’t identify any biochemical differences when comparing the effectiveness of vitamin C and calcium for alleviating cramps.

Ultimately, our findings suggest that vitamin C may not be an effective solution for leg cramps in pregnant women, as both treatments yielded similar results with minimal biochemical changes.

9.5

Improved skin condition

Most Useful Review

These vitamins are excellent for collagen production, benefiting skin, ligaments, and blood vessels. My facial inflammation has resolved and my mother's leg cramps no longer trouble her. Vitamin C has also strengthened my teeth and sped up healing. I have reduced sweet consumption as well.

Liver Disease details

Ximenes JLS, Rocha-Filho JA, Galvão FHF, Lanchotte C, Kubrusly MS, et al. The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study. Int J Mol Sci. 2024;25. doi:10.3390/ijms25168833

Vitamin C reduces liver injury

We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.

Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.

This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.

9.5

Supporting liver detoxification

Most Useful Review

I take this with iron to enhance absorption, and I notice the benefits during blood tests for ferritin. It's crucial when feeling unwell or chilled. I was thankful to have it during a recent illness, as it assisted in detoxifying and cleansing my liver. Combined with other vitamins, it boosts their effects. I've recommended it to friends, all of whom are pleased.

Menopause details

Vitamin C may reduce oxidative stress

Montoya-Estrada A, García-Cortés AY, Romo-Yañez J, Ortiz-Luna GF, Arellano-Eguiluz A, et al. The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women-A Pilot Randomized Clinical Trial. Nutrients. 2024;16. doi:10.3390/nu16213775

We conducted a randomized, double-blind clinical trial to explore the combined effects of resveratrol and vitamin C on oxidative stress in postmenopausal women. The study included forty-six women who faced insulin resistance and were divided into three groups: one received resveratrol alone, another received both resveratrol and vitamin C, and the third group got only vitamin C.

After the treatment, we observed notable results, particularly in the group that took the combination of resveratrol and vitamin C. This group exhibited a significant reduction in harmful oxidative stress markers. For instance, markers like lipohydroperoxides dropped by 33%. Additionally, malondialdehyde levels decreased by remarkable rates in all groups. Group B, which received both antioxidants, showed the most pronounced improvements, including a 39% decrease in protein damage.

While vitamin C showed benefits when combined with resveratrol, it’s crucial to note that the study did not reveal significant differences in insulin resistance among the groups. This finding suggests that while vitamin C may enhance antioxidant capacity and reduce oxidative stress, its isolated effects on menopause-related conditions were not conclusively established. Overall, our study highlights the potential of combining these antioxidants for managing oxidative stress in postmenopausal women.

9.5

Alleviates menopause discomfort

Most Useful Review

A good helper for menopause, it works wonderfully! It is naturally burden-free and effectively alleviates the discomfort associated with menopause—great!

Osteoporosis details

Jain SK, McLean WE, Stevens CM, Dhawan R. The Positive Association of Plasma Levels of Vitamin C and Inverse Association of VCAM-1 and Total Adiponectin with Bone Mineral Density in Subjects with Diabetes. Nutrients. 2022;14. doi:10.3390/nu14193893

Vitamin C may support bone health

We explored the connection between vitamin C levels and bone mineral density (BMD) in individuals with diabetes. By examining a group of 74 diabetic patients alongside 26 age-matched non-diabetic controls, we focused on how vitamin C intake could potentially influence bone health. Our goal was to see if higher vitamin C levels were associated with improved BMD and whether this effect might be related to decreases in certain inflammatory markers like VCAM-1 and adiponectin.

The results were quite promising. We observed a positive link between circulating levels of vitamin C and BMD, suggesting that higher vitamin C might indeed contribute to healthier bones. Notably, we found that this beneficial effect was closely tied to lower levels of inflammatory markers in the blood. This indicates that vitamin C might help not just in improving BMD but also in lowering inflammation, which can be particularly valuable for those living with diabetes.

Overall, our findings highlight the importance of maintaining adequate vitamin C levels as a potential strategy to reduce the risk of osteoporosis in individuals with diabetes. Incorporating vitamin C in the diet could be a simple yet effective way to support bone health while also combatting underlying inflammation.

8.8

Calcium absorption

Most Useful Review

Vitamin C aids calcium absorption, making the combination of ascorbic acid and calcium effective for preventing osteoporosis. It acts as a cofactor for collagen synthesis, which benefits connective tissue and promotes healing, as well as supporting cardiovascular health. This high-quality supplement, at a dose of 1000 mg, is excellent for adults wanting to boost their immunity; I highly recommend it.

Rash details

Effective vitamin absorption

My family has switched to using this vitamin C with bioflavonoids, as suggested by a knowledgeable specialist. Initially, I was concerned about the 1000 dosage due to potential rashes, but fortunately, everything is fine. I also drink rosehip infusion daily, which seems to enhance absorption. In times of increased risk, we sometimes take two capsules each day, believing it all works well, despite my husband's jokes suggesting otherwise.

Cardiovascular Disease details

Vitamin C enhances NK cell proliferation

Based on 4 Researches

Guo X, Xiao T, Lin L, Gao Q, Lai B, et al. Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients. Front Immunol. 2024;15:1436747. doi:10.3389/fimmu.2024.1436747

We explored the effects of vitamin C on natural killer (NK) cell activity in patients with coronary artery disease (CAD). Our research involved isolating NK cells from 29 CAD patients and treating them with various stimulatory factors, including ascorbic acid—better known as vitamin C.

What we found was quite interesting: when NK cells were treated with ascorbic acid, there was a significant increase in their ability to proliferate. This meant that the NK cells were more active and potentially more effective in responding to threats in the body, which is vital for those dealing with heart conditions.

Furthermore, we measured serum lactate dehydrogenase (LDH) levels, discovering a negative correlation between LDH and NK cell activity. Higher LDH levels seemed to indicate lower proliferation capability in NK cells influenced by interleukins.

Overall, our study suggests that vitamin C could play a positive role in enhancing immune function in CAD patients by promoting NK cell proliferation. However, it's important to note that while vitamin C shows promise, further research is needed to fully understand its impact on cardiovascular health and immune regulation.

Supports cardiovascular health

Most Useful Review

This quantity is substantial as I consumed a lot and bought this much. There are no issues with the ingredients and quality; they are consistent, and the effect is satisfactory. Some inflammations were alleviated. Vitamin C is a water-soluble vitamin, crucial for decomposing skin melanin, thus preventing pigmentation and treating melasma. It assists with collagen synthesis, promotes wound healing, and helps with cardiovascular disease.

Celiac details

Enhanced energy levels

This vitamin C has become my go-to dietary supplement for immunity support. After a few weeks of use, I’ve experienced a notable improvement in my well-being, particularly during the cold season. As a powerful antioxidant, it’s effectively absorbed due to the added bioflavonoids, enhancing its efficacy. This product is free from GMOs, gluten, dairy, and soy, making it suitable for those with dietary restrictions. It also aids collagen levels, benefiting skin and joint health. One capsule a day suffices, and the airtight packaging needs no special storage. I now feel far more energetic and resilient against stress, so I highly recommend this vitamin.

Constipation details

Vitamin C's impact on constipation

Huh KY, Chung WK, Park J, Lee S, Kim MG, et al. Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms. Clin Transl Sci. 2023;16:2177. doi:10.1111/cts.13617

We conducted a fully decentralized clinical trial to explore the effects of vitamin C on constipation symptoms. Participants who experienced functional constipation were randomly assigned to receive either Lactobacillus with vitamin C or vitamin C alone over a two-week treatment period. The study allowed us to gather data remotely, which is quite innovative and accessible.

Looking specifically at the results from the group that received vitamin C, we observed that while there was an increase in the frequency of bowel movements compared to the control group, the isolated effect of vitamin C itself wasn't entirely clear. The combination treatment appeared to improve bowel regularity, but it was difficult to determine how much vitamin C contributed independently to these results.

Additionally, we found that about 67% of participants were diligent in tracking their bowel diary entries, which helped ensure the reliability of our findings to an extent. Yet, a significant portion of the records were not kept as scheduled, highlighting potential hurdles in data collection for decentralized trials.

Overall, our observations suggest that while vitamin C, especially when paired with Lactobacillus, may provide some benefits for those struggling with constipation, we should exercise caution before attributing all improvements solely to vitamin C.

8.8

Helpful for cold

Most Useful Review

Big! Initially surprised by the size, I adjusted quickly and swallowed it without issue. I've been using it for 8 months alongside VB Complex and VE, and I've noticed improvements in my sensitivity to cold, numbness in my hands, and even constipation. Improvements became apparent from the second month. I plan to continue using it further.

Sleep Apnea details

Vitamin C improves sleep apnea endothelial function

Grebe M, Eisele HJ, Weissmann N, Schaefer C, Tillmanns H, et al. Antioxidant vitamin C improves endothelial function in obstructive sleep apnea. Am J Respir Crit Care Med. 2006;173:897.

We evaluated how vitamin C might improve endothelial function in patients with obstructive sleep apnea (OSA). In our study, we compared 10 individuals with untreated OSA to 10 matched control subjects without sleep issues. We measured how well blood vessels reacted to increased blood flow, known as flow-mediated dilation (FMD), using ultrasound before and after administering vitamin C.

Our findings revealed a significant difference: baseline FMD was lower in OSA patients compared to the control group. However, after an intravenous injection of vitamin C, the FMD in OSA patients improved dramatically, reaching levels similar to those seen in the healthy controls. Interestingly, vasoreactivity in the control subjects remained unchanged.

These results suggest that oxidative stress might be a key factor contributing to the endothelial dysfunction experienced by individuals with OSA. The positive response to vitamin C opens up exciting possibilities for exploring antioxidant treatments in managing cardiovascular issues related to OSA.

8.8

Significant improvement

Most Useful Review

MSM and vitamin C make a fantastic combination. This nutritional supplement was recommended by our good friend Bashar. Within less than a week of use, I have seen major improvements in my mental and physical strength, as well as my sleep quality. I would happily purchase this product again!

Anemia details

Haile A, Mara S, Belete Y, Dejene T. The Forgotten Disease in the 21st Century: Scurvy Outbreak in Hawassa Central Prison, Hawassa, Sidama, Southern Ethiopia, 2023. Int Med Case Rep J. 2023;16:847. doi:10.2147/IMCRJ.S438833

Based on 8 Researches

Vitamin C aids anemia treatment

We observed a fascinating phenomenon related to vitamin C and anemia during a series of cases in a prison setting in Ethiopia. Specifically, we examined how scurvy, a disease caused by a lack of vitamin C, contributed to anemia among prisoners.

Our study focused on ten patients who were admitted for treatment, all of whom presented with some form of leg swelling or pain. After administering vitamin C in the form of ascorbic acid, we noted a significant increase in hemoglobin levels, rising from an average of 4.6 to 7.1 g/dL. This improvement indicates that vitamin C may play a crucial role in alleviating some anemia symptoms when the underlying cause is related to dietary deficiencies.

Additionally, through an observational study involving 67 other patients in the same prison, we confirmed that leg swelling and pain were common symptoms among those affected. With consistent therapeutic doses of vitamin C, all patients showed considerable improvement in their conditions.

Thus, we can conclude that vitamin C does seem to have a valuable effect on anemia caused by dietary deficiencies, particularly in high-risk environments like prisons. This finding encourages healthcare providers to remain vigilant about such nutritional deficiencies and highlights the importance of vitamin C in treatment.

9.5

Effective for iron deficiency

Most Useful Review

Great Vitamin C for adults! This isn't my first order; I take it to combat iron deficiency anemia and enhance iron absorption. I highly recommend it.

Ulcer details

Gunton JE, Girgis CM, Lau T, Vicaretti M, Begg L, et al. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2021;126:1451. doi:10.1017/S0007114520003815

Based on 10 Researches

Vitamin C enhances ulcer healing

We conducted a double-blind trial involving sixteen individuals with chronic foot ulcers to see how vitamin C impacts their healing. Half of the participants received 500 mg of vitamin C, while the others got a placebo.

After eight weeks, those taking vitamin C showed significant improvement—ulcer healing was much better compared to the placebo group. Notably, everyone who received vitamin C healed without needing amputation, while 44% of the control group did not see any healing.

Our findings suggest vitamin C may be a beneficial treatment for chronic foot ulcers, given its accessibility and low cost.

9.5

Significant improvement

Most Useful Review

An excellent vitamin with a commendable composition! I provide it to my family during the autumn-winter-spring period, and now is that time. I take it daily, one capsule. My stomach does not hurt from them (I have a 12 pc ulcer). My health has significantly improved; I feel less weak and lethargic. My gums no longer bleed, and the dryness of my skin has ceased, with less hair breakage. I haven't had a cold this year! I am very pleased; this drug suits me well.

Bloating details

Vitamin C's impact on bloating

Zeitoun T, El-Sohemy A. Associations Between Dietary Vitamin C, Serum Ascorbic Acid, and Genotype and Premenstrual Symptoms. J Am Nutr Assoc. 2023;42:525. doi:10.1080/27697061.2023.2186963

We aimed to explore how different measures of vitamin C might influence premenstrual symptoms, particularly bloating. In this study, we analyzed data from 555 women aged 20 to 29 years who reported on various symptoms associated with their menstrual cycles. We looked at their dietary intake of vitamin C, measured serum ascorbic acid levels, and assessed genetic factors through DNA testing.

Our findings suggest that higher vitamin C status is linked to increased appetite changes and symptoms like bloating and swelling during the premenstrual phase. While we observed associations between vitamin C levels and these symptoms, it's important to note that our study didn't isolate the effect of vitamin C from other dietary influences. Therefore, while there's a connection between vitamin C and bloating, we cannot conclusively say that vitamin C alone is definitive in relief.

Overall, this research opens the door to understanding how nutrition, particularly vitamin C intake, may shape our experiences with premenstrual symptoms. However, it also highlights the complexity of diet's role in our health.

9.5

No bloating issues

Most Useful Review

The best part is the substantial content. High doses of vitamin C can lead to bloating, but this NOW Foods product does not seem to cause that for me.

Pelvic Pain details

Effective pain relief

During the epidemic, I didn’t visit the dentist. When I experienced bleeding gums or mouth sores, I took high doses of vitamin C every couple of hours. Within a day or two, the pain disappeared, and I felt better. I have been consuming around seven vitamin C capsules daily for over three years, and I remain in good health without any medication or flu.

Gastritis details

Sasazuki S, Hayashi T, Nakachi K, Sasaki S, Tsubono Y, et al. Protective effect of vitamin C on oxidative stress: a randomized controlled trial. Int J Vitam Nutr Res. 2008;78:121. doi:10.1024/0300-9831.78.3.121

Based on 12 Researches

Vitamin C lessens oxidative stress

We aimed to discover how vitamin C supplementation affects oxidative stress in individuals diagnosed with chronic gastritis. In this study, we looked at 244 Japanese patients suffering from atrophic gastritis. They were randomly assigned to receive either 50 mg or 500 mg of vitamin C every day for five years.

After analyzing the results, we found notable differences between the two groups. The high-dose group experienced a significant decrease in reactive oxygen species (ROS), suggesting that vitamin C may help reduce oxidative stress associated with chronic gastritis. In contrast, the low-dose group reported an increase in ROS levels. These findings prompt further interest in how vitamin C can protect against oxidative stress in similar conditions.

Overall, our study supports the idea that higher doses of vitamin C could have a beneficial effect on oxidative stress, particularly in those dealing with gastritis. This insight opens avenues for considering vitamin C as a potential supportive treatment for managing oxidative stress-related issues in digestive health.

9.5

Eliminated discomfort

Most Useful Review

Vitamin C with bioflavonoids is essential for every cell in the body. I take one capsule daily after meals for a month. My overall health has improved; I feel more energised. Remarkably, the stomach discomfort from gastritis vanished. Initially, I hesitated to take vitamin C due to my stomach inflammation, but I took the plunge and my worries were unfounded. My stomach expressed gratitude as the cramps, belching, and heartburn ceased. I continue to use this vitamin and recommend it to my acquaintances.

Kidney Stones details

Ferraro PM, Curhan GC, Gambaro G, Taylor EN. Total, Dietary, and Supplemental Vitamin C Intake and Risk of Incident Kidney Stones. Am J Kidney Dis. 2016;67:400. doi:10.1053/j.ajkd.2015.09.005

Based on 8 Researches

Vitamin C intake risks explored

We examined the relationship between vitamin C intake and the risk of developing kidney stones in a large cohort. This study included a significant number of participants: 156,735 women from the Nurses' Health Studies and 40,536 men from the Health Professionals Follow-up Study.

Our findings revealed that total and supplemental vitamin C intake was linked to a higher risk of kidney stones in men, but there was no such association evident in women. Specifically, among men, those who consumed higher amounts of vitamin C had greater likelihoods of developing stones when compared to those with lower intakes.

However, dietary vitamin C did not show a connection with kidney stones in either men or women. This suggests that while supplements may pose risks for men, dietary sources of vitamin C might not have the same impact. Overall, the study indicates that we should be cautious about high vitamin C supplement consumption, especially for men, while highlighting that dietary intake appears safe.

5.8

Negative impact on kidneys

Most Useful Review

The dosage of vitamin C is excessive and negatively impacts my kidneys. I will not continue with such large doses, although everyone manages their own health differently.

Diarrhea details

Vitamin C improves diarrheic calf health

Zakariya MR, Ghasemi E, Hashemzadeh F, Ghorbani GR, Ahmadi F. Does vitamin C supplementation in milk improve growth and health of diarrheic calves?. Prev Vet Med. 2024;224:106122. doi:10.1016/j.prevetmed.2024.106122

We investigated how adding vitamin C to milk influences the growth and health of young calves, particularly those experiencing diarrhea. The study involved 48 Holstein calves, which were sorted into two groups based on their health status: healthy calves and those with diarrhea. Each calf was fed the same amount of pasteurized milk and monitored until they reached 74 days of age.

Calves that received vitamin C showed an impressive increase in weight by weaning—74.3 kg compared to 72.2 kg for those without vitamin C. Additionally, calves treated with vitamin C demonstrated improved blood antioxidant levels, suggesting better overall health. Notably, calves suffering from diarrhea benefitted significantly from the vitamin C, needing fewer days of medication for treatment compared to those who did not receive the supplement.

The research highlights that vitamin C can play a critical role in supporting the health of calves during episodes of diarrhea. This is especially relevant for those that faced even mild cases early in life, as they seemed to gain the most benefits from the supplementation. Overall, it appears that vitamin C can positively impact both growth and health in calves suffering from diarrhea.

9.5

Quick recovery

Most Useful Review

I order it for the whole family; when someone has a cold, we take 1g every hour. If diarrhoea occurs, we adjust the dosage. This approach helps everyone recover swiftly.

Bone Pain details

During the epidemic, I avoided the dentist. When dealing with bleeding gums or mouth sores, I took a high dose of vitamin C, which alleviated my pain within a day or two. For over three years, I've taken about seven high-dose vitamin C capsules daily. My health has been excellent—I haven't taken any other medication and haven't caught the flu.

Heartburn details

Vitamin C reduces heartburn symptoms

Jin D, Wang J, Zhan Q, Huang K, Wang H, et al. The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial. Gastrointest Endosc. 2020;92:554. doi:10.1016/j.gie.2019.11.028

We investigated how vitamin C, specifically in the form of a 2% vitamin C solution spray, could help alleviate heartburn symptoms following Lugol chromoendoscopy, a procedure that involves staining the esophagus to better visualize abnormalities. In a well-structured study with 240 participants, we used a randomized, double-blind approach to compare the effectiveness of vitamin C to normal saline and sodium thiosulfate solutions.

Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.

Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.

9.5

No heartburn observed

Most Useful Review

I've just started taking these capsules, which do not cause any heartburn, making them suitable for older individuals or those with stomach issues. The large dose is effective; I feel invigorated, more productive, and my mood has improved. It seems to have enhanced my memory and skin appearance too.

Chest Pain details