B12
8
We examined the case of a 40-year-old woman suffering from a decade of vague symptoms, including pain and cognitive issues, before being diagnosed with vitamin B12 deficiency due to pernicious anemia.
Despite low B12 levels showing no typical signs of anemia, the use of parenteral B12 treatment led to her neurological improvement. This case reinforces how vital it is to recognize B12 deficiency even when classic symptoms aren't present, ensuring timely treatment to avoid serious complications.
Despite low B12 levels showing no typical signs of anemia, the use of parenteral B12 treatment led to her neurological improvement. This case reinforces how vital it is to recognize B12 deficiency even when classic symptoms aren't present, ensuring timely treatment to avoid serious complications.
10
Burning feet relieved
Most Useful Review
70 people found this helpful
THE ONLY PRODUCT FOR ME!!! LITERALLY SAVED MY LIFE. I cannot speak for others, only for myself. When you suffer from diabetic neuropathy and your feet burn, taking Jarrow Formula Methyl B-12 (5000 mcg) stops the burning! It works wonders. No buzzing or pins and needles, and I keep my stress down while controlling my sugar. I once bought a cheaper brand with folic acid and Vitamin C, but that was a BIG MISTAKE – my feet started burning again. I returned to the lovely Jarrow Methyl B-12 5000, and it was the best decision ever. Thanks, Jarrow!
Vitamin Bs
8
We examined how a combination of vitamins B1, B6, and B12 may improve recovery in peripheral neuropathy. Our research showed that using all three vitamins together led to better healing and nerve connectivity than vitamin B12 on its own.
This combination encourages cell maturation and counters oxidative stress, which are key for recovering damaged nerves. The findings point to the potential benefits of taking all three vitamins for those suffering from nerve-related issues.
This combination encourages cell maturation and counters oxidative stress, which are key for recovering damaged nerves. The findings point to the potential benefits of taking all three vitamins for those suffering from nerve-related issues.
9
Improved foot pain
Most Useful Review
18 people found this helpful
Now Foods, B-100mg, 100 tablets: For a week, I took the Now Foods 100mg B1 tablets, starting with 50 mg daily, now reduced to 25 mg per day for ankle edema and peripheral neuropathy due to thiamine deficiency. Correcting this deficiency orally takes time; however, my edema and foot pain are significantly better. I'll continue using them long-term to prevent recurrence. I've generally been pleased with Now Food products, and this one is no exception.
Alpha Lipoic Acid
8
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
9
Good dosage
Most Useful Review
33 people found this helpful
I bought this for my wife, and it helps her significantly with polyneuropathy. The dosage is commendable, and it works well.
Benfotiamine
We investigated the impact of daily thiamine (vitamin B1) supplementation on individuals with Charcot-Marie-Tooth (CMT) neuropathy. Our pilot study observed improvements in hand grip strength among patients taking 100 mg of thiamine. Additionally, we explored molecular changes related to thiamine coenzyme levels, noting differences in enzyme regulation between CMT patients and healthy controls.
While we found promising benefits for thiamine, including increased grip strength, we also noted unusual decreases in an enzyme related to thiamine, indicating that the effects can vary widely among patients.
While we found promising benefits for thiamine, including increased grip strength, we also noted unusual decreases in an enzyme related to thiamine, indicating that the effects can vary widely among patients.
9
Neuropathy relief
Most Useful Review
16 people found this helpful
This is a miracle supplement! After years of battling with neuropathy, it became increasingly difficult to stand. I also suffered from restless leg syndrome that disrupted my sleep. After switching from Gabapentin to this supplement, my symptoms have decreased significantly to almost 98% gone; I only experience slight numbness now, which I can manage.
Acetyl L Carnitine
7
We explored the impact of acetyl-L-carnitine (ALC) on neuropathic pain through a review of clinical data. The studies showed that ALC could aid nerve regeneration and enhance sensation in early-stage diabetic peripheral neuropathy, while being generally well-tolerated without major side effects. However, the overall effectiveness compared to traditional treatments seems comparable, indicating that while promising, ALC may not provide significant advantages over current first-line medications.
9
Improved sensation
Most Useful Review
16 people found this helpful
Great product! My acupuncturist suggested 1500 mg per day for neuropathy in my feet and legs. On the first day, I immediately felt sensation in my feet that I hadn’t experienced for a long time. I also have more energy and can walk further now. I will continue using this form of ALC alongside Alpha Lipoic Acid and other supplements.
Fiber
10
Burning feet relieved
Most Useful Review
70 people found this helpful
THE ONLY PRODUCT FOR ME!!! LITERALLY SAVED MY LIFE. I cannot speak for others, only for myself. When you suffer from diabetic neuropathy and your feet burn, taking Jarrow Formula Methyl B-12 (5000 mcg) stops the burning! It works wonders. No buzzing or pins and needles, and I keep my stress down while controlling my sugar. I once bought a cheaper brand with folic acid and Vitamin C, but that was a BIG MISTAKE – my feet started burning again. I returned to the lovely Jarrow Methyl B-12 5000, and it was the best decision ever. Thanks, Jarrow!
10
Pain-free living
Most Useful Review
26 people found this helpful
Methyl B-12 has been a lifesaver for my severe diabetic neuropathy. After 2 1/2 years of suffering, I’m now virtually pain-free. I can walk without a limp and have the energy to exercise, which will help me long-term. Feeling helpless for so long, I finally feel as if I have my life back. Though it may sound exaggerated, I assure you it’s the truth. People around me are amazed at the transformation.
Inositol
9
Neuropathy improved
Most Useful Review
7 people found this helpful
I have managed to stop taking prescription Neurontin for foot neuropathy by taking this along with Vitamins B6 and B12. It has proven to be more effective without side effects.
9
Improved memory noted
Most Useful Review
1 people found this helpful
I have been using Choline and Inositol for several years now and am very satisfied! During the initial days of taking it, I often experience headaches. However, I have noticed a real improvement in memory after starting this combination. Choline is essential for the neurotransmitter acetylcholine, facilitating signal transmission between neurons and muscles. It's also a primary component of the myelin sheath that protects nerves. I take this consistently with Menopause Support, which helps reduce anxiety during menopause. After about ten days, I clearly observe an improvement.