Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
USERS' SCORE
Good
Based on 8 Reviews
8.4
Supplement Facts
Serving Size:  1 Capsule
Amount Per Serving
%DV
Proprietary Blend Containing 1 billion live cultures† Lactobacillus acidophilus Lactobacillus salivarius Bifidobacterium bifidum Streptococcus thermophilus
175 mg
**

Top Medical Research Studies

We investigated the impact of Lactobacillus acidophilus and Bifidobacterium adolescentis on anxiety levels in rats facing acute hypoxia. In our study, 64 male Wistar rats were divided into four groups for comparison. The results showed that rats receiving probiotics exhibited lower oxidative stress and anxiety levels compared to those who did not. Notably, those treated with probiotics went through behavioral tests indicating increased exploratory behavior and decreased anxiety. Overall, our findings suggest that these probiotics offer both antioxidant and anxiety-reducing effects in stressful conditions.
Read More
8
Improvement in mental health via probiotics
We explored how a novel multi-strain E3 probiotic formula could impact anxiety and other mental health symptoms in a group of 68 individuals with sleep disturbances and mood issues.

Over an 8-week period, participants experienced significant improvements in sleep quality, depressive symptoms, and anxiety levels.

Remarkably, these changes were linked to shifts in their gut microbiome, suggesting that the health of our gut might play a powerful role in our overall mental well-being.
Read More
7
Probiotics reduced anxiety, depression
This double-blind trial explored how synbiotic and probiotic supplements affect mental health and anemia in hemodialysis patients.

With 75 participants, those receiving synbiotics and probiotics showed a notable decrease in anxiety and depression scores after 12 weeks, compared to a placebo group.

However, there was no meaningful improvement in quality of life reported. Interestingly, the treated group also experienced significant increases in hemoglobin levels, which is beneficial.
Read More

Most Useful Reviews

9.5
Supports anxiety relief
Really amazing! This probiotic product is of high quality with beneficial ingredients. The 150 capsules provide great value. It safeguards the digestive system and supports overall health. It's very effective for constipation and diarrhoea, promotes heart health by lowering blood pressure and harmful cholesterol, and is particularly helpful for stress relief. For those on medication, it can alleviate anxiety and depression. It also benefits skin health and aids in weight loss, best taken first thing in the morning on an empty stomach. Thank you for this excellent product!
Read More
9.5
Reduces anxiety effectively
Probiotics significantly improve digestion while also lessening depression and anxiety. They aid in balancing female hormones and enhancing fertility, and can improve skin conditions. Furthermore, probiotics help eliminate and prevent urogenital infections.
Read More
9.5
Direct anxiety addressing
Dude, I’m just taking it for anxiety. Works brilliantly!
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
  • All Researches
We investigated the impact of Lactobacillus acidophilus and Bifidobacterium adolescentis on anxiety levels in rats facing acute hypoxia. In our study, 64 male Wistar rats were divided into four groups for comparison. The results showed that rats receiving probiotics exhibited lower oxidative stress and anxiety levels compared to those who did not. Notably, those treated with probiotics went through behavioral tests indicating increased exploratory behavior and decreased anxiety. Overall, our findings suggest that these probiotics offer both antioxidant and anxiety-reducing effects in stressful conditions.
Read More
8
Improvement in mental health via probiotics
We explored how a novel multi-strain E3 probiotic formula could impact anxiety and other mental health symptoms in a group of 68 individuals with sleep disturbances and mood issues.

Over an 8-week period, participants experienced significant improvements in sleep quality, depressive symptoms, and anxiety levels.

Remarkably, these changes were linked to shifts in their gut microbiome, suggesting that the health of our gut might play a powerful role in our overall mental well-being.
Read More
7
Probiotics reduced anxiety, depression
This double-blind trial explored how synbiotic and probiotic supplements affect mental health and anemia in hemodialysis patients.

With 75 participants, those receiving synbiotics and probiotics showed a notable decrease in anxiety and depression scores after 12 weeks, compared to a placebo group.

However, there was no meaningful improvement in quality of life reported. Interestingly, the treated group also experienced significant increases in hemoglobin levels, which is beneficial.
Read More
We examined the role of probiotics, particularly lactobacillus acidophilus, in alleviating anxiety symptoms among patients with generalized anxiety disorder (GAD). In a double-blind, randomized controlled trial involving drug-free participants, we found that those taking probiotics along with sertraline experienced a notable decrease in anxiety compared to those on sertraline alone.

However, the probiotics did not show a significant impact on improving overall quality of life. While there were encouraging results on anxiety scores, the limited effect on quality of life suggests more research is needed to clarify these findings.
Read More
We examined the effects of Lactobacillus acidophilus on anxiety alongside other symptoms in irritable eye syndrome. In a clinical trial with 40 participants experiencing ocular and anxiety issues, we found that those who received a specially formulated probiotic supplement showed notable improvements in their symptoms compared to a control group.

After 8 weeks, levels of certain immune markers and anxiety symptoms decreased significantly in the treated group, suggesting that targeting inflammation and gut health may provide a new way to tackle anxiety and related disorders.
Read More

User Reviews

USERS' SCORE
Good
Based on 8 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
Supports anxiety relief
Really amazing! This probiotic product is of high quality with beneficial ingredients. The 150 capsules provide great value. It safeguards the digestive system and supports overall health. It's very effective for constipation and diarrhoea, promotes heart health by lowering blood pressure and harmful cholesterol, and is particularly helpful for stress relief. For those on medication, it can alleviate anxiety and depression. It also benefits skin health and aids in weight loss, best taken first thing in the morning on an empty stomach. Thank you for this excellent product!
Read More
9.5
Reduces anxiety effectively
Probiotics significantly improve digestion while also lessening depression and anxiety. They aid in balancing female hormones and enhancing fertility, and can improve skin conditions. Furthermore, probiotics help eliminate and prevent urogenital infections.
Read More
9.5
Direct anxiety addressing
Dude, I’m just taking it for anxiety. Works brilliantly!
Read More
8.8
Helps combat anxiety
The quality is excellent and guaranteed; it is a superb nutritional supplement with natural ingredients, including milk whey. It is very beneficial for anxiety, depression, and digestive issues, particularly constipation and flatulence. The quantity offered is right for the price. The packaging is securely closed to preserve the product. While tasteless, it helps maintain prebiotic activity in the intestine.
Read More
8.8
Improves mental health
Good for promoting intestinal health: it restores the microbiome, balances bacteria, and improves constipation. It reduces diarrhoea caused by antibiotics and enhances mental health by alleviating anxiety and depression, while assisting with autism and memory. It also supports heart health by breaking down intestinal bile and lowers cholesterol and blood pressure. Additionally, it helps prevent urinary and vaginal infections and boosts immunity by promoting natural antibody production.
Read More

Frequently Asked Questions

Anxiety is a natural and often healthy emotion characterized by feelings of worry, nervousness, or fear about an impending event or situation. While some level of anxiety is a normal reaction to stress, excessive or chronic anxiety can become a mental health issue. It may present in various forms, from everyday worries to more severe conditions such as generalized anxiety disorder (GAD), panic disorder, or social anxiety disorder. Symptoms can manifest both psychologically, such as persistent worry and difficulty concentrating, and physically, including symptoms like increased heart rate, sweating, or fatigue.

Understanding the difference between normal anxiety and an anxiety disorder is crucial. Normal anxiety can be beneficial, motivating you to prepare for important events like exams or public speaking. However, when it starts to interfere with daily activities or leads to avoidance behaviors, it may indicate the need for professional help. Treatments for anxiety often include therapy, medications, and lifestyle changes, allowing individuals to manage their symptoms effectively. If someone is struggling with anxiety that impacts their quality of life, seeking guidance from a healthcare professional is a key step toward recovery.

Acidophilus, scientifically known as Lactobacillus acidophilus, is a type of beneficial bacteria that is commonly found in the human gut, as well as in fermented foods like yogurt and dietary supplements. This probiotic strain plays a crucial role in maintaining gut health by aiding digestion, enhancing nutrient absorption, and supporting the immune system. It is particularly known for its ability to break down lactose, making it easier for lactose-intolerant individuals to digest dairy products.

In addition to its digestive benefits, acidophilus has been studied for its potential to prevent or alleviate certain gastrointestinal issues, such as diarrhea and irritable bowel syndrome (IBS). Some research also suggests that it may support vaginal health by helping to maintain a balanced microbiome in women. When selecting a probiotic supplement that contains acidophilus, it is essential to look for products that contain live and active cultures, ensuring that you receive the full benefits of this beneficial bacteria. Always consult with a healthcare professional before beginning any new supplement regimen.

Based on user reviews, the time it takes to see results when taking this supplement for anxiety can vary. Many users report experiencing significant benefits soon after starting the regimen. For example, one user stated, "Works brilliantly!" within an unspecified timeframe, indicating relatively quick results for anxiety relief (Read Review). Additionally, another user mentioned that probiotics significantly lessen anxiety and improve mental health (Read Review).

However, it is important to note that individual experiences may differ. Some users may find relief almost immediately, while others may require consistent use over several weeks to notice a significant change in their anxiety levels. For instance, one reviewer mentioned the overall benefits of probiotics in managing anxiety and depression, suggesting that patience may be necessary (Read Review). Consequently, users are encouraged to remain attentive to their bodies and possibly allow a few weeks to fully gauge the supplement's effectiveness.

When it comes to anxiety, the scientific research surrounding the use of probiotics presents a mixed but intriguing picture. One notable study examined the effect of a specific multi-strain E3 probiotic formula on individuals with sleep disturbances and mood issues, revealing significant improvements in anxiety levels after just eight weeks [2]. Another trial involving hemodialysis patients showed that participants receiving synbiotics and probiotics experienced reduced anxiety and depression scores compared to those on a placebo [3]. However, while these results are promising, some studies indicate that the improvements might not translate to overall quality of life enhancements, suggesting that while probiotics may help alleviate anxiety, their efficacy can vary among individuals and contexts [5].

Further reinforcing the potential benefits, animal studies also provide encouragement; for instance, research on Lactobacillus acidophilus demonstrated reduced anxiety in rats exposed to stress, promoting an increase in exploratory behavior [4]. Nonetheless, it's worth noting that other studies have pointed to a lack of significant differences compared to placebo groups, which emphasizes that more extensive research is crucial to fully understand how probiotics might influence anxiety [1]. Overall, while the evidence is still developing, the potential link between gut health and mental well-being makes probiotics an area of interest for supporting anxiety treatment.

Based on user reviews, a number of individuals have reported improvements in their symptoms related to anxiety and depression after taking the probiotic supplement. For instance, one user noted, "Works brilliantly!" when addressing anxiety specifically (Read Review). Another reviewer emphasized that probiotics significantly improve not only digestion but also lessen depression and anxiety overall (Read Review). Furthermore, several users mentioned that the probiotics promote heart health, reduce harmful cholesterol, and even assist with stress relief, showcasing a wide range of potential health benefits beyond just mental well-being (Read Review).

It is vital to recognize, however, that individual results can vary significantly. While many users find alleviation of their anxiety symptoms, a few have experienced discomfort and heightened anxiety after using the probiotics, underscoring the need for caution and possibly consulting a healthcare professional before starting a new supplement regimen (Read Review). As with any supplement, outcomes will depend on the individual, their specific health circumstances, and the regularity of use.

Based on user reviews, many individuals have reported positive experiences when combining this probiotic supplement with other approaches to managing anxiety. Users noted that the probiotics not only assisted with anxiety relief but also supported overall mental health. One reviewer specifically highlighted the supplement's efficacy for anxiety, stating, "Works brilliantly!" (Read Review). Another user remarked on the overall enhancement of mental well-being, linking improvements in both anxiety and depression to their use of probiotics (Read Review).

However, it's worth mentioning that not all experiences were entirely positive. A few users reported adverse effects, such as increased anxiety and intestinal discomfort after consumption, suggesting that the probiotics may not suit everyone (Read Review). This underscores the importance of personalized approaches when considering combining supplements, as reactions can vary significantly from one individual to another. As always, users are encouraged to monitor their responses and consult with healthcare professionals if they are unsure about the best regimen for their needs.

Based on user reviews, there seems to be a consensus that probiotics like Acidophilus can significantly assist in alleviating anxiety. Users consistently report positive effects on their mental health, with one stating, "Dude, I’m just taking it for anxiety. Works brilliantly!" (Read Review). Another reviewer mentioned the beneficial impact on "anxiety and depression" and emphasized the overall quality of the product (Read Review).

While the reviews do not specify a precise dosage for Acidophilus related to anxiety treatment, many users highlight the general health benefits, including mental well-being, as a consistent outcome. Some users also warned of potential discomfort associated with probiotics, suggesting that they may not be suitable for everyone (Read Review). For individuals considering taking Acidophilus for anxiety, it would be advisable to start with a standard dose and observe how their body responds, as personal tolerance and effectiveness can vary.

9.5
Direct anxiety addressing
Dude, I’m just taking it for anxiety. Works brilliantly!
9.5
Reduces anxiety effectively
Probiotics significantly improve digestion while also lessening depression and anxiety. They aid in balancing female hormones and enhancing fertility, and can improve skin conditions. Furthermore, probiotics help eliminate and prevent urogenital infections.
8.8
Helps combat anxiety
The quality is excellent and guaranteed; it is a superb nutritional supplement with natural ingredients, including milk whey. It is very beneficial for anxiety, depression, and digestive issues, particularly constipation and flatulence. The quantity offered is right for the price. The packaging is securely closed to preserve the product. While tasteless, it helps maintain prebiotic activity in the intestine.
9.5
Supports anxiety relief
Really amazing! This probiotic product is of high quality with beneficial ingredients. The 150 capsules provide great value. It safeguards the digestive system and supports overall health. It's very effective for constipation and diarrhoea, promotes heart health by lowering blood pressure and harmful cholesterol, and is particularly helpful for stress relief. For those on medication, it can alleviate anxiety and depression. It also benefits skin health and aids in weight loss, best taken first thing in the morning on an empty stomach. Thank you for this excellent product!
3.5
Could worsen anxiety
Probiotics may not be unsuitable for everyone; they caused some anxiety and discomfort in my intestines after taking them.
8
Improvement in mental health via probiotics
We explored how a novel multi-strain E3 probiotic formula could impact anxiety and other mental health symptoms in a group of 68 individuals with sleep disturbances and mood issues.

Over an 8-week period, participants experienced significant improvements in sleep quality, depressive symptoms, and anxiety levels.

Remarkably, these changes were linked to shifts in their gut microbiome, suggesting that the health of our gut might play a powerful role in our overall mental well-being.
7
Probiotics reduced anxiety, depression
This double-blind trial explored how synbiotic and probiotic supplements affect mental health and anemia in hemodialysis patients.

With 75 participants, those receiving synbiotics and probiotics showed a notable decrease in anxiety and depression scores after 12 weeks, compared to a placebo group.

However, there was no meaningful improvement in quality of life reported. Interestingly, the treated group also experienced significant increases in hemoglobin levels, which is beneficial.
We examined the role of probiotics, particularly lactobacillus acidophilus, in alleviating anxiety symptoms among patients with generalized anxiety disorder (GAD). In a double-blind, randomized controlled trial involving drug-free participants, we found that those taking probiotics along with sertraline experienced a notable decrease in anxiety compared to those on sertraline alone.

However, the probiotics did not show a significant impact on improving overall quality of life. While there were encouraging results on anxiety scores, the limited effect on quality of life suggests more research is needed to clarify these findings.
We investigated the impact of Lactobacillus acidophilus and Bifidobacterium adolescentis on anxiety levels in rats facing acute hypoxia. In our study, 64 male Wistar rats were divided into four groups for comparison. The results showed that rats receiving probiotics exhibited lower oxidative stress and anxiety levels compared to those who did not. Notably, those treated with probiotics went through behavioral tests indicating increased exploratory behavior and decreased anxiety. Overall, our findings suggest that these probiotics offer both antioxidant and anxiety-reducing effects in stressful conditions.
5
Probiotics did not significantly affect anxiety
We looked into how combining caloric restriction with probiotics affects anxiety in adult men facing obesity. In a well-structured, double-blind, placebo-controlled study, participants followed a 12-week regimen of caloric restriction while taking a specific blend of probiotics.

While we found that anxiety and depressive symptoms improved within the group taking probiotics, there was no significant difference when compared to those on a placebo. This suggests that further research is necessary to fully understand the relationship between probiotics and anxiety in this context.

References

  1. Marques CG, Dos Santos Quaresma MVL, França Ferracini CB, Alves Carrilho FB, Nakamoto FP, et al. Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial. Clin Nutr. 2025;45:234. doi:10.1016/j.clnu.2024.12.031
  2. Chan HHY, Siu PLK, Choy CT, Chan UK, Zhou J, et al. Novel Multi-Strain E3 Probiotic Formulation Improved Mental Health Symptoms and Sleep Quality in Hong Kong Chinese. Nutrients. 2023;15. doi:10.3390/nu15245037
  3. Haghighat N, Mohammadshahi M, Shayanpour S, Haghighizadeh MH, Rahmdel S, et al. The Effect of Synbiotic and Probiotic Supplementation on Mental Health Parameters in Patients Undergoing Hemodialysis: A Double-blind, Randomized, Placebo-controlled Trial. Indian J Nephrol. 2021;31:149. doi:10.4103/ijn.IJN_341_19
  4. Kozin SV, Kravtsov AA, Kravchenko SV, Ivashchenko LI. [Antioxidant and anxiolytic effect of and under conditions of normobaric hypoxia with hypercapnia]. Vopr Pitan. 2021;90:63. doi:10.33029/0042-8833-2021-90-2-63-72
  5. Eskandarzadeh S, Effatpanah M, Khosravi-Darani K, Askari R, Hosseini AF, et al. Efficacy of a multispecies probiotic as adjunctive therapy in generalized anxiety disorder: a double blind, randomized, placebo-controlled trial. Nutr Neurosci. 2021;24:102. doi:10.1080/1028415X.2019.1598669
  6. Feher J, Pinter E, Kovács I, Helyes Z, Kemény A, et al. Irritable eye syndrome: neuroimmune mechanisms and benefits of selected nutrients. Ocul Surf. 2014;12:134. doi:10.1016/j.jtos.2013.09.002
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