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Notably, the probiotics influenced the expression of key genes related to cell death and cancer growth, showing an upregulation of tumor-suppressing genes and microRNAs, while downregulating oncogenes. This suggests they could play a significant role in fighting colorectal cancer and contributing to prevention.
Our study involved various mouse models treated with a specific diet and liver cancer-inducing compounds.
We found that L. acidophilus significantly reduced the occurrence of NAFLD-HCC and inhibited the growth of cancer cells by producing a key metabolite called valeric acid.
This suggests that L. acidophilus may serve as a protective supplement against this type of cancer, improving liver health and function.
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This innovative approach led to a significant boost in hydroxyl radical production within the tumor microenvironment, resulting in a remarkable tumor inhibition rate of 96.4%.
The findings suggest that probiotics can help target tumors more effectively and improve treatment outcomes.
Results showed that the combined therapy significantly reduced markers of tumor initiation and improved liver histology. Importantly, these treatments maintained normal function in liver and kidney markers. This suggests that Lactobacillus acidophilus, along with calcium and Moringa, could play a promising role in cancer prevention.
Notably, the probiotics influenced the expression of key genes related to cell death and cancer growth, showing an upregulation of tumor-suppressing genes and microRNAs, while downregulating oncogenes. This suggests they could play a significant role in fighting colorectal cancer and contributing to prevention.
Our study involved various mouse models treated with a specific diet and liver cancer-inducing compounds.
We found that L. acidophilus significantly reduced the occurrence of NAFLD-HCC and inhibited the growth of cancer cells by producing a key metabolite called valeric acid.
This suggests that L. acidophilus may serve as a protective supplement against this type of cancer, improving liver health and function.
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Frequently Asked Questions
Cancer is a complex group of diseases characterized by uncontrolled growth and spread of abnormal cells in the body. These cells can form tumors, invade nearby tissues, and metastasize to other parts of the body via the bloodstream or lymphatic system. While cancer can affect nearly any part of the body, it is classified into various types, including carcinomas, sarcomas, leukemia, and lymphomas, each originating from different types of cells. Risk factors for developing cancer can include genetic predisposition, lifestyle choices such as smoking and diet, environmental exposures, and certain infections.
Diagnosis typically involves medical imaging, biopsies, and a thorough review of personal and family health histories. Treatment options vary widely depending on the type and stage of cancer and may include surgery, chemotherapy, radiation therapy, immunotherapy, and targeted therapies. Early detection is crucial and can significantly improve treatment outcomes, leading to better survival rates. As awareness and research continue to advance, new methods for prevention, detection, and treatment of cancer are consistently being developed, offering hope to those affected by this challenging disease.
Acidophilus, scientifically known as Lactobacillus acidophilus, is a type of beneficial bacteria that is commonly found in the human gut, as well as in fermented foods like yogurt and dietary supplements. This probiotic strain plays a crucial role in maintaining gut health by aiding digestion, enhancing nutrient absorption, and supporting the immune system. It is particularly known for its ability to break down lactose, making it easier for lactose-intolerant individuals to digest dairy products.
In addition to its digestive benefits, acidophilus has been studied for its potential to prevent or alleviate certain gastrointestinal issues, such as diarrhea and irritable bowel syndrome (IBS). Some research also suggests that it may support vaginal health by helping to maintain a balanced microbiome in women. When selecting a probiotic supplement that contains acidophilus, it is essential to look for products that contain live and active cultures, ensuring that you receive the full benefits of this beneficial bacteria. Always consult with a healthcare professional before beginning any new supplement regimen.
Based on user reviews, the time frame for seeing results from Lactobacillus acidophilus can vary significantly. Some users report feeling improvement in their gastrointestinal comfort relatively quickly, stating that it made their daily routine more comfortable after consistent use over time (Read Review). However, specific timelines for cancer-related benefits aren't extensively covered in the feedback.
Many users emphasize the importance of consistent, long-term use to experience the full benefits of this probiotic, particularly in terms of immune support and inhibiting certain cancer mechanisms (Read Review). While exact timelines are not provided, those interested in incorporating Lactobacillus acidophilus for cancer support should be prepared for a gradual process rather than immediate results.
Scientific research has indicated that Lactobacillus acidophilus, a type of probiotic, may play a potential role in cancer treatment and prevention. For instance, studies have shown that engineered forms of this probiotic could help manage tumor lactate levels, ultimately enhancing the effectiveness of other cancer therapies ([1]). Additionally, investigations found that L. acidophilus, when combined with other compounds like calcium and Moringa, might significantly reduce tumor markers and improve liver health, suggesting its benefits in cancer prevention ([4]). Furthermore, it has shown some promise in reducing the growth of various cancer cells, including colon and renal cancers, and has been noted for its potential in enhancing recovery post-surgery in gastric cancer patients ([7]).
However, it is crucial to note that while many studies suggest positive outcomes, none establish L. acidophilus as a standalone treatment for cancer. Some evidence highlights a lack of significant cancer-fighting benefits associated directly with this probiotic when compared to other strains ([6]). Overall, while the research provides intriguing insights into the potential usefulness of Lactobacillus acidophilus in the context of cancer, further studies are needed to validate and understand its efficacy and mechanisms in comprehensive clinical settings.
Users report a variety of improvements related to the use of Lactobacillus acidophilus, particularly in gastrointestinal health and immune system support. Many have noted enhanced comfort in their daily routines, with some specifically mentioning a reduction in constipation related to cancer treatments (Read Review). Others have highlighted its role in maintaining healthy intestinal microflora, aiding digestion, and preventing issues such as chronic indigestion (Read Review). Users emphasize the importance of consistent use to experience these benefits fully.
In terms of immune support, several reviews indicate that Lactobacillus acidophilus may inhibit tumour growth and modulate immune responses, leading to potentially significant immunological benefits (Read Review) (Read Review). Additionally, some users have reported improvements in genitourinary health, showcasing the probiotic’s versatility in addressing various health concerns, from digestion to infection prevention (Read Review). However, it's important to remember that individual results may vary, with a consistent regimen being crucial for achieving the desired outcomes.
Users report that combining Lactobacillus acidophilus with other supplements and dietary approaches may enhance overall health benefits, particularly in the context of cancer management. Many emphasize the probiotic's ability to stimulate the immune system, which could complement other treatments. For example, reviews highlight its immunological benefits, such as enhancing lymphocyte proliferation, reducing tumor growth, and inhibiting bacterial cancer enzymes (Read Review) (Read Review). This suggests that when used alongside other cancer-targeting supplements, Lactobacillus acidophilus may contribute to a more comprehensive approach to managing the disease.
Furthermore, several users mention its role in promoting digestive health, which is crucial for those undergoing cancer treatments that can affect gastrointestinal function. Many individuals have reported improvements in symptoms such as constipation and chronic indigestion, making it easier to integrate other supplements or medications into their regimen (Read Review) (Read Review). Overall, user feedback indicates that combining Lactobacillus acidophilus with other supplements may provide synergistic benefits in supporting immune function and digestive health, critical factors in managing cancer and its effects.
According to user reviews, many individuals highlight the importance of Lactobacillus acidophilus for enhancing overall health, particularly in the context of cancer treatment. Users reported that consistent use of acidophilus can lead to significant immunological benefits, including the reduction of tumor growth and the modulation of immune response, resulting in lower production of cytokines that protect tumors from immune surveillance (Read Review)(Read Review). While there isn't one definitive "right dose" mentioned across the reviews, some users suggested taking acidophilus twice daily, particularly before or during meals, to maximize its efficacy against cancer-related digestive issues (Read Review).
Furthermore, the reviews did not provide a standardized dosage but emphasized that daily consumption, even in smaller amounts, can promote digestive health and support the immune system. Users noted that this probiotic can inhibit certain cancer types and manage gastrointestinal symptoms effectively, contributing positively to their cancer treatment journey (Read Review)(Read Review). It is crucial for individuals to consult healthcare providers for personalized recommendations on dosage tailored to their specific health conditions.
By doing so, we observed a reduction in the immunosuppressive environment, which can help boost the effectiveness of cancer therapies. Moreover, this engineered probiotic not only delivers enzymes but also converts certain immune cells to better fight tumors. However, the overall effectiveness of this approach appears to require more research to assess its viability in cancer treatment.
Results showed that the combined therapy significantly reduced markers of tumor initiation and improved liver histology. Importantly, these treatments maintained normal function in liver and kidney markers. This suggests that Lactobacillus acidophilus, along with calcium and Moringa, could play a promising role in cancer prevention.
Our findings showed that those taking probiotics had less inflammation and recovered quicker. They also had better nutritional markers and overall health post-surgery. This points to the possibility that probiotics like Lactobacillus acidophilus can play a helpful role in enhancing recovery times for cancer surgery patients.
While various probiotic strains were tested, it was Lacticaseibacillus rhamnosus that stood out, showing impressive growth and acidity levels during fermentation.
Both the probiotics and their combinations demonstrated cytotoxic effects against colon and liver cancer cells. However, overall findings don't indicate a significant advantage of Lactobacillus acidophilus specifically in combating cancer compared to other strains.
References
- Mao L, Xarpidin B, Shi R, Lin Y, Hu H, et al. Natural Enzyme-Loaded Polymeric Stealth Coating-Armed Engineered Probiotics by Disrupting Tumor Lactate Homeostasis to Synergistic Metabolism-Immuno-Enzyme Dynamic Therapy. Adv Sci (Weinh). 2025. doi:10.1002/advs.202417172
- Nasri F, Alizadeh A, İncili GK, Hayaloğlu AA, Moradi M. Investigating Chemical Composition and Functionality of Lactobacillus acidophilus LA-5 Postbiotics Prepared in Classic and Cheese Whey Media. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10435-9
- Si R, Hu T, Williams GR, Yang Y, Yang S, et al. Coupling Probiotics with CaO Nanoparticle-Loaded CoFeCe-LDH Nanosheets to Remodel the Tumor Microenvironment for Precise Chemodynamic Therapy. Adv Healthc Mater. 2025;14:e2403373. doi:10.1002/adhm.202403373
- Kumawat M, Une H. Effect of Lactobacillus acidophilus, Calcium, and Moringa oleifera leaves extract co-administration can prevent chemical-induced carcinogenesis. Arab J Gastroenterol. 2024;25:421. doi:10.1016/j.ajg.2024.07.015
- Karim MR, Iqbal S, Mohammad S, Kim JH, Ling L, et al. Upgrading Isoquercitrin Concentration via Submerge Fermentation of Mulberry Fruit Extract with Edible Probiotics to Suppress Gene Targets for Controlling Kidney Cancer and Inflammation. J Microbiol. 2024;62:919. doi:10.1007/s12275-024-00163-8
- Gad AI, Orabi MM, Abou-Taleb KA, Abdelghani DY, Amin SA. In vitro digestive system simulation and anticancer activity of soymilk fermented by probiotics and synbiotics immobilised on agro-industrial residues. Sci Rep. 2024;14:18518. doi:10.1038/s41598-024-68086-3
- Xiong H, He Z, Wei Y, Li Q, Xiao Q, et al. Probiotic Compounds Enhanced Recovery after Surgery for Patients with Distal Gastric Cancer: A Prospective, Controlled Clinical Trial. Ann Surg Oncol. 2024;31:5240. doi:10.1245/s10434-024-15394-7
- Al-Asfour A, Bhardwaj RG, Karched M. Growth Suppression of Oral Squamous Cell Carcinoma Cells by Lactobacillus Acidophilus. Int Dent J. 2024;74:1151. doi:10.1016/j.identj.2024.03.017
- Mirzadeh MA, Eslami M, Ghanbari A, Zarbakhsh S, Yosefi S, et al. Coadministration of doxorubicin with vitamin D3, Lactobacillus acidophilus, and Lactobacillus casei in the 4T1 mouse model of breast cancer: anticancer and enteroprotective effects. Med Oncol. 2024;41:111. doi:10.1007/s12032-024-02346-0
- Reis SK, Socca EAR, de Souza BR, Genaro SC, Durán N, et al. Effects of probiotic supplementation on chronic inflammatory process modulation in colorectal carcinogenesis. Tissue Cell. 2024;87:102293. doi:10.1016/j.tice.2023.102293
- Saffar KN, Larypoor M, Torbati MB. Analyzing of colorectal cancerrelated genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines. Mol Biol Rep. 2024;51:122. doi:10.1007/s11033-023-09008-w
- Lau HC, Zhang X, Ji F, Lin Y, Liang W, et al. Lactobacillus acidophilus suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma through producing valeric acid. EBioMedicine. 2024;100:104952. doi:10.1016/j.ebiom.2023.104952
- Erfanian N, Nasseri S, Miraki Feriz A, Safarpour H, Namaei MH. Characterization of Wnt signaling pathway under treatment of Lactobacillus acidophilus postbiotic in colorectal cancer using an integrated in silico and in vitro analysis. Sci Rep. 2023;13:22988. doi:10.1038/s41598-023-50047-x
- Zamani F, Khalighfard S, Kalhori MR, Poorkhani A, Amiriani T, et al. Expanding CYLD protein in NF-κβ/TNF-α signaling pathway in response to Lactobacillus acidophilus in non-metastatic rectal cancer patients. Med Oncol. 2023;40:302. doi:10.1007/s12032-023-02170-y
- Shen S, Ren F, Qin H, Bukhari I, Yang J, et al. NCFM and Lp-115 inhibit colonization and gastric inflammation in a murine model. Front Cell Infect Microbiol. 2023;13:1196084. doi:10.3389/fcimb.2023.1196084
- Abo-Zaid GA, Kenawy AM, El-Deeb NM, Al-Madboly LA. Improvement and enhancement of oligosaccharide production from Lactobacillus acidophilus using statistical experimental designs and its inhibitory effect on colon cancer. Microb Cell Fact. 2023;22:148. doi:10.1186/s12934-023-02153-8
