Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Proprietary Blend Containing 1 billion live cultures† Lactobacillus acidophilus Lactobacillus salivarius Bifidobacterium bifidum Streptococcus thermophilus
175 mg
**
Top Medical Research Studies
9
We investigated whether administering Lactobacillus acidophilus could alleviate anxiety and oxidative stress in rats, particularly during challenging conditions like hypoxia.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.
Read More
7
Probiotics may aid depression treatment
We explored how probiotics, particularly Lactobacillus acidophilus, might impact depression in patients diagnosed with major depressive disorder (MDD). In a double-blind, placebo-controlled trial involving 40 participants, we found that after eight weeks of probiotic treatment, symptoms of depression improved along with certain metabolic markers.
However, it's important to note that while there were positive changes, probiotics did not significantly affect glucose levels or lipid profiles. Overall, our findings suggest that probiotics might be a helpful addition to depression treatment strategies.
However, it's important to note that while there were positive changes, probiotics did not significantly affect glucose levels or lipid profiles. Overall, our findings suggest that probiotics might be a helpful addition to depression treatment strategies.
Read More
8
We investigated the effects of lactobacillus acidophilus strains on depression in mice. The study involved administering different dosages of probiotics to mice made depressed by ampicillin.
Behavioral tests revealed that the mice given probiotics showed signs of recovery from their depressive symptoms. The treatment also impacted their gut microbiota composition, favorably altering the levels of certain beneficial bacteria.
However, while the results are promising, more research is needed to confirm the long-term effectiveness of these probiotics on depression in humans.
Behavioral tests revealed that the mice given probiotics showed signs of recovery from their depressive symptoms. The treatment also impacted their gut microbiota composition, favorably altering the levels of certain beneficial bacteria.
However, while the results are promising, more research is needed to confirm the long-term effectiveness of these probiotics on depression in humans.
Read More
Most Useful Reviews
7.5
Overall health benefits
7 people found this helpful
Truly incredible! A beautiful probiotic product with high quality and useful ingredients. The 150-capsule package is perfect. It offers numerous advantages for overall health, containing beneficial bacteria to protect the digestive system. It supports digestion and is effective for constipation and diarrhoea. Additionally, it promotes heart health by lowering blood pressure and reducing harmful cholesterol. It's particularly beneficial for those taking medication, relieving anxiety and depression, while also enhancing skin health and aiding in weight loss. Taken once daily on an empty stomach in the morning—thank you!
Read More
7.5
Improves anxiety
Probiotics enhance digestion and effectively reduce depression and anxiety. They also assist in balancing female hormones and improving fertility, while enhancing skin condition and preventing urogenital infections.
Read More
7.5
Beneficial for colon
It is very helpful for the colon and for depression. I purchased it for my sister suffering from severe colon pain, and she greatly benefited from it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
- All Researches
9
We investigated the impact of a novel multi-strain E3 probiotic on mental health, sleep quality, and gut microbiome in 68 participants from Hong Kong. After an 8-week treatment, significant improvements were reported in depressive symptoms, anxiety, and sleep quality. Participants showed decreased scores on standardized surveys, with notable changes in gut microbiome composition linked to these improvements. Our findings highlight the potential benefits of probiotics for those experiencing mood disorders and sleep issues, suggesting that these strategies may effectively enhance mental well-being.
Read More
9
We investigated whether administering Lactobacillus acidophilus could alleviate anxiety and oxidative stress in rats, particularly during challenging conditions like hypoxia.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.
Read More
8
Probiotic yogurt alleviates depression
We explored the effects of fortified yogurt on women with polycystic ovary syndrome (PCOS) over an 8-week period. In this randomized, double-blind study, one group enjoyed yogurt enriched with probiotics, vitamin E, and vitamin D, while the other had a standard yogurt placebo.
Participants in the yogurt group showed significant improvement in depression levels compared to the placebo group, though no gains were noted in sleep quality. This suggests that incorporating probiotics in dietary interventions may help manage depression in PCOS patients, serving as an alternative for those hesitant to use traditional antidepressants. However, we recognize the need for further research to solidify these findings.
Participants in the yogurt group showed significant improvement in depression levels compared to the placebo group, though no gains were noted in sleep quality. This suggests that incorporating probiotics in dietary interventions may help manage depression in PCOS patients, serving as an alternative for those hesitant to use traditional antidepressants. However, we recognize the need for further research to solidify these findings.
Read More
8
Lactobacillus shows limited anti-depressant effects
We examined the effects of a cultured milk drink containing Lactobacillus acidophilus on depression in individuals with irritable bowel syndrome (IBS). Our study involved 110 IBS participants, some experiencing subthreshold depression, who consumed the drink daily for 12 weeks.
While we found significant reductions in depression scores and improvements in quality of life across groups, only the probiotics showed notable increases in serotonin levels. This suggests that while Lactobacillus might provide some benefits, it may not be a singular solution for depression in IBS.
While we found significant reductions in depression scores and improvements in quality of life across groups, only the probiotics showed notable increases in serotonin levels. This suggests that while Lactobacillus might provide some benefits, it may not be a singular solution for depression in IBS.
Read More
8
We investigated the effects of lactobacillus acidophilus strains on depression in mice. The study involved administering different dosages of probiotics to mice made depressed by ampicillin.
Behavioral tests revealed that the mice given probiotics showed signs of recovery from their depressive symptoms. The treatment also impacted their gut microbiota composition, favorably altering the levels of certain beneficial bacteria.
However, while the results are promising, more research is needed to confirm the long-term effectiveness of these probiotics on depression in humans.
Behavioral tests revealed that the mice given probiotics showed signs of recovery from their depressive symptoms. The treatment also impacted their gut microbiota composition, favorably altering the levels of certain beneficial bacteria.
However, while the results are promising, more research is needed to confirm the long-term effectiveness of these probiotics on depression in humans.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Overall health benefits
7 people found this helpful
Truly incredible! A beautiful probiotic product with high quality and useful ingredients. The 150-capsule package is perfect. It offers numerous advantages for overall health, containing beneficial bacteria to protect the digestive system. It supports digestion and is effective for constipation and diarrhoea. Additionally, it promotes heart health by lowering blood pressure and reducing harmful cholesterol. It's particularly beneficial for those taking medication, relieving anxiety and depression, while also enhancing skin health and aiding in weight loss. Taken once daily on an empty stomach in the morning—thank you!
Read More
7.5
Improves anxiety
Probiotics enhance digestion and effectively reduce depression and anxiety. They also assist in balancing female hormones and improving fertility, while enhancing skin condition and preventing urogenital infections.
Read More
7.5
Beneficial for colon
It is very helpful for the colon and for depression. I purchased it for my sister suffering from severe colon pain, and she greatly benefited from it.
Read More
Frequently Asked Questions
7.5
Overall health benefits
7 people found this helpful
Truly incredible! A beautiful probiotic product with high quality and useful ingredients. The 150-capsule package is perfect. It offers numerous advantages for overall health, containing beneficial bacteria to protect the digestive system. It supports digestion and is effective for constipation and diarrhoea. Additionally, it promotes heart health by lowering blood pressure and reducing harmful cholesterol. It's particularly beneficial for those taking medication, relieving anxiety and depression, while also enhancing skin health and aiding in weight loss. Taken once daily on an empty stomach in the morning—thank you!
7.5
Improves anxiety
Probiotics enhance digestion and effectively reduce depression and anxiety. They also assist in balancing female hormones and improving fertility, while enhancing skin condition and preventing urogenital infections.
7.5
Beneficial for colon
It is very helpful for the colon and for depression. I purchased it for my sister suffering from severe colon pain, and she greatly benefited from it.
8
Probiotic yogurt alleviates depression
We explored the effects of fortified yogurt on women with polycystic ovary syndrome (PCOS) over an 8-week period. In this randomized, double-blind study, one group enjoyed yogurt enriched with probiotics, vitamin E, and vitamin D, while the other had a standard yogurt placebo.
Participants in the yogurt group showed significant improvement in depression levels compared to the placebo group, though no gains were noted in sleep quality. This suggests that incorporating probiotics in dietary interventions may help manage depression in PCOS patients, serving as an alternative for those hesitant to use traditional antidepressants. However, we recognize the need for further research to solidify these findings.
Participants in the yogurt group showed significant improvement in depression levels compared to the placebo group, though no gains were noted in sleep quality. This suggests that incorporating probiotics in dietary interventions may help manage depression in PCOS patients, serving as an alternative for those hesitant to use traditional antidepressants. However, we recognize the need for further research to solidify these findings.
5
We examined the effects of caloric restriction combined with probiotic supplementation on depression symptoms in adult men with obesity. In our randomized, double-blind study over 12 weeks, participants adhered to a specific diet while receiving either probiotics or a placebo.
While we observed improvements in anxiety and depressive symptoms in those taking probiotics, there were no significant differences between the two groups overall. This suggests that while probiotics may offer some benefits, more research is needed to fully understand their impact on mental health.
While we observed improvements in anxiety and depressive symptoms in those taking probiotics, there were no significant differences between the two groups overall. This suggests that while probiotics may offer some benefits, more research is needed to fully understand their impact on mental health.
5
We examined the effects of probiotics, specifically Lactobacillus and Bifidobacterium strains, on symptoms of depression and anxiety through a comprehensive meta-analysis.
Although our findings suggested that probiotics may lead to a notable reduction in depressive symptoms as measured by the Beck Depression Inventory, the overall impact was mixed. We found no significant results on other well-established scales like HAMD, DASS, and MADRS.
This variability highlights the complexity of these mental health conditions and suggests that further research is essential to fully understand how probiotics can influence mood.
Although our findings suggested that probiotics may lead to a notable reduction in depressive symptoms as measured by the Beck Depression Inventory, the overall impact was mixed. We found no significant results on other well-established scales like HAMD, DASS, and MADRS.
This variability highlights the complexity of these mental health conditions and suggests that further research is essential to fully understand how probiotics can influence mood.
8
Probiotics improve mental health markers
We investigated how synbiotic and probiotic supplements could influence mental health and quality of life in hemodialysis (HD) patients. In a well-structured double-blind trial with 75 participants, those receiving probiotics showed a notable reduction in depression and anxiety scores compared to the placebo group.
However, these improvements did not translate to enhanced quality of life or measurable benefits in overall health. Interestingly, there was a significant rise in hemoglobin levels in those taking the supplements.
However, these improvements did not translate to enhanced quality of life or measurable benefits in overall health. Interestingly, there was a significant rise in hemoglobin levels in those taking the supplements.
References
- Askarpour M, Hejazi N, Jahromi BN, Eskandari MH, Famouri M, et al. Effects of a Novel Fortified Dairy Product on the Psychological Status and Sleep Quality of Patients with Polycystic Ovary Syndrome: A Double-Blind Randomized Controlled Trial. Prev Nutr Food Sci. 2025;30:37. 10.3746/pnf.2025.30.1.37
- Marques CG, Dos Santos Quaresma MVL, França Ferracini CB, Alves Carrilho FB, Nakamoto FP, et al. Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial. Clin Nutr. 2025;45:234. 10.1016/j.clnu.2024.12.031
- Rahmannia M, Poudineh M, Mirzaei R, Aalipour MA, Shahidi Bonjar AH, et al. Strain-specific effects of probiotics on depression and anxiety: a meta-analysis. Gut Pathog. 2024;16:46. 10.1186/s13099-024-00634-8
- Sarkawi M, Raja Ali RA, Abdul Wahab N, Abdul Rathi ND, Mokhtar NM. A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for depression in irritable bowel syndrome. Sci Rep. 2024;14:9478. 10.1038/s41598-024-60029-2
- Hashemi-Mohammadabad N, Taghavi SA, Lambert N, Moshtaghi R, Bazarganipour F, et al. Adjuvant administration of probiotic effects on sexual function in depressant women undergoing SSRIs treatment: a double-blinded randomized controlled trial. BMC Psychiatry. 2024;24:44. 10.1186/s12888-023-05429-w
- Chan HHY, Siu PLK, Choy CT, Chan UK, Zhou J, et al. Novel Multi-Strain E3 Probiotic Formulation Improved Mental Health Symptoms and Sleep Quality in Hong Kong Chinese. Nutrients. 2023;15. 10.3390/nu15245037
- Tsai WH, Yeh WL, Chou CH, Wu CL, Lai CH, et al. Suppressive Effects of on Depression through Regulating the Gut Microbiota and Metabolites in C57BL/6J Mice Induced by Ampicillin. Biomedicines. 2023;11. 10.3390/biomedicines11041068
- Haghighat N, Mohammadshahi M, Shayanpour S, Haghighizadeh MH, Rahmdel S, et al. The Effect of Synbiotic and Probiotic Supplementation on Mental Health Parameters in Patients Undergoing Hemodialysis: A Double-blind, Randomized, Placebo-controlled Trial. Indian J Nephrol. 2021;31:149. 10.4103/ijn.IJN_341_19
- Kozin SV, Kravtsov AA, Kravchenko SV, Ivashchenko LI. [Antioxidant and anxiolytic effect of and under conditions of normobaric hypoxia with hypercapnia]. Vopr Pitan. 2021;90:63. 10.33029/0042-8833-2021-90-2-63-72
- Gu F, Wu Y, Liu Y, Dou M, Jiang Y, et al. Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota. Food Funct. 2020;11:6148. 10.1039/d0fo00373e
- Hadi A, Sepandi M, Marx W, Moradi S, Parastouei K. Clinical and psychological responses to synbiotic supplementation in obese or overweight adults: A randomized clinical trial. Complement Ther Med. 2019;47:102216. 10.1016/j.ctim.2019.102216
- Haghighat N, Rajabi S, Mohammadshahi M. Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial. Nutr Neurosci. 2021;24:490. 10.1080/1028415X.2019.1646975
- Akkasheh G, Kashani-Poor Z, Tajabadi-Ebrahimi M, Jafari P, Akbari H, et al. Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial. Nutrition. 2016;32:315. 10.1016/j.nut.2015.09.003
- Steenbergen L, Sellaro R, van Hemert S, Bosch JA, Colzato LS. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behav Immun. 2015;48:258. 10.1016/j.bbi.2015.04.003
- Feher J, Pinter E, Kovács I, Helyes Z, Kemény A, et al. Irritable eye syndrome: neuroimmune mechanisms and benefits of selected nutrients. Ocul Surf. 2014;12:134. 10.1016/j.jtos.2013.09.002
