Last update
5/21/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 63 Researches
7.6
USERS' SCORE
Moderately Good
Based on 60 Reviews
7.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Proprietary Blend Containing 1 billion live cultures† Lactobacillus acidophilus Lactobacillus salivarius Bifidobacterium bifidum Streptococcus thermophilus
175 mg
**
Top Medical Research Studies
9
We explored the impact of Lactobacillus salivarius SNK-6 on treating and preventing diarrhea in pigeons. In our research, we compared healthy pigeons with those infected with specific strains of E. coli known to cause diarrhea. After administering L. salivarius SNK-6, we observed a notable reduction in diarrhea among treated pigeons, while control pigeons still experienced a 10% incidence of diarrhea. This suggests that boosting levels of Lactobacillus can help maintain a healthy balance in the gut, potentially preventing diarrhea in the future.
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9.5
We explored the impact of adding probiotics, specifically two Lactobacillus strains, to standard treatment for patients with diarrhea-predominant irritable bowel syndrome (IBS-D). In a randomized, single-blinded trial, 100 patients were divided into two groups—one receiving standard care and the other receiving probiotics along with the standard treatment over 12 weeks.
Both groups showed improvement in IBS symptoms, but the group receiving probiotics experienced greater reductions. Notably, 100% of probiotic-treated patients saw either full remission or mild symptoms, contrasting with 14.3% from the standard treatment. Overall, these findings suggest probiotics can significantly enhance IBS management.
Both groups showed improvement in IBS symptoms, but the group receiving probiotics experienced greater reductions. Notably, 100% of probiotic-treated patients saw either full remission or mild symptoms, contrasting with 14.3% from the standard treatment. Overall, these findings suggest probiotics can significantly enhance IBS management.
Read More
9
We examined how a special strain of Bifidobacterium bifidum, known as BGN4-SK, can help alleviate diarrhea associated with inflammatory bowel disease (IBD). This strain produces beneficial antioxidant enzymes that defend against inflammation and strengthen the gut's barrier function.
Our findings showed that BGN4-SK significantly reduces inflammation in the gut, leading to improved symptoms of colitis. However, another strain, BGN4-pBESIL10, showed limited effects in enhancing anti-inflammatory responses.
Overall, BGN4-SK appears promising in treating diarrhea related to IBD by addressing underlying inflammation.
Our findings showed that BGN4-SK significantly reduces inflammation in the gut, leading to improved symptoms of colitis. However, another strain, BGN4-pBESIL10, showed limited effects in enhancing anti-inflammatory responses.
Overall, BGN4-SK appears promising in treating diarrhea related to IBD by addressing underlying inflammation.
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Most Useful Reviews
9
Prevents travel diarrhea
237 people found this helpful
This probiotic blend is excellent and does not require refrigeration. I take it in the morning before meals and recommend it especially before travelling, as it prevents traveller's diarrhoea effectively while remaining affordable compared to other options.
Read More
9
Dramatic help
6 people found this helpful
This probiotic has been immensely beneficial for my IBS, significantly reducing stomach pains, constipation, and diarrhoea. My doctor recommended pairing it with a fibre supplement, which has dramatically improved my condition. I used to dread being away from a bathroom, but now I feel much more secure. This probiotic is easy to swallow and offers incredible value for money!
Read More
9
No more diarrhoea
3 people found this helpful
After two months of taking these probiotics, my intestines feel stronger and I'm free from diarrhoea and stomachaches. My stools are also regular and healthy. I've found them beneficial after keeping them in the fridge and consuming with food.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 63 Researches
7.6
- All Researches
9.5
We explored the impact of adding probiotics, specifically two Lactobacillus strains, to standard treatment for patients with diarrhea-predominant irritable bowel syndrome (IBS-D). In a randomized, single-blinded trial, 100 patients were divided into two groups—one receiving standard care and the other receiving probiotics along with the standard treatment over 12 weeks.
Both groups showed improvement in IBS symptoms, but the group receiving probiotics experienced greater reductions. Notably, 100% of probiotic-treated patients saw either full remission or mild symptoms, contrasting with 14.3% from the standard treatment. Overall, these findings suggest probiotics can significantly enhance IBS management.
Both groups showed improvement in IBS symptoms, but the group receiving probiotics experienced greater reductions. Notably, 100% of probiotic-treated patients saw either full remission or mild symptoms, contrasting with 14.3% from the standard treatment. Overall, these findings suggest probiotics can significantly enhance IBS management.
Read More
9.5
We explored the impact of Lactobacillus acidophilus and L. plantarum on patients suffering from diarrhea-predominant irritable bowel syndrome (IBS-D). In a randomized, single-blinded clinical trial of 100 patients, some received standard IBS treatment alone while others added probiotics to their therapy.
After 12 weeks, both groups saw improvements, but those who took probiotics reported significantly better outcomes. Patients using probiotics experienced greater reductions in IBS symptoms, achieving near complete relief, while some on standard treatment still faced moderate symptoms. This suggests probiotics could enhance IBS management.
After 12 weeks, both groups saw improvements, but those who took probiotics reported significantly better outcomes. Patients using probiotics experienced greater reductions in IBS symptoms, achieving near complete relief, while some on standard treatment still faced moderate symptoms. This suggests probiotics could enhance IBS management.
Read More
9
Acidophilus shows potential for diarrhea relief
We examined how acidophilus combined with montmorillonite powder impacts diarrhea in children suffering from rotavirus enteritis. In our study, 94 children were randomized into two groups. While one group received standard treatment plus montmorillonite, the other was given acidophilus.
The group taking acidophilus had faster relief from diarrhea, vomiting, fever, and dehydration. Their overall effectiveness rate was also high at nearly 96%. Although they showed some improvement in inflammatory markers, this was not statistically significant.
Both treatments had a good safety profile, making this combination a promising option for symptom relief.
The group taking acidophilus had faster relief from diarrhea, vomiting, fever, and dehydration. Their overall effectiveness rate was also high at nearly 96%. Although they showed some improvement in inflammatory markers, this was not statistically significant.
Both treatments had a good safety profile, making this combination a promising option for symptom relief.
Read More
9
We explored the impact of multistrain probiotics, specifically Sensi-Biome, on diarrhea in a controlled rat model. The results showed that the probiotics led to significant improvements in stool moisture, intestinal movement, and pH levels.
Interestingly, serotonin levels decreased, indicating a potential link to how these probiotics affect gut health. While some positive changes were observed, the overall findings suggest that while Sensi-Biome has potential, its effectiveness in controlling diarrhea may vary and doesn’t guarantee relief in every instance.
Interestingly, serotonin levels decreased, indicating a potential link to how these probiotics affect gut health. While some positive changes were observed, the overall findings suggest that while Sensi-Biome has potential, its effectiveness in controlling diarrhea may vary and doesn’t guarantee relief in every instance.
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9
We evaluated the role of the probiotic Neobiotic Lactobalance® in alleviating diarrhea linked to irritable bowel syndrome (IBS) and antibiotic-associated diarrhea (AAD).
Our study involved 54 patients who took one capsule daily for 21 days.
We found significant reductions in diarrhea symptoms and abdominal discomfort, particularly in those with IBS and AAD. Microbiota analysis revealed improvements in beneficial bacteria levels, suggesting that this probiotic can help restore gut health and reduce diarrhea severity effectively.
Our study involved 54 patients who took one capsule daily for 21 days.
We found significant reductions in diarrhea symptoms and abdominal discomfort, particularly in those with IBS and AAD. Microbiota analysis revealed improvements in beneficial bacteria levels, suggesting that this probiotic can help restore gut health and reduce diarrhea severity effectively.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 60 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Prevents travel diarrhea
237 people found this helpful
This probiotic blend is excellent and does not require refrigeration. I take it in the morning before meals and recommend it especially before travelling, as it prevents traveller's diarrhoea effectively while remaining affordable compared to other options.
Read More
9
Dramatic help
6 people found this helpful
This probiotic has been immensely beneficial for my IBS, significantly reducing stomach pains, constipation, and diarrhoea. My doctor recommended pairing it with a fibre supplement, which has dramatically improved my condition. I used to dread being away from a bathroom, but now I feel much more secure. This probiotic is easy to swallow and offers incredible value for money!
Read More
9
No more diarrhoea
3 people found this helpful
After two months of taking these probiotics, my intestines feel stronger and I'm free from diarrhoea and stomachaches. My stools are also regular and healthy. I've found them beneficial after keeping them in the fridge and consuming with food.
Read More
9
Noticeable effects
3 people found this helpful
Since taking this, I've noticed remarkable improvements: no bad breath or severe diarrhoea. One tablet daily suffices for 150 days, and it enhances the effects of soy isoflavones. It's an essential supplement for my health!
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9
Diarrhea relief
3 people found this helpful
Work Well assisted with my diarrhoea.
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Frequently Asked Questions
9
Prevents travel diarrhea
237 people found this helpful
This probiotic blend is excellent and does not require refrigeration. I take it in the morning before meals and recommend it especially before travelling, as it prevents traveller's diarrhoea effectively while remaining affordable compared to other options.
9
Acidophilus shows potential for diarrhea relief
We examined how acidophilus combined with montmorillonite powder impacts diarrhea in children suffering from rotavirus enteritis. In our study, 94 children were randomized into two groups. While one group received standard treatment plus montmorillonite, the other was given acidophilus.
The group taking acidophilus had faster relief from diarrhea, vomiting, fever, and dehydration. Their overall effectiveness rate was also high at nearly 96%. Although they showed some improvement in inflammatory markers, this was not statistically significant.
Both treatments had a good safety profile, making this combination a promising option for symptom relief.
The group taking acidophilus had faster relief from diarrhea, vomiting, fever, and dehydration. Their overall effectiveness rate was also high at nearly 96%. Although they showed some improvement in inflammatory markers, this was not statistically significant.
Both treatments had a good safety profile, making this combination a promising option for symptom relief.
7
We explored the effectiveness of probiotics, specifically those available in Japan, on children suffering from acute gastroenteritis. By reviewing 14 randomized controlled studies, we observed that children taking probiotics experienced diarrhea almost a day earlier than those on placebo.
Furthermore, hospital stays were also shorter for the probiotic group. However, it’s important to note that the evidence regarding these benefits is very weak. While there’s some promise in using probiotics for treating diarrhea, we remain cautious about the strength of these findings.
Furthermore, hospital stays were also shorter for the probiotic group. However, it’s important to note that the evidence regarding these benefits is very weak. While there’s some promise in using probiotics for treating diarrhea, we remain cautious about the strength of these findings.
9.5
We explored the impact of adding probiotics, specifically two Lactobacillus strains, to standard treatment for patients with diarrhea-predominant irritable bowel syndrome (IBS-D). In a randomized, single-blinded trial, 100 patients were divided into two groups—one receiving standard care and the other receiving probiotics along with the standard treatment over 12 weeks.
Both groups showed improvement in IBS symptoms, but the group receiving probiotics experienced greater reductions. Notably, 100% of probiotic-treated patients saw either full remission or mild symptoms, contrasting with 14.3% from the standard treatment. Overall, these findings suggest probiotics can significantly enhance IBS management.
Both groups showed improvement in IBS symptoms, but the group receiving probiotics experienced greater reductions. Notably, 100% of probiotic-treated patients saw either full remission or mild symptoms, contrasting with 14.3% from the standard treatment. Overall, these findings suggest probiotics can significantly enhance IBS management.
7
We examined the impact of probiotics on critically ill patients requiring mechanical ventilation. This comprehensive review combined data from thirty meta-analyses, specifically focusing on clinical outcomes like ventilator-associated pneumonia, infection rates, and length of hospital stays.
Remarkably, we found that probiotics reduced incidents of diarrhea among other complications. However, we also noted that the effectiveness varied due to the different types of probiotics studied. Overall, probiotics may serve as supportive treatment, but we cannot definitively recommend a specific probiotic approach.
Remarkably, we found that probiotics reduced incidents of diarrhea among other complications. However, we also noted that the effectiveness varied due to the different types of probiotics studied. Overall, probiotics may serve as supportive treatment, but we cannot definitively recommend a specific probiotic approach.
References
- Li S, Lu T, Lin Z, Zhang Y, Zhou X, et al. Supplementation with probiotics co-cultivation improves the reproductive performance in a sow-piglet model by mother-infant microbiota transmission and placental mTOR signaling. World J Microbiol Biotechnol. 2024;41:13. 10.1007/s11274-024-04222-5
- Wei Q, Song LY, Rao R, Yang HW, Wen YP, et al. The Impact of Combined Therapy with Lactobacillus acidophilus and Montmorillonite Powder on the Inflammatory Response in Pediatric Rotavirus Enteritis. Int Arch Allergy Immunol. 2024. 10.1159/000542593
- Luo J, Xiao S, Ma D, Xiang J, Wang B, et al. Investigating the Impact of Pineapple-Whey Protein Fermentation Products on Cefixime-Induced Intestinal Flora Dysbiosis in Mice Using 16S Sequencing and Untargeted Metabolomics Techniques. Foods. 2024;13. 10.3390/foods13121927
- Anvarifard P, Anbari M, Ghalichi F, Ghoreishi Z, Zarezadeh M. The effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis. Food Funct. 2024;15:5737. 10.1039/d3fo04653b
- Jeong JJ, Jin YJ, Ganesan R, Park HJ, Min BH, et al. Multistrain Probiotics Alleviate Diarrhea by Modulating Microbiome-Derived Metabolites and Serotonin Pathway. Probiotics Antimicrob Proteins. 2024. 10.1007/s12602-024-10232-4
- Alharbi BF, Alateek AA. Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review. Travel Med Infect Dis. 2024;59:102703. 10.1016/j.tmaid.2024.102703
- Miranda-Yuquilema J, Taboada J, Once V, Coyago M, Briñez W. Effect of Agroindustrial Waste Substrate Fermented with Lactic Acid Bacteria and Yeast on Changes in the Gut Microbiota of Guinea Pigs. Microorganisms. 2024;12. 10.3390/microorganisms12010133
- Shanshal SA, Alsaaty MH, Al-Qazaz H, Al-Zidan RN. Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial. Ceska Slov Farm. 2024;72:233. PubMed
- Higuchi T, Furuichi M, Maeda N, Tsugawa T, Ito K. Effects of probiotics in children with acute gastroenteritis: A systematic review and meta-analysis focusing on probiotics utilized in Japan. J Infect Chemother. 2024;30:337. 10.1016/j.jiac.2023.11.005
- Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. 10.33029/0042-8833-2023-92-4-92-103
- Sharma AN, Chaudhary P, Grover CR, Kumar S, Mondal G. Impact of synbiotics on growth performance and gut health in Murrah buffalo calves. Vet Res Commun. 2024;48:179. 10.1007/s11259-023-10194-y
- Li W, Zhang S, Wang Y, Bian H, Yu S, et al. Complex probiotics alleviate ampicillin-induced antibiotic-associated diarrhea in mice. Front Microbiol. 2023;14:1156058. 10.3389/fmicb.2023.1156058
- Fan H, Gao L, Yin Z, Ye S, Zhao H, et al. Probiotics and rifaximin for the prevention of travelers' diarrhea: A systematic review and network meta-analysis. Medicine (Baltimore). 2022;101:e30921. 10.1097/MD.0000000000030921
- Wu Y, Dong XY, Zhou XZ, Li ZS, Du YQ. Effects of probiotics on gastric microbiota and its precombination with quadruple regimen for Helicobacter pylori eradication. J Dig Dis. 2022;23:462. 10.1111/1751-2980.13138
- Lukasik J, Dierikx T, Besseling-van der Vaart I, de Meij T, Szajewska H. Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial. JAMA Pediatr. 2022;176:860. 10.1001/jamapediatrics.2022.1973
- Cheng H, Ma Y, Liu X, Tian C, Zhong X, et al. A Systematic Review and Meta-Analysis: for Treating Acute Gastroenteritis in Children. Nutrients. 2022;14. 10.3390/nu14030682
- Hashem B, Gaston M, Carlisle JD, Van Wick P. COMPARISON OF HAND-REARED PRONGHORN () MILK REPLACER COMPOSITIONS AND GROWTH RATES. J Zoo Wildl Med. 2024;55:1056. 10.1638/2023-0112
- Shanshal SA, Alsaaty MH, Al-Qazaz H, Al-Zidan RN. Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial. Ceska Slov Farm. 2024;73:233. PubMed
- Huang R, Xing HY, Liu HJ, Chen ZF, Tang BB. Efficacy of probiotics in the treatment of acute diarrhea in children: a systematic review and meta-analysis of clinical trials. Transl Pediatr. 2021;10:3248. 10.21037/tp-21-511
- Gandhar JS, De UK, Kala A, Malik YS, Yadav S, et al. Efficacy of Microencapsulated Probiotic as Adjunct Therapy on Resolution of Diarrhea, Copper-Zinc Homeostasis, Immunoglobulins, and Inflammatory Markers in Serum of Spontaneous Rotavirus-Infected Diarrhoetic Calves. Probiotics Antimicrob Proteins. 2022;14:1054. 10.1007/s12602-021-09862-9
- Kumar M, Kala A, Chaudhary LC, Agarwal N, Kochewad SA. Microencapsulated and Lyophilized Lactobacillus acidophilus Improved Gut Health and Immune Status of Preruminant Calves. Probiotics Antimicrob Proteins. 2022;14:523. 10.1007/s12602-021-09821-4
- Chorawala MR, Chauhan S, Patel R, Shah G. Cell Wall Contents of Probiotics (Lactobacillus species) Protect Against Lipopolysaccharide (LPS)-Induced Murine Colitis by Limiting Immuno-inflammation and Oxidative Stress. Probiotics Antimicrob Proteins. 2021;13:1005. 10.1007/s12602-020-09738-4
- Gunaratnam S, Diarra C, Paquette PD, Ship N, Millette M, et al. The Acid-Dependent and Independent Effects of Lactobacillus acidophilus CL1285, Lacticaseibacillus casei LBC80R, and Lacticaseibacillus rhamnosus CLR2 on Clostridioides difficile R20291. Probiotics Antimicrob Proteins. 2021;13:949. 10.1007/s12602-020-09729-5
- He Q, Lu S, Wang J, Xu C, Qu W, et al. and Berberine Alleviated Yak Calves' Diarrhea via Accommodating Oxidation Resistance, Inflammatory Factors, and Intestinal Microbiota. Animals (Basel). 2024;14. 10.3390/ani14162419
- Fan W, Zhu Y, Hou H, Yao J, Zhu L, et al. Treatment and prevention of pigeon diarrhea through the application of Lactobacillus SNK-6. Poult Sci. 2024;103:103476. 10.1016/j.psj.2024.103476
- Cuevas-Gómez I, de Andrés J, Cardenas N, Espinosa-Martos I, Jiménez E. Feed supplementation with Ligilactobacillus salivarius PS21603 optimises intestinal morphology and gut microbiota composition in weaned piglets. Benef Microbes. 2024;15:195. 10.1163/18762891-bja00001
- Molina RA, Villar MD, Miranda MH, Maldonado NC, Vignolo GM, et al. A multi-strain probiotic promoted recovery of puppies from gastroenteritis in a randomized, double-blind, placebo-controlled study. Can Vet J. 2023;64:666. PubMed
- Cuevas-Gómez I, de Andrés J, Cardenas N, Espinosa-Martos I, Jiménez E. Safety assessment and characterisation of PS21603 as potential feed additive for swine. Benef Microbes. 2022;13:397. 10.3920/BM2022.0020
- Sun Z, Li H, Li Y, Qiao J. , a Potential Probiotic to Improve the Health of LPS-Challenged Piglet Intestine by Alleviating Inflammation as Well as Oxidative Stress in a Dose-Dependent Manner During Weaning Transition. Front Vet Sci. 2020;7:547425. 10.3389/fvets.2020.547425
- Azagra-Boronat I, Massot-Cladera M, Knipping K, Garssen J, Ben Amor K, et al. Strain-Specific Probiotic Properties of Bifidobacteria and Lactobacilli for the Prevention of Diarrhea Caused by Rotavirus in a Preclinical Model. Nutrients. 2020;12. 10.3390/nu12020498
- Sayan H, Assavacheep P, Angkanaporn K, Assavacheep A. Effect of Lactobacillus salivarius on growth performance, diarrhea incidence, fecal bacterial population and intestinal morphology of suckling pigs challenged with F4+ enterotoxigenic Escherichia coli. Asian-Australas J Anim Sci. 2018;31:1308. 10.5713/ajas.17.0746
- Skórka A, Pieścik-Lech M, Kołodziej M, Szajewska H. To add or not to add probiotics to infant formulae? An updated systematic review. Benef Microbes. 2017;8:717. 10.3920/BM2016.0233
- Maldonado NC, Chiaraviglio J, Bru E, De Chazal L, Santos V, et al. Effect of Milk Fermented with Lactic Acid Bacteria on Diarrheal Incidence, Growth Performance and Microbiological and Blood Profiles of Newborn Dairy Calves. Probiotics Antimicrob Proteins. 2018;10:668. 10.1007/s12602-017-9308-4
- Lomasney KW, Cryan JF, Hyland NP. Converging effects of a Bifidobacterium and Lactobacillus probiotic strain on mouse intestinal physiology. Am J Physiol Gastrointest Liver Physiol. 2014;307:G241. 10.1152/ajpgi.00401.2013
- Tsai CC, Lin PP, Hsieh YM. Three Lactobacillus strains from healthy infant stool inhibit enterotoxigenic Escherichia coli grown in vitro. Anaerobe. 2008;14:61. 10.1016/j.anaerobe.2007.11.003
- Casey PG, Gardiner GE, Casey G, Bradshaw B, Lawlor PG, et al. A five-strain probiotic combination reduces pathogen shedding and alleviates disease signs in pigs challenged with Salmonella enterica Serovar Typhimurium. Appl Environ Microbiol. 2007;73:1858. PubMed
- Sartor RB. Probiotic therapy of intestinal inflammation and infections. Curr Opin Gastroenterol. 2005;21:44. PubMed
- Xin H, Zhang X, Li P, Li H, Feng G, et al. Bifidobacterium bifidum supplementation improves ischemic stroke outcomes in elderly patients: A retrospective study. Medicine (Baltimore). 2024;103:e37682. 10.1097/MD.0000000000037682
- Hashimoto Y, Kobayashi G, Kitagawa N, Okada H, Hamaguchi M, et al. Protocol of efficacy of bifidobacteria intake on gastrointestinal symptoms in symptomatic type 2 diabetes mellitus patients in abdominis: An open-label, randomized controlled trial (Binary STAR study). PLoS One. 2024;19:e0295998. 10.1371/journal.pone.0295998
- Tomita T, Fukui H, Okugawa T, Nakanishi T, Mieno M, et al. Effect of G9-1 on the Intestinal Environment and Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)-like Symptoms in Patients with Quiescent Crohn's Disease: A Prospective Pilot Study. J Clin Med. 2023;12. 10.3390/jcm12103368
- Yalcin G, Demirbas F, Bacalan F, Toy EB. Evaluation of treatment in acute gastroenteritis: A comparative study. J Pak Med Assoc. 2022;72:2019. 10.47391/JPMA.4438
- Kang S, Lin Z, Xu Y, Park M, Ji GE, et al. A recombinant Bifidobacterium bifidum BGN4 strain expressing the streptococcal superoxide dismutase gene ameliorates inflammatory bowel disease. Microb Cell Fact. 2022;21:113. 10.1186/s12934-022-01840-2
- Hata S, Nakajima H, Hashimoto Y, Miyoshi T, Hosomi Y, et al. Effects of probiotic Bifidobacterium bifidum G9-1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open-label, single-arm, exploratory research trial. J Diabetes Investig. 2022;13:489. 10.1111/jdi.13698
- Ivashkin V, Fomin V, Moiseev S, Brovko M, Maslennikov R, et al. Efficacy of a Probiotic Consisting of Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301 in the Treatment of Hospitalized Patients with COVID-19: a Randomized Controlled Trial. Probiotics Antimicrob Proteins. 2023;15:460. 10.1007/s12602-021-09858-5
- Yang B, Huang Z, He Z, Yue Y, Zhou Y, et al. Protective effect of Bifidobacterium bifidum FSDJN7O5 and Bifidobacterium breve FHNFQ23M3 on diarrhea caused by enterotoxigenic Escherichia coli. Food Funct. 2021;12:7271. 10.1039/d1fo00504a
- Meskina ER, Tselipanova EE, Khadisova MK, Galkina LA, Stashko TV. [Efficiency of application of sorbed probiotics in complex therapy of pneumonia caused by SARS-CoV-2. Part 1. Heating clinical displays period]. Ter Arkh. 2021;93:456. 10.26442/00403660.2021.04.200835
- Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, Majsiak E, Bierła JB, et al. The Effectiveness of Synbiotic Preparation Containing and Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Nutrients. 2020;12. 10.3390/nu12071999
- Makizaki Y, Maeda A, Oikawa Y, Tamura S, Tanaka Y, et al. Probiotic Bifidobacterium bifidum G9-1 ameliorates phytohemagglutinin-induced diarrhea caused by intestinal dysbiosis. Microbiol Immunol. 2019;63:481. 10.1111/1348-0421.12743
- Renaud DL, Kelton DF, Weese JS, Noble C, Duffield TF. Evaluation of a multispecies probiotic as a supportive treatment for diarrhea in dairy calves: A randomized clinical trial. J Dairy Sci. 2019;102:4498. 10.3168/jds.2018-15793
- Huang L, Chiang Chiau JS, Cheng ML, Chan WT, Jiang CB, et al. SCID/NOD mice model for 5-FU induced intestinal mucositis: Safety and effects of probiotics as therapy. Pediatr Neonatol. 2019;60:252. 10.1016/j.pedneo.2018.07.007
- Shin SY, Park S, Moon JM, Kim K, Kim JW, et al. Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial. J Neurogastroenterol Motil. 2022;28:642. 10.5056/jnm21202
- Shen SR, Chen WJ, Chu HF, Wu SH, Wang YR, et al. Amelioration of 5-fluorouracil-induced intestinal mucositis by Streptococcus thermophilus ST4 in a mouse model. PLoS One. 2021;16:e0253540. 10.1371/journal.pone.0253540
- Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, Majsiak E, Bierła JB, et al. The Effectiveness and Safety of Multi-Strain Probiotic Preparation in Patients with Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized Controlled Study. Nutrients. 2021;13. 10.3390/nu13030756
- Kluijfhout S, Trieu TV, Vandenplas Y. Efficacy of the Probiotic Probiotical Confirmed in Acute Gastroenteritis. Pediatr Gastroenterol Hepatol Nutr. 2020;23:464. 10.5223/pghn.2020.23.5.464
- Velasco M, Requena T, Delgado-Iribarren A, Peláez C, Guijarro C. Probiotic Yogurt for the Prevention of Antibiotic-associated Diarrhea in Adults: A Randomized Double-blind Placebo-controlled Trial. J Clin Gastroenterol. 2019;53:717. 10.1097/MCG.0000000000001131
- Levit R, Savoy de Giori G, de Moreno de LeBlanc A, LeBlanc JG. Folate-producing lactic acid bacteria reduce inflammation in mice with induced intestinal mucositis. J Appl Microbiol. 2018;125:1494. 10.1111/jam.14038
- Zhou H, Li S, Chen Y, Zhang Q, Bai X, et al. Evaluation of Streptococcus thermophilus IFFI 6038 Microcapsules Prepared Using an Ultra-fine Particle Processing System. AAPS PharmSciTech. 2018;19:1020. 10.1208/s12249-017-0907-x
- Feng JR, Wang F, Qiu X, McFarland LV, Chen PF, et al. Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Eur J Clin Pharmacol. 2017;73:1199. 10.1007/s00228-017-2291-6
- Yoon H, Park YS, Lee DH, Seo JG, Shin CM, et al. Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Biochem Nutr. 2015;57:129. 10.3164/jcbn.15-14
- Ringel-Kulka T, Kotch JB, Jensen ET, Savage E, Weber DJ. Randomized, double-blind, placebo-controlled study of synbiotic yogurt effect on the health of children. J Pediatr. 2015;166:1475. 10.1016/j.jpeds.2015.02.038
- Ivakhnenko ES, Nian'kovskiĭ SL. [Effect of probiotics on the dynamics of gastrointestinal symptoms of food allergy to cow's milk protein in infants]. Georgian Med News. 2013. PubMed
- Kolling GL, Wu M, Warren CA, Durmaz E, Klaenhammer TR, et al. Lactic acid production by Streptococcus thermophilus alters Clostridium difficile infection and in vitro Toxin A production. Gut Microbes. 2012;3:523. 10.4161/gmic.21757
- Ki Cha B, Mun Jung S, Hwan Choi C, Song ID, Woong Lee H, et al. The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Gastroenterol. 2012;46:220. 10.1097/MCG.0b013e31823712b1
