Last update
8/22/2025

Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%

Top Medical Research Studies

We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.

We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.

Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.

We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
9
Vitamin D3 derivatives improve cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.

Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.

Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
Vitamin D's potential in CRC
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).

Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.

We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More

Most Useful Reviews

7.5
Positive results noted
This calcium supplement has proven effective with a good combination of vitamin D3. I purchased it for a friend's parents dealing with cancer, relying on positive reviews from cancer patients' forums. The packaging is great and priced reasonably. There has already been noticeable improvement after taking it, so I highly recommend it!
Read More
7.5
Doctor-recommended approach
My mother, after thyroid cancer, must continuously take calcium. This form and dosage were prescribed by her doctor, and she is pleased with the results. It helps with muscle spasms, but we strictly follow the doctor's advice.
Read More
6
Gentle absorption
Citrate calcium is what I chose for my mother, given her age and previous cancer. After 50, calcium is crucial, and this form is gently absorbed where needed. I am satisfied with the product and noted no side effects.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.3
  • All Researches
9
Vitamin D3 derivatives improve cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.

Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.

Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.

We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.

Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.

We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
8
Vitamin D's potential in CRC
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).

Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.

We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More
8
Vitamin D3 enhances glioma treatment
We developed an innovative treatment approach using a special type of nanoplatform that combines vitamin D3 with neutrophil membranes and chemotherapy medication doxorubicin. This platform was specifically designed to target glioblastoma, which is known as one of the most aggressive and challenging brain cancers.

Not only did we find that this treatment method was effective in delivering chemotherapy and promoting cell death in tumor cells, but we also observed that it significantly boosted the immune response against cancer. The combination activated a specific immune pathway, leading to increased production of important signaling molecules that can help fight tumors. This resulted in a shift from an immune-resistant environment to one more responsive to treatment, encouraging immune cells to attack the cancer more effectively.

Overall, the use of vitamin D3 in this multimodal strategy shows great promise for enhancing cancer therapy, opening the door for further exploration into its potential for improving glioma treatment outcomes and possibly developing more effective immune therapies.
Read More
8
Vitamin D3 improves nutritional status
We assessed the effects of vitamin D3 supplementation in women newly diagnosed with breast cancer, focusing on how it can enhance nutritional health. In a randomized controlled trial, 88 women were split into four groups to receive either omega-3 fatty acids, vitamin D3, both, or none at all.

Over nine weeks, we noticed that those who took daily omega-3s and weekly vitamin D3 showed notable improvements in their nutritional status. We used various tools—including self-assessments and blood tests—to gauge changes. The results indicated better dietary intake, higher blood albumin levels, and improved subjective assessments of their overall nutrition in those who received supplementation.

Although vitamin D3 was part of the combination therapy with omega-3, it contributed positively to the participants' health during active cancer treatment. Thus, supplementing with vitamin D3 appears to be a beneficial strategy in managing the nutritional challenges faced by women undergoing treatment for breast cancer.
Read More

User Reviews

USERS' SCORE
Good
Based on 4 Reviews
8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Positive results noted
This calcium supplement has proven effective with a good combination of vitamin D3. I purchased it for a friend's parents dealing with cancer, relying on positive reviews from cancer patients' forums. The packaging is great and priced reasonably. There has already been noticeable improvement after taking it, so I highly recommend it!
Read More
7.5
Doctor-recommended approach
My mother, after thyroid cancer, must continuously take calcium. This form and dosage were prescribed by her doctor, and she is pleased with the results. It helps with muscle spasms, but we strictly follow the doctor's advice.
Read More
6
Gentle absorption
Citrate calcium is what I chose for my mother, given her age and previous cancer. After 50, calcium is crucial, and this form is gently absorbed where needed. I am satisfied with the product and noted no side effects.
Read More
6
Vital calcium support
I ordered this supplement for my father, who has been battling cancer for a long time, and maintaining calcium levels is crucial for him. I am pleased with the high dosage and the easy absorption of calcium citrate, especially important in case of deficiency.
Read More

Frequently Asked Questions

7.5
Positive results noted
This calcium supplement has proven effective with a good combination of vitamin D3. I purchased it for a friend's parents dealing with cancer, relying on positive reviews from cancer patients' forums. The packaging is great and priced reasonably. There has already been noticeable improvement after taking it, so I highly recommend it!
7.5
Doctor-recommended approach
My mother, after thyroid cancer, must continuously take calcium. This form and dosage were prescribed by her doctor, and she is pleased with the results. It helps with muscle spasms, but we strictly follow the doctor's advice.
6
Vital calcium support
I ordered this supplement for my father, who has been battling cancer for a long time, and maintaining calcium levels is crucial for him. I am pleased with the high dosage and the easy absorption of calcium citrate, especially important in case of deficiency.
6
Gentle absorption
Citrate calcium is what I chose for my mother, given her age and previous cancer. After 50, calcium is crucial, and this form is gently absorbed where needed. I am satisfied with the product and noted no side effects.
8
Vitamin D's potential in CRC
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).

Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.

We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.

We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.

Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.

We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
8
Vitamin D3 improves nutritional status
We assessed the effects of vitamin D3 supplementation in women newly diagnosed with breast cancer, focusing on how it can enhance nutritional health. In a randomized controlled trial, 88 women were split into four groups to receive either omega-3 fatty acids, vitamin D3, both, or none at all.

Over nine weeks, we noticed that those who took daily omega-3s and weekly vitamin D3 showed notable improvements in their nutritional status. We used various tools—including self-assessments and blood tests—to gauge changes. The results indicated better dietary intake, higher blood albumin levels, and improved subjective assessments of their overall nutrition in those who received supplementation.

Although vitamin D3 was part of the combination therapy with omega-3, it contributed positively to the participants' health during active cancer treatment. Thus, supplementing with vitamin D3 appears to be a beneficial strategy in managing the nutritional challenges faced by women undergoing treatment for breast cancer.
7
Vitamin D3 contributes to cancer treatment
We explored the potential of vitamin D3 as part of a treatment combination with curcumin, examining its effects on human osteosarcoma cells. The study involved using calcium phosphate materials loaded with both curcumin and vitamin D3, which were then tested in a specific 3D-printed format designed to promote bone health.

Our observations indicated that as part of this combination, vitamin D3 plays a supportive role. We found that using these loaded materials improved the survival of bone-forming cells (osteoblasts) over an 11-day period. Additionally, the combination treatment significantly increased new bone formation when compared to control groups.

However, it's important to note that the study's focus on the dual impact of curcumin and vitamin D3 limits our ability to assess the isolated effects of vitamin D3 alone. The results showed a decrease in the proliferation of osteosarcoma cells, highlighting the potential anti-cancer properties of the treatment combination. Yet, these findings suggest that while vitamin D3 contributes positively, more research is needed to fully understand its effectiveness on its own.

References

  1. Xu N, Lin H, Ding X, Wang P, Lin JM. Isotope tracing-assisted chip-based solid-phase extraction mass spectrometry for monitoring metabolic changes and vitamin D3 regulation in cells. Talanta. 2025;288:127754. 10.1016/j.talanta.2025.127754
  2. Jo Y, Kushram P, Bose S. Curcumin and vitamin D3 release from calcium phosphate enhances bone regeneration. Biomater Sci. 2025. 10.1039/d4bm01188k
  3. Ezcurra-Hualde M, Zalba S, Bella Á, Arrizabalaga L, Risson A, et al. Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth. Front Immunol. 2025;16:1529007. 10.3389/fimmu.2025.1529007
  4. Wang L, Xu R, Wang M, Wang M, Su S, et al. Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors. Onco Targets Ther. 2025;18:129. 10.2147/OTT.S495066
  5. Evans H, Greenhough A, Perry L, Lasanta G, Gonzalez CM, et al. Hypoxia Compromises the Differentiation of Human Osteosarcoma Cells to CAR-R, a Hydroxylated Derivative of Lithocholic Acid and Potent Agonist of the Vitamin D Receptor. Int J Mol Sci. 2025;26. 10.3390/ijms26010365
  6. Kittaka A. Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities. Chem Pharm Bull (Tokyo). 2025;73:1. 10.1248/cpb.c24-00598
  7. He W, Lv W, Liu L, Gong Y, Song K, et al. Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform. ACS Nano. 2024;18:35559. 10.1021/acsnano.4c13470
  8. Almassri HF, Abdul Kadir A, Srour M, Foo LH. The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial. Nutrients. 2024;16. 10.3390/nu16223960
  9. Maturana-Ramiìrez A, Aitken-Saavedra J, Rojas-Zúñiga G, Rojas-Alcayaga G, Espinoza-Santander I, et al. Hypovitaminosis D in patients with oral squamous cell carcinoma: Is a risk factor of developing this neoplasia?. Med Oral Patol Oral Cir Bucal. 2025;30:e24. 10.4317/medoral.26692
  10. Almassri HF, Abdul Kadir A, Srour M, Foo LH. The effects of Omega-3 fatty acids and vitamin D supplementation on the quality of life and blood inflammation markers in newly diagnosed breast cancer women: An open-labelled randomised controlled trial. Clin Nutr ESPEN. 2025;65:64. 10.1016/j.clnesp.2024.11.014
  11. García-Martínez JM, Chocarro-Calvo A, Martínez-Useros J, Regueira-Acebedo N, Fernández-Aceñero MJ, et al. SIRT1 Mediates the Antagonism of Wnt/β-Catenin Pathway by Vitamin D in Colon Carcinoma Cells. Int J Biol Sci. 2024;20:5495. 10.7150/ijbs.95875
  12. Barauskaitė-Šarkinienė N, Novickij V, Šatkauskas S, Ruzgys P. Investigation of the Bystander Effect on Cell Viability After Application of Combined Electroporation-Based Methods. Int J Mol Sci. 2025;26. 10.3390/ijms26052297
  13. Sun L, Lin X, Li N, Zhang Q, Jiang Y, et al. Effects of vitamin D and calcium supplementation on bone of young adults after thyroidectomy of differentiated thyroid carcinoma. Endocrine. 2025. 10.1007/s12020-025-04195-x
  14. Morris K, Masri S, Schnoor B, Papa AL. Calcium levels modulate platelet function, platelet-cancer cell interaction, and cancer cell invasion. Sci Rep. 2025;15:7750. 10.1038/s41598-024-79280-8
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