21st Century B 100 Complex Prolonged Release

Niacin helps alleviate anxiety symptoms

Based on 7 Researches

Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. doi:10.1016/j.exger.2024.112624

We examined the impact of Niacin on anxiety and memory loss caused by aging in a rat study. Rats were grouped and treated with various doses of Niacin and D-galactose for 14 days, followed by behavioral tests to assess anxiety and memory.

Our results showed that Niacin significantly reduced anxiety-like symptoms and improved memory deficits. Additionally, it mitigated factors like oxidative stress and inflammation, enhancing brain health. Overall, Niacin's antioxidant and neuro-modulatory properties suggest it may be beneficial in addressing aging-related psychiatric issues.

Life-changing peace

Most Useful Review

25 people found this helpful

This is the BEST HELP for the Neurotic! Super! I had depression and anxiety-depressive disorder, with a sensation of constant alarm for 10 years. However, after taking a pill, I felt peace for the first time in a decade, transforming my life immediately. I shed the fears that had tormented me for years. Although I had relied on tranquilizers for calmness, now, my friends also use this remedy. It's a shame I didn't discover it earlier; this is REAL HELP. I ADVISE EVERYONE!

Bone Pain details

Carnitine aids bone pain relief

Tabei SM, Mazloom M, Shahriari M, Zareifar S, Azimi A, et al. Determining and surveying the role of carnitine and folic acid to decrease fatigue in β-thalassemia minor subjects. Pediatr Hematol Oncol. 2013;30:742. doi:10.3109/08880018.2013.771388

We examined the potential benefits of carnitine and folic acid in reducing bone pain and fatigue in patients with beta-thalassemia minor. Over three months, 73 participants received either carnitine alone, a combination of carnitine and folic acid, or folic acid alone, while a control group went without supplementation.

Our results showed that carnitine significantly improved plasma levels and reduced bone pain and muscle weakness for those affected by this condition. Although folic acid improved red blood cell levels, its impact on bone pain was not directly highlighted. Overall, our findings suggest that carnitine can be beneficial in addressing bone pain in these patients.

Relieved pain

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3 people found this helpful

The wand is a lifesaver! During my second trimester of pregnancy, I had bone pain due to a pinched sciatic nerve. My gynaecologist recommended B vitamins, and after just four days, I no longer felt any pain. Although I used a different brand afterward, this complex is more effective. If my review was helpful, click Like.

Leg Cramps details

Vitamin B complex effective for cramps

Based on 2 Researches

Chan P, Huang TY, Chen YJ, Huang WP, Liu YC. Randomized, double-blind, placebo-controlled study of the safety and efficacy of vitamin B complex in the treatment of nocturnal leg cramps in elderly patients with hypertension. J Clin Pharmacol. 1998;38:1151.

We conducted a randomized, double-blind study to see if vitamin B complex could help older adults with nighttime leg cramps. Over three months, participants reported their cramp frequency and intensity.

The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.

Cramps stopped

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1 people found this helpful

I ordered a set from this company for testing. After a month of taking it, I noticed improvements. I became much calmer, more balanced, full of energy, and leg cramps no longer bothered me. The small tablets are easy to take. I recommend!

Ulcer details

Benfotiamine improves ulcer healing

Based on 7 Researches

Shokati Sayyad M, Khanjani MH, Amirbeik M, Seyedabadi M, Talebpour Amiri F, et al. The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study. J Mol Histol. 2024;55:863. doi:10.1007/s10735-024-10237-x

We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.

Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.

However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.

Immediate relief noted

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2 people found this helpful

GOOD for mouth ulcers! After a vitamin-deficient holiday period, I had a mouth ulcer. I took it immediately, recalling I bought the B-100 from iHerb. Drinking in the morning made the inflammation subside by night. I was surprised by the immediate effect! This continuous release type is highly effective and recommended as a regular remedy.

Chronic Cough details

Calms nervousness effectively

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1 people found this helpful

Excellent! The B vitamins in this complex have been perfect for helping me calm down after a busy day and ensuring a good night's sleep. Just one tablet at night works wonders. I take them periodically, and they significantly alleviate chronic fatigue and nervousness.

Depression details

Vitamin B may alleviate depression symptoms

Based on 12 Researches

Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. doi:10.12182/20250160608

Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.

We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.

The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.

7.5

Alleviated symptoms

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31 people found this helpful

I use it to relieve depression. I was feeling quite unwell when I discovered the impact of B vitamins online, prompting me to start taking them. As they are water-soluble, I noticed their effect relatively quickly. I believe the symptom has improved. If this is beneficial for you, I hope you appreciate it. Thank you.

Heart Disease details

Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. doi:10.1016/j.ejphar.2025.177413

Based on 5 Researches

VB6 helps heart recovery post-AMI

We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.

Reduces fatigue

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5 people found this helpful

This time-release vitamin B is excellent and surprisingly affordable. I felt the effects the day after starting the supplement! I no longer experience mid-day sleepiness, which has significantly helped me during the day. Prior to this, I tried another vitamin B that wasn't time-released, but its effectiveness paled in comparison. This product has truly worked wonders!

Pelvic Pain details

Gokhale LB. Curative treatment of primary (spasmodic) dysmenorrhoea. Indian J Med Res. 1996;103:227.

Based on 4 Researches

Vitamin B1 shows promising results

We assessed how effective oral vitamin B1 could be in treating primary dysmenorrhea, which causes significant pelvic pain in young women. In a robust study involving 556 participants aged 12-21 years, we administered 100 mg of vitamin B1 daily for 90 days.

The results were promising, with 87% of participants reportedly completely cured, while 8% experienced some relief. Notably, these positive outcomes persisted for two months after treatment ended, showcasing vitamin B1 as a safe and cost-effective approach to address the root cause of pelvic pain.

Improved emotional state

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3 people found this helpful

I ordered these vitamins for my husband after a neurologist recommended a B vitamin complex. He had complaints about back pain, leg issues and numbness in his hands. Our relationship was strained due to his emotional state. However, after a week on these vitamins, his emotional swings subsided, and I noticed a significant improvement. The doctor confirmed that the vitamins enhanced his psychological well-being. This product is excellent, and I hope it becomes available again soon. I highly recommend it.

Rash details

Adie MA, Martes Gomez M, Yom J, Durand M, Wertheimer F, et al. Twin Premature Infants With Riboflavin and Biotin Deficiency Presenting With Refractory Lactic Acidosis, Rash, and Multiorgan Failure During Prolonged Parenteral Nutrition. J Investig Med High Impact Case Rep. 2023;11:23247096231168111. doi:10.1177/23247096231168111

Likely Very Effective

Based on 2 Researches

Vitamin B deficiency leads to rash

We explored the effects of riboflavin and biotin deficiencies in premature twins, who initially presented with skin rashes among other severe symptoms. After being diagnosed, one twin began supplementation with these vitamins.

Remarkably, this led to a quick improvement in clinical condition and laboratory findings within days. Though one twin experienced tragic complications resulting in death, the surviving twin went home in stable condition, highlighting the importance of addressing vitamin deficiencies early.

No more rashes

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1 people found this helpful

I've already purchased this vitamin B complex for the second time, indicating my satisfaction with its effects. It provides energy and vitality, and I've started getting sufficient sleep, waking up early without issues. The few rashes I had on my skin have disappeared. Additionally, my hair has stopped falling out, and I've noticed a lot of new growth. I highly recommend it!

We examined a new strain derived from the human microbiome, Cicaria, to see how it helps with hair loss. Through testing on individuals with hair loss and comparing them to a control group with normal scalps, we found that Cicaria produced key compounds like adenosine and biotin. Notably, hair follicles treated with these elements displayed longer lengths and maintained healthier root diameters. Furthermore, these treatments appeared to support the phases of hair growth, slowing the transition to hair loss. Thus, Cicaria shows potential as a treatment for hair loss.

Hair recovery noted

Most Useful Review

I purchased this B vitamin complex for my hair loss concerns. Prior to this, I solely relied on biotin. This complex, enriched with zinc, has worked wonders; my hair shedding has normalised, and the overall appearance has improved, now looking stronger and livelier.

Cold details

Best as always. I have been using it for years and have never caught a cold or infection! I highly recommend it.

Back Pain details

Vitamin B12 effectively reduces pain

Based on 14 Researches

Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4:53.

We sought to understand how intramuscular vitamin B12 could help alleviate low back pain in patients with mechanical lumbago. In a rigorous study involving 60 participants, we compared the effects of vitamin B12 to a placebo.

Our findings indicated that those receiving the vitamin reported significantly less pain and disability, as measured by a visual scale and disability questionnaire. Notably, those on vitamin B12 also used less paracetamol than the placebo group.

Overall, our study confirmed that vitamin B12 can be effective for treating low back pain without nutritional deficiency.

Back pain gone

Most Useful Review

An excellent vitamin B complex with long-term release and proper dosages for each component. After a week of taking it, my back pain completely went away.

Headache details

Pediatric migraine treatment with riboflavin

Based on 15 Researches

Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. doi:10.1016/j.pediatrneurol.2020.09.009

Our examination focused on the effectiveness of riboflavin, a form of Vitamin B2, in treating migraines in children and adolescents aged six to 18. We conducted a retrospective observational study involving 42 patients, where we measured the frequency, intensity, and duration of their headaches.

Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.

Headaches relieved

Most Useful Review

I was impressed by the quality and price of these B vitamins. They alleviated my headaches and improved my motor skills and concentration. I will definitely order more.

Liver Disease details

Methylcobalamin protects against liver failure

Based on 4 Researches

Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. doi:10.1038/s41467-024-54826-6

We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.

In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.

Mouth disease improvement

Most Useful Review

After taking this product daily for several months, I noticed a significant improvement. When I felt exhausted, I often suffered from mouth sores, but since taking this high-dose formulation, those issues have almost entirely resolved. I plan to continue using it.

Sleep Apnea details

1 people found this helpful

This well-balanced complex of B vitamins greatly improved my sleep. I found that I stopped hearing the alarm in the morning, as I was able to wake up without it. Although I never had sleep issues, I experienced a minor side effect that lasted about a month after I stopped taking them. For those who struggle with falling asleep, this could be beneficial. I also no longer lay in bed feeling tired; during the day, I felt alert and energised.

Autoimmune Disorder details

Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4

Based on 5 Researches

USERS' SCORE

Good

Based on 9 Reviews

Pernicious anemia case in Uganda

We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.

Real help

Most Useful Review

25 people found this helpful

This is the BEST HELP for the neurotic! Having struggled with depression and anxiety-depressive disorder for a decade, I felt an overwhelming sense of calm after taking this pill. It transformed my life almost immediately, alleviating fears that had tormented me. After consuming it for two months and now on a break, I am grateful for this discovery, which I wish I had known about sooner. It truly provides real help. I recommend it to everyone!

Chronic Fatigue Syndrome details

B12 and folic acid show variability

Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. doi:10.1371/journal.pone.0124648

We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.

Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.

However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.

Significant improvement noted

Most Useful Review

2 people found this helpful

I started taking the Vital B Complete Complex as I was perpetually exhausted and needed an energy boost. After just one week, I felt significantly more alert and less fatigued. My mood has stabilised, likely thanks to the B vitamins supporting my nervous system.

Brain Tumor details

Pyridoxine promotes glioblastoma cell death

Based on 2 Researches

Martínez-Mendiola CA, Estrada JA, Zapi-Colín LÁ, Contreras-Chávez GG, Contreras I. Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line. Int J Neurosci. 2024;134:1320. doi:10.1080/00207454.2023.2263815

We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.

Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.

Life restoration

Most Useful Review

4 people found this helpful

Life-changing! I have tried every type of B12 vitamin available, including injectable, designer prescription, and compounded forms, but this is the only one that works for me. The quality and ingredients are excellent. Although I’m not one to pen reviews, this supplement has transformed my life. I went from struggling to get through the day due to relentless fatigue to actively engaging in life again with full energy. The brain fog has disappeared, and so have the pins and needles. Not to sound clichéd, but I finally feel like I have my life back.

High Cholesterol details

Niacin reduces cholesterol and oxidative stress

Based on 10 Researches

Hamoud S, Kaplan M, Meilin E, Hassan A, Torgovicky R, et al. Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol. Am J Med Sci. 2013;345:195. doi:10.1097/MAJ.0b013e3182548c28

We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.

The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.

7.5

Enhanced energy levels

Most Useful Review

1 people found this helpful

The composition is good with fast delivery, high quality, and convenient packaging. The capsules are somewhat large but easy to swallow, with a citrus taste that I enjoy. I take one daily as a supplement alongside vitamin D3+K2, magnesium, and vitamin B6. Within ten days, I've noticed substantial benefits; my energy levels have improved significantly, headaches have disappeared, and my mood is consistently excellent. I also recommend it for individuals involved in sports, fitness, or those on a specific diet. Omega-3 truly revitalises and replenishes what the body needs.

Acne details

Panthenol mask improves skin barrier

Likely Very Effective

Zhang X, Tao H, Deng Y, He X, Zhang Z, et al. Efficacy and safety of a panthenol-enriched mask for individuals with distinct impaired skin barrier subtypes. J Cosmet Dermatol. 2024;23:2109. doi:10.1111/jocd.16231

We aimed to evaluate how a panthenol-enriched mask, specifically La Roche-Posay Mask Pro, performs in improving skin barriers for different types, such as dry sensitive, oily sensitive, and oily acne-prone skin.

Over 177 participants used the mask under guidance, and we measured factors like hydration, sebum content, and redness at multiple intervals.

The results showed significant improvements across all skin types, particularly for oily acne skin, which saw reductions in sebum and redness. Importantly, there were no adverse effects reported, indicating that this mask can be a trusty companion for those with various skin concerns.

Dermatologist recommended

Most Useful Review

This product was recommended by my dermatologist as part of a comprehensive therapy for treating acne.

Cardiovascular Disease details

Effective cold prevention

Based on 5 Researches

Vitamin B6 aids heart recovery

We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.

Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.

7.5

Boosts energy levels

Most Useful Review

1 people found this helpful

B100 has been transformative for my energy levels and overall vitality. This powerful B-vitamin supplement made a significant difference in my daily life, particularly by alleviating negative side effects after two years of chemotherapy. B100 acts like an all-in-one wellness package, supporting multiple bodily functions, including both nervous system and cardiovascular health.

Adenoiditis details

Most Useful Review

I take this when my throat feels peculiar, I feel exhausted, or I sense a cold coming on. Since I've been using it, I've practically stopped catching colds. It has a high vitamin B content, which I believe makes it fairly effective.

Nausea details