' 
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
6
USERS' SCORE
Very Good
Based on 38 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Iron (as Dried Ferrous Sulfate)
45 mg
250%
Top Medical Research Studies
7
Iron's minimal effect on constipation
Low-Dose Prophylactic Oral Iron Supplementation (Ferrous Fumarate, Ferrous Bisglycinate, and Ferrous Sulphate) in Pregnancy Is Not Associated With Clinically Significant Gastrointestinal Complaints: Results From Two Randomized Studies.
Study explores iron and constipation
We explored the effects of low-dose iron supplementation on gastrointestinal complaints, particularly constipation, in pregnant women. Conducting two randomized studies, we aimed to determine how different forms of iron—ferrous fumarate, ferrous bisglycinate, and ferrous sulphate—would affect the frequency of GI issues among healthy women throughout their pregnancy.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
Read More
7
Lactoferrin aids iron-deficiency anemia
Lactoferrin as treatment for iron-deficiency anemia in children: a systematic review.
Study supports lactoferrin benefits
We carefully looked at the impact of lactoferrin (Lf) on treating iron deficiency anemia (IDA) in children, especially focusing on its connection to constipation. In an extensive review of 11 studies, including 10 randomized controlled trials, we saw promising results where children receiving Lf showed notable improvements in their hemoglobin and serum ferritin levels compared to those who only received iron or a placebo.
Interestingly, we found that while some adverse effects like constipation, vomiting, and abdominal pain were reported, those treated with Lf experienced a significant decrease in constipation. This suggests that Lf not only helps in boosting iron levels but may also be easier on the digestive system than traditional iron supplements.
Overall, our exploration indicates that incorporating lactoferrin in the treatment of IDA in children not only helps address anemia effectively but also might provide a gentler alternative for the gut. Users considering iron supplements for their children might find lactoferrin to be a beneficial option.
Interestingly, we found that while some adverse effects like constipation, vomiting, and abdominal pain were reported, those treated with Lf experienced a significant decrease in constipation. This suggests that Lf not only helps in boosting iron levels but may also be easier on the digestive system than traditional iron supplements.
Overall, our exploration indicates that incorporating lactoferrin in the treatment of IDA in children not only helps address anemia effectively but also might provide a gentler alternative for the gut. Users considering iron supplements for their children might find lactoferrin to be a beneficial option.
Read More
4
Iron supplementation effects on constipation
Efficacy of daily versus intermittent oral iron supplementation for prevention of anaemia among pregnant women: a systematic review and meta-analysis.
Impact on constipation noted
We examined how different types of iron supplementation affect pregnant women, particularly focusing on potential constipation as a side effect. In a systematic review and meta-analysis, we gathered data from 26 studies involving nearly 4,400 participants to compare daily and intermittent iron supplementation.
Interestingly, we found that daily oral iron supplementation was associated with a higher occurrence of constipation compared to intermittent supplementation. The adjusted odds ratio for constipation was 1.95, indicating a nearly two-fold increase in risk for those taking daily iron. However, our analysis revealed that both daily and intermittent iron supplements could increase hemoglobin levels effectively, showing no significant difference in overall efficacy.
Ultimately, while daily iron supplementation led to better ferritin levels, women experienced more adverse effects such as nausea, diarrhea, and constipation. This suggests that intermittent iron supplementation could be a more favorable option, especially for those who are sensitive to the side effects associated with daily doses.
Interestingly, we found that daily oral iron supplementation was associated with a higher occurrence of constipation compared to intermittent supplementation. The adjusted odds ratio for constipation was 1.95, indicating a nearly two-fold increase in risk for those taking daily iron. However, our analysis revealed that both daily and intermittent iron supplements could increase hemoglobin levels effectively, showing no significant difference in overall efficacy.
Ultimately, while daily iron supplementation led to better ferritin levels, women experienced more adverse effects such as nausea, diarrhea, and constipation. This suggests that intermittent iron supplementation could be a more favorable option, especially for those who are sensitive to the side effects associated with daily doses.
Read More
Most Useful Reviews
0
Stomach upset
This product did not suit me. My husband and I switched from heme iron to try this time-release variant after reading reviews. I’ve only taken it for a short while but experienced stomach upset and constipation. I will return to heme iron due to my concerns over gastrointestinal side effects.
Read More
9.5
No constipation!
I’ve noticed improvements in my energy, especially during menstruation, and I’ve not experienced any constipation, unlike with other iron supplements. The small size of the tablets makes them easy to take.
Read More
9.3
No stomach issues
I appreciate that this iron doesn't irritate my gastrointestinal tract as other domestic options did. The small tablets are easy to swallow. Regular intake is key, but avoid certain foods and supplements that can inhibit absorption. Be cautious about overdosing, as too much iron can lead to health issues.
Read More
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
6
7
Iron's minimal effect on constipation
Low-Dose Prophylactic Oral Iron Supplementation (Ferrous Fumarate, Ferrous Bisglycinate, and Ferrous Sulphate) in Pregnancy Is Not Associated With Clinically Significant Gastrointestinal Complaints: Results From Two Randomized Studies.
Study explores iron and constipation
We explored the effects of low-dose iron supplementation on gastrointestinal complaints, particularly constipation, in pregnant women. Conducting two randomized studies, we aimed to determine how different forms of iron—ferrous fumarate, ferrous bisglycinate, and ferrous sulphate—would affect the frequency of GI issues among healthy women throughout their pregnancy.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
Read More
7
Lactoferrin aids iron-deficiency anemia
Lactoferrin as treatment for iron-deficiency anemia in children: a systematic review.
Study supports lactoferrin benefits
We carefully looked at the impact of lactoferrin (Lf) on treating iron deficiency anemia (IDA) in children, especially focusing on its connection to constipation. In an extensive review of 11 studies, including 10 randomized controlled trials, we saw promising results where children receiving Lf showed notable improvements in their hemoglobin and serum ferritin levels compared to those who only received iron or a placebo.
Interestingly, we found that while some adverse effects like constipation, vomiting, and abdominal pain were reported, those treated with Lf experienced a significant decrease in constipation. This suggests that Lf not only helps in boosting iron levels but may also be easier on the digestive system than traditional iron supplements.
Overall, our exploration indicates that incorporating lactoferrin in the treatment of IDA in children not only helps address anemia effectively but also might provide a gentler alternative for the gut. Users considering iron supplements for their children might find lactoferrin to be a beneficial option.
Interestingly, we found that while some adverse effects like constipation, vomiting, and abdominal pain were reported, those treated with Lf experienced a significant decrease in constipation. This suggests that Lf not only helps in boosting iron levels but may also be easier on the digestive system than traditional iron supplements.
Overall, our exploration indicates that incorporating lactoferrin in the treatment of IDA in children not only helps address anemia effectively but also might provide a gentler alternative for the gut. Users considering iron supplements for their children might find lactoferrin to be a beneficial option.
Read More
4
Iron supplementation effects on constipation
Efficacy of daily versus intermittent oral iron supplementation for prevention of anaemia among pregnant women: a systematic review and meta-analysis.
Impact on constipation noted
We examined how different types of iron supplementation affect pregnant women, particularly focusing on potential constipation as a side effect. In a systematic review and meta-analysis, we gathered data from 26 studies involving nearly 4,400 participants to compare daily and intermittent iron supplementation.
Interestingly, we found that daily oral iron supplementation was associated with a higher occurrence of constipation compared to intermittent supplementation. The adjusted odds ratio for constipation was 1.95, indicating a nearly two-fold increase in risk for those taking daily iron. However, our analysis revealed that both daily and intermittent iron supplements could increase hemoglobin levels effectively, showing no significant difference in overall efficacy.
Ultimately, while daily iron supplementation led to better ferritin levels, women experienced more adverse effects such as nausea, diarrhea, and constipation. This suggests that intermittent iron supplementation could be a more favorable option, especially for those who are sensitive to the side effects associated with daily doses.
Interestingly, we found that daily oral iron supplementation was associated with a higher occurrence of constipation compared to intermittent supplementation. The adjusted odds ratio for constipation was 1.95, indicating a nearly two-fold increase in risk for those taking daily iron. However, our analysis revealed that both daily and intermittent iron supplements could increase hemoglobin levels effectively, showing no significant difference in overall efficacy.
Ultimately, while daily iron supplementation led to better ferritin levels, women experienced more adverse effects such as nausea, diarrhea, and constipation. This suggests that intermittent iron supplementation could be a more favorable option, especially for those who are sensitive to the side effects associated with daily doses.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 38 Reviews
7.7
9.5
No constipation!
I’ve noticed improvements in my energy, especially during menstruation, and I’ve not experienced any constipation, unlike with other iron supplements. The small size of the tablets makes them easy to take.
9.5
Avoids constipation
This vitamin has been fantastic for me. Its slow-release formulation means I don't suffer from constipation, which I experienced with other iron pills.
9.5
Helpful for anemia
I tried this product for my daughter’s anaemia, as we both experienced side effects like nausea and constipation from other irons. It’s worked well for her, and I’m thankful for it.
9.5
No GI problems
The slow-release iron from iHerb is reasonably priced and does not cause stomach issues or constipation.
9.5
No constipation experienced
For the first time, I haven’t experienced constipation with iron supplements! I believe this is due to the slow release of the iron, and I’m looking forward to continuing with it.
