Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%
Top Medical Research Studies
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Read More
7
We investigated the impact of folic acid (FA) on anxiety and ovarian function in female mice exposed to radiation. By dividing the mice into groups treated with FA and others that weren’t, we observed that those receiving FA showed significantly reduced anxiety levels alongside improvements in ovarian health. The findings highlighted that FA not only supports reproductive performance by preserving ovarian function but may also help manage emotional symptoms linked to radiation exposure. This suggests that folic acid could be a beneficial aid for women undergoing radiation therapy.
Read More
7
We examined the effects of long-term folic acid treatment on chronic inflammatory pain and associated anxiety in rats. By injecting adjuvant into the rats’ hindpaw, we created a model to study pain behavior. Our findings showed that folic acid effectively reduced expressions of MMP2, a protein linked to inflammation, resulting in significant pain relief and lowering anxiety levels among the subjects. Overall, this study suggests that folic acid could be a beneficial treatment option for chronic inflammatory pain coupled with anxiety.
Read More
Most Useful Reviews
9
Healthier mood
100 people found this helpful
I've been using this vitamin for six months, and it has honestly transformed my life. I can work longer hours and feel healthier overall. I’m not frequently ill now, which is crucial for workplace health. My mood has also vastly improved; I experience no more anxiety!
Read More
9
Improved mood
90 people found this helpful
Excellent! I previously struggled with both depression and anxiety, but everything changed when I started taking this. I can't express how much my daily feelings have transformed! My quality of life has significantly improved, and my mood is continually uplifting. I adore this product; it truly has been a lifesaver for me.
Read More
9
Subdued anxiety
Good purchase! This has been worth it; my hair shines, my acne has improved tremendously, and I’ve not had any new breakouts since starting it. My mood has enhanced significantly, and my mind feels clearer while my anxiety has notably subsided. I just wish I had discovered this sooner!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
- All Researches
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Read More
8
We explored the effects of chlorzoxazone and folic acid on anxiety and cognitive functions in mice suffering from spinocerebellar ataxia type 3 (SCA3).
By administering these treatments, we found that while both chlorzoxazone and the combination with folic acid improved motor skills, only the combination significantly reduced anxiety and enhanced memory.
This highlights the potential of combination therapies in addressing both cognitive deficits and emotional symptoms associated with this condition.
By administering these treatments, we found that while both chlorzoxazone and the combination with folic acid improved motor skills, only the combination significantly reduced anxiety and enhanced memory.
This highlights the potential of combination therapies in addressing both cognitive deficits and emotional symptoms associated with this condition.
Read More
7
We examined the effects of long-term folic acid treatment on chronic inflammatory pain and associated anxiety in rats. By injecting adjuvant into the rats’ hindpaw, we created a model to study pain behavior. Our findings showed that folic acid effectively reduced expressions of MMP2, a protein linked to inflammation, resulting in significant pain relief and lowering anxiety levels among the subjects. Overall, this study suggests that folic acid could be a beneficial treatment option for chronic inflammatory pain coupled with anxiety.
Read More
7
Folic acid alleviates nicotine withdrawal symptoms
We explored how folic acid (FA) could ease anxiety and depression in adolescent male rats going through nicotine withdrawal.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
Read More
7
We explored how folate supplementation might counteract anxiety-like behaviors caused by prenatal ethanol exposure in rodents. Administering folate alongside ethanol during crucial developmental days showed promising results.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Healthier mood
100 people found this helpful
I've been using this vitamin for six months, and it has honestly transformed my life. I can work longer hours and feel healthier overall. I’m not frequently ill now, which is crucial for workplace health. My mood has also vastly improved; I experience no more anxiety!
Read More
9
Improved mood
90 people found this helpful
Excellent! I previously struggled with both depression and anxiety, but everything changed when I started taking this. I can't express how much my daily feelings have transformed! My quality of life has significantly improved, and my mood is continually uplifting. I adore this product; it truly has been a lifesaver for me.
Read More
9
Subdued anxiety
Good purchase! This has been worth it; my hair shines, my acne has improved tremendously, and I’ve not had any new breakouts since starting it. My mood has enhanced significantly, and my mind feels clearer while my anxiety has notably subsided. I just wish I had discovered this sooner!
Read More
7.5
Stress relief
21 people found this helpful
Excellent essential product! As a specialist, I recommend Frelac as essential for everyone at least once in their life. It plays a fundamental role in brain function and combating various conditions, including reducing anxiety and stress. The product is organic, cost-effective, and worth consulting with a doctor.
Read More
6
Mood improvement
1 people found this helpful
Folic acid is vital for producing red blood cells and is necessary for DNA and RNA synthesis. My colleagues suggested I supplement with folic acid to enhance my mood and manage anxiety.
Read More
Frequently Asked Questions
9
Healthier mood
100 people found this helpful
I've been using this vitamin for six months, and it has honestly transformed my life. I can work longer hours and feel healthier overall. I’m not frequently ill now, which is crucial for workplace health. My mood has also vastly improved; I experience no more anxiety!
9
Improved mood
90 people found this helpful
Excellent! I previously struggled with both depression and anxiety, but everything changed when I started taking this. I can't express how much my daily feelings have transformed! My quality of life has significantly improved, and my mood is continually uplifting. I adore this product; it truly has been a lifesaver for me.
9
Subdued anxiety
Good purchase! This has been worth it; my hair shines, my acne has improved tremendously, and I’ve not had any new breakouts since starting it. My mood has enhanced significantly, and my mind feels clearer while my anxiety has notably subsided. I just wish I had discovered this sooner!
6
Mood improvement
1 people found this helpful
Folic acid is vital for producing red blood cells and is necessary for DNA and RNA synthesis. My colleagues suggested I supplement with folic acid to enhance my mood and manage anxiety.
7.5
Stress relief
21 people found this helpful
Excellent essential product! As a specialist, I recommend Frelac as essential for everyone at least once in their life. It plays a fundamental role in brain function and combating various conditions, including reducing anxiety and stress. The product is organic, cost-effective, and worth consulting with a doctor.
7
We examined the effects of long-term folic acid treatment on chronic inflammatory pain and associated anxiety in rats. By injecting adjuvant into the rats’ hindpaw, we created a model to study pain behavior. Our findings showed that folic acid effectively reduced expressions of MMP2, a protein linked to inflammation, resulting in significant pain relief and lowering anxiety levels among the subjects. Overall, this study suggests that folic acid could be a beneficial treatment option for chronic inflammatory pain coupled with anxiety.
7
Folic acid alleviates nicotine withdrawal symptoms
We explored how folic acid (FA) could ease anxiety and depression in adolescent male rats going through nicotine withdrawal.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
7
We explored how folate supplementation might counteract anxiety-like behaviors caused by prenatal ethanol exposure in rodents. Administering folate alongside ethanol during crucial developmental days showed promising results.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
7
B vitamins linked to mental health
This cross-sectional study explored the connection between B vitamin intake, including folic acid, and anxiety, depression, and stress symptoms in 7,387 Iranian adults.
We found that a higher intake of dietary B vitamins, particularly biotin, was linked with lower rates of these psychological disorders. While moderate folic acid intake showed a potential association with reduced depression symptoms, results were not strong enough to draw definitive conclusions.
This suggests that these nutrients could play a role in mental health, but more research is needed through randomized controlled trials.
We found that a higher intake of dietary B vitamins, particularly biotin, was linked with lower rates of these psychological disorders. While moderate folic acid intake showed a potential association with reduced depression symptoms, results were not strong enough to draw definitive conclusions.
This suggests that these nutrients could play a role in mental health, but more research is needed through randomized controlled trials.
References
- Ni WH, Wang K, Wang Y, Lu J, Lu CT, et al. Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats. Neuropharmacology. 2025;269:110352. 10.1016/j.neuropharm.2025.110352
- Marinina KS, Bezprozvanny IB, Egorova PA. A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice. Hum Mol Genet. 2024;33:1406. 10.1093/hmg/ddae079
- Rezaei Moghadam M, Khoshrou A, Kakhki S, Hosseini SH, Shirinzadeh Feizabadi A, et al. Folic Acid Ameliorates Anxiety- and Depressive-Like Behavior Induced by Nicotine Withdrawal Through Restoration of Behavioral and Biochemical Alterations in Adolescent Male Rats. Nicotine Tob Res. 2024;26:733. 10.1093/ntr/ntad227
- Marengo L, Barey A, Salguero A, Fabio MC, Cendán CM, et al. Neurobehavioral alterations induced by third-trimester gestation-equivalent ethanol exposure are inhibited by folate administration. Dev Psychobiol. 2023;65:e22426. 10.1002/dev.22426
- Kakhki S, Goodarzi M, Abbaszade-Cheragheali A, Rajabi M, Masoumipour AH, et al. Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring. Int J Dev Neurosci. 2023;83:615. 10.1002/jdn.10289
- Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. 10.1016/j.msard.2023.104743
- Zhang Q, Wei Z, Weng H, Chen Y, Zhang J, et al. Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice. Front Nutr. 2022;9:854655. 10.3389/fnut.2022.854655
- Ono T, Hino K, Kimura T, Uchimura Y, Ashihara T, et al. Excessive folic acid intake combined with undernutrition during gestation alters offspring behavior and brain monoamine profiles. Congenit Anom (Kyoto). 2022;62:169. 10.1111/cga.12472
- Zhao T, Wu D, Du J, Liu G, Ji G, et al. Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation. Front Pharmacol. 2022;13:818423. 10.3389/fphar.2022.818423
- Eszlari N, Bruncsics B, Millinghoffer A, Hullam G, Petschner P, et al. Biology of Perseverative Negative Thinking: The Role of Timing and Folate Intake. Nutrients. 2021;13. 10.3390/nu13124396
- Zhang Q, Huang Q, Yao L, Liu W, Ruan J, et al. Gestational Folic Acid Administration Alleviated Maternal Postpartum Emotional and Cognitive Dysfunction in Mice. Front Pharmacol. 2021;12:701009. 10.3389/fphar.2021.701009
- Mahdavifar B, Hosseinzadeh M, Salehi-Abargouei A, Mirzaei M, Vafa M. Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey. J Affect Disord. 2021;288:92. 10.1016/j.jad.2021.03.055
- de Carvalho J, Lerner A, Feingold D. Management of Hyperhomocysteinemia, Low Vitamin Levels, and Low Cortisol in Cannabis Users: A Report of 2 Cases. J Chiropr Med. 2022;21:322. 10.1016/j.jcm.2022.03.001
