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This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
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This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
Following treatment, her blood tests showed consistent improvement, indicating that oral B12 replacement can be an effective management strategy, especially for patients who can’t tolerate injections. This case underscores the importance of genetic testing for accurate diagnoses.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
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Frequently Asked Questions
Anemia is a medical condition characterized by a deficiency of red blood cells or hemoglobin in the blood, which can result in reduced oxygen flow to the body's organs. The most common type of anemia is iron-deficiency anemia, which occurs when the body does not have enough iron to produce adequate hemoglobin. Other types can arise from chronic diseases, genetic conditions, or a lack of certain vitamins such as B12 or folate. Symptoms often include fatigue, weakness, pale skin, and shortness of breath, particularly during physical activity.
Diagnosing anemia typically involves blood tests to measure levels of red blood cells, hemoglobin concentration, and other related factors. Treatment varies depending on the underlying cause but may include dietary changes, supplements, or medications. In some cases, more serious interventions may be necessary, such as blood transfusions or treatments for associated conditions. If you suspect you have anemia, it's essential to consult a healthcare professional for appropriate evaluation and management.
Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a crucial role in several vital functions in the human body. It is essential for red blood cell formation, neurological function, and DNA synthesis. Naturally occurring in animal products, the vitamin can be found in high concentrations in meat, fish, eggs, and dairy, making it particularly important for those following a vegetarian or vegan diet, as plant-based sources of B12 are limited and often require supplementation.
A deficiency in vitamin B12 can lead to serious health issues, including anemia, fatigue, memory problems, and nerve damage. Due to its significance, it's crucial for individuals, particularly those at risk of deficiency, to ensure adequate intake through diet or supplementation. For most adults, the recommended daily allowance (RDA) is around 2.4 micrograms, though pregnant or breastfeeding women may require higher amounts. If you're considering B12 supplements, it's advisable to consult with a healthcare provider to determine the best option for your specific needs and health status.
B12 plays a crucial role in the formation of red blood cells, and a deficiency can lead to a specific type of anemia called pernicious anemia. In this condition, the body lacks sufficient vitamin B12, which is essential for producing healthy red blood cells, resulting in a decreased ability to transport oxygen throughout the body. Symptoms of this type of anemia can include fatigue, weakness, and even neurological issues if left untreated.
Supplementing with B12 can alleviate these symptoms and correct the deficiency, making it an effective part of the treatment plan for those diagnosed with pernicious anemia. However, it's essential to consult with a healthcare professional before starting supplementation, as the specific needs can vary significantly between individuals. They may recommend dietary adjustments or injections depending on the severity of the deficiency and the underlying causes. In sum, while B12 can certainly help with certain types of anemia, addressing the root cause with professional guidance is key for effective treatment.
Based on user reviews, many individuals taking vitamin B12 for anemia report noticeable improvements within a relatively short time frame. For instance, one user mentioned experiencing health benefits and increased energy levels after just two weeks of starting the supplement (Read Review). Another user saw their B12 levels double after 30 days of use, indicating a positive response to the supplementation (Read Review).
However, individual experiences may vary, and some users felt significant changes in their condition within a month, linking this timeframe to resolution of their anemia symptoms. It's important to note that combining vitamin B12 with other nutrients like iron and folic acid may also impact the effectiveness and speed at which results are observed (Read Review). Overall, while many users have reported improvements in energy and anemia-related symptoms as soon as two weeks, a consistent regimen for at least 30 days seems to be common for more significant changes.
This supplement, particularly forms of vitamin B12, is well-supported by scientific research for addressing anemia, especially in cases associated with vitamin B12 deficiency. Studies have shown that vitamin B12 supplementation can significantly improve symptoms and hematological parameters in individuals diagnosed with various types of anemia, including pernicious anemia and megaloblastic anemia. For instance, a case review demonstrated that patients treated with parenteral vitamin B12 exhibited significant neurological and hematological improvements, highlighting the necessity of this vitamin in managing anemia effectively, especially in resource-limited settings [1] [13].
Furthermore, various studies have found that oral supplementation of vitamin B12 can also be effective, with research indicating that oral cyanocobalamin led to substantially improved vitamin B12 levels in patients previously diagnosed with vitamin B12 deficiency [10]. Additionally, a comparison of conventional and innovative formulations of vitamin B12 supplements, such as Sucrosomial vitamin B12, demonstrated superior efficacy in elevating serum B12 levels, making it promising for those who experience malabsorption issues [23]. Collectively, these findings underscore the critical role of vitamin B12 supplementation in effectively managing and treating different forms of anemia.
Based on user reviews, many individuals taking vitamin B12 for anemia report significant improvements in their symptoms, often within a relatively short timeframe. For example, one user noted that after transitioning from a lower dosage to 2500mcg, their anemia resolved, and they even recommended the supplement for neuralgia, reporting reduced pain (Read Review). Others have shared similarly positive experiences, such as a user whose B12 levels spiked significantly after one month, highlighting the effectiveness of this supplement for reversing B12 anemia (Read Review).
Furthermore, users have reported enhancements in overall energy levels and health after beginning supplementation. For instance, one reviewer experienced an energy boost and improved health after just two weeks of use (Read Review). Another user reflected on their experience, linking a marked decrease in fatigue and enhancements in their iron levels to consistent B12 intake (Read Review). While many users have shared success stories, individual results can vary, and it's wise to consult a healthcare provider for personalized advice regarding supplementation.
Users have reported that combining vitamin B12 with other supplements, such as iron and folic acid, can significantly enhance its effectiveness in managing anemia. One user highlighted the importance of taking vitamin B12 alongside these nutrients, stating that it aids in the treatment of anemia and is vital for overall health improvements (Read Review). Many individuals found that while B12 supplementation alone offered benefits, incorporating iron was especially beneficial for addressing deficiencies that lead to anemia, resulting in increased energy levels and improved health (Read Review).
Additionally, users have shared that after starting a regimen that included vitamin B12 and iron, improvements in their anemia symptoms became more pronounced over time. One reviewer noted substantial increases in B12 levels after a month, confirming that a comprehensive approach to supplementation can yield faster and more effective results in reversing symptoms of anemia (Read Review). Overall, the consensus among users suggests that combining vitamin B12 with iron and folic acid not only optimizes treatment outcomes but also promotes a broader spectrum of health benefits.
According to recent studies, the optimal dose for Vitamin B12 supplementation in treating anemia can vary depending on the individual's specific condition and absorption capability. For instance, a case report indicated that patients with pernicious anemia, which severely impairs B12 absorption, benefited significantly from parenteral (injection) treatment. This treatment often involves administering methylcobalamin, a form of B12, with doses tailored based on individual needs. In some instances, oral supplementation at doses around 1000 μg daily has shown remarkable results as well; participants experienced notable increases in their B12 levels and improvements in anemia symptoms within a month ([10]).
Research has highlighted that for those severely deficient in Vitamin B12, higher daily doses, such as 50 μg to 200 μg, may be effective in correcting anemia and stabilizing related health markers ([15]). However, it is crucial to consult with a healthcare provider before starting any supplementation regimen, as they can provide personalized dosing and detailed monitoring based on the individual’s unique health status and needs.
After starting parenteral B12 treatment, we observed significant neurological improvements, underscoring how vital it is to recognize vitamin B12 deficiency as a potential cause of anemia, even when classic symptoms aren't present. This case reminds us to maintain a broad perspective for accurate diagnosis.
Initially presenting with macrocytic anemia, our patient had a history of similar symptoms seven years prior, which were treated for vitamin B12 deficiency. This time, additional tests confirmed that pernicious anemia was at play, allowing for targeted treatment.
After starting parenteral methylcobalamin therapy, he showed significant improvement in his symptoms. This case underscores that vitamin B12 is crucial not just for red blood cell production but also for neurological health, emphasizing the need for increased awareness and diagnosis of vitamin B12 deficiencies in resource-limited settings.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Our research spanned across three centers in Pakistan, where participants received either a new formulation of Sucrosomial vitamin B12 or conventional B12 supplements. They took a daily dose for seven days, and we measured their serum B12 levels at various points before and after the treatment.
What we found was quite significant: the Sucrosomial vitamin B12 was notably better at elevating and maintaining higher B12 levels in the bloodstream compared to traditional options. This is important because low vitamin B12 can lead to serious health issues, like megaloblastic anemia and neurological problems.
Overall, this innovative supplement could offer a valuable solution for individuals with B12 deficiency, especially those who may have absorption issues. Our findings support the potential of Sucrosomial vitamin B12 in enhancing health through improved nutrient bioavailability.
There’s a clear relationship between the amount of B12 consumed and the body’s response. Supplements offering up to 20 µg of B12 daily are deemed safe and unlikely to trigger side effects.
For those severely affected, higher dosages—like 50 µg—may help stabilize abnormal markers in the blood, while foods designed for medical purposes can contain up to 150 µg.
However, anything beyond 200 µg per day should be treated as a drug, as it can effectively address anemia and related symptoms. Importantly, for individuals diagnosed with deficiency, proper medical treatment remains essential, leaning towards higher doses of B12.
References
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- Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. doi:10.1016/S2214-109X(24)00559-X
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Hirakata K, Ishii Y, Yoshida T, Tanaka F, Nakae Y. [A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12]. Rinsho Shinkeigaku. 2025;65:120. doi:10.5692/clinicalneurol.cn-002023
- Zhang D, Liu S, Xi B, Zhu Y, Chen Y, et al. Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report. Ital J Pediatr. 2024;50:191. doi:10.1186/s13052-024-01757-z
- Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x
- Shen M, Luo X, Wu C, Wang J, Wang Z, et al. Pernicious anemia is a common cause of cobalamin deficiency-caused megaloblastic anemia in Hainan, China. Hematology. 2024;29:2399375. doi:10.1080/16078454.2024.2399375
- Iqbal N, Meghani MA, Khalid W, Ansari AH, Ansari MUH, et al. Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report. Ann Hematol. 2024;103:3243. doi:10.1007/s00277-024-05878-7
- Song JH, Park SH, Cho M, Kim YM, Hyung WJ, et al. Proximal Gastrectomy Is Associated with Lower Incidence of Anemia and Vitamin B12 Deficiency Compared to Total Gastrectomy in Patients with Upper Gastric Cancer. Cancer Res Treat. 2025;57:174. doi:10.4143/crt.2024.319
- Lacombe V, Vinatier E, Roquin G, Copin MC, Delattre E, et al. Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study. Am J Clin Nutr. 2024;120:217. doi:10.1016/j.ajcnut.2024.05.019
- Chakrabarti S, Ajjampur SSR, Waddington HS, Kishore A, Nguyen PH, et al. Deworming and micronutrient status by community open defecation prevalence: An observational study using nationally representative data from India, 2016-2018. PLoS Med. 2024;21:e1004402. doi:10.1371/journal.pmed.1004402
- Sawada Y, Sakamoto K, Tsukamura A, Sawai C. Vitamin B12 deficiency-induced megaloblastic anemia in a pediatric patient with autism spectrum disorder with a chronically unbalanced diet. Int J Hematol. 2024;119:613. doi:10.1007/s12185-024-03759-3
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Sachdeva M, Purohit A, Malik M, Jain L, Pradhan P, et al. Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review. Nutr Rev. 2025. doi:10.1093/nutrit/nuae227
- Obeid R, Geisel J, Pietrzik K, Andres E. A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements. Curr Nutr Rep. 2025;14:32. doi:10.1007/s13668-025-00622-7
- Hirakata K, Ishii Y, Yoshida T, Tanaka F, Nakae Y. [A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12]. Rinsho Shinkeigaku. 2025;65:120. doi:10.5692/clinicalneurol.cn-002023
- Belhaj R, Maaloul I, Kolsi R, Rekik T, Chabchoub I, et al. Study of clinical manifestations and etiologies of megaloblastic anemia in children. Transfus Clin Biol. 2025. doi:10.1016/j.tracli.2025.01.006
- Goncalves H, De Oliveira Simões F, Sá R, Fraga Campos B, Domingues RM, et al. Severe Symptomatic Anemia as a Rare Initial Manifestation of Type 3 Polyglandular Autoimmune Syndrome: A Case Report. Cureus. 2024;16:e75800. doi:10.7759/cureus.75800
- Moreira AP, Vasconcelos M, Costa E Silva T, Relvas C, Espírito Santo J. An Unusual Case of Hemolytic Anemia: A Case Report. Cureus. 2024;16:e75676. doi:10.7759/cureus.75676
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. doi:10.1186/s12887-024-05262-4
- Tavares Pereira J, Barbosa Barroso J, Azevedo A, Ribeiro A, Tonel C. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Cureus. 2024;16:e73620. doi:10.7759/cureus.73620
- Jamil M, Nasser Z, Jamil D, Sheqwara JZ. Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. Case Rep Hematol. 2024;2024:3258227. doi:10.1155/2024/3258227
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