Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 12 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Pantothenic Acid (as d-Calcium Pantothenate)
500 mg
10,000%
Calcium (as d-Calcium Pantothenate)
49 mg
4%

Top Medical Research Studies

This study explored how an app-based mindfulness program could help lower anxiety levels in people with HIV who smoke.

Over eight weeks, we followed 16 participants as they tackled 30 mindfulness modules, aiming to reduce their anxiety before quitting smoking.

Encouragingly, we observed reductions in anxiety and an increase in their willingness to quit by the end of the four-week period.

The feedback was positive, indicating that the app was both feasible and well received among participants.
Read More
8
Online CBT improves postpartum anxiety
We examined the impact of a 9-week online group therapy session, led by recovered mothers, on postpartum depression (PPD) and related anxiety. In a randomized controlled trial with 183 participants, those who received the therapy alongside traditional care showed significant improvement in PPD and anxiety levels after 9 weeks.

The results also indicated enhancements in social support and bonding with infants. This unique approach has the potential to broaden the accessibility of essential mental health support for new mothers and their families.
Read More
We explored how acupressure could help reduce fatigue, improve sleep quality, and enhance psychological well-being in patients with end-stage renal disease undergoing hemodialysis.

Conducted in a medical center in Indonesia, this single-blinded randomized controlled trial involved 106 patients, who received either acupressure or a sham treatment for four weeks.

The results showed that acupressure significantly improved fatigue, sleep quality, and even reduced anxiety and depression levels compared to the control group. Overall, no adverse effects were reported, indicating that acupressure can be a beneficial, safe treatment option.
Read More

Most Useful Reviews

9.5
Alleviates anxiety feelings
After two weeks of regular use to support my adrenal glands, I noticed significant improvements. The uncomfortable sensation in my kidney area vanished, and my overall self-awareness greatly enhanced. Falling asleep became easier, and I forgot about the anxiety I previously experienced in the kidney region. I recommend taking it with your evening meal, as this aligns with the natural secretion of cortisol by the adrenal glands at night.
Read More
9.5
Calms anxiety and stress
An important component for alleviating anxiety and promoting calmness, this vitamin is also beneficial for beauty.
Read More
9.5
Relieves anxiety and stress
I take this at night to address my sleep issues, and it effectively alleviates anxiety and depression. After extended mental strain, it has become a vital support in relieving chronic fatigue. Excellent quality.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
  • All Researches
We examined the mental health benefits of forest bathing (FB) in Mediterranean regions during the COVID-19 pandemic. Involving eighty-six adults, we compared FB effects to those of a hiking control group.

Our findings revealed that forest bathing significantly reduces anxiety and enhances mindfulness compared to hiking, exhibiting strong effects. While both activities showed positive impacts on mental well-being, FB outperformed hiking, making it a promising strategy for promoting psychological recovery in these unique environments.

Ultimately, our research suggests that forest bathing could be a valuable tool for fostering well-being as we adapt to life post-pandemic.
Read More
8
Interviews lower anxiety in surgery
We aimed to find out if preoperative educational interviews could help ease anxiety and discomfort for patients undergoing oral and maxillofacial surgery.

This study involved randomizing patients into two groups—one received the interviews, while the other did not. We found that those who had informational chats experienced noticeably lower anxiety levels before surgery.

Additionally, these patients reported less postoperative pain and nausea. Clearly, such preoperative approaches can significantly improve the surgical experience for many patients.
Read More
8
Online CBT improves postpartum anxiety
We examined the impact of a 9-week online group therapy session, led by recovered mothers, on postpartum depression (PPD) and related anxiety. In a randomized controlled trial with 183 participants, those who received the therapy alongside traditional care showed significant improvement in PPD and anxiety levels after 9 weeks.

The results also indicated enhancements in social support and bonding with infants. This unique approach has the potential to broaden the accessibility of essential mental health support for new mothers and their families.
Read More
We explored how acupressure could help reduce fatigue, improve sleep quality, and enhance psychological well-being in patients with end-stage renal disease undergoing hemodialysis.

Conducted in a medical center in Indonesia, this single-blinded randomized controlled trial involved 106 patients, who received either acupressure or a sham treatment for four weeks.

The results showed that acupressure significantly improved fatigue, sleep quality, and even reduced anxiety and depression levels compared to the control group. Overall, no adverse effects were reported, indicating that acupressure can be a beneficial, safe treatment option.
Read More
8
Calcium blockers reduce cocaine withdrawal anxiety
We explored how blocking L-type calcium channels (LTCCs) could influence anxiety-like behaviors during cocaine abstinence in both female and male rats. In this study, rats were trained to self-administer cocaine or saline, followed by a two-week abstinence period. Throughout this withdrawal phase, we examined their behavior using several tests designed to measure anxiety and mood, notably the elevated plus maze and forced swim test, while also checking for changes in their preference for a sweet solution.

Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.

This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Read More

User Reviews

USERS' SCORE
Good
Based on 12 Reviews
8.6
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
Alleviates anxiety feelings
After two weeks of regular use to support my adrenal glands, I noticed significant improvements. The uncomfortable sensation in my kidney area vanished, and my overall self-awareness greatly enhanced. Falling asleep became easier, and I forgot about the anxiety I previously experienced in the kidney region. I recommend taking it with your evening meal, as this aligns with the natural secretion of cortisol by the adrenal glands at night.
Read More
9.5
Calms anxiety and stress
An important component for alleviating anxiety and promoting calmness, this vitamin is also beneficial for beauty.
Read More
9.5
Relieves anxiety and stress
I take this at night to address my sleep issues, and it effectively alleviates anxiety and depression. After extended mental strain, it has become a vital support in relieving chronic fatigue. Excellent quality.
Read More
9.5
Anxiety relief
Been looking at her for a long time. Decided to try this excellent supplement; my anxiety and apathy have vanished.
Read More
9.5
Relieves anxiety
I ordered it myself. Vitamin B5 is essential for our adrenal glands. I consume it once a day in the evening. Panthenothenic acid also enhances skin condition. I take it alongside other vitamins. It certainly alleviates anxiety. Definitely, yes! 🙌
Read More

Frequently Asked Questions

Anxiety is a natural and often healthy emotion characterized by feelings of worry, nervousness, or fear about an impending event or situation. While some level of anxiety is a normal reaction to stress, excessive or chronic anxiety can become a mental health issue. It may present in various forms, from everyday worries to more severe conditions such as generalized anxiety disorder (GAD), panic disorder, or social anxiety disorder. Symptoms can manifest both psychologically, such as persistent worry and difficulty concentrating, and physically, including symptoms like increased heart rate, sweating, or fatigue.

Understanding the difference between normal anxiety and an anxiety disorder is crucial. Normal anxiety can be beneficial, motivating you to prepare for important events like exams or public speaking. However, when it starts to interfere with daily activities or leads to avoidance behaviors, it may indicate the need for professional help. Treatments for anxiety often include therapy, medications, and lifestyle changes, allowing individuals to manage their symptoms effectively. If someone is struggling with anxiety that impacts their quality of life, seeking guidance from a healthcare professional is a key step toward recovery.

B5, also known as pantothenic acid, is a vital B vitamin that plays a crucial role in various bodily functions. It is essential for synthesizing coenzyme A, which is key in fatty acid metabolism and the conversion of carbohydrates into energy. Additionally, B5 is involved in the production of red blood cells and helps to maintain healthy skin, hair, and eyes. It can be found in a variety of foods, including meat, fish, dairy products, whole grains, and legumes, making it relatively easy for most people to meet their daily requirements through diet.

While deficiencies in B5 are rare due to its widespread availability in food sources, those who have certain medical conditions, strict vegetarian or vegan diets, or poor nutrition may be more susceptible. Symptoms of a deficiency might include fatigue, irritability, and symptoms related to energy metabolism. Moreover, B5 is also commonly available as a dietary supplement and is often included in multivitamins. However, it's important to consult a healthcare professional before starting any new supplement regimen, particularly if you have underlying health issues or take other medications.

Based on user reviews, many people report seeing noticeable improvements in anxiety symptoms within two weeks of regular use of this supplement. For instance, one user mentioned that after two weeks, they experienced significant improvements in their self-awareness, better sleep, and a reduction in anxiety sensations in their kidney area ((Read Review)). Additionally, another reviewer stated that since starting the supplement, their anxiety levels and nighttime awakenings have significantly improved, although they plan to provide further updates as they continue using it ((Read Review)).

Overall, the general sentiment among users seems to be that this supplement begins to have a positive effect relatively quickly, often within a couple of weeks, especially when combined with proper timing related to meals ((Read Review)) or as part of an evening routine ((Read Review)). However, results can vary depending on individual health circumstances and lifestyle factors.

This research suggests that calcium channel blockers, specifically isradipine, may have potential in alleviating anxiety symptoms during cocaine withdrawal. In a study conducted with rats, those who were abstaining from cocaine exhibited increased anxiety-like behaviors, which could be mitigated by administering isradipine. The effects appeared to vary between male and female rats, indicating that the dosage and sex may influence the outcomes. The results indicate a promising avenue for treating anxiety disorders that are associated with substance withdrawal, although the relationship is complex and necessitates further exploration [6].

However, while these findings are encouraging, they primarily focus on a specific context of cocaine withdrawal rather than broader anxiety disorders. Therefore, while there is some scientific basis for the use of calcium channel blockers in a particular scenario, more research is needed to generalize these effects to various forms of anxiety disorders. Patients should consult with healthcare professionals before considering any new treatment based on preliminary research findings.

Users report a variety of improvements in their symptoms after using this supplement, particularly in relation to anxiety and sleep quality. Many have experienced significant alleviation of anxiety, with one user noting the complete disappearance of discomfort and anxiety sensations in their kidney area after just two weeks of regular use ((Read Review)). Others echoed similar sentiments, stating that their anxiety and feelings of apathy have vanished or significantly decreased since beginning the supplement ((Read Review)).

Additionally, improvements in sleep quality were frequently mentioned, with reviewers highlighting better rest and a reduction in nocturnal awakenings ((Read Review)). Many users suggest that taking the supplement in the evening aligns well with its benefits for adrenal health and sleep normalization ((Read Review), (Read Review)). While many found the effects positive, it’s important to note that individual experiences can vary widely, and some users had different reactions when adjusting dosage ((Read Review)).

Based on user reviews, many individuals report positive experiences when combining this supplement with other vitamins, particularly for managing anxiety. One user mentioned taking Vitamin B5 along with other vitamins in the evening, stating that it contributed significantly to alleviating anxiety ((Read Review)). Others highlighted the overall calming effects attributed to this supplement, with one user noting its effectiveness alongside antidepressant benefits, leading to a more stable nervous system and better sleep quality ((Read Review)).

However, it's important to note that some users had varied experiences with dosage adjustments. For instance, a user reported heightened anxiety and discomfort when taking higher doses, suggesting that while combining this supplement with others can be beneficial, caution is necessary to avoid adverse reactions ((Read Review)). Overall, users seem to find that strategic combinations can enhance the supplement's effects on anxiety, but personal experiences can vary widely.

Based on user reviews, it appears that most individuals taking Vitamin B5 for anxiety typically recommend dosages aligned with their evening routines. Users report that taking the supplement once a day in the evening can enhance sleep quality and reduce anxiety levels significantly. One user, for example, noted, "I consume it once a day in the evening," which suggests they found this dosage effective in alleviating anxiety and supporting adrenal function (Read Review).

However, it's important to note that while many users found benefits from lower to moderate doses, one reviewer had an adverse experience with a much higher intake, reporting increased anxiety and other side effects when taking up to 15 pills (Read Review). This indicates that while maintaining a regular, moderate dose may be beneficial for anxiety relief, excessive dosages could lead to negative reactions, emphasizing the need for users to find a dosage that works for their individual needs.

9.5
Alleviates anxiety feelings
After two weeks of regular use to support my adrenal glands, I noticed significant improvements. The uncomfortable sensation in my kidney area vanished, and my overall self-awareness greatly enhanced. Falling asleep became easier, and I forgot about the anxiety I previously experienced in the kidney region. I recommend taking it with your evening meal, as this aligns with the natural secretion of cortisol by the adrenal glands at night.
8.3
Removes anxiety effects
Since I began taking this supplement, my anxiety and nocturnal awakenings have significantly improved. I plan to provide further feedback later as I continue its use.
8.8
Stable mood
The quality of the brand and supplement is high. The ingredient pantethine supports the adrenal glands, leading to a stable nervous system. I have experienced improved sleep along with an antidepressant and anti-anxiety effect.
9.5
Anxiety relief
Been looking at her for a long time. Decided to try this excellent supplement; my anxiety and apathy have vanished.
9.5
Calming effects
For adrenal glands, the best vitamin B5 in the form of pantothenic acid is used to support tired adrenal glands; it normalises sleep and alleviates anxiety. Highly recommend it!
3.8
Increases anxiety issues
Initially purchased for acne, I noticed that higher doses (like 15 pills) are effective. However, I experienced heightened anxiety, along with numbness and tingling when megadosing.
9.5
Relieves anxiety
I ordered it myself. Vitamin B5 is essential for our adrenal glands. I consume it once a day in the evening. Panthenothenic acid also enhances skin condition. I take it alongside other vitamins. It certainly alleviates anxiety. Definitely, yes! 🙌
8
Calcium blockers reduce cocaine withdrawal anxiety
We explored how blocking L-type calcium channels (LTCCs) could influence anxiety-like behaviors during cocaine abstinence in both female and male rats. In this study, rats were trained to self-administer cocaine or saline, followed by a two-week abstinence period. Throughout this withdrawal phase, we examined their behavior using several tests designed to measure anxiety and mood, notably the elevated plus maze and forced swim test, while also checking for changes in their preference for a sweet solution.

Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.

This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.

References

  1. Kocaturk S, Gur ZB, Gursoytrak B. Can Verbal Interview Decrease Preoperative Anxiety and Postoperative Discomfort in Oral and Maxillofacial Surgery Patients?: A Randomized Clinical Trial. J Oral Maxillofac Surg. 2024;82:1425. doi:10.1016/j.joms.2024.06.178
  2. Merza D, Amani B, Savoy C, Babiy Z, Bieling PJ, et al. Online peer-delivered group cognitive-behavioral therapy for postpartum depression: A randomized controlled trial. Acta Psychiatr Scand. 2024;150:422. doi:10.1111/acps.13611
  3. Cioe PA, Sokolovsky AW, Brewer JA, Kahler CW. App-Delivered Mindfulness Training to Reduce Anxiety in People with HIV Who Smoke: A One-Armed Feasibility Trial. Int J Environ Res Public Health. 2023;20. doi:10.3390/ijerph20064826
  4. Muro A, Mateo C, Parrado E, Subirana-Malaret M, Moya M, et al. Forest bathing and hiking benefits for mental health during the COVID-19 pandemic in Mediterranean regions. Eur J For Res. 2023;142:415. doi:10.1007/s10342-023-01531-6
  5. Suandika M, Chen SY, Fang JT, Yang SH, Tsai YF, et al. Effect of Acupressure on Fatigue in Hemodialysis Patients: A Single-Blinded Randomized Controlled Trial. J Integr Complement Med. 2023;29:111. doi:10.1089/jicm.2022.0644
  6. Nunes EJ, Kimble V, Rajadhyaksha AM, Addy NA. L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats. Neuroscience. 2025;568:314. doi:10.1016/j.neuroscience.2025.01.003
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