Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Good
Based on 8 Reviews
8.7
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Acetyl-L-Carnitine (from 1,250 mg Acetyl-L-Carnitine HCl)
1 g (1,000 mg)
**
Top Medical Research Studies
9
We investigated how acetyl-L-carnitine (ALC) might help patients suffering from chemotherapy-induced peripheral neuropathy (CIPN). In a well-structured study involving 239 patients, we divided participants into two groups—one receiving ALC and the other a placebo.
After eight weeks, a significant number of ALC patients showed improvement in their neuropathy symptoms compared to those receiving the placebo.
Additionally, ALC treatment not only reduced neuropathy but also eased cancer-related fatigue without notable safety concerns. Our findings suggest ALC can be an effective option in treating CIPN.
After eight weeks, a significant number of ALC patients showed improvement in their neuropathy symptoms compared to those receiving the placebo.
Additionally, ALC treatment not only reduced neuropathy but also eased cancer-related fatigue without notable safety concerns. Our findings suggest ALC can be an effective option in treating CIPN.
Read More
8
We examined the effects of Acetyl-L-Carnitine (ALCAR) on nerve regeneration in animal studies, particularly focusing on peripheral neuropathies caused by injuries.
This systematic review and meta-analysis considered various studies that administered ALCAR to rats with sciatic nerve injuries.
While ALCAR showed promise in improving pain tolerance and reducing damage, the specific mechanisms behind its benefits remain unclear and warrant further investigation.
This systematic review and meta-analysis considered various studies that administered ALCAR to rats with sciatic nerve injuries.
While ALCAR showed promise in improving pain tolerance and reducing damage, the specific mechanisms behind its benefits remain unclear and warrant further investigation.
Read More
8
We examined the effectiveness of acetyl-L-carnitine (ALC) in treating painful peripheral neuropathy. Our analysis included 14 trials featuring patients suffering from this condition, notably those with diabetes or HIV-related neuropathy.
A meta-analysis demonstrated that ALC led to a significant 20.2% reduction in pain compared to a placebo. Additionally, ALC showed promising results regarding nerve function improvement and regeneration, along with a favorable safety profile.
Although findings are encouraging, further research is needed to fine-tune dosage and treatment duration.
A meta-analysis demonstrated that ALC led to a significant 20.2% reduction in pain compared to a placebo. Additionally, ALC showed promising results regarding nerve function improvement and regeneration, along with a favorable safety profile.
Although findings are encouraging, further research is needed to fine-tune dosage and treatment duration.
Read More
Most Useful Reviews
9
Prevents progression
141 people found this helpful
It really helps stave off neuropathy. Recommended by the cancer doctors treating me, I take two capsules in the morning and evening, and one at midday. This keeps my neuropathy from worsening.
Read More
9
Remarkable improvement
32 people found this helpful
I suffered from ulnar neuropathy for months due to poor workplace ergonomics. After consulting multiple doctors and feeling hopeless about surgery, I researched alternative treatments and found ALC. After just one day, I noticed a remarkable improvement! The pain is manageable, and I can lift small items and open jars without discomfort! I highly recommend this supplement; it's puzzling why it's not suggested by doctors despite FDA approval for treating neuropathy.
Read More
9
Miracle combination found
27 people found this helpful
My foot neuropathy has improved by about 80%. I purchased this product to take alongside alpha lipoic acid. Together, they significantly reduced my neuropathy symptoms. Before using them, I struggled to sleep due to tingling and burning sensations. The combination worked almost instantly, and I now take two of each supplement nightly to maintain relief.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
- All Researches
9
ALCAR enhances nerve regeneration
We explored how acetyl-l-carnitine (ALCAR) treatment could boost nerve regeneration when combined with decellularized nerve allografts and adipose-derived stromal cells (ASCs). In our study with seventy rats, we used various groups to assess outcomes after bridging a 10-mm sciatic nerve defect.
ALCAR notably supported the survival of ASCs and increased neurotrophic factor expression in the grafts. Overall, results showed that ALCAR enhanced the regenerative effects of ASCs and acellular grafts, achieving results comparable to traditional nerve autografts.
ALCAR notably supported the survival of ASCs and increased neurotrophic factor expression in the grafts. Overall, results showed that ALCAR enhanced the regenerative effects of ASCs and acellular grafts, achieving results comparable to traditional nerve autografts.
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9
We investigated how acetyl L-carnitine (LAC) influences neuroprotection, pain relief, and hand function in patients suffering from carpal tunnel syndrome (CTS). In this blind study featuring 82 patients over four months, we noted significant improvements in nerve conduction and sensory abilities after LAC treatment.
Pain levels also decreased markedly, especially in pressure-related discomfort. These findings suggest that LAC could be a beneficial therapeutic option for managing symptoms in mild to moderate CTS cases, thanks to its neuroprotective and anti-nociceptive effects.
Pain levels also decreased markedly, especially in pressure-related discomfort. These findings suggest that LAC could be a beneficial therapeutic option for managing symptoms in mild to moderate CTS cases, thanks to its neuroprotective and anti-nociceptive effects.
Read More
9
We investigated how acetyl-L-carnitine (ALC) might help patients suffering from chemotherapy-induced peripheral neuropathy (CIPN). In a well-structured study involving 239 patients, we divided participants into two groups—one receiving ALC and the other a placebo.
After eight weeks, a significant number of ALC patients showed improvement in their neuropathy symptoms compared to those receiving the placebo.
Additionally, ALC treatment not only reduced neuropathy but also eased cancer-related fatigue without notable safety concerns. Our findings suggest ALC can be an effective option in treating CIPN.
After eight weeks, a significant number of ALC patients showed improvement in their neuropathy symptoms compared to those receiving the placebo.
Additionally, ALC treatment not only reduced neuropathy but also eased cancer-related fatigue without notable safety concerns. Our findings suggest ALC can be an effective option in treating CIPN.
Read More
8
We examined the effectiveness of various drug treatments for cardiovascular autonomic neuropathy (CAN) in diabetic patients. Our study included a comprehensive review of randomized controlled trials, focusing on treatments that impact heart rate and blood pressure.
We found that several options, including angiotensin-converting enzyme inhibitors and acetyl L-carnitine, showed significant improvements in autonomic function. However, vitamin B12 alone did not demonstrate efficacy. Our findings suggest that while some treatments are beneficial, others like vitamin B12 monotherapy may not be recommended.
We found that several options, including angiotensin-converting enzyme inhibitors and acetyl L-carnitine, showed significant improvements in autonomic function. However, vitamin B12 alone did not demonstrate efficacy. Our findings suggest that while some treatments are beneficial, others like vitamin B12 monotherapy may not be recommended.
Read More
8
We examined the effects of Acetyl-L-Carnitine (ALCAR) on nerve regeneration in animal studies, particularly focusing on peripheral neuropathies caused by injuries.
This systematic review and meta-analysis considered various studies that administered ALCAR to rats with sciatic nerve injuries.
While ALCAR showed promise in improving pain tolerance and reducing damage, the specific mechanisms behind its benefits remain unclear and warrant further investigation.
This systematic review and meta-analysis considered various studies that administered ALCAR to rats with sciatic nerve injuries.
While ALCAR showed promise in improving pain tolerance and reducing damage, the specific mechanisms behind its benefits remain unclear and warrant further investigation.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Prevents progression
141 people found this helpful
It really helps stave off neuropathy. Recommended by the cancer doctors treating me, I take two capsules in the morning and evening, and one at midday. This keeps my neuropathy from worsening.
Read More
9
Remarkable improvement
32 people found this helpful
I suffered from ulnar neuropathy for months due to poor workplace ergonomics. After consulting multiple doctors and feeling hopeless about surgery, I researched alternative treatments and found ALC. After just one day, I noticed a remarkable improvement! The pain is manageable, and I can lift small items and open jars without discomfort! I highly recommend this supplement; it's puzzling why it's not suggested by doctors despite FDA approval for treating neuropathy.
Read More
9
Miracle combination found
27 people found this helpful
My foot neuropathy has improved by about 80%. I purchased this product to take alongside alpha lipoic acid. Together, they significantly reduced my neuropathy symptoms. Before using them, I struggled to sleep due to tingling and burning sensations. The combination worked almost instantly, and I now take two of each supplement nightly to maintain relief.
Read More
9
Tremendous improvement
23 people found this helpful
Has helped TREMENDOUSLY with my neuropathy! My doctor suggested Alpha Lipoic Acid as a supplement for my neuropathy in my left leg and foot, which helped somewhat. However, I heard about Acetyl L-Carnitine's effectiveness from someone in a forum, and I decided to try it. WOW! My symptoms have improved by 80% after just a few days of taking two pills daily. It has made my neuropathy pain manageable, and I've recommended it to many friends. Just give it a go...
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9
Improved sensation
16 people found this helpful
Great product! My acupuncturist suggested 1500 mg per day for neuropathy in my feet and legs. On the first day, I immediately felt sensation in my feet that I hadn’t experienced for a long time. I also have more energy and can walk further now. I will continue using this form of ALC alongside Alpha Lipoic Acid and other supplements.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Aldendail CF, Chen P, Dibble HS, Baute Penry V. A Comprehensive Review of Safety, Efficacy, and Indications for the Use of Alpha-Lipoic Acid and Acetyl-L-Carnitine in Neuropathic Pain. Integr Med (Encinitas). 2024;23:32.
- Frediani JK, Lal AA, Kim E, Leslie SL, Boorman DW, et al. The role of diet and non-pharmacologic supplements in the treatment of chronic neuropathic pain: A systematic review. Pain Pract. 2024;24:186. doi:10.1111/papr.13291
- Goh JK, Koh L. Evaluating treatment options for cardiovascular autonomic neuropathy in patients with diabetes mellitus: a systematic review. Diabetol Int. 2023;14:224. doi:10.1007/s13340-023-00629-x
- Pourshahidi S, Shamshiri AR, Derakhshan S, Mohammadi S, Ghorbani M. The Effect of Acetyl-L-Carnitine (ALCAR) on Peripheral Nerve Regeneration in Animal Models: A Systematic Review. Neurochem Res. 2023;48:2335. doi:10.1007/s11064-023-03911-1
- Kencebay Manas C, Derin N, Arican RY, Tanriover G, Dilmac S, et al. Comparison of the therapeutic effects of erythropoietin and acetyl-l-carnitine on sciatic nerve injury in rats. Neurol Res. 2022;44:659. doi:10.1080/01616412.2022.2029293
- Parisi S, Ditto MC, Borrelli R, Fusaro E. Efficacy of a fixed combination of palmitoylethanolamide and acetyl-l-carnitine (PEA+ALC FC) in the treatment of neuropathies secondary to rheumatic diseases. Minerva Med. 2021;112:492. doi:10.23736/S0026-4806.21.07486-3
- Baute V, Zelnik D, Curtis J, Sadeghifar F. Complementary and Alternative Medicine for Painful Peripheral Neuropathy. Curr Treat Options Neurol. 2019;21:44. doi:10.1007/s11940-019-0584-z
- Di Stefano G, Di Lionardo A, Galosi E, Truini A, Cruccu G. Acetyl-L-carnitine in painful peripheral neuropathy: a systematic review. J Pain Res. 2019;12:1341. doi:10.2147/JPR.S190231
- Mohammad-Bagher G, Arash A, Morteza BR, Naser MS, Ali M. Synergistic Effects of Acetyl-l-Carnitine and Adipose-Derived Stromal Cells on Improving Regenerative Capacity of Acellular Nerve Allograft in Sciatic Nerve Defect. J Pharmacol Exp Ther. 2019;368:490. doi:10.1124/jpet.118.254540
- Dinicola S, Fuso A, Cucina A, Santiago-Reyes M, Verna R, et al. Natural products - alpha-lipoic acid and acetyl-L-carnitine - in the treatment of chemotherapy-induced peripheral neuropathy. Eur Rev Med Pharmacol Sci. 2018;22:4739. doi:10.26355/eurrev_201807_15534
- Hershman DL, Unger JM, Crew KD, Till C, Greenlee H, et al. Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L-Carnitine (SWOG S0715). J Natl Cancer Inst. 2018;110:669. doi:10.1093/jnci/djx259
- Cruccu G, Di Stefano G, Fattapposta F, Jann S, Padua L, et al. L-Acetyl-carnitine in Patients with Carpal Tunnel Syndrome: Effects on Nerve Protection, Hand Function and Pain. CNS Drugs. 2017;31:1103. doi:10.1007/s40263-017-0476-2
- Mostacci B, Liguori R, Cicero AF. Nutraceutical Approach to Peripheral Neuropathies: Evidence from Clinical Trials. Curr Drug Metab. 2018;19:460. doi:10.2174/1389200218666171031145419
- Sun Y, Shu Y, Liu B, Liu P, Wu C, et al. A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy. Exp Ther Med. 2016;12:4017. doi:10.3892/etm.2016.3871
- Li S, Chen X, Li Q, Du J, Liu Z, et al. Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial. J Diabetes Investig. 2016;7:777. doi:10.1111/jdi.12493
- Callander N, Markovina S, Eickhoff J, Hutson P, Campbell T, et al. Acetyl-L-carnitine (ALCAR) for the prevention of chemotherapy-induced peripheral neuropathy in patients with relapsed or refractory multiple myeloma treated with bortezomib, doxorubicin and low-dose dexamethasone: a study from the Wisconsin Oncology Network. Cancer Chemother Pharmacol. 2014;74:875. doi:10.1007/s00280-014-2550-5
