Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.8
USERS' SCORE
Good
Based on 5 Reviews
8.1
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Acetyl-L-Carnitine (from 1,250 mg Acetyl-L-Carnitine HCl)
1 g (1,000 mg)
**
Top Medical Research Studies
9
ALC shows neuroprotective potential
The study aimed to assess whether acetyl-l-carnitine (ALC) could protect neurons in a rat model of Parkinson's disease.
We found that ALC at 200mg/kg significantly improved motor functions and reduced indicators of neuroinflammation and oxidative stress.
Additionally, it helped preserve important dopaminergic neurons and reduced cell death markers.
Overall, our results suggest ALC could serve as a supplementary treatment for Parkinson's by combating the illness's damaging processes.
We found that ALC at 200mg/kg significantly improved motor functions and reduced indicators of neuroinflammation and oxidative stress.
Additionally, it helped preserve important dopaminergic neurons and reduced cell death markers.
Overall, our results suggest ALC could serve as a supplementary treatment for Parkinson's by combating the illness's damaging processes.
Read More
9
ALCAR improves cognition in rats
We explored how acetyl-L-carnitine (ALCAR) might help improve cognitive functions in Parkinson's disease by studying its effects on rats with induced Parkinsonism. ALCAR treatment showed promise by enhancing memory and reducing neuroinflammation. This was linked to increased levels of the D1 dopamine receptor, which is important for cognition, and a decrease in inflammatory responses. While the findings are encouraging, we should note that this study focused on animal models, so further research in humans is necessary to fully understand ALCAR's potential benefits.
Read More
9
ALCAR shows promise for neuron protection
We investigated how acetyl-L-carnitine (ALCAR) could help protect brain cells in a rat model of Parkinson's disease. By using ALCAR before and after a lesion, we observed enhancements in neuron survival, glial cell suppression, and antioxidant levels.
The treatment also improved motor skills, indicating a protective role for ALCAR in promoting neuron health. Our findings suggest that ALCAR might use the Wnt/β-catenin pathway to offer neuroprotective benefits, which could inform future therapies for neurodegenerative diseases.
The treatment also improved motor skills, indicating a protective role for ALCAR in promoting neuron health. Our findings suggest that ALCAR might use the Wnt/β-catenin pathway to offer neuroprotective benefits, which could inform future therapies for neurodegenerative diseases.
Read More
Most Useful Reviews
7.5
Tremors improved
7 people found this helpful
Being a vegetarian, both my mental and physical strength have diminished. However, after eating this product, my physical energy and spirits have noticeably improved, prompting me to consider purchasing it again. Now, the prices are quite reasonable. My father-in-law was recently diagnosed with Parkinson's disease, suffering from constant hand tremors. Previously, he overused his L-rotator muscle, making the symptoms more pronounced. After switching to carnitine, his hand tremors have shown improvement, although he needs to take two pills daily, which he is reluctant to do, fearing it may exacerbate his symptoms.
Read More
8
Tremors significantly improved
5 people found this helpful
My mother has Parkinson's disease, leading to tremors in her hands and feet, making her body unstable. After nearly a month of taking this product, her hand and foot tremors have significantly improved, though her instability has only slightly improved. However, her reactions are quicker now, and I am hopeful that continued consumption will lead to further improvements.
Read More
6
Memory improvement noted
5 people found this helpful
Acetyl-L-carnitine offers various benefits, including the reduction of fat cells, lowering the risk of Alzheimer's and Parkinson's diseases. It supports better memory retention, attention development, and helps filter necessary information amid a large data influx. It converts fat tissue into energy without burning it. The quality of this product is excellent, making it suitable for pre-workout use, providing a feeling of alertness and strength.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.8
- All Researches
9
ALC shows neuroprotective potential
The study aimed to assess whether acetyl-l-carnitine (ALC) could protect neurons in a rat model of Parkinson's disease.
We found that ALC at 200mg/kg significantly improved motor functions and reduced indicators of neuroinflammation and oxidative stress.
Additionally, it helped preserve important dopaminergic neurons and reduced cell death markers.
Overall, our results suggest ALC could serve as a supplementary treatment for Parkinson's by combating the illness's damaging processes.
We found that ALC at 200mg/kg significantly improved motor functions and reduced indicators of neuroinflammation and oxidative stress.
Additionally, it helped preserve important dopaminergic neurons and reduced cell death markers.
Overall, our results suggest ALC could serve as a supplementary treatment for Parkinson's by combating the illness's damaging processes.
Read More
9
ALCAR improves cognition in rats
We explored how acetyl-L-carnitine (ALCAR) might help improve cognitive functions in Parkinson's disease by studying its effects on rats with induced Parkinsonism. ALCAR treatment showed promise by enhancing memory and reducing neuroinflammation. This was linked to increased levels of the D1 dopamine receptor, which is important for cognition, and a decrease in inflammatory responses. While the findings are encouraging, we should note that this study focused on animal models, so further research in humans is necessary to fully understand ALCAR's potential benefits.
Read More
9
ALCAR shows promise for neuron protection
We investigated how acetyl-L-carnitine (ALCAR) could help protect brain cells in a rat model of Parkinson's disease. By using ALCAR before and after a lesion, we observed enhancements in neuron survival, glial cell suppression, and antioxidant levels.
The treatment also improved motor skills, indicating a protective role for ALCAR in promoting neuron health. Our findings suggest that ALCAR might use the Wnt/β-catenin pathway to offer neuroprotective benefits, which could inform future therapies for neurodegenerative diseases.
The treatment also improved motor skills, indicating a protective role for ALCAR in promoting neuron health. Our findings suggest that ALCAR might use the Wnt/β-catenin pathway to offer neuroprotective benefits, which could inform future therapies for neurodegenerative diseases.
Read More
8
Acetyl-L-Carnitine shows neuroprotective effects
We investigated the potential of acetyl-l-carnitine (ALC) to mitigate the effects of Parkinson's disease in a mouse model. Our study included several treatment groups, comparing ALC's impact against a control and MPTP challenge.
The findings showed that ALC significantly reduced the degeneration of key neurons and helped preserve dopamine levels. Additionally, it lessened the activation of inflammatory cells, suggesting ALC may offer protection from neuroinflammatory damage.
Overall, our results indicate that ALC shows promise for slowing the progression of Parkinson's pathology in clinical scenarios.
The findings showed that ALC significantly reduced the degeneration of key neurons and helped preserve dopamine levels. Additionally, it lessened the activation of inflammatory cells, suggesting ALC may offer protection from neuroinflammatory damage.
Overall, our results indicate that ALC shows promise for slowing the progression of Parkinson's pathology in clinical scenarios.
Read More
8
ALCAR impacts neurogenesis in Parkinson's
We investigated how acetyl-l-carnitine (ALCAR) impacts brain cell growth in a rat model mimicking Parkinson's disease.
Using a method that simulates the disease, we found that ALCAR treatment significantly improved the proliferation and survival of neural progenitor cells in the hippocampus.
ALCAR appears to encourage cell survival by activating protective signals while reducing those that lead to cell death.
Although ALCAR shows promise, more research is needed to fully understand its effects on Parkinson's disease in humans.
Using a method that simulates the disease, we found that ALCAR treatment significantly improved the proliferation and survival of neural progenitor cells in the hippocampus.
ALCAR appears to encourage cell survival by activating protective signals while reducing those that lead to cell death.
Although ALCAR shows promise, more research is needed to fully understand its effects on Parkinson's disease in humans.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Tremors improved
7 people found this helpful
Being a vegetarian, both my mental and physical strength have diminished. However, after eating this product, my physical energy and spirits have noticeably improved, prompting me to consider purchasing it again. Now, the prices are quite reasonable. My father-in-law was recently diagnosed with Parkinson's disease, suffering from constant hand tremors. Previously, he overused his L-rotator muscle, making the symptoms more pronounced. After switching to carnitine, his hand tremors have shown improvement, although he needs to take two pills daily, which he is reluctant to do, fearing it may exacerbate his symptoms.
Read More
8
Tremors significantly improved
5 people found this helpful
My mother has Parkinson's disease, leading to tremors in her hands and feet, making her body unstable. After nearly a month of taking this product, her hand and foot tremors have significantly improved, though her instability has only slightly improved. However, her reactions are quicker now, and I am hopeful that continued consumption will lead to further improvements.
Read More
6
Memory improvement noted
5 people found this helpful
Acetyl-L-carnitine offers various benefits, including the reduction of fat cells, lowering the risk of Alzheimer's and Parkinson's diseases. It supports better memory retention, attention development, and helps filter necessary information amid a large data influx. It converts fat tissue into energy without burning it. The quality of this product is excellent, making it suitable for pre-workout use, providing a feeling of alertness and strength.
Read More
7.5
Nerve regeneration helped
1 people found this helpful
Superior L-carnitine is crucial for our body's metabolic processes, helping fatty acids enter the mitochondria for breakdown. Acetylated L-carnitine can cross the blood-brain barrier more effectively, aiding nerve regeneration and repair, which may alleviate symptoms of Parkinson's disease. It also enhances concentration and mental clarity. I recommend purchasing more while the product is on sale; stock up!
Read More
9
Pain relief achieved
I purchased this product to help my mother alleviate pain from shingles and later gifted it to a friend showing early symptoms of Parkinson's disease. The intention was to support his nerve cell repair, and the feedback has been exceedingly positive.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Burks S, Raymick J, Robinson B, Hanig J, Sarkar S. Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson's disease mouse model: Endothelial and microglial effects. Neurosci Lett. 2019;703:86. doi:10.1016/j.neulet.2019.03.015
- Singh S, Mishra A, Mishra SK, Shukla S. ALCAR promote adult hippocampal neurogenesis by regulating cell-survival and cell death-related signals in rat model of Parkinson's disease like-phenotypes. Neurochem Int. 2017;108:388. doi:10.1016/j.neuint.2017.05.017
- Afshin-Majd S, Bashiri K, Kiasalari Z, Baluchnejadmojarad T, Sedaghat R, et al. Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat. Biomed Pharmacother. 2017;89:1. doi:10.1016/j.biopha.2017.02.007
- Singh S, Mishra A, Srivastava N, Shukla R, Shukla S. Acetyl-L-Carnitine via Upegulating Dopamine D1 Receptor and Attenuating Microglial Activation Prevents Neuronal Loss and Improves Memory Functions in Parkinsonian Rats. Mol Neurobiol. 2018;55:583. doi:10.1007/s12035-016-0293-5
- Singh S, Mishra A, Shukla S. ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/β-Catenin Signaling in Parkinsonian Rats. Mol Neurobiol. 2016;53:4286. doi:10.1007/s12035-015-9361-5
- Villa RF, Ferrari F, Gorini A. ATP-ases of synaptic plasma membranes in striatum: enzymatic systems for synapses functionality by in vivo administration of L-acetylcarnitine in relation to Parkinson's Disease. Neuroscience. 2013;248:414. doi:10.1016/j.neuroscience.2013.06.027
- Zaitone SA, Abo-Elmatty DM, Shaalan AA. Acetyl-L-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy. Pharmacol Biochem Behav. 2012;100:347. doi:10.1016/j.pbb.2011.09.002
- Bodis-Wollner I, Chung E, Ghilardi MF, Glover A, Onofrj M, et al. Acetyl-levo-carnitine protects against MPTP-induced parkinsonism in primates. J Neural Transm Park Dis Dement Sect. 1991;3:63.
- Puca FM, Genco S, Specchio LM, Brancasi B, D'Ursi R, et al. Clinical pharmacodynamics of acetyl-L-carnitine in patients with Parkinson's disease. Int J Clin Pharmacol Res. 1990;10:139.
