Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 8 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Milk Thistle Extract(Silybum marianum) (Fruit/Seed)(Standardized to 240 mg Silymarin Flavonoids - equivalent 80%)
300 mg
**
Dandelion Root (Taraxacum officinale)
100 mg
**
Artichoke (Cynara scolymus) (Leaf)
50 mg
**
Top Medical Research Studies
8
Silibinin shows promise for anxiety
We explored how silibinin, a compound from the Silybum marianum plant, might alleviate anxiety and depression in a mouse model of Parkinson's disease. Using various behavioral tests, we found that silibinin treatment significantly reduced anxiety-like behaviors while also improving the condition of hippocampal neurons.
Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.
Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.
Read More
8
We investigated the effects of silibinin, a compound from milk thistle, on anxiety and depression-like behavior in rats exposed to amyloid beta. The findings were promising, showing that silibinin significantly reduced anxiety and depression symptoms in various behavioral tests.
Additionally, it was effective in minimizing brain damage associated with these conditions. The treatment appears to work by enhancing the BDNF/TrkB pathway and reducing autophagy in the hippocampus, suggesting a multifaceted role in improving mental health.
Additionally, it was effective in minimizing brain damage associated with these conditions. The treatment appears to work by enhancing the BDNF/TrkB pathway and reducing autophagy in the hippocampus, suggesting a multifaceted role in improving mental health.
Read More
8
Our study aimed to determine whether silibinin and naringenin, two flavonoids, could reduce anxiety caused by acute stress using a zebrafish model.
We assessed their effects through behavioral tests, noting that the treated zebrafish showed increased exploration in the upper and well-lit areas of their tanks compared to the control group.
The results suggest that these flavonoids may have potential as therapeutic agents for anxiety with their significant anxiolytic properties.
We assessed their effects through behavioral tests, noting that the treated zebrafish showed increased exploration in the upper and well-lit areas of their tanks compared to the control group.
The results suggest that these flavonoids may have potential as therapeutic agents for anxiety with their significant anxiolytic properties.
Read More
Most Useful Reviews
9
Reduced anxiety symptoms
1 people found this helpful
This is my third bottle. I take it to support my liver and I've found it helps significantly with anxiety during parties. A couple of capsules in the morning helps me manage anxiety, which I previously couldn't overcome without beer.
Read More
9
Morning anxiety relief
A good product that helped me with my anxiety in the mornings.
Read More
7.5
Improved anxiety relief
1 people found this helpful
The ingredients are of excellent quality! I've noticed the benefits of milk thistle on my liver after just a week. The flavour and size of the capsules are easy to ingest. Since taking this supplement, I've experienced a significant improvement in my anxiety around food!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
- All Researches
8
Our study aimed to determine whether silibinin and naringenin, two flavonoids, could reduce anxiety caused by acute stress using a zebrafish model.
We assessed their effects through behavioral tests, noting that the treated zebrafish showed increased exploration in the upper and well-lit areas of their tanks compared to the control group.
The results suggest that these flavonoids may have potential as therapeutic agents for anxiety with their significant anxiolytic properties.
We assessed their effects through behavioral tests, noting that the treated zebrafish showed increased exploration in the upper and well-lit areas of their tanks compared to the control group.
The results suggest that these flavonoids may have potential as therapeutic agents for anxiety with their significant anxiolytic properties.
Read More
8
Silibinin shows promise for anxiety
We explored how silibinin, a compound from the Silybum marianum plant, might alleviate anxiety and depression in a mouse model of Parkinson's disease. Using various behavioral tests, we found that silibinin treatment significantly reduced anxiety-like behaviors while also improving the condition of hippocampal neurons.
Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.
Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.
Read More
8
We investigated the effects of silibinin, a compound from milk thistle, on anxiety and depression-like behavior in rats exposed to amyloid beta. The findings were promising, showing that silibinin significantly reduced anxiety and depression symptoms in various behavioral tests.
Additionally, it was effective in minimizing brain damage associated with these conditions. The treatment appears to work by enhancing the BDNF/TrkB pathway and reducing autophagy in the hippocampus, suggesting a multifaceted role in improving mental health.
Additionally, it was effective in minimizing brain damage associated with these conditions. The treatment appears to work by enhancing the BDNF/TrkB pathway and reducing autophagy in the hippocampus, suggesting a multifaceted role in improving mental health.
Read More
4
We delved into the effects of silybum marianum, among other herbs, on anxiety disorders based on a thorough review of clinical studies.
Our findings suggest that silybum marianum, along with several other plant-based remedies, has shown potential for alleviating anxiety when used over extended periods.
However, we must note that conclusions should be taken cautiously due to some study limitations, including small sample sizes and short treatment durations.
Overall, while there is some support for silybum marianum's effectiveness, further rigorous research is necessary to confirm its benefits for anxiety.
Our findings suggest that silybum marianum, along with several other plant-based remedies, has shown potential for alleviating anxiety when used over extended periods.
However, we must note that conclusions should be taken cautiously due to some study limitations, including small sample sizes and short treatment durations.
Overall, while there is some support for silybum marianum's effectiveness, further rigorous research is necessary to confirm its benefits for anxiety.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced anxiety symptoms
1 people found this helpful
This is my third bottle. I take it to support my liver and I've found it helps significantly with anxiety during parties. A couple of capsules in the morning helps me manage anxiety, which I previously couldn't overcome without beer.
Read More
9
Morning anxiety relief
A good product that helped me with my anxiety in the mornings.
Read More
7.5
Improved anxiety relief
1 people found this helpful
The ingredients are of excellent quality! I've noticed the benefits of milk thistle on my liver after just a week. The flavour and size of the capsules are easy to ingest. Since taking this supplement, I've experienced a significant improvement in my anxiety around food!
Read More
7.5
Alleviated liver anxiety
1 people found this helpful
It's great for those concerned about their liver, especially in today's hectic lifestyle. I believe anyone who exercises hard or enjoys a night out should consider silymarin. Personally, I find that one tablet each morning suffices.
Read More
7.5
Suitable for anxiety
The doctor prescribed it for my anxiety. I’m reordering it for the second time; it works well for me.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Nachammai V, Jeyabalan S, Muthusamy S. Anxiolytic effects of silibinin and naringenin on zebrafish model: A preclinical study. Indian J Pharmacol. 2021;53:457. doi:10.4103/ijp.IJP_18_20
- Liu X, Chen W, Wang C, Liu W, Hayashi T, et al. Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. Physiol Behav. 2021;241:113593. doi:10.1016/j.physbeh.2021.113593
- Song X, Liu B, Cui L, Zhou B, Liu W, et al. Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus. Physiol Behav. 2017;179:487. doi:10.1016/j.physbeh.2017.07.023
- Sarris J, McIntyre E, Camfield DA. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. CNS Drugs. 2013;27:301. doi:10.1007/s40263-013-0059-9
