Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Moderately Good
Based on 23 Reviews
7.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Milk Thistle Extract(Silybum marianum) (Fruit/Seed)(Standardized to 240 mg Silymarin Flavonoids - equivalent 80%)
300 mg
**
Dandelion Root (Taraxacum officinale)
100 mg
**
Artichoke (Cynara scolymus) (Leaf)
50 mg
**
Top Medical Research Studies
9
We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Read More
8
We explored the impact of silymarin, a compound from Silybum marianum, on SPC212 human mesothelioma cells. Through a series of laboratory tests, we observed that silymarin exhibits a dose-dependent cytotoxic effect, with notable markers of apoptosis like cell shrinkage and nuclear changes. Although silymarin shows promise in inducing cell death in cancer cells, further research is needed to fully understand its potential as a cancer treatment.
Read More
7
We explored the effects of Silybum marianum on nerve damage caused by the chemotherapy drug cisplatin in cancer patients. In a double-blind study involving 60 participants, we divided them into two groups: one receiving Silybum and the other a placebo.
Our findings revealed that those treated with Silybum experienced a significant reduction in symptoms of peripheral neuropathy compared to those who received the placebo. This suggests that Silybum marianum may offer relief for patients dealing with the harsh side effects of chemotherapy.
Our findings revealed that those treated with Silybum experienced a significant reduction in symptoms of peripheral neuropathy compared to those who received the placebo. This suggests that Silybum marianum may offer relief for patients dealing with the harsh side effects of chemotherapy.
Read More
Most Useful Reviews
9
Natural hepatoprotector
18 people found this helpful
Silymarin, derived from milk thistle, is a non-toxic natural substance known for its hepatoprotective and antioxidant properties. It exhibits anti-cancer effects, improves liver function, and has been extensively studied in over 3,000 scientific papers. Its zero toxicity has been noted in various clinical studies.
Read More
9
Antitumour properties
1 people found this helpful
Milk thistle is a renowned medicinal plant known for its liver-protective properties and antineoplastic effects against various cancers. Silymarin is believed to inhibit malignancy factors and promotes apoptosis in tumour cells. Experimental studies have demonstrated its potential in treating different cancers, including lung cancer, by interfering with metastasis.
Read More
7.5
Liver protection
68 people found this helpful
Milk thistle, used for over 2000 years, is well-regarded for its liver-protective qualities and regeneration of damaged liver cells. Given the chemicals and stressors we face, taking milk thistle daily is vital for liver health and may help combat cancer and other ailments.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
9
We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Read More
9
We investigated how grape seed procyanidin extract (GSE) and milk thistle silymarin extract (MTE) work together to combat lung cancer. Our study involved cell line experiments, along with testing on mice to see how these extracts affect tumor growth.
The results showed that GSE and MTE not only slowed down cancer cell growth but also worked better together. They boosted the levels of specific tumor suppressors, which play a key role in their effectiveness. Overall, this combination appears promising for lung cancer treatment.
The results showed that GSE and MTE not only slowed down cancer cell growth but also worked better together. They boosted the levels of specific tumor suppressors, which play a key role in their effectiveness. Overall, this combination appears promising for lung cancer treatment.
Read More
8
We explored the impact of silymarin, a compound from Silybum marianum, on SPC212 human mesothelioma cells. Through a series of laboratory tests, we observed that silymarin exhibits a dose-dependent cytotoxic effect, with notable markers of apoptosis like cell shrinkage and nuclear changes. Although silymarin shows promise in inducing cell death in cancer cells, further research is needed to fully understand its potential as a cancer treatment.
Read More
8
We aimed to understand how the combination of silymarin, derived from the milk thistle plant, and cisplatin, a well-known chemotherapy drug, affects ovarian cancer cells. Our study involved treating A2780 cells with these substances, both separately and together.
The results were promising: the combination treatment significantly reduced cell proliferation and promoted cancer cell death more effectively than either treatment alone. Additionally, it was found that this co-treatment altered the expression of certain cancer-related genes.
Overall, we believe this combination therapy could represent a valuable approach for future ovarian cancer treatments.
The results were promising: the combination treatment significantly reduced cell proliferation and promoted cancer cell death more effectively than either treatment alone. Additionally, it was found that this co-treatment altered the expression of certain cancer-related genes.
Overall, we believe this combination therapy could represent a valuable approach for future ovarian cancer treatments.
Read More
8
Milk thistle affects liver cancer cells
We examined how milk thistle, particularly its nano-micelle formulation, affects liver cancer cells. By testing these formulations on different cell lines, we discovered that the nano-milk thistle (N-MT) can effectively halt cell growth and induce cancer cell death.
This happens by altering key genes involved in the cell cycle and apoptosis pathways. Importantly, the treatment influenced the expression levels of specific genes like miR-155-3p, SOCS2, and PHLDA1, suggesting a targeted action of N-MT in combatting cancer in liver cells.
This happens by altering key genes involved in the cell cycle and apoptosis pathways. Importantly, the treatment influenced the expression levels of specific genes like miR-155-3p, SOCS2, and PHLDA1, suggesting a targeted action of N-MT in combatting cancer in liver cells.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 23 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Natural hepatoprotector
18 people found this helpful
Silymarin, derived from milk thistle, is a non-toxic natural substance known for its hepatoprotective and antioxidant properties. It exhibits anti-cancer effects, improves liver function, and has been extensively studied in over 3,000 scientific papers. Its zero toxicity has been noted in various clinical studies.
Read More
9
Antitumour properties
1 people found this helpful
Milk thistle is a renowned medicinal plant known for its liver-protective properties and antineoplastic effects against various cancers. Silymarin is believed to inhibit malignancy factors and promotes apoptosis in tumour cells. Experimental studies have demonstrated its potential in treating different cancers, including lung cancer, by interfering with metastasis.
Read More
7.5
Liver protection
68 people found this helpful
Milk thistle, used for over 2000 years, is well-regarded for its liver-protective qualities and regeneration of damaged liver cells. Given the chemicals and stressors we face, taking milk thistle daily is vital for liver health and may help combat cancer and other ailments.
Read More
6
Improved skin rash
34 people found this helpful
I have a history of liver cancer and hepatitis B, having undergone electric treatment for liver tumours twice. I consume milk thistle with lecithin to repair my liver. I've noticed a significant improvement in my skin rash after a few weeks of taking it, along with faster wound healing.
Read More
7.5
Reduces chemotherapy effects
9 people found this helpful
Milk thistle offers numerous benefits, including aiding in fatty liver repair and hepatitis. It helps reduce inflammation and includes anti-cancer compounds. This nutritionally complete supplement is highly effective and supports liver health, making it an excellent choice for detoxifying and protecting the liver.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Karbasforooshan H, Rahimi H, Arasteh O, Allahyari A, Varmaghani M, et al. Evaluation of Oral Nano-Silymarin Formulation Efficacy in the Prevention of Hand-Foot Syndrome and Neuropathy Induced by XELOX or m-FOLFOX6 Regimens in Metastatic Colorectal Cancer: A Triple-Blinded, Randomized Clinical Trial. Iran J Pharm Res. 2024;23:e152364. doi:10.5812/ijpr-152364
- Tomsuk Ö, Kaçar S. Mechanistic Insights into Silymarin-Induced Apoptosis and Growth Inhibition in SPC212 Human Mesothelioma Cells. Cell Biochem Biophys. 2025. doi:10.1007/s12013-024-01650-w
- Fatemi Shandiz A, Karimi G, Dayyani M, Hosseini S, Elyasi S. Evaluation of oral silymarin formulation efficacy in prevention of doxorubicin induced hepatotoxicity in patients with non-metastatic breast cancer. J Oncol Pharm Pract. 2024. doi:10.1177/10781552241268778
- Gholami AH, Ansari H, Dadkhah A. Effect of Silybum Marianum on Reduction of Chemotherapy-Induced Peripheral Neurotoxicity with Cisplatin. Adv Biomed Res. 2024;13:21. doi:10.4103/abr.abr_365_21
- Li P, Wang D, Yang X, Liu C, Li X, et al. Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification. Molecules. 2024;29. doi:10.3390/molecules29081901
- Verdura S, Encinar JA, Gratchev A, Llop-Hernández À, López J, et al. Silibinin is a suppressor of the metastasis-promoting transcription factor ID3. Phytomedicine. 2024;128:155493. doi:10.1016/j.phymed.2024.155493
- Karimzadeh MR, Masoudi Chelegahi A, Shahbazi S, Reiisi S. Co-treatment of silymarin and cisplatin inhibited cell proliferation, induced apoptosis in ovarian cancer. Mol Biol Rep. 2024;51:118. doi:10.1007/s11033-023-09026-8
- Zhang X, Jiang Y, Guo N, Ding Y, Feng J, et al. Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn. J Pharm Biomed Anal. 2024;238:115816. doi:10.1016/j.jpba.2023.115816
- Rahnama S, Tehrankhah ZM, Mohajerani F, Mohammadi FS, Yeganeh ZY, et al. Milk thistle nano-micelle formulation promotes cell cycle arrest and apoptosis in hepatocellular carcinoma cells through modulating miR-155-3p /SOCS2 /PHLDA1 signaling axis. BMC Complement Med Ther. 2023;23:337. doi:10.1186/s12906-023-04168-5
- Gheybi F, Rajabian F, Tayarani-Najaran Z, Adibi AR, Alavizadeh SH, et al. Liposomal silymarin anti-oxidative and anti-apoptotic features in lung cells: An implication in cadmium toxicity. J Trace Elem Med Biol. 2023;80:127291. doi:10.1016/j.jtemb.2023.127291
- Wu S, Chen G, Chen EY, Farshidpour LS, Zhang Q, et al. Core Structure-Activity Relationship Studies of 5,7,20--Trimethylsilybins in Prostate Cancer Cell Models. Pharmaceuticals (Basel). 2023;16. doi:10.3390/ph16040531
- Parsa L, Motafakkerazad R, Soheyli ST, Haratian A, Kosari-Nasab M, et al. Silymarin in combination with ATRA enhances apoptosis induction in human acute promyelocytic NB4 cells. Toxicon. 2023;228:107127. doi:10.1016/j.toxicon.2023.107127
- Nawaz A, Zaib S, Khan I, Ahmed A, Shahzadi K, et al. : An Overview of its Phytochemistry and Pharmacological Activities with Emphasis on Potential Anticancer Properties. Anticancer Agents Med Chem. 2023;23:1519. doi:10.2174/1871520623666230412111152
- Faixová D, Ratvaj M, Maruščáková IC, Hrčková G, Karaffová V, et al. Silybin Showed Higher Cytotoxic, Antiproliferative, and Anti-Inflammatory Activities in the CaCo Cancer Cell Line while Retaining Viability and Proliferation in Normal Intestinal IPEC-1 Cells. Life (Basel). 2023;13. doi:10.3390/life13020492
- Mao JT, Xue B, Lu QY, Lundmark L, Burns W, et al. Combinations of grape seed procyanidin extract and milk thistle silymarin extract against lung cancer - The role of MiR-663a and FHIT. Life Sci. 2023;318:121492. doi:10.1016/j.lfs.2023.121492
- Ghodousi M, Karbasforooshan H, Arabi L, Elyasi S. Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. Eur J Clin Pharmacol. 2023;79:15. doi:10.1007/s00228-022-03434-8
