Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 7 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Pantothenic Acid (Vitamin B-5) (From Calcium Pantothenate)
500 mg
10,000%
Calcium (From Calcium Pantothenate)
45 mg
3%
Top Medical Research Studies
8
We explored how blocking L-type calcium channels (LTCCs) could influence anxiety-like behaviors during cocaine abstinence in both female and male rats. In this study, rats were trained to self-administer cocaine or saline, followed by a two-week abstinence period. Throughout this withdrawal phase, we examined their behavior using several tests designed to measure anxiety and mood, notably the elevated plus maze and forced swim test, while also checking for changes in their preference for a sweet solution.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Read More
Most Useful Reviews
9
Reduced anxiety
18 people found this helpful
I have been advised by my therapist that this may significantly reduce anxiety.
Read More
9
Effective treatment
9 people found this helpful
It truly helps! I started taking this for anxiety, and it has worked remarkably well. I'm now a month into my trial of this supplement and have been recommending it to my family.
Read More
9
Quality product
This is a fantastic product to aid with anxiety and stress. I’ve reordered multiple times, as the quality is consistently good.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We explored how blocking L-type calcium channels (LTCCs) could influence anxiety-like behaviors during cocaine abstinence in both female and male rats. In this study, rats were trained to self-administer cocaine or saline, followed by a two-week abstinence period. Throughout this withdrawal phase, we examined their behavior using several tests designed to measure anxiety and mood, notably the elevated plus maze and forced swim test, while also checking for changes in their preference for a sweet solution.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced anxiety
18 people found this helpful
I have been advised by my therapist that this may significantly reduce anxiety.
Read More
9
Effective treatment
9 people found this helpful
It truly helps! I started taking this for anxiety, and it has worked remarkably well. I'm now a month into my trial of this supplement and have been recommending it to my family.
Read More
9
Quality product
This is a fantastic product to aid with anxiety and stress. I’ve reordered multiple times, as the quality is consistently good.
Read More
8
ADHD improvement
Initially intended for my acne, this product surprisingly alleviated my anxiety and ADHD symptoms significantly. I've experienced reduced stress and improved focus since beginning daily intake.
Read More
8
Calming effect
Works wonderfully with pantethine for the adrenal glands. It lessens anxiety and promotes calmness.
Read More
Frequently Asked Questions
9
Effective treatment
9 people found this helpful
It truly helps! I started taking this for anxiety, and it has worked remarkably well. I'm now a month into my trial of this supplement and have been recommending it to my family.
8
ADHD improvement
Initially intended for my acne, this product surprisingly alleviated my anxiety and ADHD symptoms significantly. I've experienced reduced stress and improved focus since beginning daily intake.
0
Strange reaction
It had an odd effect on me; after taking it before bed, I woke up feeling broken and anxious. I recommend being cautious with this supplement.
7
Increased calmness
During stressful periods, I take one capsule at breakfast as prescribed by my doctor, leading to decreased anxiety and increased energy.
8
Calming effect
Works wonderfully with pantethine for the adrenal glands. It lessens anxiety and promotes calmness.
9
Reduced anxiety
18 people found this helpful
I have been advised by my therapist that this may significantly reduce anxiety.
8
We explored how blocking L-type calcium channels (LTCCs) could influence anxiety-like behaviors during cocaine abstinence in both female and male rats. In this study, rats were trained to self-administer cocaine or saline, followed by a two-week abstinence period. Throughout this withdrawal phase, we examined their behavior using several tests designed to measure anxiety and mood, notably the elevated plus maze and forced swim test, while also checking for changes in their preference for a sweet solution.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
References
- Nunes EJ, Kimble V, Rajadhyaksha AM, Addy NA. L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats. Neuroscience. 2025;568:314. 10.1016/j.neuroscience.2025.01.003
