We conducted a randomized, double-blind clinical trial to investigate the effects of silymarin on patients with beta-thalassemia major.
Over three months, 59 patients received either silymarin along with desferrioxamine or a placebo.
While silymarin showed promising benefits, particularly in liver and red blood cell health, there was no significant difference in serum ferritin levels between groups after treatment.
However, we believe that this combination can be safely integrated into therapies for iron-overloaded patients.
Read More
9
Silymarin reduces iron overload effectively
A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
We examined how silymarin, derived from silybum marianum, impacts iron overload in patients with β-thalassemia major undergoing treatment with desferrioxamine. Over nine months, patients who received silymarin alongside desferrioxamine saw marked reductions in ferritin, iron, and total iron-binding capacity compared to those taking a placebo.
Additionally, participants using silymarin experienced improved liver function and lowered hepcidin levels. This suggests that silymarin could effectively alleviate body iron burden, enhancing treatment outcomes for anemia in thalassemia patients.
Read More
Most Useful Reviews
9
Boosted energy levels
I've just started taking this supplement and was pleasantly surprised by the surge of energy it provides while I tackle my anaemia. My hair had been falling out in clumps for four years, and now I feel more confident while washing and combing it again.
Read More
7.5
Symptoms alleviated
45 people found this helpful
I believed that my hair loss, angular cheilitis, and pressing discomfort around my ribs were linked to anaemia and liver fatigue. After discovering this product, I took one capsule and was amazed that the unpleasant rib symptoms quickly vanished. I plan to continue using it for a while.
Read More
7.5
Reduced dark circles
I took this for my skin and hair, as anaemia often leaves me with dark circles under my eyes. After a long period of use, I finally noticed a result. I combined it with astaxanthin and krill oil, which helped me avoid sunburn during the holidays, and the blemishes under my eyes diminished.
We examined how silymarin, derived from silybum marianum, impacts iron overload in patients with β-thalassemia major undergoing treatment with desferrioxamine. Over nine months, patients who received silymarin alongside desferrioxamine saw marked reductions in ferritin, iron, and total iron-binding capacity compared to those taking a placebo.
Additionally, participants using silymarin experienced improved liver function and lowered hepcidin levels. This suggests that silymarin could effectively alleviate body iron burden, enhancing treatment outcomes for anemia in thalassemia patients.
Read More
4
Silymarin shows potential in thalassemia
Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: a randomized double-blind clinical trial.
We conducted a randomized, double-blind clinical trial to investigate the effects of silymarin on patients with beta-thalassemia major.
Over three months, 59 patients received either silymarin along with desferrioxamine or a placebo.
While silymarin showed promising benefits, particularly in liver and red blood cell health, there was no significant difference in serum ferritin levels between groups after treatment.
However, we believe that this combination can be safely integrated into therapies for iron-overloaded patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
All Reviews
Positive Reviews
Negative Reviews
9
Boosted energy levels
I've just started taking this supplement and was pleasantly surprised by the surge of energy it provides while I tackle my anaemia. My hair had been falling out in clumps for four years, and now I feel more confident while washing and combing it again.
Read More
7.5
Symptoms alleviated
45 people found this helpful
I believed that my hair loss, angular cheilitis, and pressing discomfort around my ribs were linked to anaemia and liver fatigue. After discovering this product, I took one capsule and was amazed that the unpleasant rib symptoms quickly vanished. I plan to continue using it for a while.
Read More
7.5
Reduced dark circles
I took this for my skin and hair, as anaemia often leaves me with dark circles under my eyes. After a long period of use, I finally noticed a result. I combined it with astaxanthin and krill oil, which helped me avoid sunburn during the holidays, and the blemishes under my eyes diminished.
Read More
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References
Moayedi B, Gharagozloo M, Esmaeil N, Maracy MR, Hoorfar H, et al. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine. Eur J Haematol. 2013;90:202. 10.1111/ejh.12061
Gharagozloo M, Moayedi B, Zakerinia M, Hamidi M, Karimi M, et al. Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: a randomized double-blind clinical trial. Fundam Clin Pharmacol. 2009;23:359. 10.1111/j.1472-8206.2009.00681.x