Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.9
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%**
Total Sugars
0 g
†
Incl. 0 g Added Sugars
0%**
Intelliflora™ Blend:
150 mg5 billion CFUs
Lactobacillus crispatus LBV 88
†
Lactobacillus rhamnosus LBV 96
†
Lactobacillus gasseri LBV 150N
†
Lactobacillus jensenii LBV 116
†
Top Medical Research Studies
9
We examined how Lactobacillus rhamnosus SP1 impacts acne through a 12-week study involving 20 adults. Participants were split into two groups: one received a liquid probiotic supplement, while the other got a placebo. Notably, those in the probiotic group showed significant improvements in skin gene expression linked to insulin signalling and had a higher chance of being rated as improved by physicians. Our findings suggest that this probiotic not only alters critical skin genes but also visibly enhances adult acne.
Read More
8
We explored how oral intake of Lactobacillus plantarum CCFM8661 affects acne, using a mouse model to examine its effects on skin inflammation and hormone production. Our findings revealed that live L. plantarum significantly reduced acne-related skin inflammation and regulated hormone levels, likely benefiting skin lipid metabolism. In contrast, inactivated L. plantarum showed limited effects on inflammation. Both forms of the probiotic positively influenced gut health, which may also play a role in managing acne. Overall, the evidence suggests that live Lactobacillus may offer a promising avenue for acne treatment.
Read More
8
Lactobacillus aids mild acne treatment
We investigated the effects of lactobacillus plantarum, a beneficial bacteria, on acne treatment. Clinical studies showed that when applied in a 5% solution, lactobacillus extract significantly reduced erythema and improved the skin barrier, which in turn led to smaller acne lesions. However, the lower concentration of 1% did not show these benefits. Overall, the findings suggest that lactobacillus could be a viable option for treating mild acne.
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Most Useful Reviews
9.5
Effective acne treatment
So far, after taking it (I have finished a whole bottle), my itchy problem and acne in the private area have not returned. I consider this a positive indication that it has worked.
Read More
0
Worsened acne condition
It caused me to break out, and after using it for a week, my acne worsened significantly. If you have acne-prone skin, I would advise against using this product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
- All Researches
9
We examined how Lactobacillus rhamnosus SP1 impacts acne through a 12-week study involving 20 adults. Participants were split into two groups: one received a liquid probiotic supplement, while the other got a placebo. Notably, those in the probiotic group showed significant improvements in skin gene expression linked to insulin signalling and had a higher chance of being rated as improved by physicians. Our findings suggest that this probiotic not only alters critical skin genes but also visibly enhances adult acne.
Read More
8
We evaluated how effective probiotics, specifically lactobacillus, might be for treating acne. Analyzing numerous studies revealed that these probiotics can help reduce acne lesions and improve skin health. Interestingly, both oral and topical applications showed promising results, sometimes even matching conventional treatments like antibiotics.
However, we also noticed that responses to specific probiotic strains varied, and some participants experienced rare side effects. Overall, our findings suggest that while probiotics could offer a natural treatment option, further research is essential to establish the best practices for use.
However, we also noticed that responses to specific probiotic strains varied, and some participants experienced rare side effects. Overall, our findings suggest that while probiotics could offer a natural treatment option, further research is essential to establish the best practices for use.
Read More
8
We examined how lactobacillus might improve acne vulgaris through changes in gut bacteria and tryptophan metabolism. Using a rat model that mimicked human gut conditions, we introduced gut microbiota from both healthy individuals and acne patients.
Our findings showed that lactobacillus significantly reduced acne-like symptoms by lowering inflammation and promoting beneficial bacteria. It also enhanced tryptophan metabolites linked to skin health, suggesting its potential as a natural treatment option.
Our findings showed that lactobacillus significantly reduced acne-like symptoms by lowering inflammation and promoting beneficial bacteria. It also enhanced tryptophan metabolites linked to skin health, suggesting its potential as a natural treatment option.
Read More
8
We explored how oral intake of Lactobacillus plantarum CCFM8661 affects acne, using a mouse model to examine its effects on skin inflammation and hormone production. Our findings revealed that live L. plantarum significantly reduced acne-related skin inflammation and regulated hormone levels, likely benefiting skin lipid metabolism. In contrast, inactivated L. plantarum showed limited effects on inflammation. Both forms of the probiotic positively influenced gut health, which may also play a role in managing acne. Overall, the evidence suggests that live Lactobacillus may offer a promising avenue for acne treatment.
Read More
8
Probiotics show promise for acne
We aimed to understand how lactobacillus, combined with topical treatments, impacts acne-prone skin. Over three months, 20 participants took a daily probiotic and applied a topical treatment.
We noticed that clinically visible non-inflammatory lesions decreased from 11.5 to 7.3, suggesting positive effects. Additionally, imaging techniques revealed decreased microscopic acne features, which may not be observable through simple clinical assessments.
This research shows that acne-prone skin responds well to treatment, highlighting lactobacillus as a potential player in managing acne.
We noticed that clinically visible non-inflammatory lesions decreased from 11.5 to 7.3, suggesting positive effects. Additionally, imaging techniques revealed decreased microscopic acne features, which may not be observable through simple clinical assessments.
This research shows that acne-prone skin responds well to treatment, highlighting lactobacillus as a potential player in managing acne.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Effective acne treatment
So far, after taking it (I have finished a whole bottle), my itchy problem and acne in the private area have not returned. I consider this a positive indication that it has worked.
Read More
0
Worsened acne condition
It caused me to break out, and after using it for a week, my acne worsened significantly. If you have acne-prone skin, I would advise against using this product.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Sutema IAMP, Latarissa IR, Widowati IGAR, Sartika CR, Ciptasari NWE, et al. Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne: A Scoping Review of Current Results. J Exp Pharmacol. 2025;17:1. doi:10.2147/JEP.S498769
- Atefi N, Mohammadi M, Bodaghabadi M, Mehrali M, Behrangi E, et al. Evaluating the Effectiveness of Probiotic Supplementation in Combination With Doxycycline for the Treatment of Moderate Acne: A Randomized Double-Blind Controlled Clinical Trial. J Cosmet Dermatol. 2025;24:e16614. doi:10.1111/jocd.16614
- Huang Y, Huang Y, Xia D, Liu L, Xiong X, et al. ameliorates acne vulgaris in SD rats changes in gut microbiota and associated tryptophan metabolism. Front Immunol. 2023;14:1293048. doi:10.3389/fimmu.2023.1293048
- Cao Q, Guo J, Chang S, Huang Z, Luo Q. Gut microbiota and acne: A Mendelian randomization study. Skin Res Technol. 2023;29:e13473. doi:10.1111/srt.13473
- Ai J, Ma W, Pan Z, Mao B, Tang X, et al. Ameliorative effect of Lactobacillus plantarum CCFM8661 on oleic acid-induced acne: integrated gut microbiota link to acne pathogenesis. J Sci Food Agric. 2024;104:328. doi:10.1002/jsfa.12921
- Manfredini M, Sticchi A, Lippolis N, Pedroni G, Giovani M, et al. Characterization of Acne-Prone Skin with Reflectance Confocal Microscopy and Optical Coherence Tomography and Modifications Induced by Topical Treatment and Probiotic Supplementation. J Clin Med. 2023;12. doi:10.3390/jcm12144787
- Sathikulpakdee S, Kanokrungsee S, Vitheejongjaroen P, Kamanamool N, Udompataikul M, et al. Efficacy of probiotic-derived lotion from Lactobacillus paracasei MSMC 39-1 in mild to moderate acne vulgaris, randomized controlled trial. J Cosmet Dermatol. 2022;21:5092. doi:10.1111/jocd.14971
- Lebeer S, Oerlemans EFM, Claes I, Henkens T, Delanghe L, et al. Selective targeting of skin pathobionts and inflammation with topically applied lactobacilli. Cell Rep Med. 2022;3:100521. doi:10.1016/j.xcrm.2022.100521
- Kim MJ, Kim KP, Choi E, Yim JH, Choi C, et al. Effects of CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2021;13. doi:10.3390/nu13041368
- Cha H, Kim SK, Kook M, Yi TH. Lactobacillus paraplantarum THG-G10 as a potential anti-acne agent with anti-bacterial and anti-inflammatory activities. Anaerobe. 2020;64:102243. doi:10.1016/j.anaerobe.2020.102243
- Khmaladze I, Butler É, Fabre S, Gillbro JM. Lactobacillus reuteri DSM 17938-A comparative study on the effect of probiotics and lysates on human skin. Exp Dermatol. 2019;28:822. doi:10.1111/exd.13950
- Deidda F, Amoruso A, Nicola S, Graziano T, Pane M, et al. New Approach in Acne Therapy: A Specific Bacteriocin Activity and a Targeted Anti IL-8 Property in Just 1 Probiotic Strain, the L. salivarius LS03. J Clin Gastroenterol. 2018;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017:S78. doi:10.1097/MCG.0000000000001053
- Fabbrocini G, Bertona M, Picazo Ó, Pareja-Galeano H, Monfrecola G, et al. Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne. Benef Microbes. 2016;7:625.
- Kwon HH, Yoon JY, Park SY, Min S, Suh DH. Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study. Dermatology. 2014;229:102. doi:10.1159/000362491
- Jung GW, Tse JE, Guiha I, Rao J. Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne. J Cutan Med Surg. 2013;17:114.
- Muizzuddin N, Maher W, Sullivan M, Schnittger S, Mammone T. Physiological effect of a probiotic on skin. J Cosmet Sci. 2012;63:385.
