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Our results highlighted significant benefits, with the probiotics maintaining microbiota stability in the vagina and gut, unlike the placebo group. Participants taking probiotics showed less variation in their microbiota, which is crucial for overall health. While the treatment showed promise in preserving microbiota composition, individual experiences may vary.
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What’s exciting is the potential of L. gasseri VHProbi E09 as a probiotic for improving vaginal health, either taken orally or applied directly. However, more research is needed to fully explore its effects and effectiveness in restoring balance in the vaginal ecosystem.
Our analysis of 159 strains showed that many have inhibitory effects on Candida, altering its metabolism through key metabolites like L-lactate and formate. Interestingly, we found a positive link between the presence of these beneficial strains and lower Candida levels in vaginal samples.
This research informs future strategies focused on enhancing vaginal health by utilizing these powerful strains and their metabolites to hinder candidiasis.
Additionally, VAGINNE significantly decreased inflammation markers, which is essential for tissue health. This promising approach suggests VAGINNE could be a valuable alternative to traditional antifungals, especially for women facing drug resistance or side effects from standard treatments.
The results were promising! Participants who took probiotics showed better clinical and mycological outcomes, along with a reduced rate of relapse compared to those on antifungal treatment alone. This suggests that probiotics may be a valuable addition to VVC management.
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Frequently Asked Questions
Candidiasis, commonly known as a yeast infection, is an infection caused by the overgrowth of Candida, a type of fungus that naturally occurs in various locations in the body, including the mouth, gut, and vagina. Under normal circumstances, Candida exists in balance with other microorganisms, but factors such as antibiotic use, high sugar diets, and compromised immune systems can disrupt this balance, leading to an overgrowth. This can manifest in various forms, including oral thrush (affecting the mouth), vaginal yeast infections, and invasive candidiasis (which can affect the bloodstream and internal organs).
Symptoms of candidiasis vary depending on the area affected; for example, a vaginal yeast infection can cause itching, burning, and unusual discharge, while oral thrush may lead to white patches in the mouth, soreness, and difficulty swallowing. Treatment typically involves antifungal medications, which can be prescribed or obtained over-the-counter, depending on the severity and type of the infection. To prevent recurrence, it's essential to maintain a healthy diet, manage stress, and practice good hygiene. If you suspect you have candidiasis, particularly in more severe cases, consulting a healthcare provider is recommended for appropriate diagnosis and treatment options.
Lactobacillus is a genus of bacteria that plays a crucial role in the fermentation of various foods and is found naturally in the human gut. Known for their probiotic properties, strains of Lactobacillus are commonly utilized in the production of yogurt, sauerkraut, and other fermented products. They are characterized by their rod-shaped structure and ability to convert sugars into lactic acid, which not only helps preserve food but also contributes to the tangy flavor of fermented foods.
In addition to their culinary uses, Lactobacillus bacteria can offer several health benefits. They are known to support gut health by enhancing the balance of beneficial bacteria in the microbiome, potentially aiding in digestion and alleviating symptoms of issues like irritable bowel syndrome (IBS). Regular consumption of Lactobacillus-containing foods or supplements may also bolster the immune system and improve overall digestive health. With a growing interest in gut health, Lactobacillus remains a key player in both dietary and therapeutic contexts.
Research suggests that Lactobacillus, a genus of probiotic bacteria, may play a beneficial role in managing Candidiasis, a fungal infection caused by an overgrowth of Candida species, particularly Candida albicans. Probiotics like Lactobacillus can help maintain a healthy balance of vaginal flora, potentially inhibiting the growth of harmful organisms, including yeast. Studies have indicated that supplementation with Lactobacillus can help restore the natural microbiome, which may reduce the frequency and severity of candidiasis symptoms.
While incorporating Lactobacillus through dietary sources like yogurt, fermented foods, or probiotic supplements can support overall gut and vaginal health, it is essential to consult with a healthcare professional for personalized advice. Probiotics may not replace traditional antifungal treatments, but they may complement them and promote a more resilient microbiome. If you’re experiencing recurrent candidiasis, discussing the potential benefits of Lactobacillus with your healthcare provider can help you determine the best course of action.
Based on user reviews, the timeline for seeing results from this supplement can vary significantly. Some users report noticeable relief and improvement within just a few days of taking the probiotics, suggesting prompt benefits for issues like thrush and general candida symptoms (Read Review). For others, more extended use has led to sustained improvements, with one user noting that after three months of consistent use, they experienced no further outbreaks of candida (Read Review).
However, not all experiences are positive; some users have reported that the probiotics did not provide relief even after several months of consistent use (Read Review). There are also mentions of continuous symptoms persisting despite long-term usage guidelines, illustrating that while many find benefits within a few weeks, it may take longer or may not work for everyone. Overall, users recommend an initial trial of at least a month to gauge effectiveness while being open to the possibility of needing longer periods for some individuals.
The use of probiotics, particularly certain strains of Lactobacillus, in combating candidiasis is supported by several scientific studies. Research has shown that Lactobacillus strains can effectively inhibit the growth of Candida species, thereby promoting vaginal and oral health. One study highlighted Lactobacillus fermentum KBL674, which demonstrated significant antifungal effects against Candida albicans, suggesting it may be a viable option for managing vaginal candidiasis [7]. Furthermore, a review compiling multiple trials indicated that probiotics generally helped restore healthy microbiota in individuals suffering from vulvovaginal candidiasis, albeit with varying outcomes [10].
Other studies have reinforced the notion that combining probiotics with traditional antifungal treatments yields improved results, reducing relapse rates compared to antifungal therapy alone [5]. Notably, specific Lactobacillus strains, such as LM1215 and LM1209, have shown potential in disrupting biofilms associated with Candida, indicating they could effectively combat recurrent infections [6]. While not every probiotic trial yielded positive results in reducing infection rates, the overall evidence suggests that probiotics may offer a complementary strategy in the fight against candidiasis, particularly for those looking for alternatives to conventional antifungal therapies. Still, more research is needed to fully characterize the benefits and mechanisms involved.
Users have reported a range of positive improvements in their symptoms while using these probiotics, particularly for issues related to thrush and candida. For instance, several individuals have mentioned significant relief from discomfort, with one user offering that after starting the probiotics, their wife's intense discomfort in the intimate area disappeared, and the benefits persisted even after completing the treatment (Read Review). Others have noted a complete absence of candida outbreaks after consistent usage over months, praising the product's effectiveness (Read Review). Additionally, some users experienced improved vaginal health and balanced microflora, with one user highlighting an improvement in symptoms like bloating and regular bowel movements when combining probiotics with antibiotic treatment (Read Review).
However, while many report positive outcomes, there are also instances where users did not find relief even after extended use, indicating that individual results can vary significantly. For example, one user shared that despite taking the probiotics for six months, their symptoms persisted without improvement (Read Review). Thus, while a number of users can attest to the benefits and recommend giving the product a try, it's important to note that what works for one person may not necessarily work for another, and effectiveness can depend on various factors including individual health conditions and diet.
Users report a variety of experiences when combining this probiotic supplement with other treatments for candidiasis. For instance, one user noted significant improvements in their intimate health after using the probiotics alongside AZO boric acid suppositories and dual yeast treatments, stating that they felt much better once their pH was restored (Read Review). Similarly, another user confirmed that they had been advised by their doctor to use this probiotic in conjunction with suppositories and tablets from the same brand, effectively addressing their thrush issues (Read Review).
Moreover, some users highlighted the importance of pairing the probiotics with specific dietary measures. One reviewer mentioned that while using the probiotics post-anti-candidal treatment, they achieved satisfactory results and emphasized the necessity of adhering to an anti-candida diet for optimal outcomes (Read Review). However, it is worth noting that not all users experienced the same success; some reported limited effectiveness, underscoring that individual results can significantly vary depending on various factors, including the specific combination of treatments used and personal health circumstances (Read Review).
Based on user reviews, there seems to be a varied consensus on the appropriate dosage of Lactobacillus for treating Candidiasis. Some users reported successful outcomes with a regimen of one capsule daily, indicating that this frequency was manageable and effective for their symptoms. For instance, one user said, "I appreciated the convenience of one capsule per day, which I used while addressing candida thrush" (Read Review). Additionally, another user noted taking "one pill daily and two during sensitive periods," suggesting that increasing the dosage could be beneficial during flare-ups (Read Review).
However, some users felt that the dosages they were taking were insufficient for their needs, with one stating, "While not containing the daily 50 billion lactobacilli I believe necessary, it did provide partial help" (Read Review). This highlights the potential for individual variability in how different people respond to quantities of Lactobacillus in managing their Candidiasis. Users emphasized that alongside dosage, factors like combined treatments and dietary changes may also affect overall effectiveness.
However, the results varied across studies, signaling that more research is necessary to fully understand their benefits in treating these infections.
The results were promising! Participants who took probiotics showed better clinical and mycological outcomes, along with a reduced rate of relapse compared to those on antifungal treatment alone. This suggests that probiotics may be a valuable addition to VVC management.
In addition, LM1215 showed remarkable ability to disrupt biofilms and induce cellular damage against these pathogens. Our findings suggest that LM1215 is not only effective but also safe, positioning it as a viable probiotic option for preventing VVC and bacterial vaginosis.
References
- Hu T, Meng Y, Zhao C, Sheng D, Yang S, et al. Genome-scale metabolic modeling reveals specific vaginal strains and their metabolites as key inhibitors of . Microbiol Spectr. 2025. doi:10.1128/spectrum.02984-24
- Nachum Z, Suleiman A, Colodner R, Battino S, Wattad M, et al. Oral Probiotics to Prevent Recurrent Vulvovaginal Infections During Pregnancy-Multicenter Double-Blind, Randomized, Placebo-Controlled Trial. Nutrients. 2025;17. doi:10.3390/nu17030460
- Rajão A, Silva JPN, Almeida-Nunes DL, Rompante P, Rodrigues CF, et al. AJCR4: A Potential Probiotic in the Fight Against Oral spp. Biofilms. Int J Mol Sci. 2025;26. doi:10.3390/ijms26020638
- Horng HC, Xu JW, Kuo YS, Chen YS, Chiu YH, et al. Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of Fermentation Broth in Treating Vulvovaginal Candidiasis. J Fungi (Basel). 2024;11. doi:10.3390/jof11010018
- Thekho AJ, Mendiratta V, Garg T, Kaur R, Yadav V. Role of Probiotic in Vulvovaginal Candidiasis: A Randomised Controlled Non-blinded Trial from India. Indian J Dermatol. 2024;69:422. doi:10.4103/ijd.ijd_193_24
- Bae WY, Lee YJ, Jo S, Shin SL, Kim TR, et al. Effects of LM1215 on and . Yonsei Med J. 2024;65:727. doi:10.3349/ymj.2023.0490
- Jang SJ, Jo EJ, Lee C, Cho BR, Shin YJ, et al. Limosilactobacillus fermentum KBL674 Alleviates Vaginal Candidiasis. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10403-3
- Ferreira RLPS, Nova BGV, Carmo MS, Abreu AG. Mechanisms of action of Lactobacillus spp. in the treatment of oral candidiasis. Braz J Biol. 2024;84:e282609. doi:10.1590/1519-6984.282609
- Vazquez-Munoz R, Thompson A, Sobue T, Dongari-Bagtzoglou A. is a dominant in the murine oral mucosa and has chitinase activity that compromises fungal cell wall integrity. mBio. 2024;15:e0241624. doi:10.1128/mbio.02416-24
- Zuñiga Vinueza AM. Probiotics for the Prevention of Vaginal Infections: A Systematic Review. Cureus. 2024;16:e64473. doi:10.7759/cureus.64473
- Zhang J, Li K, Cao T, Duan Z. Characterization of a Lactobacillus gasseri strain as a probiotic for female vaginitis. Sci Rep. 2024;14:14426. doi:10.1038/s41598-024-65550-y
- Elsayes SA, El Attar MS, ElHadary A, Aboulela AG, Essawy MM, et al. Antimycotic prophylaxis with multispecies probiotics against oral candidiasis in new complete denture wearers: A randomized clinical trial. J Prosthet Dent. 2024. doi:10.1016/j.prosdent.2024.05.018
- Zahedifard T, Khadivzadeh T, Rakhshkhorshid M. The Role of Probiotics in the Treatment of Vulvovaginal Candidiasis: A Systematic Review and Meta-Analysis. Ethiop J Health Sci. 2023;33:881. doi:10.4314/ejhs.v33i5.18
- Ang XY, Roslan NS, Ahmad N, Yusof SM, Abdullah N, et al. Lactobacillus probiotics restore vaginal and gut microbiota of pregnant women with vaginal candidiasis. Benef Microbes. 2023;14:421. doi:10.1163/18762891-20220103
- Bertarello C, Savio D, Morelli L, Bouzalov S, Davidova D, et al. Efficacy and safety of Lactobacillus plantarum P 17630 strain soft vaginal capsule in vaginal candidiasis: a randomized non-inferiority clinical trial. Eur Rev Med Pharmacol Sci. 2024;28:384. doi:10.26355/eurrev_202401_34927
- Faustino M, Pereira JO, Pereira AM, Oliveira AS, Ferreira CMH, et al. Vaginal prevention of Candida albicans: synergistic effect of lactobacilli and mannan oligosaccharides (MOS). Appl Microbiol Biotechnol. 2024;108:73. doi:10.1007/s00253-023-12909-2
