Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
USERS' SCORE
Moderately Good
Based on 107 Reviews
7.9
Supplement Facts
Serving Size: 5 Drops
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
L.reuteriDSM 17938(L. reuteriProtectis®)
100 million CFU
†
Top Medical Research Studies
8
L. reuteri enhances bowel movements
We conducted a double-blind, placebo-controlled trial involving 40 adults with functional constipation to see if Lactobacillus reuteri could improve their condition. Over four weeks, those receiving L. reuteri had a notable increase in weekly bowel movements, averaging 2.6 more compared to just 1.0 in the placebo group.
While this probiotic showed promise in enhancing bowel movement frequency, it did not significantly change stool consistency. This suggests that L. reuteri may be a beneficial option for adults struggling with constipation.
While this probiotic showed promise in enhancing bowel movement frequency, it did not significantly change stool consistency. This suggests that L. reuteri may be a beneficial option for adults struggling with constipation.
Read More
4
Probiotics may aid constipation relief
We investigated the effectiveness of the probiotic Lactobacillus reuteri DSM 17938 for treating constipation in young patients suffering from anorexia nervosa.
In a randomized, double-blind study with 31 pediatric female patients, we compared those taking the probiotic to a placebo over three months alongside nutritional therapy.
While we did not see a significant difference in constipation relief between the two groups immediately, there may be potential benefits in stool frequency and nutritional recovery after six months.
In a randomized, double-blind study with 31 pediatric female patients, we compared those taking the probiotic to a placebo over three months alongside nutritional therapy.
While we did not see a significant difference in constipation relief between the two groups immediately, there may be potential benefits in stool frequency and nutritional recovery after six months.
Read More
2
This study set out to examine whether Lactobacillus reuteri DSM 17938 could help children suffering from functional constipation. Conducted as a controlled trial, it compared children who received this probiotic alongside lactulose to those who received a placebo with lactulose.
Unfortunately, results showed no notable differences in stool frequency, consistency, or discomfort between the two groups. Therefore, it concluded that Lactobacillus reuteri DSM 17938 doesn't provide additional benefits in managing constipation in children. However, the small sample size suggests we should take these findings with caution.
Unfortunately, results showed no notable differences in stool frequency, consistency, or discomfort between the two groups. Therefore, it concluded that Lactobacillus reuteri DSM 17938 doesn't provide additional benefits in managing constipation in children. However, the small sample size suggests we should take these findings with caution.
Read More
Most Useful Reviews
9
Effective against constipation
107 people found this helpful
The most remarkable product I received! It genuinely alleviates my baby’s gas and constipation. A few drops work wonders, providing relief quickly. Previously, we struggled with colic and sleepless nights despite trying various methods. I wholeheartedly recommend this drop for anyone in a similar situation.
Read More
9
Improved digestion
23 people found this helpful
I bought this for my nephew who had constipation since birth due to being delivered by caesarean section. The quality is excellent, and it contains beneficial bacteria. After using it, his constipation disappeared, and it significantly improved his digestion. Plus, it's easier to use than pharmacy products.
Read More
9
Constipation relief
21 people found this helpful
I used this for my one-year-old son, who often suffers from constipation. Initially unsure of the timing, I gave it in the morning. After a few days, his constipation improved dramatically, resulting in normal stools. This product appears beneficial for overall digestive health, and I plan to continue using it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
- All Researches
9
Lactobacillus reuteri enhances H. pylori treatment
We explored the effectiveness of Lactobacillus reuteri DSM 17648 as an adjunct treatment for patients with Helicobacter pylori infection. In a rigorous randomized, double-blind, placebo-controlled trial involving 90 treatment-naïve patients, we found that adding this probiotic significantly boosted the H. pylori eradication rate.
Additionally, participants taking Lactobacillus reuteri reported notable relief from gastrointestinal symptoms like constipation and abdominal pain, along with fewer treatment-related side effects. This suggests that Lactobacillus reuteri could be a valuable tool in enhancing conventional H. pylori treatments.
Additionally, participants taking Lactobacillus reuteri reported notable relief from gastrointestinal symptoms like constipation and abdominal pain, along with fewer treatment-related side effects. This suggests that Lactobacillus reuteri could be a valuable tool in enhancing conventional H. pylori treatments.
Read More
9
Lactobacillus reuteri improves gut motility
We explored how microvesicles from Lactobacillus reuteri impact gut motility, specifically in relation to constipation. Our study involved comparing the effects of the bacterium itself, its microvesicles, and the surrounding culture medium on mouse jejunum and colon segments.
We found that both the bacteria and their microvesicles effectively decreased contractions in the jejunum while boosting them in the colon. Notably, the removal of microvesicles significantly reduced their effects on motility, highlighting their critical role. These findings suggest exciting possibilities for bacterial treatments for constipation.
We found that both the bacteria and their microvesicles effectively decreased contractions in the jejunum while boosting them in the colon. Notably, the removal of microvesicles significantly reduced their effects on motility, highlighting their critical role. These findings suggest exciting possibilities for bacterial treatments for constipation.
Read More
8
Walnut fiber and probiotics relieve constipation
We examined how water-insoluble dietary fiber from walnuts, along with Limosilactobacillus reuteri, can help relieve constipation. Our analysis found that this fiber effectively lessened constipation symptoms in mice by enhancing gut motility and changing gut bacteria composition.
L. reuteri showed impressive results, working through specific neurochemical pathways that influence bowel movements. The findings suggest that incorporating walnut fiber and L. reuteri into diets could be a promising natural strategy for managing constipation.
L. reuteri showed impressive results, working through specific neurochemical pathways that influence bowel movements. The findings suggest that incorporating walnut fiber and L. reuteri into diets could be a promising natural strategy for managing constipation.
Read More
8
L. reuteri improves infant constipation
We explored the effects of Lactobacillus reuteri NCIMB 30351 on infants experiencing functional gastrointestinal disorders, including constipation. In a randomized, placebo-controlled trial, 90 infants aged 1 to 4 months received either the probiotic or a placebo for 25 days.
The results indicated a noteworthy increase in evacuation frequency for infants with constipation. We also saw significant reductions in colic symptoms, including crying duration. With no reported side effects, L. reuteri seems to be a promising option for easing constipation in young children.
The results indicated a noteworthy increase in evacuation frequency for infants with constipation. We also saw significant reductions in colic symptoms, including crying duration. With no reported side effects, L. reuteri seems to be a promising option for easing constipation in young children.
Read More
8
We examined the effects of a new infant formula on functional gastrointestinal disorders, including constipation, in 196 infants. Over two weeks, this formula, enriched with various nutrients and a specific probiotic, was found to significantly reduce gastrointestinal issues.
Notably, constipation rates dropped from 18.8% to just 6.5% within three days. Additionally, we recorded overall improvements in the infants' quality of life by the end of the study. This research highlights the beneficial role nutrition can play in managing infant FGIDs.
Notably, constipation rates dropped from 18.8% to just 6.5% within three days. Additionally, we recorded overall improvements in the infants' quality of life by the end of the study. This research highlights the beneficial role nutrition can play in managing infant FGIDs.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 107 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective against constipation
107 people found this helpful
The most remarkable product I received! It genuinely alleviates my baby’s gas and constipation. A few drops work wonders, providing relief quickly. Previously, we struggled with colic and sleepless nights despite trying various methods. I wholeheartedly recommend this drop for anyone in a similar situation.
Read More
9
Improved digestion
23 people found this helpful
I bought this for my nephew who had constipation since birth due to being delivered by caesarean section. The quality is excellent, and it contains beneficial bacteria. After using it, his constipation disappeared, and it significantly improved his digestion. Plus, it's easier to use than pharmacy products.
Read More
9
Constipation relief
21 people found this helpful
I used this for my one-year-old son, who often suffers from constipation. Initially unsure of the timing, I gave it in the morning. After a few days, his constipation improved dramatically, resulting in normal stools. This product appears beneficial for overall digestive health, and I plan to continue using it.
Read More
7.5
Daily bowel movements
17 people found this helpful
This product significantly relieved my son's constipation and overall mood. Initially skeptical about using it, I should have tried it earlier. After a week, he was having regular bowel movements every day, and his sleep improved notably, allowing longer stretches at night. I wish I had found it sooner!
Read More
7.5
Effective solution
15 people found this helpful
Within five days, this product did wonders for my son's constipation. Previously, he had regular issues, but since trying this, his stool improved markedly. I am thankful for this effective solution which relieved his discomfort.
Read More
Frequently Asked Questions
9
Effective constipation relief
3 people found this helpful
Great for relieving constipation in babies. We bought this for our 1.5-month-old baby on our paediatrician's advice. After suffering from gases and constipation, the probiotics resolved the constipation by the third day. Although gases occasionally still bother us, it’s manageable. I appreciate that it includes vitamin D, which is convenient. I recommend it.
7.5
Effective solution
15 people found this helpful
Within five days, this product did wonders for my son's constipation. Previously, he had regular issues, but since trying this, his stool improved markedly. I am thankful for this effective solution which relieved his discomfort.
9
Effective against constipation
107 people found this helpful
The most remarkable product I received! It genuinely alleviates my baby’s gas and constipation. A few drops work wonders, providing relief quickly. Previously, we struggled with colic and sleepless nights despite trying various methods. I wholeheartedly recommend this drop for anyone in a similar situation.
7.5
Daily bowel movements
17 people found this helpful
This product significantly relieved my son's constipation and overall mood. Initially skeptical about using it, I should have tried it earlier. After a week, he was having regular bowel movements every day, and his sleep improved notably, allowing longer stretches at night. I wish I had found it sooner!
9
Reduces colic
10 people found this helpful
This product has helped with my baby's constipation and colic since I started using it when he was three weeks old. It provided immediate relief for constipation, although the effect on colic was gradual. Overall, it has improved my baby's well-being.
9
Constipation remedy
8 people found this helpful
On discovering this miracle product for my child's constipation, I am grateful for the helpful reviews that guided my purchase. It has effectively alleviated our constipation woes, replacing a myriad of prescribed medications. Truly, it works!
9
Effective probiotics
12 people found this helpful
This probiotic with vitamin D has worked well for my two-month-old baby, addressing both constipation and bloating. It didn't cause any side effects, which is a relief. I appreciate its effectiveness and will definitely purchase it again!
9
Relieves constipation
7 people found this helpful
I find it amazing. I give it to my children after their course of antibiotics, as it eliminates both beneficial and harmful bacteria. I've also used it for my child, who suffers from constipation due to formula milk. The taste is acceptable, and my children take it well. The quality is good, and the package lasts a long time since I don't use it daily. It improves bowel movement and helps relax my children.
8
L. reuteri enhances bowel movements
We conducted a double-blind, placebo-controlled trial involving 40 adults with functional constipation to see if Lactobacillus reuteri could improve their condition. Over four weeks, those receiving L. reuteri had a notable increase in weekly bowel movements, averaging 2.6 more compared to just 1.0 in the placebo group.
While this probiotic showed promise in enhancing bowel movement frequency, it did not significantly change stool consistency. This suggests that L. reuteri may be a beneficial option for adults struggling with constipation.
While this probiotic showed promise in enhancing bowel movement frequency, it did not significantly change stool consistency. This suggests that L. reuteri may be a beneficial option for adults struggling with constipation.
8
L. reuteri improves infant constipation
We explored the effects of Lactobacillus reuteri NCIMB 30351 on infants experiencing functional gastrointestinal disorders, including constipation. In a randomized, placebo-controlled trial, 90 infants aged 1 to 4 months received either the probiotic or a placebo for 25 days.
The results indicated a noteworthy increase in evacuation frequency for infants with constipation. We also saw significant reductions in colic symptoms, including crying duration. With no reported side effects, L. reuteri seems to be a promising option for easing constipation in young children.
The results indicated a noteworthy increase in evacuation frequency for infants with constipation. We also saw significant reductions in colic symptoms, including crying duration. With no reported side effects, L. reuteri seems to be a promising option for easing constipation in young children.
8
Walnut fiber and probiotics relieve constipation
We examined how water-insoluble dietary fiber from walnuts, along with Limosilactobacillus reuteri, can help relieve constipation. Our analysis found that this fiber effectively lessened constipation symptoms in mice by enhancing gut motility and changing gut bacteria composition.
L. reuteri showed impressive results, working through specific neurochemical pathways that influence bowel movements. The findings suggest that incorporating walnut fiber and L. reuteri into diets could be a promising natural strategy for managing constipation.
L. reuteri showed impressive results, working through specific neurochemical pathways that influence bowel movements. The findings suggest that incorporating walnut fiber and L. reuteri into diets could be a promising natural strategy for managing constipation.
8
We explored how the probiotic Lactobacillus reuteri DSM 17938 can help alleviate chronic functional constipation in young children. In a rigorous study involving 60 kids, we compared L. reuteri alone, L. reuteri with magnesium oxide, and a placebo.
While all groups showed improved defecation frequency after four weeks, magnesium oxide usage raised some microbiome concerns. Importantly, we found that L. reuteri didn’t disrupt gut bacteria, suggesting it may be a cleaner option for addressing constipation without those side effects.
While all groups showed improved defecation frequency after four weeks, magnesium oxide usage raised some microbiome concerns. Importantly, we found that L. reuteri didn’t disrupt gut bacteria, suggesting it may be a cleaner option for addressing constipation without those side effects.
4
Probiotics may aid constipation relief
We investigated the effectiveness of the probiotic Lactobacillus reuteri DSM 17938 for treating constipation in young patients suffering from anorexia nervosa.
In a randomized, double-blind study with 31 pediatric female patients, we compared those taking the probiotic to a placebo over three months alongside nutritional therapy.
While we did not see a significant difference in constipation relief between the two groups immediately, there may be potential benefits in stool frequency and nutritional recovery after six months.
In a randomized, double-blind study with 31 pediatric female patients, we compared those taking the probiotic to a placebo over three months alongside nutritional therapy.
While we did not see a significant difference in constipation relief between the two groups immediately, there may be potential benefits in stool frequency and nutritional recovery after six months.
2
This study set out to examine whether Lactobacillus reuteri DSM 17938 could help children suffering from functional constipation. Conducted as a controlled trial, it compared children who received this probiotic alongside lactulose to those who received a placebo with lactulose.
Unfortunately, results showed no notable differences in stool frequency, consistency, or discomfort between the two groups. Therefore, it concluded that Lactobacillus reuteri DSM 17938 doesn't provide additional benefits in managing constipation in children. However, the small sample size suggests we should take these findings with caution.
Unfortunately, results showed no notable differences in stool frequency, consistency, or discomfort between the two groups. Therefore, it concluded that Lactobacillus reuteri DSM 17938 doesn't provide additional benefits in managing constipation in children. However, the small sample size suggests we should take these findings with caution.
References
- Yang W, Gao X, Lin J, Liu L, Peng L, et al. Water-insoluble dietary fiber from walnut relieves constipation through Limosilactobacillus reuteri-mediated serotonergic synapse and neuroactive ligand-receptor pathways. Int J Biol Macromol. 2024;283:137931. doi:10.1016/j.ijbiomac.2024.137931
- Tyrsin OY, Tyrsin DY, Nemenov DG, Ruzov AS, Odintsova VE, et al. Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial. Eur J Pediatr. 2024;183:2311. doi:10.1007/s00431-024-05473-y
- Ismail NI, Nawawi KNM, Hsin DCC, Hao KW, Mahmood NRKN, et al. Probiotic containing Lactobacillus reuteri DSM 17648 as an adjunct treatment for Helicobacter pylori infection: A randomized, double-blind, placebo-controlled trial. Helicobacter. 2023;28:e13017. doi:10.1111/hel.13017
- Žaja O, Fiolić M, Ćuk MC, Tiljak MK. "The role of L. reuteri DSM17938 in nutritional recovery and treatment of constipation in children and adolescents with anorexia nervosa - a randomized, double blind, placebo controlled study". Clin Nutr ESPEN. 2021;46:47. doi:10.1016/j.clnesp.2021.08.016
- Vandenplas Y, Gerlier L, Caekelbergh K, Possner M. An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders. Nutrients. 2021;13. doi:10.3390/nu13103336
- Saviano A, Brigida M, Migneco A, Gunawardena G, Zanza C, et al. Lactobacillus Reuteri DSM 17938 in Diarrhea and Constipation: Two Sides of the Same Coin?. Medicina (Kaunas). 2021;57. doi:10.3390/medicina57070643
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
- Kubota M, Ito K, Tomimoto K, Kanazaki M, Tsukiyama K, et al. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial. Nutrients. 2020;12. doi:10.3390/nu12010225
- West CL, Stanisz AM, Mao YK, Champagne-Jorgensen K, Bienenstock J, et al. Microvesicles from Lactobacillus reuteri (DSM-17938) completely reproduce modulation of gut motility by bacteria in mice. PLoS One. 2020;15:e0225481. doi:10.1371/journal.pone.0225481
- Riezzo G, Chimienti G, Orlando A, D'Attoma B, Clemente C, et al. Effects of long-term administration of Lactobacillus reuteri DSM-17938 on circulating levels of 5-HT and BDNF in adults with functional constipation. Benef Microbes. 2019;10:137. doi:10.3920/BM2018.0050
- Jadrešin O, Sila S, Trivić I, Mišak Z, Hojsak I, et al. Lack of Benefit of Lactobacillus reuteri DSM 17938 as an Addition to the Treatment of Functional Constipation. J Pediatr Gastroenterol Nutr. 2018;67:763. doi:10.1097/MPG.0000000000002134
- Riezzo G, Orlando A, D'Attoma B, Linsalata M, Martulli M, et al. Randomised double blind placebo controlled trial on Lactobacillus reuteri DSM 17938: improvement in symptoms and bowel habit in functional constipation. Benef Microbes. 2018;9:51. doi:10.3920/BM2017.0049
- Ojetti V, Petruzziello C, Migneco A, Gnarra M, Gasbarrini A, et al. Effect of Lactobacillus reuteri (DSM 17938) on methane production in patients affected by functional constipation: a retrospective study. Eur Rev Med Pharmacol Sci. 2017;21:1702.
- Cruchet S, Furnes R, Maruy A, Hebel E, Palacios J, et al. The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Paediatr Drugs. 2015;17:199. doi:10.1007/s40272-015-0124-6
- Ojetti V, Ianiro G, Tortora A, D'Angelo G, Di Rienzo TA, et al. The effect of Lactobacillus reuteri supplementation in adults with chronic functional constipation: a randomized, double-blind, placebo-controlled trial. J Gastrointestin Liver Dis. 2014;23:387. doi:10.15403/jgld.2014.1121.234.elr
- Urbańska M, Szajewska H. The efficacy of Lactobacillus reuteri DSM 17938 in infants and children: a review of the current evidence. Eur J Pediatr. 2014;173:1327. doi:10.1007/s00431-014-2328-0
