Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.4
USERS' SCORE
Good
Based on 4 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Thiamin (as thiamine hydrochloride)
25 mg
2,083%
Riboflavin (as riboflavin 5'-phosphate sodium)
20 mg
1,538%
Niacin (as inositol hexanicotinate and nicotinic acid)
95 mg NE
594%
Vitamin B6 (as pyridoxal 5'-phosphate)
20 mg
1,176%
Folate [as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt and calcium folinate]
680 mcg DFE (400 mcg)
170%
Vitamin B12 (as MECOBALACTIVE® methylcobalamin and adenosylcobalamin)
50 mcg
2,083%
Biotin
750 mcg
2,500%
Pantothenic Acid (as d-calcium pantothenate)
125 mg
2,500%
Choline (as choline bitartrate)
50 mg
9%
Top Medical Research Studies
9.5
We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Read More
9
We examined a rare genetic condition, Transcobalamin deficiency, which affects vitamin B12 transport in the body. This deficiency can lead to serious issues like pancytopenia and megaloblastic anemia.
A fascinating case was reported about a 2-year-old boy suffering from these issues. After using advanced genetic testing, doctors found a new variant in the TCN2 gene and treated him with high doses of methylcobalamin.
As a result, significant health improvements were noted, highlighting the importance of early diagnosis and treatment in preventing severe complications.
A fascinating case was reported about a 2-year-old boy suffering from these issues. After using advanced genetic testing, doctors found a new variant in the TCN2 gene and treated him with high doses of methylcobalamin.
As a result, significant health improvements were noted, highlighting the importance of early diagnosis and treatment in preventing severe complications.
Read More
8
WIFAS improving folate and hemoglobin
We explored how a school-based weekly iron and folic acid supplementation program (WIFAS) impacts serum folate levels among adolescent girls in the Sidama Region of Ethiopia.
Using a cross-sectional study design, we compared serum folate levels between girls at schools with WIFAS and those without. Our findings showed that girls participating in the program had significantly higher serum folate and hemoglobin levels.
This suggests that WIFAS could be an effective approach to combat anemia and improve folate status, advocating for its expansion in areas facing similar deficiencies.
Using a cross-sectional study design, we compared serum folate levels between girls at schools with WIFAS and those without. Our findings showed that girls participating in the program had significantly higher serum folate and hemoglobin levels.
This suggests that WIFAS could be an effective approach to combat anemia and improve folate status, advocating for its expansion in areas facing similar deficiencies.
Read More
Most Useful Reviews
10
Anemia resolved
2 people found this helpful
None was making me feel better. Then, I was recommended by my doctors to take this complex B. Since then, it has been two years that my anemia is resolved, and I feel so much more energetic.
Read More
7.5
Highly satisfied
7 people found this helpful
Having an autoimmune disease called pernicious anemia, I’m very fussy about the B vitamins I take! When I saw this one, I immediately ordered it and have been very satisfied. I still need injections of B12 twice a month, but I require all the B's to feel better!
Read More
7.5
Supports nervous system
Excellent quality, top brand. I believe nearly everyone, including children and adults, should take this complex. It’s beneficial for the nervous system, serving as a B complex iron cofactor, which is therefore good for anaemia.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.4
- All Researches
9.5
We assessed the impact of nutrition education paired with iron-folic acid supplementation on anemia levels in pregnant women in Ethiopia.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
Read More
9.5
Thiamine resolves rare anemia effectively
In our examination, we focused on thiamine-responsive megaloblastic anemia (TRMA), a rare genetic disorder affecting young individuals. We learned about a young man with diabetes who faced pancytopenia, initially linked to a COVID-19 infection.
Genetic testing revealed pathogenic variants indicating TRMA, and following treatment with oral thiamine supplementation, we observed a complete resolution of his symptoms. This case underscores the importance of considering genetic factors in anemia, emphasizing that early diagnosis and treatment can significantly improve health outcomes.
Genetic testing revealed pathogenic variants indicating TRMA, and following treatment with oral thiamine supplementation, we observed a complete resolution of his symptoms. This case underscores the importance of considering genetic factors in anemia, emphasizing that early diagnosis and treatment can significantly improve health outcomes.
Read More
9.5
We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Read More
9
Health education improves anemia outcomes
We explored the effectiveness of a family-centered health education intervention aimed at boosting the adherence to iron-folic acid supplements and improving anemia in rural pregnant women.
In our quasi-experimental study involving women with mild to moderate anemia, we utilized a multi-stage sampling method to separate intervention and control groups.
The results were promising; the intervention group showed a significant reduction in anemia prevalence and an increase in hemoglobin levels, demonstrating the positive impact of education on health behaviors and outcomes.
In our quasi-experimental study involving women with mild to moderate anemia, we utilized a multi-stage sampling method to separate intervention and control groups.
The results were promising; the intervention group showed a significant reduction in anemia prevalence and an increase in hemoglobin levels, demonstrating the positive impact of education on health behaviors and outcomes.
Read More
9
We examined a rare genetic condition, Transcobalamin deficiency, which affects vitamin B12 transport in the body. This deficiency can lead to serious issues like pancytopenia and megaloblastic anemia.
A fascinating case was reported about a 2-year-old boy suffering from these issues. After using advanced genetic testing, doctors found a new variant in the TCN2 gene and treated him with high doses of methylcobalamin.
As a result, significant health improvements were noted, highlighting the importance of early diagnosis and treatment in preventing severe complications.
A fascinating case was reported about a 2-year-old boy suffering from these issues. After using advanced genetic testing, doctors found a new variant in the TCN2 gene and treated him with high doses of methylcobalamin.
As a result, significant health improvements were noted, highlighting the importance of early diagnosis and treatment in preventing severe complications.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
10
Anemia resolved
2 people found this helpful
None was making me feel better. Then, I was recommended by my doctors to take this complex B. Since then, it has been two years that my anemia is resolved, and I feel so much more energetic.
Read More
7.5
Highly satisfied
7 people found this helpful
Having an autoimmune disease called pernicious anemia, I’m very fussy about the B vitamins I take! When I saw this one, I immediately ordered it and have been very satisfied. I still need injections of B12 twice a month, but I require all the B's to feel better!
Read More
7.5
Supports nervous system
Excellent quality, top brand. I believe nearly everyone, including children and adults, should take this complex. It’s beneficial for the nervous system, serving as a B complex iron cofactor, which is therefore good for anaemia.
Read More
6
Boosts vitamin levels
I trust this brand. I have B12 deficiency anaemia and a deficiency in all B vitamins. This vitamin offers excellent and plentiful forms of B vitamins. I sincerely hope it will assist in raising my vitamin B level.
Read More
Frequently Asked Questions
6
Boosts vitamin levels
I trust this brand. I have B12 deficiency anaemia and a deficiency in all B vitamins. This vitamin offers excellent and plentiful forms of B vitamins. I sincerely hope it will assist in raising my vitamin B level.
7.5
Supports nervous system
Excellent quality, top brand. I believe nearly everyone, including children and adults, should take this complex. It’s beneficial for the nervous system, serving as a B complex iron cofactor, which is therefore good for anaemia.
9.5
We assessed the impact of nutrition education paired with iron-folic acid supplementation on anemia levels in pregnant women in Ethiopia.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
8
We examined the impact of daily oral iron supplementation on anemia in pregnant women. Our analysis included 57 trials with nearly 49,000 participants.
We found that iron supplementation could significantly reduce maternal anemia and iron deficiency by the end of pregnancy. However, other outcomes showed limited effects, with uncertainty around the benefits for infant health.
Overall, while iron could be beneficial, there's a need for future studies to explore its broader impacts on maternal and child health.
We found that iron supplementation could significantly reduce maternal anemia and iron deficiency by the end of pregnancy. However, other outcomes showed limited effects, with uncertainty around the benefits for infant health.
Overall, while iron could be beneficial, there's a need for future studies to explore its broader impacts on maternal and child health.
8
We explored a compelling case of pernicious anemia in a 51-year-old Ugandan man presenting with lower limb weakness. Initially treated for vitamin B12 deficiency years earlier, he experienced similar symptoms once again.
Through careful testing, he was diagnosed with pernicious anemia, confirming that a lack of vitamin B12 affects many aspects of health. The patient showed improvement after receiving parenteral methylcobalamin therapy, indicating that vitamin B complex can be beneficial in treating anemia caused by deficiencies.
This case underlines the need for awareness and early diagnosis of vitamin B12 deficiency, especially in resource-limited settings.
Through careful testing, he was diagnosed with pernicious anemia, confirming that a lack of vitamin B12 affects many aspects of health. The patient showed improvement after receiving parenteral methylcobalamin therapy, indicating that vitamin B complex can be beneficial in treating anemia caused by deficiencies.
This case underlines the need for awareness and early diagnosis of vitamin B12 deficiency, especially in resource-limited settings.
7
We explored a case involving a 3-year-old girl diagnosed with Imerslund-Gräsbeck syndrome (IGS), a disorder leading to vitamin B12 malabsorption and resulting anemia. Through a retrospective analysis, we noted that long-term oral vitamin B12 therapy significantly improved her condition, indicated by normal blood tests during follow-up.
Genetic testing revealed novel mutations in the AMN gene linking to her symptoms. This case highlights the utility of genetic diagnosis and the effectiveness of oral vitamin B12 as a treatment option for patients unable to receive injections.
Genetic testing revealed novel mutations in the AMN gene linking to her symptoms. This case highlights the utility of genetic diagnosis and the effectiveness of oral vitamin B12 as a treatment option for patients unable to receive injections.
References
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. 10.1186/s13256-025-05095-4
- Anato A, Reshid M. Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study. Sci Rep. 2025;15:3556. 10.1038/s41598-025-87957-x
- Aziz Ali S, Genkinger J, Kahe K, Valeri L, Khowaja N, et al. Role of preconception nutrition supplements in maternal anemia and intrauterine growth: a systematic review and meta-analysis of randomized controlled trials. Syst Rev. 2025;14:11. 10.1186/s13643-024-02726-7
- Bolka A, Bosha T, Gebremedhin S. Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study. Food Nutr Bull. 2025. 10.1177/03795721241304475
- Singh G, Ranjitha R, Baskaran P, Goel AD, Gupta MK, et al. Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study. Indian J Public Health. 2024;68:495. 10.4103/ijph.ijph_844_23
- Zhang C, Cha R, Long K, Liu Y, Dong Y, et al. Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis. ACS Appl Mater Interfaces. 2024;16:68905. 10.1021/acsami.4c15206
- Pascoe MA, Hall AM, Gray A. Thiamine-responsive megaloblastic anaemia in a young adult with acute pancytopenia. BMJ Case Rep. 2024;17. 10.1136/bcr-2024-261435
- Zhang D, Liu S, Xi B, Zhu Y, Chen Y, et al. Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report. Ital J Pediatr. 2024;50:191. 10.1186/s13052-024-01757-z
- Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. 10.1186/s13052-024-01759-x
- Finkelstein JL, Cuthbert A, Weeks J, Venkatramanan S, Larvie DY, et al. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2024;8:CD004736. 10.1002/14651858.CD004736.pub6
- Iqbal N, Meghani MA, Khalid W, Ansari AH, Ansari MUH, et al. Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report. Ann Hematol. 2024;103:3243. 10.1007/s00277-024-05878-7
