Omega-3 fatty acids inhibit tumorsUltra-High Dose Oral ω3 Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), or Oxidation-Resistant Deuterated DHA Block Tumorigenesis in a -Driven Neuroblastoma Model.
We conducted a study to explore the effects of high doses of omega-3 fatty acids—specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—on tumor formation in a model of neuroblastoma, a challenging pediatric cancer. Using a syngeneic mouse model, we administered these fatty acids at doses equivalent to those safely tolerable in humans.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
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Omega-3s may aid pancreatic cancerNovel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.
We explored the potential of omega-3 fatty acids in managing pancreatic cancer using a specially designed mouse model that closely mimics human disease. Our study found that a diet enriched with omega-3s significantly reduced tumor size, lung and liver metastasis, and even suggested improved survival rates when compared to controls.
Additionally, these fatty acids altered tumor composition and induced cancer cell death without hindering cell growth. Importantly, our research points to omega-3s as promising dietary interventions that could help tackle this aggressive cancer.
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Perilla seed oil reduces CRC tumorsCold-pressed extraction of perilla seed oil enriched with alpha-linolenic acid mitigates tumour progression and restores gut microbial homeostasis in the AOM/DSS mice model of colitis-associated colorectal cancer.
We investigated the role of alpha-linolenic acid (ALA), a plant-based omega-3 found in perilla seed oil, in preventing colitis-associated colorectal cancer (CRC) using a mouse model.
Mice were given different diets, while only the control group received soybean oil.
The results showed that those on a 5% perilla seed oil diet had fewer tumors and lower markers of inflammation compared to those on fish oil or soybean oil.
Overall, perilla seed oil appeared to help slow tumor progression and restore gut health.
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Eicosapentaenoic acid's role exploredCarrageenan-ferrocene-eicosapentaenoic acid composite hydrogel induce ferroptosis and apoptosis for anti-tumor recurrence and metastasis.
We developed a special hydrogel that mixes different components including eicosapentaenoic acid (EPA) to study its effects on cancer treatment. The hydrogel helps target the tumor environment more effectively due to its unique structure.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
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EPA's role in cancer treatmentIs Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer.
We focused our research on the potential of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, particularly its derivatives known as specialized pro-resolving mediators (SPMs). These mediators have shown promise in playing a role in the resolution of inflammation, which is crucial in various health conditions, including cancer.
Our observations highlight how SPMs, derived from EPA, exhibit powerful effects in reducing inflammation and can influence cancer cell behavior. Specifically, we noted that these mediators help decrease the proliferation and metastasis of cancer cells, which may lead to slower tumor growth.
Evidence suggests that EPA derivatives, such as Resolvins, not only help in controlling immune cell functions but also aid in clearing out debris in tumor environments. This clearing process can potentially enhance therapeutic outcomes by making the area less conducive to tumor progression.
Altogether, our findings contribute to the idea that EPA has compelling implications for helping manage cancer more effectively, particularly through its ability to modulate the inflammatory response in the body.
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