Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 57 Researches
7.5
USERS' SCORE
Good
Based on 15 Reviews
8.3
Supplement Facts
Serving Size: 1 Teaspoon (5 ml)
Amount Per Serving
%DV
Calories
40
Total Fat
4.5 g
6%**
Saturated Fat
0.5 g
3%**
Cholesterol
15 mg
5%
Vitamin A (from cod liver oil and retinyl palmitate)
255 mcg RAE(850 IU)
28%
Vitamin D (from cod liver oil and cholecalciferol)
10 mcg (400 IU)
50%
Vitamin E (as d-alpha tocopherol)
6.7 mg
45%
Norwegian Cod Liver Oil
4.6 g
†
Total Omega-3 Fatty Acids*
1,100 mg
†
DHA (Docosahexaenoic Acid)*
500 mg
†
EPA (Eicosapentaenoic Acid)*
370 mg
†
DPA (Docosapentaenoic Acid)*
50 mg
†
Top Medical Research Studies
9
We investigated how cod liver oil affects coronary artery disease in pigs on a high-fat diet over eight months. By comparing 7 pigs that received cod liver oil to 11 control pigs, we observed significantly less disease in the oil-fed group. Notably, lesion size and arterial narrowing were reduced, suggesting that cod liver oil may influence heart health. Both groups had high lipid levels, but the differences in atherosclerosis weren't linked to these levels. This study hints at the oil's potential to slow coronary disease progression via changes in metabolism.
Read More
9
We delved into how cod liver oil (CLO) influences heart health, especially in the context of diabetes. Using a study with streptozotocin (STZ)-induced diabetic rats, we treated them with CLO and monitored various cardiovascular metrics over 12 weeks. What we found was quite telling: untreated diabetic rats faced significant increases in blood sugar and harmful lipid levels, while those receiving CLO showed improved weight gain and complete prevention of lipid problems.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
Read More
9
We examined the effects of cod liver oil, enriched with essential fatty acids, on heart stability after inducing myocardial infarction in rats. Over 30 days, we found that the oil significantly raised the heart's fibrillation threshold by 50% and halved the occurrence of spontaneous extrasystoles. While there were improvements in the heart's functionality during rest, overall heart pressures and contraction speeds showed no significant changes. This suggests that cod liver oil may contribute positively to heart stability, but it doesn't dramatically alter all heart functions.
Read More
Most Useful Reviews
9
Thyroid support
6 people found this helpful
For thyroid health, vitamin A deficiency is linked to heart disease. Research shows that vitamin A can lower TSH levels and raise T3, the key thyroid hormone. Cod liver oil is a fantastic source of active vitamin A and omega-3 fatty acids EPA for heart health and DHA for brain function.
Read More
9
Energy boost
1 people found this helpful
Carlson cod liver oil is excellent for heart health and skin. It is easy to use and has a pleasant flavour. After regular use, my energy levels and overall well-being improved. I recommend it for anyone seeking a natural dietary supplement.
Read More
7.5
Skin and heart health
4 people found this helpful
Cod liver oil is vital for skin clarity and combating heart disease. It aids memory, supports a stress-resilient nervous system, and boosts immunity against infections. Unlike regular fish oil, it is extracted from cod livers, offering higher vitamins A and D.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 57 Researches
7.5
- All Researches
9
We explored the effects of docosahexaenoic acid (DHA), found in cod liver oil, on heart health after a heart attack. Using lab tests on heart cells and mouse models, we found that DHA helped protect heart cells from damage due to low oxygen levels.
Remarkably, DHA not only reduced heart damage but also improved heart function overall. It seemed to support a process called autophagy, which helps clear out damaged cells, thereby benefiting heart health after injury.
However, it's important to note that while DHA shows promising results, more research is needed to fully understand its role.
Remarkably, DHA not only reduced heart damage but also improved heart function overall. It seemed to support a process called autophagy, which helps clear out damaged cells, thereby benefiting heart health after injury.
However, it's important to note that while DHA shows promising results, more research is needed to fully understand its role.
Read More
9
We delved into how cod liver oil (CLO) influences heart health, especially in the context of diabetes. Using a study with streptozotocin (STZ)-induced diabetic rats, we treated them with CLO and monitored various cardiovascular metrics over 12 weeks. What we found was quite telling: untreated diabetic rats faced significant increases in blood sugar and harmful lipid levels, while those receiving CLO showed improved weight gain and complete prevention of lipid problems.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
Read More
9
We examined the effects of cod liver oil, enriched with essential fatty acids, on heart stability after inducing myocardial infarction in rats. Over 30 days, we found that the oil significantly raised the heart's fibrillation threshold by 50% and halved the occurrence of spontaneous extrasystoles. While there were improvements in the heart's functionality during rest, overall heart pressures and contraction speeds showed no significant changes. This suggests that cod liver oil may contribute positively to heart stability, but it doesn't dramatically alter all heart functions.
Read More
9
Cod liver oil's potential heart benefits
We explored the relationship between n-3 polyunsaturated fatty acids, particularly from cod liver oil, and coronary heart disease (CHD). The research found that cod liver oil significantly reduced harmful arachidonic acid levels in heart cells, promoting a healthier balance with beneficial docosahexaenoic acid. This balance may lower risks of heart issues, including sudden cardiac death. However, while diets rich in fish oil show promise, the study does not claim that cod liver oil is a guaranteed solution to heart disease.
Read More
9
We investigated how cod liver oil affects coronary artery disease in pigs on a high-fat diet over eight months. By comparing 7 pigs that received cod liver oil to 11 control pigs, we observed significantly less disease in the oil-fed group. Notably, lesion size and arterial narrowing were reduced, suggesting that cod liver oil may influence heart health. Both groups had high lipid levels, but the differences in atherosclerosis weren't linked to these levels. This study hints at the oil's potential to slow coronary disease progression via changes in metabolism.
Read More
User Reviews
USERS' SCORE
Good
Based on 15 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Thyroid support
6 people found this helpful
For thyroid health, vitamin A deficiency is linked to heart disease. Research shows that vitamin A can lower TSH levels and raise T3, the key thyroid hormone. Cod liver oil is a fantastic source of active vitamin A and omega-3 fatty acids EPA for heart health and DHA for brain function.
Read More
9
Energy boost
1 people found this helpful
Carlson cod liver oil is excellent for heart health and skin. It is easy to use and has a pleasant flavour. After regular use, my energy levels and overall well-being improved. I recommend it for anyone seeking a natural dietary supplement.
Read More
7.5
Skin and heart health
4 people found this helpful
Cod liver oil is vital for skin clarity and combating heart disease. It aids memory, supports a stress-resilient nervous system, and boosts immunity against infections. Unlike regular fish oil, it is extracted from cod livers, offering higher vitamins A and D.
Read More
7.5
Brain development aid
2 people found this helpful
Good quality fish oil rich in omega-3, beneficial for brain development, especially in babies, and heart disease. My family and I take it daily. However, I hope the company reconsiders the price, as it is a bit expensive.
Read More
7.5
Long-term investment
1 people found this helpful
The packaging is substantial. This quality cod liver oil significantly benefits heart health. Though it may seem pricey, the health advantages, especially against heart disease, far outweigh the cost.
Read More
Frequently Asked Questions
7.5
Anti-inflammation effect
1 people found this helpful
I switched from capsules to liquid cod liver oil and noticed a difference in heart health and inflammation within a week. I will definitely buy this again as it seems effective. It's a great product for overall well-being.
7
Consistency needed
1 people found this helpful
The quality of Norwegian cod liver oil is excellent and priced favourably. I've just started my first bottle and will continue taking it. Patience is key; results for heart disease and overall health may take at least six months. The taste is acceptable.
9
Cognitive support
This high-quality cod liver oil is superb. It lowers bad cholesterol and reduces inflammation, enhancing heart health and cognitive function. It's my top supplement, especially when paired with vitamin D each morning.
9
Blood circulation improvement
This brand has worked wonders for my teenage children, stopping hair loss. Omega-3 fatty acids positively impact blood circulation and brain function, crucial for preventing heart disease and improving overall health.
7.5
Skin and heart health
4 people found this helpful
Cod liver oil is vital for skin clarity and combating heart disease. It aids memory, supports a stress-resilient nervous system, and boosts immunity against infections. Unlike regular fish oil, it is extracted from cod livers, offering higher vitamins A and D.
9
Anti-inflammatory benefits
Cod liver oil is high in EPA and DHA, along with vitamins A and D. Its strong anti-inflammatory benefits promote heart disease, brain, vision, joint, and immune health. This brand is highly recommended due to its quality.
9
We explored the effects of docosahexaenoic acid (DHA), found in cod liver oil, on heart health after a heart attack. Using lab tests on heart cells and mouse models, we found that DHA helped protect heart cells from damage due to low oxygen levels.
Remarkably, DHA not only reduced heart damage but also improved heart function overall. It seemed to support a process called autophagy, which helps clear out damaged cells, thereby benefiting heart health after injury.
However, it's important to note that while DHA shows promising results, more research is needed to fully understand its role.
Remarkably, DHA not only reduced heart damage but also improved heart function overall. It seemed to support a process called autophagy, which helps clear out damaged cells, thereby benefiting heart health after injury.
However, it's important to note that while DHA shows promising results, more research is needed to fully understand its role.
8
We assessed the long-term relationship between cod liver oil supplements and heart disease mortality in a large UK cohort over 22 years. By analyzing data from 22,035 participants, we looked at various factors that could affect heart health, including age and lifestyle choices.
While we found that recent use of omega-3 supplements was linked to a lower risk of dying from coronary heart disease, uncertainties remain. Some factors may still confound these results, but the connection primarily seemed to benefit those using n-3 supplements.
While we found that recent use of omega-3 supplements was linked to a lower risk of dying from coronary heart disease, uncertainties remain. Some factors may still confound these results, but the connection primarily seemed to benefit those using n-3 supplements.
8
Cardiovascular benefits of eicosapentaenoic acid
We explored the effectiveness of icosapent ethyl, a formulation of eicosapentaenoic acid, in reducing cardiovascular risks among patients who were already on statin therapy. The focus was on individuals with elevated triglyceride levels and low-density lipoprotein cholesterol (LDL-C) at a baseline of 41 to 100 mg/dL.
In this comprehensive analysis of the REDUCE-IT trial, we observed that patients were randomly assigned to receive either icosapent ethyl or a placebo, allowing for a clear comparison of results. The findings revealed that even those with well-controlled LDL-C levels, categorized as less than 55 mg/dL, exhibited significant benefits in cardiovascular outcomes when treated with icosapent ethyl.
Specifically, patients with LDL-C below 55 mg/dL experienced a notable reduction in primary cardiovascular events, with a reported decrease in rates from 22.8% to 16.2%. We also found similar outcomes in patients with LDL-C of 55 mg/dL or higher, further emphasizing the drug's potential effectiveness across different baseline cholesterol levels.
Overall, the study suggests that icosapent ethyl can confer cardiovascular benefits regardless of a patient's baseline LDL-C, indicating its importance in heart disease management, particularly for those at high cardiovascular risk.
In this comprehensive analysis of the REDUCE-IT trial, we observed that patients were randomly assigned to receive either icosapent ethyl or a placebo, allowing for a clear comparison of results. The findings revealed that even those with well-controlled LDL-C levels, categorized as less than 55 mg/dL, exhibited significant benefits in cardiovascular outcomes when treated with icosapent ethyl.
Specifically, patients with LDL-C below 55 mg/dL experienced a notable reduction in primary cardiovascular events, with a reported decrease in rates from 22.8% to 16.2%. We also found similar outcomes in patients with LDL-C of 55 mg/dL or higher, further emphasizing the drug's potential effectiveness across different baseline cholesterol levels.
Overall, the study suggests that icosapent ethyl can confer cardiovascular benefits regardless of a patient's baseline LDL-C, indicating its importance in heart disease management, particularly for those at high cardiovascular risk.
9
We delved into how cod liver oil (CLO) influences heart health, especially in the context of diabetes. Using a study with streptozotocin (STZ)-induced diabetic rats, we treated them with CLO and monitored various cardiovascular metrics over 12 weeks. What we found was quite telling: untreated diabetic rats faced significant increases in blood sugar and harmful lipid levels, while those receiving CLO showed improved weight gain and complete prevention of lipid problems.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
8
Cod liver oil lowers triglycerides
We explored the effectiveness of cod liver oil, rich in omega-3 fatty acids, in managing heart disease, particularly focusing on atherosclerosis. Research shows that cod liver oil can significantly lower triglyceride levels, especially when combined with statins for patients facing hypertriglyceridemia.
Additionally, its anti-inflammatory properties make it a beneficial option in other conditions like rheumatoid arthritis. However, while promising for lowering heart disease risk factors, its direct impact on heart health requires more investigation.
Additionally, its anti-inflammatory properties make it a beneficial option in other conditions like rheumatoid arthritis. However, while promising for lowering heart disease risk factors, its direct impact on heart health requires more investigation.
8
We explored how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects cardiovascular health by reviewing various studies that compared DHA to eicosapentaenoic acid (EPA). Our analysis included 24 publications from nine randomized controlled trials that provided insights into the separate effects of these two fatty acids.
DHA has been shown to lower triglyceride levels and possibly has a more significant impact on raising high-density lipoprotein (HDL) cholesterol, which is considered protective for the heart. Interestingly, while DHA appears to increase low-density lipoprotein (LDL) cholesterol, it also increases the size of LDL particles, making them less likely to contribute to heart disease.
Furthermore, we observed that DHA demonstrates better results than EPA in reducing heart rate and lowering blood pressure. Both DHA and EPA have beneficial effects on platelet function, reducing the risk of clotting, and they also worked to lower markers of inflammation.
Notably, the effects on blood glucose levels were inconsistent, indicating that more research is needed. Overall, while there are promising benefits of DHA regarding various cardiovascular risk factors, the study suggests a need for further high-quality research to understand its impacts fully.
DHA has been shown to lower triglyceride levels and possibly has a more significant impact on raising high-density lipoprotein (HDL) cholesterol, which is considered protective for the heart. Interestingly, while DHA appears to increase low-density lipoprotein (LDL) cholesterol, it also increases the size of LDL particles, making them less likely to contribute to heart disease.
Furthermore, we observed that DHA demonstrates better results than EPA in reducing heart rate and lowering blood pressure. Both DHA and EPA have beneficial effects on platelet function, reducing the risk of clotting, and they also worked to lower markers of inflammation.
Notably, the effects on blood glucose levels were inconsistent, indicating that more research is needed. Overall, while there are promising benefits of DHA regarding various cardiovascular risk factors, the study suggests a need for further high-quality research to understand its impacts fully.
References
- Shi Y, Li H, Wu T, Wang Q, Zhu Q, et al. Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway. Oxid Med Cell Longev. 2022;2022:1509421. 10.1155/2022/1509421
- Nilsen DWT, Myhre PL, Kalstad A, Schmidt EB, Arnesen H, et al. Serum Levels of Dihomo-Gamma (γ)-Linolenic Acid (DGLA) Are Inversely Associated with Linoleic Acid and Total Death in Elderly Patients with a Recent Myocardial Infarction. Nutrients. 2021;13. 10.3390/nu13103475
- Lentjes MAH, Keogh RH, Welch AA, Mulligan AA, Luben RN, et al. Longitudinal associations between marine omega-3 supplement users and coronary heart disease in a UK population-based cohort. BMJ Open. 2017;7:e017471. 10.1136/bmjopen-2017-017471
- Ceylan-Isik A, Hünkar T, Aşan E, Kaymaz F, Ari N, et al. Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats. J Pharm Pharmacol. 2007;59:1629.
- Vermel' AE. [Clinical application of omega-3-fatty acids (cod-liver oil)]. Klin Med (Mosk). 2005;83:51.
- Pedersen JI, Tverdal A, Kirkhus B. [Diet changes and the rise and fall of cardiovascular disease mortality in Norway]. Tidsskr Nor Laegeforen. 2004;124:1532.
- Kulakova SN, Gapparova KM, Pogozheva AV, Levachev MM. [Evaluation of the effects of fish and vegetable omega-3 PUFA complex on the erythrocyte fatty acid composition in patients with ischemic heart disease and impaired glucose tolerance]. Vopr Pitan. 1999;68:26.
- Kim DN, Eastman A, Baker JE, Mastrangelo A, Sethi S, et al. Fish oil, atherogenesis, and thrombogenesis. Ann N Y Acad Sci. 1995;748:474.
- Meerson FZ, Belkina LM, Fu STs, Isaev VA. [Correction of disorders of cardiac electric stability in post-infarction cardiosclerosis using a diet enriched with polyunsaturated fatty acids]. Biull Eksp Biol Med. 1993;115:343.
- Skúladóttir GV, Gudmundsdóttir E, Olafsdóttir E, Gudmundsson TV, Hardarson T, et al. Influence of dietary cod liver oil on fatty acid composition of plasma lipids in human male subjects after myocardial infarction. J Intern Med. 1990;228:563.
- Schmidt EB, Pedersen JO, Ekelund S, Grunnet N, Jersild C, et al. Cod liver oil inhibits neutrophil and monocyte chemotaxis in healthy males. Atherosclerosis. 1989;77:53.
- Gudbjarnason S, Benediktsdóttir VE, Skúladóttir G. Effects of n-3 polyunsaturated fatty acids on coronary heart disease. Bibl Nutr Dieta. 1989.
- Gudbjarnason S. Dynamics of n-3 and n-6 fatty acids in phospholipids of heart muscle. J Intern Med Suppl. 1989;731:117.
- Simonsen T, Nordøy A. Ischaemic heart disease, serum lipids and platelets in Norwegian populations with traditionally low or high fish consumption. J Intern Med Suppl. 1989;731:83.
- Shimokawa H, Vanhoutte PM. Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolemic and atherosclerotic porcine coronary arteries. Circulation. 1988;78:1421.
- Vanhoutte PM. Platelets, endothelium and blood vessel wall. Experientia. 1988;44:105.
- Weiner BH, Ockene IS, Levine PH, Cuénoud HF, Fisher M, et al. Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model. N Engl J Med. 1986;315:841.
- Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events. Am J Clin Nutr. 2025. 10.1016/j.ajcnut.2025.02.028
- Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. 10.1016/j.advnut.2025.100366
- Kim JY, Kong SYJ, Jung E, Cho YS. Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis. J Clin Med. 2024;14. 10.3390/jcm14010026
- O'Keefe EL, O'Keefe JH, Abuissa H, Metzinger M, Murray E, et al. Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword. Prog Cardiovasc Dis. 2024. 10.1016/j.pcad.2024.11.003
- Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. 10.3389/fnut.2024.1423228
- Shi F, Chowdhury R, Sofianopoulou E, Koulman A, Sun L, et al. Association of circulating fatty acids with cardiovascular disease risk: analysis of individual-level data in three large prospective cohorts and updated meta-analysis. Eur J Prev Cardiol. 2025;32:233. 10.1093/eurjpc/zwae315
- Amangurbanova M, Daher R, Asbeutah AA, Vemuri B, Mirza H, et al. Higher epicardial adipose tissue volume is associated with higher coronary fatty plaque volume and is regulated by waist circumference but not EPA+DHA supplementation. J Clin Lipidol. 2024;18:e773. 10.1016/j.jacl.2024.06.006
- Lv L, Guo Y, Zheng Z, Li B. Blood metabolites mediate effects of breakfast skipping on heart failure via Mendelian randomization analysis. Sci Rep. 2024;14:18957. 10.1038/s41598-024-69874-7
- Wang Y, Yang B, Wang C. The association between fatty acids and atherosclerotic diseases: A mendelian randomization study. Clin Nutr ESPEN. 2024;63:447. 10.1016/j.clnesp.2024.06.018
- Tian S, Guo T, Qian F, Qiu Z, Lu Q, et al. Fish Oil, Plasma n-3 PUFAs, and Risk of Macro- and Microvascular Complications among Individuals with Type 2 Diabetes. J Clin Endocrinol Metab. 2024. 10.1210/clinem/dgae482
- Asbeutah AA, Daher R, Malik A, Hariri E, Alfaddagh A, et al. The Effect of Eicosapentaenoic and Docosahexaenoic Acid Supplementation on Coronary Artery Calcium Progression in Subjects With Diabetes and Coronary Artery Disease: A Secondary Analysis of a Randomized Trial. Am J Cardiol. 2024;225:98. 10.1016/j.amjcard.2024.06.001
- Dinu M, Sofi F, Lotti S, Colombini B, Mattioli AV, et al. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis. Eur J Prev Cardiol. 2024;31:1863. 10.1093/eurjpc/zwae184
- Braun TS, Drobner T, Kipp K, Kiehntopf M, Schlattmann P, et al. Validation of Nutritional Approaches to Modulate Cardiovascular and Diabetic Risk Factors in Patients with Hypertriglyceridemia or Prediabetes-The MoKaRi II Randomized Controlled Study. Nutrients. 2024;16. 10.3390/nu16091261
- O'Keefe EL, O'Keefe JH, Tintle NL, Westra J, Albuisson L, et al. Circulating Docosahexaenoic Acid and Risk of All-Cause and Cause-Specific Mortality. Mayo Clin Proc. 2024;99:534. 10.1016/j.mayocp.2023.11.026
- Zeinalabedini M, Ladaninezhad M, Mobarakeh KA, Hoshiar-Rad A, Shekari S, et al. Association of dietary fats with ischemic heart disease (IHD): a case-control study. J Health Popul Nutr. 2024;43:19. 10.1186/s41043-023-00489-w
- Rennemo J, Berge K, Yousaf MN, Eriksen TB, Welde E, et al. An Atypical Course of Cardiomyopathy Syndrome (CMS) in Farmed Atlantic Salmon () Fed a Clinical Nutrition Diet. Microorganisms. 2023;12. 10.3390/microorganisms12010026
- Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. 10.1161/JAHA.124.038656
- Patil T, Gregory M, Savona N, Jarmukli N, Leonard CE. Evaluating the Real-World Safety of Icosapent Ethyl Versus Omega-3 Polyunsaturated Fatty Acid in Nationwide US Veterans Cohort: Examining Atrial Fibrillation and Bleeding Endpoints. Clin Drug Investig. 2025;45:69. 10.1007/s40261-024-01417-4
- Capece U, Gugliandolo S, Morciano C, Avolio A, Splendore A, et al. Erythrocyte Membrane Fluidity and Omega-3 Fatty Acid Intake: Current Outlook and Perspectives for a Novel, Nutritionally Modifiable Cardiovascular Risk Factor. Nutrients. 2024;16. 10.3390/nu16244318
- Fukuda T, Nakajima T, Hasegawa T, Amano H, Arikawa T, et al. Relationship Between Serum ω-3 Polyunsaturated Fatty Acid Concentration and Fatty Acid Fraction of Epicardial Adipose Tissue in Patients With Cardiovascular Disease. Cureus. 2024;16:e73417. 10.7759/cureus.73417
- Li J, Nan W, Huang X, Meng H, Wang S, et al. Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. EMBO Rep. 2024;25:5507. 10.1038/s44319-024-00271-x
- Kumakura H, Funada R, Matsuo Y, Iwasaki T, Nakashima K, et al. Eicosapentaenoic Acid Level Predicts Long-Term Survival and Cardiovascular or Limb Event in Peripheral Arterial Disease. Ann Vasc Dis. 2024;17:135. 10.3400/avd.oa.23-00079
- Xiao Y, Chen Y, Pietzner A, Elbelt U, Fan Z, et al. Circulating Omega-3 Polyunsaturated Fatty Acids Levels in Coronary Heart Disease: Pooled Analysis of 36 Observational Studies. Nutrients. 2024;16. 10.3390/nu16111610
- Sudo Y, Morimoto T, Tsushima R, Oka A, Sogo M, et al. Eicosapentaenoic Acid and the Outcomes in Older Patients Undergoing Atrial Fibrillation Ablation. J Am Heart Assoc. 2024;13:e033969. 10.1161/JAHA.123.033969
- Miyauchi K, Iwata H, Nishizaki Y, Inoue T, Hirayama A, et al. Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid (RESPECT-EPA). Circulation. 2024;150:425. 10.1161/CIRCULATIONAHA.123.065520
- Reiner MF, Bertschi DA, Werlen L, Wiencierz A, Aeschbacher S, et al. Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation. Nutrients. 2024;16. 10.3390/nu16020178
- Zhao M, Xiao M, Tan Q, Ji J, Lu F. Association between dietary omega-3 intake and coronary heart disease among American adults: The NHANES, 1999-2018. PLoS One. 2023;18:e0294861. 10.1371/journal.pone.0294861
- Chiusolo S, Bork CS, Gentile F, Lundbye-Christensen S, Harris WS, et al. Adipose tissue n-3/n-6 fatty acids ratios versus n-3 fatty acids fractions as predictors of myocardial infarction. Am Heart J. 2023;262:38. 10.1016/j.ahj.2023.03.019
- Maki KC, Bays HE, Ballantyne CM, Underberg JA, Kastelein JJP, et al. A Head-to-Head Comparison of a Free Fatty Acid Formulation of Omega-3 Pentaenoic Acids Versus Icosapent Ethyl in Adults With Hypertriglyceridemia: The ENHANCE-IT Study. J Am Heart Assoc. 2022;11:e024176. 10.1161/JAHA.121.024176
- Zelniker TA, Morrow DA, Scirica BM, Furtado JD, Guo J, et al. Plasma Omega-3 Fatty Acids and the Risk of Cardiovascular Events in Patients After an Acute Coronary Syndrome in MERLIN-TIMI 36. J Am Heart Assoc. 2021;10:e017401. 10.1161/JAHA.120.017401
- Harris WS, Leonard D, Radford NB, Barlow CE, Steele MR, et al. Increases in erythrocyte DHA are not associated with increases in LDL-cholesterol: Cooper center longitudinal study. J Clin Lipidol. 2021;15:212. 10.1016/j.jacl.2020.11.011
- Fosshaug LE, Colas RA, Anstensrud AK, Gregersen I, Nymo S, et al. Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction. EBioMedicine. 2019;46:264. 10.1016/j.ebiom.2019.07.024
- Desnoyers M, Gilbert K, Madingou N, Gagné MA, Daneault C, et al. A high omega-3 fatty acid diet rapidly changes the lipid composition of cardiac tissue and results in cardioprotection. Can J Physiol Pharmacol. 2018;96:916. 10.1139/cjpp-2018-0043
- Colas RA, Souza PR, Walker ME, Burton M, Zasłona Z, et al. Impaired Production and Diurnal Regulation of Vascular RvD Increase Systemic Inflammation and Cardiovascular Disease. Circ Res. 2018;122:855. 10.1161/CIRCRESAHA.117.312472
- Hamazaki K, Iso H, Eshak ES, Ikehara S, Ikeda A, et al. Plasma levels of n-3 fatty acids and risk of coronary heart disease among Japanese: The Japan Public Health Center-based (JPHC) study. Atherosclerosis. 2018;272:226. 10.1016/j.atherosclerosis.2017.12.004
- Dai Perrard XY, Lian Z, Bobotas G, Dicklin MR, Maki KC, et al. Effects of n-3 fatty acid treatment on monocyte phenotypes in humans with hypertriglyceridemia. J Clin Lipidol. 2017;11:1361. 10.1016/j.jacl.2017.08.011
- Del Gobbo LC, Imamura F, Aslibekyan S, Marklund M, Virtanen JK, et al. ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies. JAMA Intern Med. 2016;176:1155. 10.1001/jamainternmed.2016.2925
- Tajik B, Kurl S, Tuomainen TP, Virtanen JK. The association of serum long-chain n-3 PUFA and hair mercury with exercise cardiac power in men. Br J Nutr. 2016;116:487. 10.1017/S0007114516002142
- Abeywardena MY, Adams M, Dallimore J, Kitessa SM. Rise in DPA Following SDA-Rich Dietary Echium Oil Less Effective in Affording Anti-Arrhythmic Actions Compared to High DHA Levels Achieved with Fish Oil in Sprague-Dawley Rats. Nutrients. 2016;8. 10.3390/nu8010014
- Hiram R, Rizcallah E, Sirois C, Sirois M, Morin C, et al. Resolvin D1 reverses reactivity and Ca2+ sensitivity induced by ET-1, TNF-α, and IL-6 in the human pulmonary artery. Am J Physiol Heart Circ Physiol. 2014;307:H1547. 10.1152/ajpheart.00452.2014
