' 
SCIENTIFIC SCORE
Possibly Effective
Based on 50 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Soft Gel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
1%**
Cholesterol
<5mg
<2%
Vitamin A (from cod live oil and retinyl palmitate)
27 mcg RAE
3%
Vitamin D (as cholecalciferol) (from cod liver oil and cholecalciferol concentrate)
100 mcg (4,000 IU)
500%
Vitamin E (as d-alpha tocopherol)
0.67 mg
4%
Norwegian Cod Liver Oil
500 mg
†
Total Omega-3 fatty Acids☆
115 mg
†
DHA (Docosahexaenoic Acid)☆
50 mg
†
EPA (Eicosapentaenoic Acid)☆
42 mg
†
Top Medical Research Studies
9
Cod liver oil reduces pancreatic tumors
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.
High relevance to pancreatic cancer
Our research explored the effects of cod liver oil, rich in omega-3 fatty acids, on pancreatic cancer using a genetically engineered mouse model. This model mimics human pancreatic cancer biology, allowing us to gain insights relevant to real-world conditions.
We found that a diet supplemented with cod liver oil, which contains eicosapentaenoic acid and docosahexaenoic acid, significantly reduced tumor volume and limited metastasis to the lungs and liver. There was also a notable trend toward improved survival rates among the mice that received this treatment.
Notably, the intake of omega-3 fatty acids led to changes in the tumor’s fatty acid profile and reduced the release of certain inflammatory compounds. While we observed a reduction in malignancy-related characteristics and an increase in cancer cell death, normal cell growth remained unaffected.
Another intriguing finding was the significant decline in tumor fibrosis linked to lower levels of Sonic Hedgehog, a critical component involved in the tumor environment of pancreatic cancer. Overall, our findings highlight how omega-3 fatty acids may serve as a promising dietary intervention in managing pancreatic cancer.
We found that a diet supplemented with cod liver oil, which contains eicosapentaenoic acid and docosahexaenoic acid, significantly reduced tumor volume and limited metastasis to the lungs and liver. There was also a notable trend toward improved survival rates among the mice that received this treatment.
Notably, the intake of omega-3 fatty acids led to changes in the tumor’s fatty acid profile and reduced the release of certain inflammatory compounds. While we observed a reduction in malignancy-related characteristics and an increase in cancer cell death, normal cell growth remained unaffected.
Another intriguing finding was the significant decline in tumor fibrosis linked to lower levels of Sonic Hedgehog, a critical component involved in the tumor environment of pancreatic cancer. Overall, our findings highlight how omega-3 fatty acids may serve as a promising dietary intervention in managing pancreatic cancer.
Read More
9
DHA affects colorectal cancer pathways
Dietary polyunsaturated fatty acids affect PPARγ promoter methylation status and regulate the PPARγ/COX2 pathway in some colorectal cancer cell lines.
Study focuses on DHA's effects
We set out to explore how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects colorectal cancer (CRC) cells. In this study, we treated five different colorectal cancer cell lines with varying concentrations of DHA, along with other fatty acids like eicosapentaenoic acid (EPA) and linoleic acid (LA). This allowed us to see if DHA could impact the methylation patterns of the PPARγ promoter, a key player in cancer regulation, and affect the relationship between PPARγ and COX2, two important molecules involved in cancer growth.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
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9
Impact of Omega-3 on Cancer
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.
Highly relevant cancer treatment insights
We explored the effects of eicosapentaenoic acid, a type of omega-3 fatty acid, on pancreatic cancer using a specially designed mouse model that closely mimics human disease. This model allowed us to examine how adding omega-3 to the diet could impact cancer progression.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Read More
Most Useful Reviews
9.5
Improved health
Excellent. My wife has not healed from liver cancer, but the products I ordered from iherb.com, as recommended by our splendid doctor Antti Heikkilä, have made her much better and stronger. She now believes she might have more time to live, despite the oncologist stating in November 2010 that she had only two months left. Thanks to iherb.com and Antti Heikkilä for giving her more time.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 50 Researches
7.7
- All Researches
9.5
DHA shows promise against neuroblastoma
Ultra-High Dose Oral ω3 Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), or Oxidation-Resistant Deuterated DHA Block Tumorigenesis in a -Driven Neuroblastoma Model.
Strong relevance to DHA's effects
We conducted a study to explore the effects of docosahexaenoic acid (DHA) on tumor formation, particularly in a mouse model of neuroblastoma—a type of aggressive cancer in children. By using a syngeneic model, we gavaged wildtype mice with high doses of omega-3 fatty acids, including DHA, and then injected cancerous cells to monitor tumor development.
In our experiment, we noticed that while 50% of untreated control mice developed tumors, those receiving high doses of DHA or its oxidation-resistant form completely avoided tumor formation. This was quite striking and contrasts with our findings regarding arachidonic acid (ARA), which actually seemed to enhance tumor growth. Notably, when we combined ARA with EPA (another fatty acid), it led to a lower tumor burden, suggesting that DHA acts through a different, non-oxidative mechanism.
These results suggest that high-dose DHA may offer a promising, low-toxicity therapy option for neuroblastoma, paving the way for safer future treatments. It’s exciting to see the potential of omega-3 fatty acids in cancer prevention, especially given their safety and tolerability in humans over extended periods.
In our experiment, we noticed that while 50% of untreated control mice developed tumors, those receiving high doses of DHA or its oxidation-resistant form completely avoided tumor formation. This was quite striking and contrasts with our findings regarding arachidonic acid (ARA), which actually seemed to enhance tumor growth. Notably, when we combined ARA with EPA (another fatty acid), it led to a lower tumor burden, suggesting that DHA acts through a different, non-oxidative mechanism.
These results suggest that high-dose DHA may offer a promising, low-toxicity therapy option for neuroblastoma, paving the way for safer future treatments. It’s exciting to see the potential of omega-3 fatty acids in cancer prevention, especially given their safety and tolerability in humans over extended periods.
Read More
9.5
Omega-3 fatty acids inhibit tumors
Ultra-High Dose Oral ω3 Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), or Oxidation-Resistant Deuterated DHA Block Tumorigenesis in a -Driven Neuroblastoma Model.
Strong link to cancer treatment
We conducted a study to explore the effects of high doses of omega-3 fatty acids—specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—on tumor formation in a model of neuroblastoma, a challenging pediatric cancer. Using a syngeneic mouse model, we administered these fatty acids at doses equivalent to those safely tolerable in humans.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
Read More
9
Vitamin D enhances chemotherapy delivery
Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy.
Vitamin D's role in synergy
We explored the potential of vitamin D-based micelles designed to deliver paclitaxel, a key chemotherapy drug, specifically for pancreatic cancer treatment. This study focuses on developing enzyme-responsive micelles that not only carry paclitaxel but also utilize vitamin D as an integral part of the delivery system.
The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
Read More
9
Cod liver oil reduces pancreatic tumors
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.
High relevance to pancreatic cancer
Our research explored the effects of cod liver oil, rich in omega-3 fatty acids, on pancreatic cancer using a genetically engineered mouse model. This model mimics human pancreatic cancer biology, allowing us to gain insights relevant to real-world conditions.
We found that a diet supplemented with cod liver oil, which contains eicosapentaenoic acid and docosahexaenoic acid, significantly reduced tumor volume and limited metastasis to the lungs and liver. There was also a notable trend toward improved survival rates among the mice that received this treatment.
Notably, the intake of omega-3 fatty acids led to changes in the tumor’s fatty acid profile and reduced the release of certain inflammatory compounds. While we observed a reduction in malignancy-related characteristics and an increase in cancer cell death, normal cell growth remained unaffected.
Another intriguing finding was the significant decline in tumor fibrosis linked to lower levels of Sonic Hedgehog, a critical component involved in the tumor environment of pancreatic cancer. Overall, our findings highlight how omega-3 fatty acids may serve as a promising dietary intervention in managing pancreatic cancer.
We found that a diet supplemented with cod liver oil, which contains eicosapentaenoic acid and docosahexaenoic acid, significantly reduced tumor volume and limited metastasis to the lungs and liver. There was also a notable trend toward improved survival rates among the mice that received this treatment.
Notably, the intake of omega-3 fatty acids led to changes in the tumor’s fatty acid profile and reduced the release of certain inflammatory compounds. While we observed a reduction in malignancy-related characteristics and an increase in cancer cell death, normal cell growth remained unaffected.
Another intriguing finding was the significant decline in tumor fibrosis linked to lower levels of Sonic Hedgehog, a critical component involved in the tumor environment of pancreatic cancer. Overall, our findings highlight how omega-3 fatty acids may serve as a promising dietary intervention in managing pancreatic cancer.
Read More
9
Cod liver oil reduces tumor risk
Effects of dietary fat on benz-a-pyrene-induced forestomach tumorigenesis in mice chronically exposed to arsenic.
Study relevant to dietary effects
We explored how different dietary fats, particularly cod liver oil, might influence the development of tumors in the forestomach of mice exposed to arsenic and a known carcinogen, benz-a-pyrene. Over 28 weeks, groups of mice were given diets enriched with various oils, including corn oil, olein, palmstearin, and cod liver oil.
Interestingly, while arsenic alone didn’t lead to tumor formation, the addition of cod liver oil showed protective qualities. Mice on the cod liver oil diet had significantly fewer cases of epidermal hyperplasia, a precursor to tumors, compared to those on a mixed-fat diet. Furthermore, the formation of papillomas—or small tumor-like growths—was reduced in these mice, suggesting that cod liver oil may possess properties that hinder tumor development.
In contrast, the results for palmstearin and olein were more mixed and did not show the same protective effects. This highlights the potential of cod liver oil as a beneficial dietary inclusion for those concerned about cancer, especially in environments with exposure to harmful substances like arsenic and benz-a-pyrene.
Interestingly, while arsenic alone didn’t lead to tumor formation, the addition of cod liver oil showed protective qualities. Mice on the cod liver oil diet had significantly fewer cases of epidermal hyperplasia, a precursor to tumors, compared to those on a mixed-fat diet. Furthermore, the formation of papillomas—or small tumor-like growths—was reduced in these mice, suggesting that cod liver oil may possess properties that hinder tumor development.
In contrast, the results for palmstearin and olein were more mixed and did not show the same protective effects. This highlights the potential of cod liver oil as a beneficial dietary inclusion for those concerned about cancer, especially in environments with exposure to harmful substances like arsenic and benz-a-pyrene.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Improved health
Excellent. My wife has not healed from liver cancer, but the products I ordered from iherb.com, as recommended by our splendid doctor Antti Heikkilä, have made her much better and stronger. She now believes she might have more time to live, despite the oncologist stating in November 2010 that she had only two months left. Thanks to iherb.com and Antti Heikkilä for giving her more time.
Read More
